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Acquired sensorineural hearing loss,oxidative stress,and microRNAs

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Neural Regeneration Research 2025年第9期20卷 2513-2519页

作者： Desmond A.Nunez Ru c.Guo Division of Otolaryngology–Head&Neck Surgery Department of SurgeryFaculty of MedicineThe University of British ColumbiaVancouverBCCanada Division of Otolaryngology–Head&Neck Surgery Gordon&Leslie Diamond Health Care CentreVancouver General HospitalVancouverBCCanada Faculty of Medicine–The University of British columbia VancouverBCCanada

Hearing loss is the third leading cause of human ***-related hearing loss,one type of acquired sensorineural hearing loss,is largely responsible for this escalating global health ***-induced,ototoxic,and idiopathic sudden sensorineural are other less common types of acquired hearing *** etiology of these conditions is complex and multi-fa ctorial involving an interplay of genetic and environmental *** stress has recently been proposed as a likely linking cause in most types of acquired sensorineural hearing *** non-coding RNA sequences known as microRNAs(miRNAs)have increasingly been shown to play a role in cellular hypoxia and oxidative stress responses including promoting an apoptotic *** hair cell death is a central histopathological finding in sensorineural hearing *** these cells do not regenerate in humans,it underlies the irreversibility of human age-related hearing *** EMBASE,Ovid MEDLINE,Web of Science core collection,and *** databases over the period August 1,2018 to July 31,2023 were searched with"hearing loss,""hypoxamiRs,""hypoxia,""microRNAs,""ischemia,"and"oxidative stress"text words for English language primary study publications or registered clinical *** red clinical trials known to the senior author we re also assessed.A total of 222studies were thus *** excluding duplicates,editorials,retra ctions,secondary research studies,and non-English language articles,39 primary studies and clinical trials underwent full-text *** resulted in 11 animal,in vitro,and/or human subject journal articles and 8 registered clinical trial database entries which form the basis of this narrative *** miR-34a and miR-29b levels increase with age in *** miRNAs were demonstrated in human neuroblastoma and murine cochlear cell lines to target Sirtuin 1/peroxisome proliferato r-activated receptor gamma coactivator-1-alpha(SIRT1/P Gc-1α),SIRT

关键词： hearing loss hypoxia microRNAs oxidative stress sensorineural

Multiple sclerosis is at a checkpoint: advancing the program

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Neural Regeneration Research 2025年第3期20卷 811-812页

作者： Brandon c.Smith Jessica L.Williams Department of Neurosciences Lerner Research InstituteCleveland ClinicClevelandOHUSA Department of Biological Geologicaland Environmental SciencesCleveland State UniversityClevelandOHUSA

Multiple sclerosis(MS) is a chronic inflammatory and demyelinating disease of the central nervous system(cNS). Patients with MS experience sensory and motor function loss due to myelin and/or axon damage perpetuated b... 详细信息

关键词： Hauser sclerosis damage

Ultra‑Transparent and Multifunctional IZVO Mesh Electrodes for Next‑Generation Flexible Optoelectronics

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Nano-Micro Letters 2025年第1期17卷 293-309页

作者： Kiran A.Nirmal Tukaram D.Dongale Atul c.Khot chenjie Yao Nahyun Kim Tae Geun Kim School of Electrical Engineering Korea UniversityAnam‑ro 145Seongbuk‑guSeoulRepublic of Korea computational Electronics and Nanoscience Research Laboratory School of Nanoscience and BiotechnologyShivaji UniversityKolhapur 416004India

Mechanically durable transparent electrodes are essential for achieving long-term stability in flexible optoelectronic ***,they are crucial for applications in the fields of energy,display,healthcare,and soft *** meshes represent a promising alternative to traditional,brittle,metal oxide conductors due to their high electrical conductivity,optical transparency,and enhanced mechanical *** this paper,we present a simple method for fabricating an ultra-transparent conducting metal oxide mesh electrode using selfcracking-assisted *** this method,we produced an electrode with ultra-transparency(97.39%),high conductance(Rs=21.24Ωsq^(−1)),elevated work function(5.16 eV),and good mechanical *** also evaluated the effectiveness of the fabricated electrodes by integrating them into organic photovoltaics,organic light-emitting diodes,and flexible transparent memristor devices for neuromorphic computing,resulting in exceptional device *** addition,the unique porous structure of the vanadium-doped indium zinc oxide mesh electrodes provided excellent flexibility,rendering them a promising option for application in flexible optoelectronics.

关键词： Self-cracking template Vanadium-doped indium zinc oxide mesh Organic solar cells Organic light-emitting diodes Flexible transparent memory

Machine learning empowers efficient design of ternary organic solar cells with PM6 donor

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Journal of Energy chemistry 2025年第1期100卷 337-347页

作者： Kiran A.Nirmal Tukaram D.Dongale Santosh S.Sutar Atul c.Khot Tae Geun Kim School of Electrical Engineering Korea University computational Electronics and Nanoscience Research Laboratory School of Nanoscience and Biotechnology Shivaji University Yashwantrao chavan School of Rural Development Shivaji University

Organic solar cells(OScs) hold great potential as a photovoltaic technology for practical ***, the traditional experimental trial-and-error method for designing and engineering OScs can be complex, expensive, and time-consuming. Machine learning(ML) techniques enable the proficient extraction of information from datasets, allowing the development of realistic models that are capable of predicting the efficacy of materials with commendable accuracy. The PM6 donor has great potential for high-performance OScs. However, it is crucial for the rational design of a ternary blend to accurately forecast the power conversion efficiency(PcE) of ternary OScs(TOScs) based on a PM6 ***, we collected the device parameters of PM6-based TOScs and evaluated the feature importance of their molecule descriptors to develop predictive models. In this study, we used five different ML algorithms for analysis and prediction. For the analysis, the classification and regression tree provided different rules, heuristics, and patterns from the heterogeneous dataset. The random forest algorithm outperforms other prediction ML algorithms in predicting the output performance of PM6-based TOScs. Finally, we validated the ML outcomes by fabricating PM6-based TOScs. Our study presents a rapid strategy for assessing a high PcE while elucidating the substantial influence of diverse descriptors.

关键词： Random forests

Interplay between HEAT SHOcK PROTEIN 90 and HY5 controls PhANG Expression in Response to the GUN5 Plastid Signal

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Molecular Plant 2012年第4期5卷 901-913页

作者： Peter Kindgren Louise Noren Juan de Dios barajas Lopez Jehad Shaikhali Asa Strand Umea Plant Science centre Department of Plant Physiology Umea University S-901 87 Umea Sweden

The presence of genes encoding organellar proteins in different cellular compartments necessitates a tight coordination of expression by the different genomes of the eukaryotic cell. This coordination of gene expression is achieved by organelle-to-nucleus or retrograde communication. Stress-induced perturbations of the tetrapyrrole pathway trigger large changes in nuclear gene expression in plants. Recently, we identified HSP90 proteins as ligands of the pu- tative plastid signal Mg-ProtolX. In order to investigate whether the interaction between HSP90 and Mg-ProtolX is bio- logically relevant, we produced transgenic lines with reduced levels of cytosolic HSP90 in wild-type and gun5 backgrounds. Our work reveals that HSP90 proteins respond to the tetrapyrrole-mediated plastid signal to control expres- sion of photosynthesis-associated nuclear genes （PhANG） during the response to oxidative stress. We also show that the hy5 mutant is insensitive to tetrapyrrole accumulation and that Mg-ProtolX, cytosolic HSP90, and HY5 are all part of the same signaling pathway. These findings suggest that a regulatory complex controlling gene expression that includes HSP90 proteins and a transcription factor that is modified by tetrapyrroles in response to changes in the environment is evolutionarily conserved between yeast and plants.

关键词： abiotic/environmental stress cell signaling organelle biogenesis/function.

Scalability of biomass-derived graphene derivative materials as viable anode electrode for a commercialized microbial fuel cell: A systematic review

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chinese Journal of chemical Engineering 2023年第3期55卷 277-292页

作者： Mustapha Omenesa Idris claudia Guerrero-barajas Hyun-chul Kim Asim Ali Yaqoob Mohamad Nasir Mohamad Ibrahim School of chemical Sciences Universiti Sains Malaysia11800 PenangMalaysia Department of Pure and Industrial chemistry Kogi State UniversityP.M.B 1008 AnyigbaKogi StateNigeria Laboratorio de Biotecnologia Ambiental Departamento de BioprocesosUnidad Profesional Interdisciplinaria de BiotecnologiaInstituto Politecnico NacionalAv.Acueducto s/nCol.Barrio La Laguna Ticoman07340 Mexico CityMexico Research Institute for Advanced Industrial Technology College of Science and TechnologyKorea UniversitySejong 30019Republic of Korea

Microbial fuel cell(MFc) is an advanced bioelectrochemical technique that can utilize biomass materials in the process of simultaneously generating electricity and biodegrading or bio transforming toxic pollutants from wastewater. The overall performance of the system is largely dependent on the efficiency of the anode electrode to enhance electron transportation. Furthermore, the anode electrode has a significant impact on the overall cost of MFc setup. Hence, the need to explore research focused towards developing cost-effective material as anode in MFc. This material must also have favourable properties for electron transportation. Graphene oxide(GO) derivatives and its modification with nanomaterials have been identified as a viable anode material. Herein, we discussed an economically effective strategy for the synthesis of graphene derivatives from waste biomass materials and its subsequent fabrication into anode electrode for MFc applications. This review article offers a promising approach towards replacing commercial graphene materials with biomass-derived graphene derivatives in a view to achieve a sustainable and commercialized MFc.

关键词： Microbial fuel cell Biomass Anode fabrication catalyst Design cost-effective performance

Management of cancer patients during cOVID-19 pandemic at developing countries

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World Journal of clinical cases 2020年第16期8卷 3390-3404页

作者： Jaime González-Montero Guillermo Valenzuela Mónica Ahumada Olga barajas Luis Villanueva Department Faculty of MedicineUniversity of ChileSantiago 70058Chile Department Hospital Clinico Universidad de Chile and Clínica DávilaChile Department Hospital Clinico Universidad de Chile and Fundación Arturo López-PérezChile Department Hospital Clínico Universidad de Chile and Fundación Arturo López-PerezChile

cancer patient care requires a multi-disciplinary approach and multiple medical and ethical *** care during a pandemic health crisis requires prioritising the use of resources for patients with a greater chance of survival,especially in developing *** coronavirus disease 2019 crisis has generated new challenges given that cancer patients are normally not prioritised for admission in critical care ***,the development of new cancer drugs and novel adjuvant/neoadjuvant protocols has dramatically improved the prognosis of cancer patients,resulting in a more complex decision-making when prioritising intensive care in pandemic *** this context,it is essential to establish an effective and transparent communication between the oncology team,critical care,and emergency units to make the best decisions,considering the principles of justice and ***,cancer treatment protocols must be adapted to prioritise according to oncologic response and *** technologies are powerful tools to optimise cancer care during pandemics,and we must adapt quickly to this new scenario of clinical care and *** this new challenging pandemic scenario,multi-disciplinary work and effective communication between clinics,technology,science,and ethics is the key to optimising clinical care of cancer patients.

关键词： cancer Oncology Pandemic cOVID-19 SARS-coV-2

A functional tacrolimus-releasing nerve wrap for enhancing nerve regeneration following surgical nerve repair

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Neural Regeneration Research 2025年第1期20卷 291-304页

作者： Simeon c.Daeschler Katelyn J.W.So Konstantin Feinberg Marina Manoraj Jenny cheung Jennifer Zhang Kaveh Mirmoeini JPaul Santerre Tessa Gordon Gregory HBorschel SickKids Research Institute Neuroscience and Mental Health ProgramTorontoONCanada Institute of Biomaterials and Biomedical Engineering University of TorontoTorontoONCanada Indiana University School of Medicine IndianapolisINUSA Division of Plastic and Reconstructive Surgery the Hospital for Sick ChildrenTorontoONCanada Translational Biology and Engineering Program Ted Rogers Centre for Heart ResearchInstitute of Biomedical EngineeringFaculty of DentistryUniversity of TorontoTorontoONCanada

Axonal regeneration following surgical nerve repair is slow and often incomplete,resulting in poor functional recovery which sometimes contributes to lifelong ***,there are no FDA-approved therapies available to promote nerve *** accelerates axonal regeneration,but systemic side effects presently outweigh its potential benefits for peripheral nerve *** authors describe herein a biodegradable polyurethane-based drug delivery system for the sustained local release of tacrolimus at the nerve repair site,with suitable properties for scalable production and clinical application,aiming to promote nerve regeneration and functional recovery with minimal systemic drug *** is encapsulated into co-axially electrospun polycarbonate-urethane nanofibers to generate an implantable nerve wrap that releases therapeutic doses of bioactive tacrolimus over 31 *** and drug loading are adjustable for applications in small and large caliber nerves,and the wrap degrades within 120 days into biocompatible *** released from the nerve wrap promotes axon elongation in vitro and accelerates nerve regeneration and functional recovery in preclinical nerve repair models while off-target systemic drug exposure is reduced by 80%compared with systemic *** its surgical suitability and preclinical efficacy and safety,this system may provide a readily translatable approach to support axonal regeneration and recovery in patients undergoing nerve surgery.

关键词： biodegradable local drug delivery nerve injury nerve regeneration nerve wrap tacrolimus

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遗传性短QT综合征的研究进展

中华心血管病杂志 2019年第5期47卷 413-416页

作者：石少波 Hector barajas-Martinez 胡丹武汉大学人民医院心内科武汉大学心血管病研究所心血管病湖北省重点实验室 430060 美国宾夕法尼亚州温纽伍德市兰肯瑙医学研究所 19096

短QT综合征是以QT间期缩短、心脏性猝死高风险为特征的遗传性心脏离子通道病。它属于常染色体显性遗传,发病罕见,与编码钾通道和钙通道的基因突变有关,基因突变导致的IKr、IKs、IK1增大和Ica,L功能丢失,使净外向电流增加或内向电流减少... 详细信息

短QT综合征是以QT间期缩短、心脏性猝死高风险为特征的遗传性心脏离子通道病。它属于常染色体显性遗传,发病罕见,与编码钾通道和钙通道的基因突变有关,基因突变导致的IKr、IKs、IK1增大和Ica,L功能丢失,使净外向电流增加或内向电流减少,复极加速,动作电位时程缩短和复极离散度增加,最终触发室性心动过速/心室颤动(VT/VF)。植入式心脏复律除颤器是唯一有效的防治心脏性猝死的手段,奎尼丁和索他洛尔通过延长有效不应期和QT间期,可有效预防VT/VF。

关键词：短QT综合征心脏性猝死流行病学