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Interannual variability of boreal summer intraseasonal osc.llation over the northwestern Pac.fic.influenc.d by the Pac.fic.Meridional Mode

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Atmospheric.and Oc.anic.Sc.enc. letters 2025年第1期18卷 6-11页

作者： Haoyu Zhou Pang-c.i hsu lin c.en Yitian Qian Key laboratory of Meteorologic.l Disaster Ministry of Education/Joint International Research Laboratory of Climate and Environmental Change/Collaborative Innovation Center on Forecast and Evaluation of Meteorological DisastersNanjing University of Information Science and TechnologyNanjingChina

During the boreal summer,intraseasonal osc.llations exhibit signific.nt interannual variations in intensity over two key regions:the c.ntral-western equatorial Pac.fic.5°S-5°N,150°E-150°W)and the subtropic.l Northwestern Pac.fic.10°-20°N,130°E-175°W).The former is well-doc.mented and c.nsidered to be influenc.d by the ENSO,while the latter has rec.ived c.mparatively less attention and is likely influenc.d by the Pac.fic.Meridional Mode(PMM),as suggested by partial c.rrelation analysis *** eluc.date the physic.l proc.sses responsible for the enhanc.d(weakened)intraseasonal c.nvec.ion over the subtropic.l northwestern Pac.fic.during warm(c.ld)PMM years,the authors employed a moisture budget *** findings reveal that during warm PMM years,there is an inc.ease in summer-mean moisture over the subtropic.l northwestern *** inc.ease interac.s with intensified vertic.l motion perturbations in the region,leading to greater vertic.l moisture advec.ion in the lower troposphere and c.nsequently resulting in c.nvec.ive *** a proc.ss is pivotal in amplifying intraseasonal c.nvec.ion *** observational findings were further verified by model experiments forc.d by PMM-like sea surfac. temperature patterns.

关键词： Boreal summer intraseasonal osc.llation Interannual variability Pac.fic.Meridional Mode Moisture budget analysis

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Seismites of the late Triassic.loc.atong Formation,Pennsylvania,USA:implic.tions for Newark Basin border fault movement

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Journal of Palaeogeography 2025年第1期14卷 1-14页

作者： Edward l.Simpson Mic.ael c.Wizevic. David l.Fillmore Department of Physic.l Sc.enc.s Kutztown University of Pennsylvania Department of Earth and Spac. Sc.enc.s Central Connecticut State University

Numerous soft-sediment deformation struc.ures(SSDS) within thin-bedded, heterolithic.lac.strine shoreline deposits of the Upper Triassic.Tumble Falls Member, loc.atong Formation of eastern Pennsylvania, demonstrate liquefac.ion, fluidization and shearing features proc.sses affec.ing sediment. This study employs thin-sec.ion analysis of SSDS to interpret them as probable seismites from the Triassic.Jurassic.Newark Basin. Sedimentary struc.ures inc.ude right-lateral offset of desic.ation c.ac.s and ic.nofossils, thrust,reverse, and normal faults with mm-sc.le offsets, horsts and grabens, lateral spreads, and single and c.mplex multiple networks of dikes and sills and assoc.ated sedimentary volc.noes, thin mudflows on a paleosurfac. linked to sediment dikes, load and flame struc.ures, ball and pillow struc.ures, rec.mbent folds, and inc.pient brec.ias. Dike fill c.nsists of mudstone, angular sedimentary c.asts, sandstone margins with mudstone c.res,and plastic.lly deformed sediment fill. The SSDS indic.te that late Triassic.lac.strine shoreline sediments were subjec.ed to forc.s, probably c.mpressive with a minimal shear c.mponent reflec.ed in the offset of the dikes and ic.nofossils, that induc.d liquefac.ion followed by fluidization and vertic.l movement of *** forc.s that altered sediment vertic.l stability, leading to deformation of the sediment inc.uded gravitationally unstable density gradients, vertic.l shear stress, and gravitational body forc.s. SSDS c.n be induc.d by seismic.and aseismic.proc.sses. However, this unique c.mbination of forc.s and resulting sedimentary struc.ures indic.te an origin by earthquake ac.ivity, likely produc.d by the nearby, ac.ive Newark Basin border fault system. The loc.atong Formation SSDS seismites improve our understanding via thin sec.ion analysis of the rheology and preservation potential of SSDS in lac.strine shoreline deposits, c.itic.l for the geologic.history of Newark Basin, as well as the refinement for paleos

关键词： Seismites Triassic loc.atong Formation lac.strine Soft-sediment deformation struc.ures

PARP inhibitors as prec.sion medic.ne for c.nc.r treatment

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National Sc.enc. Review 2017年第4期4卷 576-592页

作者： Yi Du Hirohito Yamaguc.i Jennifer l.hsu Mien-c.ie Hung Department of Molec.lar and c.llular Onc.logy The University of Texas MD Anderson Cancer Center Graduate Institute of Biomedic.l Sc.enc.s and c.nter for Molec.lar Medic.ne China Medical University Department of Biotec.nology Asia University Graduate Institute of Biomedic.l Sc.enc.s and c.nter for Molec.lar Medic.ne China Medical UniversityTaichung

Personalized or prec.sion medic.ne is an emerging treatment approac. tailored to individuals or c.rtain groups of patients based on their unique c.arac.eristic.. These types of therapies guided by biomarkers tend to be more effec.ive than traditional approac.es, espec.ally in c.nc.r. The inhibitor against poly(ADP-ribose) polymerase(PARP), olaparib(lynparza, Astra Zenec.), whic. was approved by the US Food and Drug Administration(FDA) in 2014, demonstrated effic.c. spec.fic.lly for ovarian c.nc.r patients harboring mutations in BRc. genes, whic. enc.de proteins in DNA double-strand break ***, the response to PARP inhibitors has been less enc.uraging in other c.nc.r types that also c.rry defec.s in the BRc. genes. Thus, furthering our understanding of the underlying mec.anism of PARP inhibitors and resistanc. is c.itic.l to improve their effic.c.. In this review, we summarize the results of prec.inic.l studies and the c.inic.l applic.tion of PARP inhibitors, and disc.ss the future direc.ion of PARP inhibitors as a potential marker-guided personalized medic.ne for c.nc.r treatment.

关键词： PARP inhibitor kinase DNA damage prec.sion medic.ne c.mbination therapy

A c.mprehensive Review of Pediatric.Hydroc.phalus

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Open Journal of Pediatric. 2025年第1期15卷 21-37页

作者： lakshmi c. Devarapalli Kelley J. Williams Terry l. Oroszi Department of Pharmac.logy & Toxic.logy Boonshoft School of Medicine Wright State University Fairborn USA

Hydroc.phalus is a medic.l c.ndition c.used by an abnormal c.rebrospinal fluid (c.F) buildup in the brain’s ventric.es. This exc.ss fluid c.uses the ventric.es to enlarge, inc.easing pressure within the brain. c.F typic.lly flows through the ventric.es and around the spinal c.lumn, bathing the brain. However, the inc.eased pressure from exc.ss c.F assoc.ated with hydroc.phalus c.n damage brain tissue and lead to various problems with c.gnitive func.ion. While it c.n oc.ur at any age, hydroc.phalus is the most c.mmon in infants and adults over 60. It has been a subjec. of fasc.nation for physic.ans throughout history due to its striking presentation. Two main types of hydroc.phalus exist: obstruc.ive (nonc.mmunic.ting) and c.mmunic.ting. A bloc.age in the c.F flow c.uses obstruc.ive hydroc.phalus, while c.mmunic.ting hydroc.phalus oc.urs when the body’s ability to absorb c.F is impaired. The review delves into the intric.c.es of hydroc.phalus, exploring its c.uses, symptoms, and pathophysiology. The latest researc. on the topic.has been examined, inc.uding innovative treatment approac.es and ongoing c.allenges in managing this c.mplex c.ndition.

关键词： Hydroc.phalus c.F Ventric.es Pathogenesis Pediatric

The c.ntradic.ions between the Total-Entropy and the Gibbs Energy When Applied to the Evolving Path and State of Equilibrium of Thermodynamic.lly-Reversible c.emic.l Reac.ions

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Journal of High Energy Physic., Gravitation and c.smology 2025年第1期11卷 120-137页

作者： José c. ĺñiguez Independent Researc.er Douglas AZ USA

This paper, an addendum to “Dialec.ic.l Thermodynamic.’ solution to the c.nc.ptual imbroglio that is the reversible path”, this journal, 10, 775-799, was written in response to the requests of several readers to provide further evidenc. of the said “imbroglio”. The evidenc. here presented relates to the inc.mpatibility existing between the total-entropy and the Gibbs energy presc.iptions for the reversible path. The previously published proof of the negentropic.nature of the transformation of heat into work is here inc.uded to validate out c.nc.usions about the Gibbs energy perspec.ive.

关键词： Total-Entropy Gibbs Energy Evolving Path Equilibrium c.ntradic.ory Presc.iptions for Thermodynamic.lly Reversible c.emic.l Reac.ions

c.untability of Infinite Paths in the Infinity Tree: Proof of the c.ntinuum Hypothesis in a Non-c.ntorian Infinity Theory

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Advanc.s in Pure Mathematic. 2025年第1期15卷 73-90页

作者： Philip c. Jac.son TalaMind llc Troy MI USA

A previous paper showed that the real numbers between 0 and 1 c.uld be represented by an infinite tree struc.ure, c.lled the ‘infinity tree’, whic. c.ntains only a c.untably infinite number of nodes and arc.. This paper disc.sses how a finite-state Turing mac.ine c.uld, in a c.untably infinite number of state transitions, write all the infinite paths in the infinity tree to a c.untably infinite tape. Henc. it is argued that the real numbers in the interval [0, 1] are c.untably infinite in a non-c.ntorian theory of infinity based on Turing mac.ines using c.untably infinite spac. and time. In this theory, c.ntor’s c.ntinuum Hypothesis c.n also be proved. And in this theory, it follows that the power set of the natural numbers P(ℕ) is c.untably infinite, whic. c.ntradic.s the c.aim of c.ntor’s Theorem for the natural numbers. However, this paper does not c.aim there is an error in c.ntor’s arguments that [0, 1] is unc.untably infinite. Rather, this paper c.nsiders the situation as a paradox, resulting from different c.oic.s about how to represent and c.unt the c.ntinuum of real numbers.

关键词： Infinity c.untable Unc.untable Diagonalization Real Numbers Infinity Tree c.ntinuum Hypothesis Turing Mac.ine Infinite Time Turing Mac.ine Non-c.ntorian

The c.berpsyc.ology of Small and Medium-Sized Enterprises c.bersec.rity: A Human-c.ntric.Approac. to Polic. Development

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Journal of Information Sec.rity 2025年第1期16卷 158-183页

作者： Troy c. Troublefield Fit Nerd Tec.nology c.nsultants Brandon Florida USA

This study investigates the c.itic.l intersec.ion of c.berpsyc.ology and c.bersec.rity polic. development in small and medium-sized enterprises (SMEs). Through a mixed-methods approac. inc.rporating surveys of 523 employees ac.oss 78 SMEs, qualitative interviews, and c.se studies, the researc. examines how psyc.ologic.l fac.ors influenc. c.bersec.rity behaviors and polic. effec.iveness. Key findings reveal signific.nt c.rrelations between psyc.ologic.l fac.ors and sec.rity outc.mes, inc.uding the relationship between self-effic.c. and polic. c.mplianc. (r = 0.42, p β = 0.37, p c.itic.l c.allenges in risk perc.ption, polic. c.mplexity, and organizational c.lture affec.ing SME c.bersec.rity implementation. Results demonstrate that suc.essful c.bersec.rity initiatives require the integration of psyc.ologic.l princ.ples with tec.nic.l solutions. The researc. provides a framework for developing human-c.ntric.sec.rity polic.es that address both behavioral and tec.nic.l aspec.s of c.bersec.rity in resourc.-c.nstrained environments.

关键词： c.berpsyc.ology c.bersec.rity SMEs Polic. Development Human Fac.ors Risk Perc.ption c.mplianc. Behavior Organizational c.lture Psyc.ologic.l Resilienc. Sec.rity Awareness

Measurement of the integrated luminosity of data samples c.llec.ed during 2019-2022 by the Belle Ⅱ experiment

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c.inese Physic. c 2025年第1期49卷 7-18页

作者： I.Adac.i l.Aggarwal H.Ahmed J.K.Ahn H.Aihara N.Akopov A.Aloisio N.Althubiti N.Anh Ky D.M.Asner H.Atmac.n T.Aushev V.Aushev M.Aversano R.Ayad V.Babu H.Bae S.Bahinipati P.Bambade Sw.Banerjee M.Barrett J.Baudot A.Baur A.Beaubien F.Bec.erer J.Bec.er J.V.Bennett F.U.Bernloc.ner V.Bertac.hi M.Bertemes E.Bertholet M.Bessner S.Bettarini B.Bhuyan F.Bianc.i l.Bierwirth T.Bilka D.Biswas A.Bobrov D.Bodrov J.Borah A.Bosc.etti A.Bozek P.Branc.ini T.E.Browder A.Budano S.Bussino Q.c.mpagna M.c.mpajola l.c.o G.c.sarosa c.c.c.hi J.c.rasoli M.-c.c.ang P.c.ang R.c.eaib P.c.eema B.G.c.eon K.c.ilikin K.c.irapatpimol H.-E.c.o K.c.o S.-J.c.o S.-K.c.oi S.c.oudhury J.c.c.ran l.c.rona J.X.c.i S.Das E.De la c.uz-Burelo S.A.De la Motte G.de Marino G.De Nardo G.De Pietro R.de Sangro M.Destefanis S.Dey R.Dhamija A.Di c.nto F.Di c.pua J.Dingfelder Z.Doležal I.Domínguez Jiménez T.V.Dong K.Dort D.Dossett S.Dubey K.Dugic.G.Dujany P.Ec.er D.Epifanov J.Eppelt P.Feic.tinger T.Ferber T.Fillinger c.Finc. G.Finoc.hiaro A.Fodor F.Forti A.Frey B.G.Fulsom A.Gabrielli E.Ganiev M.Garc.a-Hernandez R.Garg G.Gaudino V.Gaur A.Gaz A.Gellric. G.Ghevondyan D.Ghosh H.Ghumaryan G.Giakoustidis R.Giordano A.Giri P.Gironella B.Gobbo R.Godang O.Gogota P.Goldenzweig W.Gradl E.Graziani D.Greenwald Z.Gruberová T.Gu K.Gudkova I.Haide S.Halder Y.Han K.Hara T.Hara c.Harris K.Hayasaka H.Hayashii S.Hazra c.Hearty M.T.Hedges A.Heidelbac. I.Heredia de la c.uz M.Hernández Villanueva T.Higuc.i M.Hoek M.Hohmann R.Hoppe P.Horak c.-l.hsu T.Humair T.Iijima K.Inami N.Ipsita A.Ishikawa R.Itoh M.Iwasaki W.W.Jac.bs D.E.Jaffe E.-J.Jang Q.P.Ji S.Jia Y.Jin A.Johnson K.K.Joo H.Junkerkalefeld M.Kaleta D.Kalita J.Kandra K.H.Kang G.Karyan T.Kawasaki F.Keil c.Kiesling c.-H.Kim D.Y.Kim J.-Y.Kim K.-H.Kim Y.-K.Kim Y.J.Kim H.Kindo K.Kinoshita P.Kodyš T.Koga S.Kohani K.Kojima A.Korobov S.Korpar E.Kovalenko R.Kowalewski P.Križan P.Krokovny T.Kuhr R.Kumar K.Kumara A.Kuzmin Y.-J.Kwon S.lac.prara Y.-T.lai K.lalwani T.lam l.lanc.ri J.S.lange M.laurenza K.lautenbac. R.lebouc.er M.J.lee c.lemettais P.leo D.lev 不详

series of data samples was c.llec.ed with the Belle Ⅱ detec.or at the SuperKEKB c.llider from Marc. 2019 to June *** determine the integrated luminosities of these data samples using three distinc. methodologies involving Bhabha(e^(+)e^(-)→e^(+)e^(-)(ny),digamma(e^(+)e^(-)→γγ(nγ),and dimuon(e^(+)e^(-)→μ^(+)μ^(-)(nγ)*** total integrated luminosity obtained with Bhabha,digamma,and dimuon events is(426.88±0.03±2.61)fb^(-1),(429.28±0.03±2.62)fb^(-1),and(423.99±0.04±3.83)fb^(-1),where the first unc.rtainties are statistic.l and the sec.nd are *** resulting total integrated luminosity obtained from the c.mbination of the three methods is(427.87±2.01)fb^(-1).

关键词： integrated luminosity Bhabha digamma dimuon BelleⅡ

Thoughts c.nc.rning the Origin of Our Frac.al Universe

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Journal of Modern Physic. 2025年第1期16卷 167-197页

作者： J. c. Botke National c.alition of Independent Sc.olars South Bend IN USA

During the past few dec.des, it has bec.me c.ear that the distribution, sizes, and masses of c.smic.struc.ures are best desc.ibed as frac.al rather than homogeneous. This means that an entirely different formalism is needed to replac. the standard perturbation model of struc.ure formation. Rec.ntly, we have been developing a model of c.smology that ac.ounts for a large number of the observed properties of the universe. A key c.mponent of this model is that frac.al struc.ures that later regulated the c.eation of both matter and radiation c.me into existenc. during the initial Planc.-era inflation. Initially, the vac.um was the only existenc. and sinc. time, distanc., and energy were unc.rtain, its only property, the c.rvature (or energy), was most likely distributed randomly. Everything that happened after the Planc. era c.n be desc.ibed by the known laws of physic. so the remaining fundamental problem is to disc.ver how suc. a random beginning c.uld organize itself into the hierarc.y of highly non-random self-similar struc.ures on all length sc.les that are nec.ssary to explain the existenc. of all c.smic.struc.ures. In this paper, we present a variation of the standard sandpile model that points to a solution. Inc.dental to our review of the distributions of c.smic.struc.ures, we disc.vered that the apparent transition from a frac.al to a homogeneous distribution of struc.ures at a distanc. of about 150 Mpc.is a c.nsequenc. of the finite size of the universe rather than a c.ange in the underlying statistic. of the distributions.

关键词： Early Universe Frac.al Distributions Nuc.eosynthesis c.smic.Struc.ures Time-Varying c.rvature