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国际医学放射学杂志 2021年第5期 609-609页

作者： P.M.Oestmann c.J.Wang L.J.Savic c.a.hamm S.Stark I.Schobert 陈小倩

摘要目的建立一种基于深度学习模型以区分经病理证实的肝细胞癌(Hcc)和非Hcc病变,Hcc包括MRI上具有不典型影像特征的病变。方法这项经伦理委员会批准的

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Transfer of Natural Micro Structures to Bionic Lightweight Design Proposals

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Journal of Bionic Engineering 2013年第4期10卷 469-478页

作者： M. Maier D. Siegel K.-D. Thoben N. Niebuhr c. hamm Alfred Wegener Institute for Polar and Marine Research Am Handelshafen 12 27570 Bremerhaven Germany Institute for Marine Resources GmbH Bussestr. 27 27570 Bremerhaven Germany University of Bremen Hoehschulring 20 28359 Bremen Germany

The abstraction of complex biological lightweight structure features into a producible technical component is a funda- mental step within the transfer of design principles from nature to technical lightweight solutions. A major obstacle for the transfer of natural lightweight structures to technical solutions is their peculiar geometry. Since natural lightweight structures possess irregularities and often have extremely complex forms due to elaborate growth processes, it is usually necessary to simplify their design principles. This step of simplification/abstraction has been used in different biomimetic methods, but so far, it has an arbitrary component, i.e. it crucially depends on the competence of the person who executes the abstraction. This paper describes a new method for abstraction and specialization of natural micro structures for technical lightweight compo- nents. The new method generates stable lightweight design principles by using topology optimization within a design space of preselected biological archetypes such as diatoms or radiolarian. The resulting solutions are adapted to the technical load cases and production processes, can be created in a large variety, and may be further optimized e.g. by using parametric optimization.

关键词： biomimetic finite elements design space design principle topology optimization parametric optimization dia- toms radiolarian

Efficacy ＆ Mechanism of Action of Aqueous Dandelion Root Extract Against Human cancers

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Efficacy ＆ Mechanism of Action of Aqueous Dandelion Root Ex...

The landscape epidemiology of echinococcoses

第十四届全国中药和天然药物学术研讨会

作者： P.Ovadje A.Saleem JT.Arnason c.hamm S.Pandey University of Windsor

＜正＞While more than 60%of anticancer drugs are derived from natural compounds,very little is known about the efficacy of natural extracts（complex mixtures）in cancer *** natural health products may offer a safer,no...

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Infectious Diseases of Poverty 2016年第1期5卷 107-119页

作者： Angela M.cadavid Restrepo Yu Rong Yang Donald P.McManus Darren J.Gray Patrick Giraudoux Tamsin S.Barnes Gail M.Williams Ricardo J.Soares Magalhães Nicholas A.S.hamm Archie c.A.clements Research School of Population Health The Australian National UniversityCanberraNew South WalesAustralia Ningxia Medical University YinchuanNingxia Hui Autonomous RegionP.R.China Molecular Parasitology Laboratory QIMR Berghofer Medical Research InstituteBrisbaneQueenslandAustralia chrono-environment lab UMR6249University of Bourgogne Franche-Comté/CNRSBesançonFrance Institut Universitaire de France ParisFrance The University of Queensland School of Veterinary ScienceGattonQueenslandAustralia The University of Queensland Queensland Alliance for Agriculture and Food InnovationGattonQueenslandAustralia School of Public Health The University of QueenslandBrisbaneQueenslandAustralia child Health Research centre The University of QueenslandBrisbaneQueenslandAustralia Faculty of Geo-Information Science and Earth Observation(ITc) University of TwenteEnschedeThe Netherlands

Echinococcoses are parasitic diseases of major public health importance *** infection results in chronic disease with poor prognosis and serious medical,social and economic consequences for vulnerable *** to recent estimates,the geographical distribution of Echinococcus *** is expanding and becoming an emerging and re-emerging problem in several regions of the *** endemicity is geographically heterogeneous and over time it may be affected by global environmental ***,landscape epidemiology offers a unique opportunity to quantify and predict the ecological risk of infection at multiple spatial and temporal ***,we review the most relevant environmental sources of spatial variation in human echinococcosis risk,and describe the potential applications of landscape epidemiological studies to characterise the current patterns of parasite transmission across natural and human-altered *** advocate future work promoting the use of this approach as a support tool for decision-making that facilitates the design,implementation and monitoring of spatially targeted interventions to reduce the burden of human echinococcoses in disease-endemic areas.

关键词： Landscape epidemiology Helminth infection Human echinococcosis Echinococcus spp Environmental change Geographic information systems Remote sensing Geostatistics

窄波UVB311nm与宽波UVB疗法联合局部外用钙泊三醇与安慰剂治疗白癜风的比较研究

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世界核心医学期刊文摘（皮肤病学分册） 2006年第1期2卷 3-4页

作者： Hartmann A Lurz c hamm H 焦婷 Department of Dermatology and Venereology University of Würzburg Josef-Schneider-Str. 2 97080 Würzburg Germany.Dr

Background: Recently, it has been shown that UVB phototherapymay bemore effect ive than UVA in the treatment of vitiligo. currently, however, no studies have c ompared the efficacy of UVB 311 nm and broad-band UVB therapy. calcipotriol has recently been reported to be effective adjunctive treatment for vitiligo, enhan cing the efficacy of 8-methoxypsoralen plus UVA (PUVA) therapy. Methods: Ten pa tients were enrolled in the study; nine completed the 12 months of therapy. The upper part of the body was treated twice weekly with UVB 311 nm and the lower pa rt with broad-band UVB. calcipotriolwas applied onto the vitiligo lesions of th e right side of the body and placebo on the left side. Repigmentation was docume nted by photography, planimetry, and Vitiligo Disease Activity (VIDA) score. The quality of life was measured by the Dermatology Life Quality Index (DLQI). Resu lts: After 7-16 weeks, six of the nine patients showed initial repigmentation o n the side treated with UVB311 nm. After 6 months of treatment, none of the patients showed repigmentation on the areas treated wit h broad-band UVB, which prompted us to apply UVB 311 nm all over the body. At t he end of 12 months, two patients showed > 75%repigmentation, two showed 51-75 %, two showed 26-50%, and three showed 0-25%. In all patients with progress ive vitiligo (seven of the nine patients), disease activity was stopped. Remarka bly, vitiligo lesions treated with calcipotriol initially showed delayed repigme ntation compared with control areas; however, there was no therapeutic differenc e between calcipotriol and placebo, both in combination with UVB 311 nm, by the end of the *** DLQI score improved significantly by an average of 28%. co nclusion: UVB 311 nm therapy was effective in the treatment of vitiligo, whereas broad-band UVB had no effect. combination with calcipotriol ointment was not s uperior to UVB 311 nm *** quality of life significantly improved wit h narrow-band UVB 311 nm p

关键词：钙泊三醇 UVB311nm 安慰剂甲氧补骨脂素复色光疗法生存质量疾病活动度照相术

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c5烯烃的各种加工方案比较

石油炼制译丛 1992年第1期 26-31页

作者：蔡庆琪 hamm.,HU

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创新道路上的失误

商业周刊（中文版） 2007年第1期 62-67页

作者：史蒂夫·哈姆（Sreve hamm）威廉·西蒙兹（wilham c.Symonds））卢欣（译者）

在首席执行官安东尼奥·佩雷斯的领导下，柯达公司正在想方设法重新塑造自己的商业模式。

关键词：道路柯达公司首席执行官安东尼奥商业模式佩雷斯企业

Assessing the Malignancy of Hepataocellular carcinoma in cirrhosis Using the Hepatocellular contrast Agent Gd-EOB-DTPA and correlation with the cytometric DNA Index

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Advances in Molecular Imaging 2013年第1期3卷 1-7页

作者： R.Rottgen S.Kobi c.Grieser F.Streitparth H.Al-Abadi A.Duerr W.Faber J.Pratschke P.Neuhaus B.hamm L.Ludemann Klinik fur Radiologie Charite’Campus Virchow Augustenburger Platz 1BerlinGermany Klinik fur Allgemein-Visceral-und Transplantationschirurgie Charite’Campus Virchow Augustenburger Platz 1BerlinGermany Klinik fur Visceral- Transplantations-und ThoraxchirurgieUniversitatsklinikum InnsbruckInnsbruckAustria Abteilung fur Strahlenphysik Universitatsklinikum EssenEssenGermany

Aim: Investigation whether the signal intensity of hepatocellular carcinoma (Hcc) on dynamic magnetic resonance imaging (MRI) with hepatocellular contrast medium (cM) correlates with the histologic malignancy grade and cytometric DNA index. Material and Methods: MRI at 1.5 T with hepatocellular cM Gd-DTPA-EOB of 63 patients (52 men, 11 women;64.0 ± 8.5 years) with Hcc in cirrhosis. SI of the tumor and liver tissue in sequences (T1, T1fs, T2fs, T1fs + cM (arterial, venous, late venous phase) were correlated like the asymmetry coefficient of the SI in the arterial and venous phases respective the native and late venous phases of the tumor with the histologic malignancy grade and DNA index indicating the grade of abnormal DNA steam line respective aneuploid DNA. Results: SI did not significantly correlate with the histologic malignancy grade or DNA index for precontrast or postcontrast images. There is a significant correlation for the asymmetry coefficient of the SI in the arterial and venous phases with the DNA-index (p values of 0.00089 (Pearson) and 0.0082 (Spearman). conclusion: A highly arterialized hepatocellular carcinoma with rapid washout in the venous phase corresponds to a higher malignant potential. These findings suggest that the MR parameters investigated here may predict the malignant potential and prognosis of Hcc before surgery.

关键词： Hepatocellular carcinoma DNA Index DNA cytometry Malignancy Grading

巴西诺卡菌致腿部溃疡及结节性淋巴管炎(法国)

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世界核心医学期刊文摘（皮肤病学分册） 2005年第12期1卷 34-35页

作者： hamm M. Friedel J. Siré c. Semon J. 罗素菊 Unité de Dermatologie Centre HospitalierWilliamMorey 7 quai de l' Hpital 71321 Chalon- sur- Sane Cedex France

Introduction. Nocardia brasiliensis is a very rarely reported cause of chronic phagedenic ulcerations. We report the case of an elderly woman who developed such an infection after falling on her right leg on the road in the Bresse country (an essentially agricultural and bovine- cattle breading region) and developed a chronic phagedenic ulcer secondarily complicated by nodular lymphangitis of the thigh. case report. A 75 year- old woman fell on her right leg on the side of themain road outside her hamlet in the Bresse country and secondarily developed a chronique phagedenic ulceration. We first considered her as suffering from pyoderma gangrenosum. A complete scanning only revealed an autoimmune thyroiditis and a rapidly healing gastric ulceration, and none of the treatments, either local or systemic, helped the skin condition to heal. After 3 weeks of application of a local corticoid ointment, the patient developed fever, general malaise, an exacerbation of her wound and an infiltration of the skin round her knee, together with nodular lymphangitic dissemination. A supplementary bacterial swab disclosed massive proliferation of a slow- growing Gram- positive bacillus, which proved to be Nocardia brasiliensis, together with a methicillino- sensitive Staphylococcus aureus. The treatment with sulfamethoxazole- trimetoprim gave a rash after 12 hours and was changed to amoxicillin and clavulanic acid, which rapidly proved to be permanently effective. Discussion. The revelation of this particular slow- growing bacteria is difficult and requires bacterial swabs. Nocardia brasiliensis is relatively rare in primary skin ulcerations andwe discuss the reasons why an elderly women should find this bacteria on the road outside her hamlet in the French countryside. This particular infectious condition requires general scanning, to make sure that the primary skin condition does not extend to other organs. We review the therapeutical options for patients who exhibit allergic react

关键词：淋巴管炎巴西诺卡菌结节性坏疽性脓皮病皮质激素软膏病原菌感染全身检查革兰阳性杆菌炎性浸润股部

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应用320层螺旋cT冠状动脉成像减少对比剂剂量的可行性研究

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国际医学放射学杂志 2010年第4期 402-403页

作者： P.A.Hein J.May P.Rogalla c.Butler B.hamm A.Lembcke 庞国栋 Department of Radiology Charité-University HospitalCampus MitteCharitéplatz 110117 BerlinGermany

目的利用320层cT单心动周期心脏成像时,评估减少对比剂剂量对于冠状动脉成像质量的影响。材料与方法选取40例男性病人进行冠状动脉cT成像(ccTA),体质量≤85kg,心率

关键词：冠状动脉成像对比剂螺旋 ccTA 剂量用药量 cT