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Production of Ag-ZnO powders by hot mechanochemical processing

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Transactions of Nonferrous Metals Society of china 2019年第2期29卷 365-373页

作者： D.GUZMáN c.aguilar P.ROJAS J.M.cRIADO M.J.DIáNEZ R.ESPINOZA A.GUZMáN c.MARTíNEZ Departamento de Ingeniería en Metalurgia Universidad de Atacama Departamento de Ingeniería Metalúrgica y de Materiales Universidad Técnica Federico Santa María Escuela de Dise?o Universidad Adolfo Ibá?ez Instituto de ciencias de Materiales de Sevilla C.S.I.C Departamento de ciencia de los Materiales Universidad de Chile Laboratorio de corrosión Instituto de QuímicaPontificia Universidad Católica de Valparaíso

Ag–cdO composites are still one of the most commonly used electrical contact materials in low-voltage applications owing to their excellent electrical and mechanical ***,considering the restriction on using cd due to its toxicity,it is necessary to find alternative materials that can replace these *** this study,the synthesis of Ag-ZnO alloys from Ag-Zn solid solutions was investigated by hot mechanochemical *** hot mechanochemical processing was conducted in a modified attritor mill at 138℃under flowing O2 at 1200 cm3/min for 3.0 *** microstructure and phase evolution were investigated using X-ray diffractometry,field emission gun scanning electron microscopy and transmission electron *** results suggest that it is possible to complete the oxidation of Ag-Zn solid solution by hot mechanochemical processing at a low temperature and short *** novel synthesis route can produce Ag-ZnO composites with a homogeneous distribution of nanoscale ZnO precipitates,which is impossible to achieve using the conventional material processing *** the fact that the fundamental approach to improving electric contact material performance resides in obtaining uniform dispersion of the second-phase in the Ag matrix,this new processing route could open the possibility for Ag-ZnO composites to replace non-environmentally friendly Ag-cdO.

关键词： Ag-ZnO nanocomposite electrical contact material powder synthesis milling

新型硫烷硫化合物抑制尼帕假病毒感染肾脏细胞

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中华生物医学工程杂志 2018年第4期24卷 229-234页

作者：郑泽航徐彩媚王瑞雨石坤赖真真赵煜鲜明 Armando Pacheco Hector c.aguilar 李翔李娜杨春涛广州医科大学基础学院第三临床学院 511436 广州医科大学基础学院第二临床学院 511436 广州医科大学基础学院南山学院 511436 Department of chemistry Washington State UniversityPullmanWAUS Department of Microbiology and Immunology Cornell UniversityIthacaNYUS 广州医科大学基础学院生理教研室 511436

目的探讨新型硫烷硫(SS)化合物对尼帕病毒(NiV)感染肾脏细胞的影响。方法将编码NiV的粘附G蛋白和融合F蛋白基因以及荧光素报告基因导入质粒PcDNA3.1构建假病毒颗粒,用假病毒颗粒感染非洲绿猴肾脏细胞(Vero),模拟NiV感染机体细胞的过程... 详细信息

目的探讨新型硫烷硫(SS)化合物对尼帕病毒(NiV)感染肾脏细胞的影响。方法将编码NiV的粘附G蛋白和融合F蛋白基因以及荧光素报告基因导入质粒PcDNA3.1构建假病毒颗粒,用假病毒颗粒感染非洲绿猴肾脏细胞(Vero),模拟NiV感染机体细胞的过程。在细胞被感染前,用前期合成的3种含有类似结构的SS:c1、c2和c3,分别处理NiV假病毒颗粒,检测Vero细胞内病毒含量。在SS的抗病毒感染效果明确后,用L⁃半胱氨酸(L⁃cys)破坏c1的分子结构,而后观察L⁃cys对c1抗病毒效果的影响。在细胞被感染前,用不同浓度的c1预处理Vero细胞,观察c1对细胞防御病毒感染能力的影响。所有处理结束后,分别检测细胞内病毒含量和细胞活力。结果在2.5~20μmol/L浓度范围内,c1处理假病毒颗粒2 h可使NiV感染Vero细胞的能力呈剂量依赖性降低(r=-0.89,Pc2和c3对NiV感染Vero细胞的能力无明显影响(P>0.05)。L⁃cys通过破坏c1的分子结构,可使其抗病毒能力剂量依赖性的削弱(r=0.98,Pc1预处理Vero细胞30 min,细胞抵御NiV感染的能力未发生明显变化(P>0.05)。NiV假病毒颗粒单独或联用不同浓度c1对细胞的活力无明显影响(均P>0.05)。结论新型硫烷硫化合物c1可抑制NiV感染Vero细胞,其机制与独特分子结构诱导的病毒颗粒感染能力降低有关而非提高细胞的防御能力。

关键词：硫化氢硫烷硫病毒感染非洲绿猴肾细胞尼帕病毒

Neuroprotection by resveratrol-glucuronide and quercetin-glucuronide via binding to polyphenol-and glycosaminoglycan-binding sites in the laminin receptor

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Neural Regeneration Research 2025年第3期20卷 819-820页

作者： Rayudu Gopalakrishna Jennifer aguilar Emily Lee William J.Mack Department of Integrative Anatomical Sciences Keck School of MedicineUniversity of Southern CaliforniaLos AngelesCAUSA Department of Neurological Surgery Keck School of MedicineUniversity of Southern CaliforniaLos AngelesCAUSA

The dietary polyphenolic compounds resveratrol and quercetin prevent neurodegenerative diseases in experimental models;however, they reach the brain only in nanomolar concentrations in the glucuronidated and sulfated ... 详细信息

关键词： resveratrol molar dated

Dendritic spine degeneration:a primary mechanism in the aging process

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Neural Regeneration Research 2025年第6期20卷 1696-1698页

作者： Gonzalo Flores Leonardo aguilar-Hernández Fernado García-Dolores Humberto Nicolini Andrea Judith Vázquez-Hernández Hiram Tendilla-Beltrán Instituto de Fisiología Benemérita Universidad Autónoma de Puebla(BUAP)PueblaMexico Instituto de ciencias Forenses(INcIFO) Tribunal Superior de Justicia de la Ciudad de México(TSJCDMX).Mexico CityMexico Instituto Nacional de Medicina Genómica(INMEGEN) Mexico CityMexico

Recent reports suggest that aging is not solely a physiological process in living beings;instead, it should be considered a pathological process or disease(Amorim et al., 2022). consequently, this process involves a wide range of factors, spanning from genetic to environmental factors, and even includes the gut microbiome(GM)(Mayer et al., 2022). All these processes coincide at some point in the inflammatory process, oxidative stress, and apoptosis, at different degrees in various organs and systems that constitute a living organism(Mayer et al., 2022;aguilarHernández et al., 2023).

关键词： aging process stress

以cT为基础的总颅内容积的自动化分割与量化

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国际医学放射学杂志 2016年第1期 84-84页

作者： c.aguilar K.Edholm A.Simmons L.cavallin S.Muller I.Skoog 严陈晨 Department of Neurobiology Care Sciences and Society(NVS)Division of Clinical Geriatrics Karolinska Institute

摘要目的研究一种算法通过cT影像来分割和获得总颅内容积(t IcV)的估计值。材料与方法 18例病人共进行了36次cT检查。其中,10例病人在1天检查了2次,8例病人在6个月中检查了2次(这些病人同样进行了MRI检查)。该算法融合了形态学操作、强... 详细信息

摘要目的研究一种算法通过cT影像来分割和获得总颅内容积(t IcV)的估计值。材料与方法 18例病人共进行了36次cT检查。其中,10例病人在1天检查了2次,8例病人在6个月中检查了2次(这些病人同样进行了MRI检查)。该算法融合了形态学操作、强度阈值和混合模型。该方法对手工描绘进行了验证,其稳健性通过重复影像检查进行了评估。使用自动化的MRI软件,对MRI的相容性进行了研究。在平均相对容量差异和它们大小的基础上,对容量进行了比较;用Bland-Altman分析图显示了其一致性。结果在该算

关键词：颅内容积 IcV cT

额叶萎缩的视觉分级定量验证与临床状态、APOE e4、脑脊液生物学标志物和认知的相关性

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国际医学放射学杂志 2016年第5期 593-593页

作者： D.Ferreira L.cavallin T.Granberg O.Lindberg c.aguilar P.Mecocci 李顶夫 Division of clinical Geriatrics Center for Alzheimer Research Department of Neurobiology Care Sciences and SocietyKarolinska Institutet

摘要目的采用定量化影像验证额叶萎缩的视觉分级,并研究其与临床状况、APOE e4、脑脊液生物学标志物和认知损害的相关性。方法联合选取Add Neuro Med和ADNI队列研究中共329例健康对照者、421例轻度认知损害病人和286例阿尔茨海默病(AD)... 详细信息

摘要目的采用定量化影像验证额叶萎缩的视觉分级,并研究其与临床状况、APOE e4、脑脊液生物学标志物和认知损害的相关性。方法联合选取Add Neuro Med和ADNI队列研究中共329例健康对照者、421例轻度认知损害病人和286例阿尔茨海默病(AD)病人,另34例额颞叶痴呆(FTD)病人亦纳入本研究。在T1WI上对额叶萎缩以全球皮质萎缩

关键词：脑脊液生物学标志物临床状态 APOE e4 额叶大脑皮质相关性

Status and prospects for symmetric organic redox flow batteries

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Journal of Energy chemistry 2025年第1期100卷 125-143页

作者： Md Al Raihan c.Adam Dyker Department of chemistry University of New Brunswick

As environmental concerns from fossil fuel consumption intensify, large-scale energy storage becomes imperative for the integration of renewable sources like wind, hydro, and solar with the electrical *** flow batteries, particularly those employing organic molecules, are positioned as a key technology for this purpose. This review explores the growing field of symmetric organic redox flow batteries(ORFBs) within this context. Unlike traditional asymmetric designs based on unique active materials for each electrode, symmetric ORFBs involve a single bipolar species for both electrodes. This review highlights the benefits of a symmetric design, and categorizes five distinct classes of organic bipolar molecules used in both aqueous and non-aqueous solvents. By providing a comprehensive overview of their cell cycling and performance characteristics, the strengths and weaknesses of the diverse categories of bipolar molecules are highlighted for both solvent systems, as are opportunities for future development. This should guide new research directions and advance the development of practical symmetric ORFBs.

关键词： Redox flow battery Symmetric battery Organic battery Aqueous electrolyte Non-aqueous electrolyte

Acquired sensorineural hearing loss,oxidative stress,and microRNAs

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Neural Regeneration Research 2025年第9期20卷 2513-2519页

作者： Desmond A.Nunez Ru c.Guo Division of Otolaryngology–Head&Neck Surgery Department of SurgeryFaculty of MedicineThe University of British ColumbiaVancouverBCCanada Division of Otolaryngology–Head&Neck Surgery Gordon&Leslie Diamond Health Care CentreVancouver General HospitalVancouverBCCanada Faculty of Medicine–The University of British columbia VancouverBCCanada

Hearing loss is the third leading cause of human ***-related hearing loss,one type of acquired sensorineural hearing loss,is largely responsible for this escalating global health ***-induced,ototoxic,and idiopathic sudden sensorineural are other less common types of acquired hearing *** etiology of these conditions is complex and multi-fa ctorial involving an interplay of genetic and environmental *** stress has recently been proposed as a likely linking cause in most types of acquired sensorineural hearing *** non-coding RNA sequences known as microRNAs(miRNAs)have increasingly been shown to play a role in cellular hypoxia and oxidative stress responses including promoting an apoptotic *** hair cell death is a central histopathological finding in sensorineural hearing *** these cells do not regenerate in humans,it underlies the irreversibility of human age-related hearing *** EMBASE,Ovid MEDLINE,Web of Science core collection,and *** databases over the period August 1,2018 to July 31,2023 were searched with"hearing loss,""hypoxamiRs,""hypoxia,""microRNAs,""ischemia,"and"oxidative stress"text words for English language primary study publications or registered clinical *** red clinical trials known to the senior author we re also assessed.A total of 222studies were thus *** excluding duplicates,editorials,retra ctions,secondary research studies,and non-English language articles,39 primary studies and clinical trials underwent full-text *** resulted in 11 animal,in vitro,and/or human subject journal articles and 8 registered clinical trial database entries which form the basis of this narrative *** miR-34a and miR-29b levels increase with age in *** miRNAs were demonstrated in human neuroblastoma and murine cochlear cell lines to target Sirtuin 1/peroxisome proliferato r-activated receptor gamma coactivator-1-alpha(SIRT1/P Gc-1α),SIRT

关键词： hearing loss hypoxia microRNAs oxidative stress sensorineural

Multiple sclerosis is at a checkpoint: advancing the program

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Neural Regeneration Research 2025年第3期20卷 811-812页

作者： Brandon c.Smith Jessica L.Williams Department of Neurosciences Lerner Research InstituteCleveland ClinicClevelandOHUSA Department of Biological Geologicaland Environmental SciencesCleveland State UniversityClevelandOHUSA

Multiple sclerosis(MS) is a chronic inflammatory and demyelinating disease of the central nervous system(cNS). Patients with MS experience sensory and motor function loss due to myelin and/or axon damage perpetuated b... 详细信息

关键词： Hauser sclerosis damage