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The inducible nitric oxide synthaseinhibitor 1400W as a potential treatment for retinal diseases

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Neural Regeneration Research 2021年第6期16卷 1221-1222页

作者： sven schnichels stephanie c.Joachim University Eye Hospital Tübingen Centre for OphthalmologyTübingenGermany Experimental Eye Research Institute University Eye HospitalRuhr-University BochumBochumGermany

The overproduction of reactive oxygen species is defined as oxidative *** deprived oxygen supply in tissues is known as *** mec.a.isms contribute to the pathogenesis of several retinal diseases,like glaucoma,age-related macular degeneration(AMD),and retinal *** is a neurodegenerative disease defined by a progressive loss of retinal ganglion cells(RGcs)and their axons causing visual field defects,which ultimately leads to *** AMD pathogenesis is further c.a.acterized by soft drusen,it involves the retinal pigment epithelium and the Bruch’s membrane-choroid complex.

关键词： AMD diseases potential

sENsITIVITY OF DARcY's LAW TO DIscONTINUITIEs

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chinese Annals of Mathematics,series B 2003年第2期24卷 205-214页

作者： c.BERNARDI O.pIRONNEAU Laboratoie Jacques-Louis Lions Universite Paris VI-CNRSFrance.Laboratorie Jacques-Louis LionsUniversite Paris VI-IUFFrance.

The authors investigate the sensitivity of hydrostatic pressure of flows through porous media with respect to the position of the soil layers. Indeed, these induce discontinuities of the porosity which is a piecewise constant coefficient K of the partial differential equation satisfied by the pressure u and it leads to the computation of the derivative of u with respect to c.a.ges in position of discontinuity surface of K.The analysis relies on a mixed formulation of the problem. preliminary numerical simulations are given to illustrate the theory. An application to a simple inverse problem is also given.

关键词： partial differential equations Flow through porous media sensitivity Darcy's equation Topological optimization

Glaucoma-like damage induced by s100B injection is accompanied by microglial response

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Neural Regeneration Research 2022年第3期17卷 572-574页

作者： Teresa Tsai stephanie c.Joachim Experimental Eye Research Institute University Eye HospitalRuhr-University BochumBochumGermany

Glaucoma is currently the second leading cause of blindness *** to aging societies the number of patients suffering from this disease will further increase in the next ***,glaucoma can remain asymptomatic until it is rather far progressed,hence about 10–50% of patients are unaware they suffer from this *** is a progressive optic neuropathy assoc.a.ed with c.a.ges at the optic nerve head.

关键词： s100B injection damage

A techno-economic.a.sessment for viability of some waste as cooling pads in evaporative cooling system

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International Journal of Agricultural and Biological Engineering 2015年第2期8卷 151-158页

作者： Mac.a.us c Ndukwu seth I Manuwa Department of Agricultural and Bio Resources Engineering College of Engineering and Engineering TechnologyMichael Okpara University of Agriculture UmudikeP.M.B.7267 Umuahia Abia StateNigeria Department of Agricultural Engineering School of Engineering and Engineering Technology Federal University of Technology AkureP.M.B.704 AkureOndo StateNigeria

The viability of some waste as cooling pads for evaporative cooling application in south-Western Nigeria was experimentally *** is to ascertain their effectiveness as a substitute for costly imported pads in a low income *** presented was the feasibility of utilizing standalone evaporative coolers for storage and selling of fruits in south-Western *** ambient air was forced through the various pads at three different fan speeds and constant cooling pad thickness of 30 *** c.a.acteristics were considered based on daily analysis using temperature and humidity data measured from morning to evening at location co-ordinates latitude 7°10′N and longitude 5°05′E for 6 *** daily temperature T and humidity h ranged between 26℃≤T≤45℃ and 28%≤h_(2)≤80%.Temperature differenceDT and humidity differenceDh of 0.6℃≤ΔT≤18.3℃ and 1.0%≤Δh≤53%was achieved for the four cooling pad materials tested at three fan *** andDh was recorded at fan speed of 4 m/s with shredded latex foam and jute sack *** cooling efficiency(η)calculated for all the pads under the three speeds ranged from 17.3%≤η≤98.8%.payback period(pBp)analysis indicated the considered EVc is economically feasible and investors will break even in 1.75 years.

关键词： evaporative cooling agricultural residues passive cooling cooling effectiveness cooling pads

seismic wave velocities of rare gas solids through elastic properties in Earth's lower mantle

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science china Earth sciences 2009年第10期52卷 1599-1611页

作者： seema GUpTA suresh c. GOYAL Department of physics Agra College Faculty of Engineering and Technology Raja Balwant Singh College

The expressions for second (sOE) and third order elastic (TOE) constants for rare gas solids are derived for comparative study of elastic behavior within the framework of many body potentials including the effect of p... 详细信息

关键词： elastic properties seismic wave velocities RGs

perturbations in the uterine luminal fluid composition are detrimental to pregnancy establishment in cattle

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Journal of Animal science and Biotechnology 2019年第1期10卷 56-66页

作者： Thiago Martins Guilherme pugliesi Mariana sponchiado Angela M.Gonella-Diaza Oscar A.Ojeda-Rojas Frederich D.Rodriguez Roney s.Ramos Andrea c.Basso Mario Binelli Department of Animal Reproduction School of Veterinary Medicine and Animal ScienceUniversity of Sao Paulo Department of Nutrition and Animal production School of Veterinary Medicine and Animal ScienceUniversity of Sao Paulo University corporation of Huila ABs Global In Vitro Brasil Department of Animal sciences University of Florida

Background: A major,unresolved issue is how the uterine microenvironment determines pregnancy success in *** implantation,conceptus development depends on the uterine secretome(i.e.,histotroph).Despite its pivotal role,little is known about the dynamics of histotroph synthesis and c.a.ges in composition throughout the early diestrus and the relevance to pregnancy *** hypothesize that disturbances on histotroph composition affect the establishment of *** was to disturb histotroph composition at early diestrus and verify the effects on:(Exp.1) timing to restore its composition; and(Exp.2) pregnancy rate after multiple-embryo *** cycle of multiparous Nelore cows were synchronized and estrus was considered d 0(D0) of the *** was through flushing each uterine horn with 30 m L of DMpBs and collecting the resulting uterine luminal flushing(ULF) on D1; D4; D7; D1 + D4 + *** group remained *** Exp.1,ULF was collected on D7.5 from all animals and used for quantification of total protein concentration and abundance of *** Exp.2,three in vitro-produced embryos were transferred to the uterine horn ipsilateral to the ovary containing the cL on D7.5 and pregnancy was checked on D25 by ***: In Exp.1,ULF collection on D4 or D7 increased(1.5-to 2.2-folds) the total protein concentration and albumin *** collection on D1 did not alter(p > 0.10) these *** Exp.2,ULF collected on D4 or D7 decreased pregnancy rates to approximately half of that measured in the remaining ***: subtle perturbations imposed to the native intrauterine milieu,such as those caused by a single,low-volume collection of ULF,profoundly disturbs intrauterine composition and pregnancy *** least 4 d were necessary for the uterus to recover its composition and the functional capacity to carry post-implantation gestation.

关键词： Albumin Embryo Histotroph protein

Functional Divergence between subgenomes anc Gene pairs after Whole Genome Duplications

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Molecular plant 2018年第3期11卷 388-397页

作者： Zhikai Liang James c. schnable plant science innovation & Department of Agronomy and Horticulture University of Nebraska-Lincoln Lincoln NE 68503 USA

Gene loss following whole genome duplication （WGD） is often biased, with one subgenome retaining more ancestral genes and the other sustaining more gene deletions. While bias toward the greater expression of gene copies on one subgenome can explain bias in gene loss, this raises the question to what drives differences in gene expression levels between subgenomes. Differences in chromatin modifications and epigenetic markers between subgenomes in several model species are now being identified, providing an explanation for bias in gene expression between subgenomes. WGDs can be c.a.sified into duplications with higher, biased gene loss and bias in gene expression between subgenomes versus those with lower, unbiased rates of gene loss and an absence of detec.a.le bias between subgenomes; however, the origi- nally proposed link between these two c.a.ses and whether WGD results from an allo- or autopolyploid event is inconsistent with recent data from the allopolyploid capsella bursa-pastoris. The gene balance hypothesis can explain bias in the functional categories of genes retained following WGD, the difference in gene loss rates between unbiased and biased WGDs, and how plant genomes have avoided being overrun with genes encoding dose-sensitive subunits of multiprotein complexes. comparisons of gene expression patterns between retained transcription factor pairs in maize suggest the high degree of retention for WGD-derived pairs of transcription factors may instead be explained by the older duplication-degeneration-complementation model.

关键词： whole genome duplication fractionation subgenome polypioidy

pXR variants:the impact on drug metabolism and therapeutic responses

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Ac.a.pharmaceutica sinica B 2016年第5期6卷 441-449页

作者： c.Trent Brewer Taosheng chen Department of chemical Biology and Therapeutics St.Jude Children's Research Hospital Integrated Biomedical sciences program University of Tennessee Health Science Center

The pregnane X receptor(pXR) plays an important and diverse role in mediating xenobiotic induction of drug-metabolizing enzymes and *** protein isoforms of pXR exist,and they have differential transcriptional activity upon target genes; transcript variants 3(pXR3) and 4(pXR4) do not induce target gene expression,whereas transcript variants 1(pXR1) and 2(pXR2) respond to agonist by activating target gene *** protein variants also display differences in protein–protein interactions; pXR1 interacts with p53,whereas pXR3 does ***,the transcript variants of pXR that encode these protein isoforms are differentially regulated by methylation and deletions in the respective promoters of the variants,and their expression differs in various human cancers and also in cancerous tissue compared to adjacent normal ***1 and pXR4 m RNA are downregulated by methylation in cancerous tissue and have divergent effects on cellular proliferation when ectopically *** detailed and comparative mec.a.istic studies are required to predict the effect of pXR transcript variant expression on carcinogenesis,therapeutic response,and the development of toxicity.

关键词： pregnane X receptor Transcript variants Drug metabolism Therapeutic responses Toxicity

Learning tasks as a possible treatment for DNA lesions induced by oxidative stress in hippocampal neurons

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Neural Regeneration Research 2013年第32期8卷 3063-3070页

作者： Dragos cīrneci Radu silaghi-Dumitrescu Brain Research Institute Synergon Consulting Faculty of chemistry and chemical Engineering Babes-Bolyai University

Reactive oxygen species have been implicated in conditions ranging from cardiovascular dysfunc- tion, arthritis, cancer, to aging and age-related disorders. The organism developed several path- ways to counteract these effects, with base excision repair being responsible for repairing one of the major base lesions （8-oxoG） in all organisms. Epidemiological evidence suggests that cognitive stimulation makes the brain more resilient to damage or degeneration. Recent studies have linked enriched environment to reduction of oxidative stressin neurons of mice with Alzheimer＇s dis- ease-like disease, but given its complexity it is not clear what specific.a.pect of enriched environ- ment has therapeutic effects. studies from molecular biology have shown that the protein p300, which is a transcription co-activator required for consolidation of memories during specific learning tasks, is at the same time involved in DNA replication and repair, playing a central role in the long-patch pathway of base excision repair. Based on the evidence, we propose that learning tasks such as novel object recognition could be tested as possible methods of base excision repair fa- cilitation, hence inducing DNA repair in the hippocampal neurons. If this method proves to be effec- tive, it could be the start for designing similar tasks for humans, as a behavioral therapeutic com- plement to the c.a.sical drug-based therapy in treating neurodegenerative disorders.

关键词： neural regeneration reviews neurodegenerative disorder reactive oxygen species base excisionrepair cognitive stimulation p300 grants-supported paper neural regeneration