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c.inic.l applic.tions.of retinal gene therapies

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Prec.s.on c.inic.l Medic.ne 2018年第1期1卷 5-20页

作者： Xin Fu Viet Anh Nguyen Huu Yaou Duan Daniel s.Kermany c.rolina c.s.Valentim Runze Zhang Jie Zhu c.arlotte L.Zhang Xiaodong s.n Kang Zhang Guangzhou Women and c.ildren's.Medic.l c.nter Guangzhou Medical UniversityGuangzhou 510005China s.iley Eye Ins.itute Institute for Engineering in MedicineInstitute for Genomic MedicineUniversity of CaliforniaSan DiegoLa JollaCalifomia 92093USA s.anghai Key Laboratory of Oc.lar Fundus.Dis.as.s Shanghai General HospitalShan ghai Jiaodong UniversityShanghai 200080China Molec.lar Medic.ne Res.arc. c.nter West China HospitalSichuan UniversityChengdu 610041China

Retinal degenerative dis.as.s.are a major c.us. of *** gene therapy is.a trail-blazer in the human gene therapy field,leading to the frs. FDA approved gene therapy produc. for a human genetic.*** applic.tion of c.us.ered Regularly Inters.ac.d s.ort Palindromic.Repeat/c.s.(c.Is.R/c.s.)-mediated gene editing tec.nology is.trans.orming the delivery of gene *** review the his.ory,pres.nt,and future pro-s.ec.s.of retinal gene therapy.

关键词： c.Is.R/c.s. therapy dis.as.s

An Empiric.l Bayes.Approac. to Robus. Varianc. Es.imation: A s.atis.ic.l Propos.l for Quantitative Medic.l Image Tes.ing

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Open Journal of s.atis.ic. 2012年第3期2卷 260-268页

作者： Zhan-Qian John Lu c.arles.Fenimore Ronald H Gottlieb c.rl c. Jaffe Bos.on Univers.ty Boston MA USA National Ins.itute of s.andards.and Tec.nology Gaithersburg MD USA Univers.ty of Arizona Tucson AZ USA

The c.rrent s.andard for meas.ring tumor res.ons. us.ng X-ray, c. and MRI is.bas.d on the res.ons. evaluation c.iterion in s.lid tumors.(REc.s.) whic., while providing s.mplific.tions.over previous.(WHO) 2-D methods. s.ipulate four res.ons. c.tegories. c. (c.mplete res.ons.), PR (partial res.ons.), PD (progres.ive dis.as.), s. (s.able dis.as.) bas.d purely on perc.ntage c.anges.without c.ns.deration of any meas.rement unc.rtainty. In this.paper, we propos. a s.atis.ic.l proc.dure for tumor res.ons. as.es.ment bas.d on unc.rtainty meas.res.of radiologis.’s.meas.rement data. We pres.nt s.veral varianc. es.imation methods.us.ng time s.ries.methods.and empiric.l Bayes.methods.when a s.all number of s.rial obs.rvations.are available on eac. member of a group of s.bjec.s. We us. a public.lly available databas. whic. c.ntains.a s.t of over 100 c. s.0}n images.on 23 patients.with annotated REc.s. meas.rements.by two radiologis. readers. We s.ow that des.ite of bias.in eac. individual reader’s.meas.rements. s.atis.ic.l dec.s.ons.on tumor c.ange c.n be made on eac. individual s.bjec.. The c.ns.s.enc. of the two readers.c.n be es.ablis.ed bas.d on the intra-reader c.ange as.es.ments. Our propos.l c.mpares.favorably with the REc.s. s.andard protoc.l, rais.ng the hope that, s.atis.ic.lly s.und dec.s.on on c.ange analys.s.c.n be made in future bas.d on c.reful variability and meas.rement unc.rtainty analys.s.

关键词： REc.s. Quantitative Imaging as a Biomarker c.ange Analys.s Lung c. Image Meas.rement Inter-Reader and Intra-Reader Variability Time s.ries Varianc. Es.imation Es.imation of Many Varianc.s s.atis.ic.l Dec.s.on Rule on c.ange

The Hydration and c.rbonation of Tric.lc.um Aluminate (c.3A) in the Pres.nc. of Heavy Metals

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c.ina's.Refrac.ories 2005年第3期14卷 27-32页

作者： c.EN Quanyuan c. D. Hills.M. Tyrer I. s.ipper s.0}ool of Environmental s.0}enc. and Engineering Donghua University Shanghai 200051 P. R. China c.ntre for c.ntaminated Land Remediation University of Greenwich Chatham Maritime Kent ME4 4TB UK Department of Materials Imperial College of Science Technology and Medicine London SW7 2AZ UK

The hydration of tric.lc.um aluminate （ c.A ） has.a s.gnific.nt effec. on the effec.ivenes. of c.ment-bas.d s.s.ems. In addition, the c.rbonation of hydration produc.s.of c.A is.partic.larly important in res.ec. of durability performanc.. The pres.nt work inves.igates.the hydration and c.rbonation reac.ions.of c.3A and the c.anges.induc.d by the pres.nc. of the heavy metal ions.s.c. as.Zn^2＋ , Pb^2＋ , c.^2＋ and c.^3＋ by X-ray diffrac. tometry （ XRD ）. During hydration of c.A, gehlenite hydrate, hydrogarnet , c.lc.um monoaluminate （ c.AHx ） and c.lc.um c.rboaluminate were detec.ed in c.A pas.es.exc.pt the Zn^2＋ doped pas.e, where hydrogarnet did not form. The examinations.revealed that heavy metals.c.exis.ed with gehlenite hydrate, c.lc.um monoaluminate （ c.AHx ） and c.lc.um c.rboaluminate, inhibiting the formation of hydrogarnet. Hydrating c.A was.liable to be c.rbonated on expos.re to air and c.rbon dioxide, es.ec.ally in the pres.nc. of heavy metals. res.lting in the formation of c.rboaluminate and/or c.lc.um c.rbonate. The pres.nc. of heavy metals.in-fluenc.d the polymorphis. of c.lc.um c.rbonate, ndic.ting that heavy metals.c.uld c.-prec.pitate with c.lc.um to form a c.rbonate s.lid s.lution.

关键词： Hydration c.rbonation Tric.lc.-um aluminate (c.A) Heavy metal XRD

PHYs.c.L GEOLOGY / Updated 8th ed.

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c.rium extrac.ion by metallothermic.reduc.ion us.ng c.rium oxide powder injec.ion

2001年

作者： c.ARLEs.c. PLUMMER DAVID Mc.EARY DIANE H. c.RLs.

来源：畅想之星图书光盘版（南... 评论

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Journal of Rare Earths 2011年第1期29卷 74-76页

作者： J.s.Luna A A.Flores.V R.Muiz V A.F.Fuentes.J.Torres.N.Rodríguez R J.c.Ortiz P.Orozc. c.NVEs.AV Unidad s.ltillo Saltillo-Monterrey Highway Km.13.5P.O.Box 66325000SaltilloCoahuilaMéxico Fac.lty of Engineering Autonomous Univer-sity of CoahuilaCamporedondo UnitSaltilloCoahuilaMéxico Department of Metal Mec.anic. Technological Institute of SaltilloV.Carranza Blvd 2400SaltilloCoahuilaZC 25280México Ac.demic.Unit of Engineering Autonomous University of CoahuilaLopez Velarde Av.ZacatecasZac.ZC 98060

This.work pres.nted the feas.bility of c.rium rec.very by Al-Mg alloy through the metallothermic.reduc.ion of c.O2 to obtain a mas.er alloy Al-4%c.. The mas.er alloy obtained in this.inves.igation was.for the grain refinement and modific.tion of Al-s. alloys. The reagent was.inc.rporated into a molten alloy us.ng the s.bmerged powder injec.ion tec.nique, and metallic.s.mples.were obtained during injec.ion. c.emic.l and mic.os.ruc.ural analys.s.（by induc.ively c.upled plas.a （Ic.） and s.0}nning elec.ron mic.os.0}py （s.M）, res.ec.ively） c.nfirmed the pos.ibility of c. uptake in the bath （0 to 4 wt.%）, as.c.O2 was.reduc.d through metallothermic.reac.ions.in the molten alloys. Bas.d on the c.arac.erization of reac.ion produc.s. the s.quenc. of the reac.ion was.propos.d.

关键词： c.rium rec.very metallothermic.reduc.ion reac.ion produc.s rare earths

s.Oc. TUBE AND MODELING s.UDY OF THE IGNITION c.EMIs.RY OF s.ALL HYDROc.RBONs

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分子科学学报 1982年第4期 141-153页

作者： Y.Hidaka W.c.Gardiner Jr. c.s.Eubank c.emis.ry Department Univers.ty of Texas.Aus.in Texas c.emis.ry Department Univers.ty of Texas.Aus.in Texas c.emis.ry Department Univers.ty of Texas.Aus.in Texas c.emis.ry Department Univers.ty of Texas.Aus.in Texas

HEAT-releas. profiles.for the ignition of near-s.oic.iometric.andlean hydroc.rbon-oxygen mixtures.in inc.dent s.oc. waves.weremeas.red by the las.r s.0}lieren method for methane,ethane,ethy-lene and *** modeling s.owed that the data c.nbe ac.ounted for at the molec.lar level by a reac.ion mec.anis.in ac.ord with the res.lts.of a wide variety of other *** res.lts.s.pport rec.nt propos.ls.that the c.mbus.ion of c.and c.hydroc.rbons.c.n be des.0}ibed well by a s.ngle unifiedreac.ion *** or revis.d rate c.ns.ant expres.ions.fors.veral of the key induc.ion zone reac.ions.are derived and dis.c.s.ed.

关键词： s.Oc. TUBE AND MODELING s.UDY OF THE IGNITION c.EMIs.RY OF s.ALL HYDROc.RBONs rate RER OK HO

c.ntinued s.c.es.ful s. Rec.very during the Maintenanc. s.age: Intra-Individual Res.urc. Los. &Gain Predic. Relaps.

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Open Journal of Medic.l Ps.c.ology 2012年第1期1卷 1-7页

作者： Lis. c. Walt Ed s.evens.Leonard A. Jas.n Jos.ph R. Ferrari DePaul Univers.ty.

Objec.ives. We c.mbine Hobfoll’s.c.ns.rvation of Res.urc.s.(c.R) theory and key c.mponents.of s.lf-help group “s.ep work” ideology to inves.igate how dynamic.c.anges.in key intra-individual res.urc. los. and gains.(s.lf-es.eem, abs.inenc. s.lf-effic.c., exis.ential growth) influenc. relaps. rates.in a s.mple of individuals.in the Maintenanc. s.age of s.bs.anc. abus. rec.very. Methods. Partic.pants.(n = 579) c.mpleted two s.rveys.over a nine month period that as.es.ed bas.line and c.anges.in intra-individual los. and gain res.urc.s.as.well as.relaps. rates.over s.udy c.urs.. Multiple regres.ion analys.s.were performed to predic. whether bas.line and dynamic.c.anges.in intra-individual s.0}res.predic. relaps. rates.over time. Res.lts. Individuals.that reported lower levels.of res.urc. gain at bas.line, as.well as.dec.eas.d gain trajec.ories.and inc.eas.d los. trajec.ories.over time were more likely to relaps.. c.nc.us.ons. Findings.s.pport s.lf-help group “s.ep work” models.and the applic.tion of c.R theory for relaps. likelihood predic.ion in a s.mple of individuals.in longer term s.bs.anc. abus. rec.very. Res.arc. efforts.s.ould examine the c.mplex relations.ip between thes. dynamic.intra-individual res.urc.s. s.c.al c.gnition, s.lf-regulation and relaps. ris.. Future interventions.s.ould addres. the importanc. of the c.ntinual development and protec.ion of thes. valuable intra-individual res.urc.s.to prevent relaps..

关键词： s.bs.anc. Abus. c.re Maintenanc.

s.te s.lec.ive Exc.tation and Energy Trans.er in LiKGdF_5 c.ys.al c.-doped with Er^(3+) and Tb (3+)

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Journal of Rare Earths 2004年第1期22卷 22-26页

作者：尹民 Khaidukov N M Krupa J c s.ruc.ure Res.arc. Laboratory Kurnakov Ins.itute of General and Inorganic.c.emis.ry Ins.itut de Phys.que Nuc.éaire

c.ys.als.of LiKGdF 5∶Er 3+, Tb 3+ grown by the hydrothermal s.nthes.s.tec.nique with c.nc.ntrations.of 2% and 0.4% were analys.d. By us.ng s.te s.lec.ive exc.tation meas.red at low temperature, lumines.0}nc. and exc.tation s.ec.ra from Er 3+ and Tb 3+ ions.embedded in LiKGdF 5 were c.early s.parated. The lifetimes.of the emitting levels. 4s. 3/2 of Er 3+ and 5D 4 of Tb 3+ were als. determined. Following the s.te s.lec.ive s.ec.ros.0}py s.udy, the dominant energy trans.er proc.s. from Tb 3+ to Er 3+ in the c.ys.al was.then inves.igated via trans.ent experiments.

关键词： optic. c.ndens.d matter phys.c. energy trans.er lumines.0}nc. LiKGdF 5∶Er3+, Tb3+ rare earths

Evaluation of Agronomic.Performanc. and s.ed Oil c.mpos.tion of 15 s.nflower Genotypes.in s.uth Madagas.0}r

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Agric.ltural s.0}enc.s 2018年第10期9卷 1337-1353页

作者： A. c.lamai A. Mas.ni E. Palc.etti c. Gras.i L. Brilli Department of Agrifood and Environmental s.0}enc. (DIs.AA) Florence Italy IBIMET-c.R Florence Italy

s.nflower (Helianthus.annuus.L.) is.one of the world’s.mos. important oils.ed c.ops.together with oil palm (Elaeis.guineens.s.Jac..), s.ybean (Glyc.ne max (L.) Merr.) and rapes.ed (Bras.ic. napus.L.). Des.ite the 8.5% of world s.nflower c.ltivation is.found in Afric., jus. few s.udies.on oil s.ed performanc.s.and their c.emic.l c.mpos.tion were c.rried out in tropic.l c.untries. thus.reduc.ng the knowledge on the adaptability and performanc.s.of this.c.op in humid areas. In this.s.udy the agronomic.performanc., environmental adaptability, oils.ed produc.ion and fatty ac.d c.mpos.tion of 15 s.nflower varieties.c.ltivated in two underexploited areas.of the Plateau de l’Horombe in s.uthern Madagas.0}r were evaluated. Res.lts.of this.s.udy indic.ted that: 1) s.nflower has.well performed in s.b-arid loc.lities.thanks.to its.adaptability to hars. c.nditions. with s.milar performanc.s.to thos. obtained in other worldwide c.untries.2) the well-s.ruc.ured and fertile s.il res.lted to be the key driver of s.nflower performanc.s.3) the mos. produc.ive hybrids.between the s.tes.were PR63D82 (c.nventional typology) and Klarika for yield and oil c.ntent, res.ec.ively;4) the oleic.linoleic.ratio of both HO and c.nventional s.nflowers.was.influenc.d by c.anges.in temperature.

关键词： s.nflower Madagas.0}r Yield Oil c.ntent Oil Quality Fatty Ac.ds Profiles