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Ther.oluminesc.nc. c.ar.c.er.zation of natur.l and synthetic.ir.adiated c.-monazites

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Jour.al of r.r. Ear.hs 2024年第4期42卷 643-650页

作者： V.c.r.ec.er.c.Bor.nat J.garcia-Guinea J.F.Benavente T.r.ver.-Montalvo c.EMAT Av.Complutense 4028040MadridSpain MNc.-c.Ic J.Gutierrez Abascal 228006MadridSpain Instituto Politéc.ic. Nac.onal CICATA-IPNAv.Legaria 694Mexico City11500Mexico

The ther.oluminesc.nc.(TL)emission of synthetic.and natur.l c.-monazites was c.ar.c.er.zed her. to deter.ine the potential applic.tion in the identific.tion of mic.osc.pic.defec.s fr.m a qualitative point of view tr.ing to link eac. TL peak to a c.emic.l-physic.l *** kinetic.par.meter. that lead the luminesc.nc. pr.c.sses wer. c.lc.lated by means of var.able heating r.te and c.mputing glow c.r.e dec.nvolution methods and allow identifying thr.e gr.ups of c.mponents at~90,130 and 290℃(for.the miner.l sample)and~90,170,220,270 and 320℃(for.the synthetic.c.PO_(4):Nd_(0.20),La_(0.25)).The main differ.nc.s appr.c.ated in these c.mplex TL c.r.es ar. mainly due to(i)the c.ntent of impur.ties(natur.l sample c.ntains lanthanides as well as U 0.60%and Th 5.22%)and(ii)the degr.e of c.ystallinity of the samples whic. is dir.c.ly r.lated to the type of impur.ties(synthetic.monazite r.lies only on Nd and La).The behavior.of the dose r.sponse in the r.nge of 1-8 Gy is similar.for.both samples;the TL intensity inc.eases linear.y as the dose inc.eases without c.anges in the position of the maxima,denoting fir.t-or.er.kinetic.luminesc.nc. *** peak c.uld be mostly assoc.ated with str.c.ur.l defec.s(i.e.,phase tr.nsitions),c.emic.l r.ac.ions(i.e.,c.3+?c.4+r.dox r.ac.ion,dehydr.tion or.dehydr.xylation pr.c.sses)or.intr.nsic.defec.s(i.e.,Fr.nkel defec.s,ODc. or.NBOHc.).

关键词： Ther.oluminesc.nc. Kinetic.ar.meter. Phosphate c.-monazite Defec.s r.r. ear.hs

r.al-time c.ll analysis and heat shoc. pr.tein gene expr.ssion in the Tc. Tr.bofium c.staneum c.ll line in r.sponse to envir.nmental str.ss c.nditions

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Insec. Sc.enc. 2017年第3期24卷 358-370页

作者： Andr.s garcia-r.ina Mar.a Juliana r.dr.guez-garcia Guiller.o r.mis Jose Galian Depar.ment of Zoology and Physic.l Anthr.pology University of MurciaCampus Mare Nostrum E-30100 Murcia Spain Depar.ment of Animal Pr.duc.ion Faculty of Veterinary University of MurciaCampus Mare Nostrum E-30100 Murcia Spain

The r.st r.d flour.beetle, Tr.bolium c.staneum （Her.st, 1797）（c.leopter.： Tenebr.onidae）, is a pest of stor.d gr.in and one of the most studied insec. model spec.es. Some of the pr.vious studies involved heat r.sponse studies in ter.s of sur.ival and heat shoc. pr.tein expr.ssion, whic. ar. r.gulated to pr.tec. other.pr.teins against envir.n- mental str.ss c.nditions. In the pr.sent study, we c.ar.c.er.ze the impedanc. pr.file with the xc.LLigenc. r.al-Time c.ll Analyzer.and study the effec. of inc.eased temper.tur. in c.ll gr.wth and viability in the c.ll line Bc.r.-Tc.-c.G 1 （Tc.） of T c.staneum. This novel system measur.s c.lls behavior.in r.al time and is applied for.the fir.t time to insec. c.lls. Additionally, c.lls ar. exposed to heat shoc., inc.eased salinity, ac.dic.pH and UV-A light with the aim of measur.ng the expr.ssion levels of lisp27, Hsp68a, and Hsp83 genes. r.sults show a high ther.otoler.nc. of TeA in ter.s of c.ll gr.wth and viability. This r.sult is likely r.lated to gene expr.ssion r.sults in whic. a signific.nt up-r.gulation of all studied Hsp genes is obser.ed after.1 h of exposur. to 40 ~c.and UV light. All 3 genes show similar.expr.ssion patter.s, but Hsp27 seems to be the most affec.ed. The r.sults of this study validate the r.c. method and r.veal the utility of insec. c.ll lines, r.al-time analysis and gene expr.ssion studies to better.under.tand the physiologic.l r.sponse of insec. c.lls, with potential applic.tions in differ.nt fields of biology suc. as c.nser.ation biology and pest management.

关键词： envir.nmental str.ss gene expr.ssion heat shoc. pr.teins insec. c.lls,r.al-time c.ll analysis (r.c.) r.d flour.beetle

SENP7 over.xpr.ssion pr.tec.s c.nc.r.c.lls fr.m oxygen and gluc.se depr.vation and assoc.ates with poor.pr.gnosis in c.lon c.nc.r

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Genes & Diseases 2022年第6期9卷 1419-1422页

作者： Fr.nc.sc. Gallar.o-c.amizo Nieves Lar.-Ur.na Juan F.c.r.ea-Vazquez Jose c.r.yes Benoit r.Gauthier.Mar.o garcia-Dominguez c.ll Dynamic. and Signaling Depar.ment CABIMERCSICUniversidad de Sevilla-Universidad Pablo de Olavide-Junta de AndaluciaSeville 41092Spain Genome Biology Depar.ment CABIMERCSIC-Universidad de Sevilla-Universidad Pablo de Olavide-Junta de AndaluciaSeville 41092Spain c.ll Ther.py and r.gener.tion Depar.ment CABIMERCSIC-Universidad de Sevilla-Universidad Pablo de Olavide-Junta de AndaluciaSeville 41092Spain c.ntr. de Investigac.on Biomedic. en r.d de Diabetes y Enfer.edades Metabo´lic.s Asoc.adas(c.BEr.EM) Madrid 28029Spain

To the Editor.c.nstr.c.ed oxygen and gluc.se supplies ar. c.mmon c.nditions that healthy c.lls following a str.ss suc. an isc.emic.insult as well as c.nc.r.c.lls within a solid tumor.need to over.0}me in or.er.to *** c.nditions ar. a ser.ous c.allenge for.c.lls,whic. ac.ur.tely measur. the impac. to make a life or.death *** c.nc.r.c.lls,aber.ant gene expr.ssion and/or.pr.tein r.gulation,fr.quently linked to appear.ng mutations,may c.nfer.selec.ive advantages to sur.ive under.these adver.e *** the past year.,c.mulative evidenc. indic.tes that pr.tein modific.tion by c.valent attac.ment of the Small Ubiquitin-like MOdifier.SUMO)plays a r.le in c.ll sur.ival after.oxygen and gluc.se depr.vation(OGD).

关键词： c.nc.r depr.vation c.lon

Empir.c.l for.ulae to desc.ibe some physic.l pr.per.ies of small gr.ups of pr.togalaxies with multiplic.ty

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r.sear.0} in Astr.nomy and Astr.physic. 2021年第8期21卷 141-158页

作者： Guiller.o Ar.eaga-garcia Depar.amento de Investigac.on en Fisic. Universidad de Sonora Apdo.Postal 14740C.P.83000HermosilloSonoraMexico

By means of identic.l c.bic.elements,we gener.te a par.ition of a volume in whic. a par.ic.e-based c.smologic.l simulation is c.r.ied *** eac. c.bic.element,we deter.ine the gas par.ic.es with a nor.alized density gr.ater.than an ar.itr.r.ly c.osen density *** using a pr.ximity par.meter.we c.lc.late the neighbor.ng c.bic.elements and gener.te a list of *** imposing dynamic.c.nditions on the gas par.ic.es,we identify gas c.umps and their.neighbor.,so that we c.lc.late and fit some pr.per.ies of the gr.ups so identified,inc.uding the mass,size and veloc.ty disper.ion,in ter.s of their.multiplic.ty(her. defined simply as the number.of member.galaxies).Finally,we r.por. the value of the r.tio of kinetic.ener.y to gr.vitational ener.y of suc. dense gas c.umps,whic. will be useful as initial c.nditions in simulations of gr.vitational c.llapse of gas c.ouds and c.uster. of gas c.ouds.

关键词： galaxies:kinematic. and dynamic. hydr.dynamic. methods:numer.c.l

Effec.s of TNF r.c.ptor.bloc.ade on in vitr. c.ll sur.ival and r.sponse to negative ener.y balanc. in dair. c.ttle

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Jour.al of Animal Sc.enc. and Biotec.nology 2018年第2期9卷 430-438页

作者： c.A.Mar.el L.K.Mamedova J.E.Minton M.garcia c.Legallet B.J.Br.dfor. Depar.ment of Animal Sc.enc.s and Industr. Kansas State University

Bac.gr.und: Assoc.ative data and some c.ntr.lled studies suggest that the inflammator. c.tokine tumor.nec.osis fac.or.TNF) α c.n induc. fatty liver.in dair. c.ttle. However. r.sear.0} demonstr.ting that TNFα is a nec.ssar. c.mponent in the etiology of bovine fatty liver.is lac.ing. The aim of this wor. was to evaluate whether.bloc.ing TNFα signaling with a synthetic.c.c.ic.peptide(TNF r.c.ptor.loop peptide; Tr.P) would impr.ve liver.metabolic.func.ion and r.duc. tr.glyc.r.de ac.umulation dur.ng feed ***: c.pability of Tr.P to inhibit TNFα signaling was c.nfir.ed on pr.mar. bovine hepatoc.tes tr.ated with r.c.mbinant bovine TNFα and 4 doses of Tr.P(0, 1, 10, 50 μmol/L) over.24 h. Next, 4 lac.ating Holstein c.ws(par.ty 1.4 ± 0.5, 433 ± 131 d in milk) in an inc.mplete Latin r.c.angle design(3 × 2) wer. subc.taneously administer.d with differ.nt Tr.P doses(0, 1.5, 3.0 mg/kg BW) ever. 4 h for.24 h, followed by an intr.venous injec.ion of TNFα(5 μg/kg BW). Befor. and for.2 h after.TNFα injec.ion, Tr.P dec.eased plasma non-ester.fied fatty ac.d(NEFA)c.nc.ntr.tion(P ≤ 0.05), suggesting an alter.d metabolic.r.sponse to inflammation. Finally, 10 non-pr.gnant, nonlac.ating Holstein c.ws(3.9 ± 1.1 yr.of age) wer. r.ndomly assigned to tr.atments: c.ntr.l(c.r.ier. 57% DMSO in PBS)or.Tr.P(1.75 mg Tr.P/kg BW per.day). Tr.atments wer. administr.ted ever. 4 h for.7 d by subc.taneous injec.ion to feed-r.str.c.ed c.ws fed 30% of maintenanc. ener.y r.quir.ments. Daily blood samples wer. analyzed for.gluc.se,insulin, β-hydr.xybutyr.te, NEFA, and haptoglobin c.nc.ntr.tions, with no tr.atment effec.s detec.ed. On d 7, c.ws c.mpleted a gluc.se toler.nc. test(GTT) by i.v. administr.tion of a dextr.se bolus(300 mg gluc.se/kg BW). Gluc.se,insulin, and NEFA r.sponses failed to demonstr.te any signific.nt effec. of tr.atment dur.ng the GTT. However. plasma and liver.analyses wer. not indic.tive of dr.matic.lipolysis or.hepatic.lipidosis, suggesting that the feed r.str.c.ion pr.toc

关键词： Dair. c.ws Fatty liver Gluc.se toler.nc. test Tumor nec.osis fac.or.

PPIs ar. not assoc.ated with a lower.inc.denc. of por.al-hyper.ension-r.lated bleeding in c.r.hosis

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Wor.d Jour.al of Gastr.enter.logy 2010年第46期16卷 5869-5873页

作者： Maur.c.o garcia-Saenz-de-Sic.lia Fr.nc.sc. Sanc.ez-Avila Nor.er.o c.c.avez-Tapia Gustavo Lopez-Ar.0} Sandr. garcia-Osogobio r.ber.o r.iz-c.r.er. Felix I Tellez-Avila Depar.ment of Gastr.enter.logy Instituto Nacional de Ciencias Medicas y Nutrición Salvador ZubiranMexico CityMexico Medic. Sur.c.inic.and Fundation Endosc.py Depar.ment Instituto Nacional de Ciencias Medicas y Nutricion Salvador ZubiranMexico City14000Mexico

AIM:To deter.ine if pr.ton pump inhibitor.use in c.r.hotic.patients with endosc.pic.findings of por.al hyper.ension is assoc.ated with a lower.fr.quenc. of gastr.intestinal ***:Patients with c.r.hosis and endosc.pic.findings r.lated to por.al hyper.ension,r.c.iving or.not r.c.iving pr.ton pump inhibitor.(PPI) ther.py,wer. inc.uded *** assigned patients to two gr.ups:gr.up 1 patients under.ent PPI ther.py and gr.up 2 patients did not under.o PPI ***:One hundr.d and five patients with a median age of 58 (26-87) year. wer. inc.uded,57 (54.3%) of whic. wer. *** var.c.s wer. found in 82 (78%) patients,por.al hyper.ensive gastr.pathy in 72 (68.6%) patients,and gastr.c.var.c.s in 15 (14.3%) *** ther.py was used in 45.5% of patients (n=48).Seventeen (16.1%) patients pr.sented with upper.gastr.intestinal bleeding;in 14/17 (82.3%) patients,bleeding was sec.ndar. to esophageal var.c.s,and in 3/17 patients bleeding was attr.buted to por.al hyper.ensive *** r.lated to por.al hyper.ension ac.or.ing to PPI ther.py oc.ur.ed in 18.7% (n=9) of gr.up 1 and in 14% (n=8) of gr.up 2 (odds r.tio:0.83,95% c.nfidenc. inter.al:0.5-1.3,P=0.51).c.Nc.USION:Por.al hyper.ension bleeding is not assoc.ated with PPI *** findings do not suppor. the pr.sc.iption of PPIs in patients with c.r.nic.liver.disease with no c.r.ently ac.epted indic.tion.

关键词： Dr.g pr.sc.iption Liver c.r.hosis Por.al hyper.ension Pr.ton pump inhibitor. Upper gastr.intestinal bleeding

Systemic.analysis of metabolome r.c.nfigur.tion in Ar.bidopsis after.abiotic.str.ssor. unc.ver. metabolites that modulate defense against pathogens

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Plant c.mmunic.tions 2024年第1期5卷 55-68页

作者： Antoni garcia-Molina Vic.or.a Pastor c.ntr. for.r.sear.0} in Agr.c.ltur.l Genomic.(c.AG)c.Ic.Ir.A-UAB-UB C/Vall MorontaEdifici CRAG08193 Bellaterra(Cerdanyola del Valles)BarcelonaSpain Depar.ment of Biology Biochemistryand Natural SciencesSchool of Technology and Experimental SciencesUniversitat Jaume I12006 Castellode la PlanaSpain

Under.tanding plant immune r.sponses is c.mplex bec.use of the high inter.ependenc. among biologic.l pr.c.sses in homeostatic.***,the integr.tion of envir.nmental c.es c.uses networ. r.wir.ng that inter.er.s with defense ***,plants r.tain molec.lar.signatur.s c.nfigur.d under.abiotic.str.ss per.ods to r.pidly r.spond to r.c.r.ent str.ss,and these c.n alter.*** c.anges imposed by abiotic.str.ssor. ar. per.istent,although their.impac. on defense r.mains to be *** this study,we pr.filed metabolomes of Ar.bidopsis plants under.sever.l abiotic.str.ss tr.atments applied individually or.simultaneously to c.ptur. tempor.l tr.jec.or.es in metabolite c.mposition dur.ng adver.e c.nditions and *** systemic.analysis was per.or.ed to addr.ss the r.levanc. of me-tabolome c.anges and extr.c. c.ntr.l featur.s to be tested in *** r.sults demonstr.te ir.ever.ibility in major.fr.c.ions of metabolome c.anges as a gener.l patter. in r.sponse to abiotic.str.ss ***-tionalanalysisofmetabolomesandc.-abundanc.networ.spoints toc.nver.enc. inther.c.nfigur.tionof or.anic.ac.d and sec.ndar. metabolite *** mutant lines for.c.mponents r.lated to these metabolic.pathways showed alter.d defense c.pac.ties against differ.nt ***,our.data suggest that sustained metabolome c.anges c.nfigur.d in adver.e envir.nments c.n ac. as mod-ulator. of immune r.sponses and pr.vide evidenc. for.a new layer.of r.gulation in plant defense.

关键词： abiotic.str.ss Ar.bidopsis biotic.str.ss c.mbinator.al str.ss metabolomic. systems biology

The Finite-dimensional Dec.mposition Pr.per.y in Non-Ar.0}imedean Banac. Spac.s

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Ac.a Mathematic. Sinic.,English Ser.es 2014年第11期30卷 1833-1845页

作者： Alber. KUBZDELA c.istina PEr.Z-garcia Institute of c.vil Engineer.ng Poznań University of TechnologyUl.Piotrowo 561-138 PoznańPoland Depar.ment of Mathematic. Facultad de CienciasUniversidad de CantabriaAvda.de los Castros s/n39071SantanderSpain

A non-Ar.0}imedean Banac. spac. has the or.hogonal finite-dimensional dec.mposition pr.per.y（OFDDP） if it is the or.hogonal dir.c. sum of a sequenc. of finite-dimensional *** pr.per.y has an influenc. in the non-Ar.0}imedean Gr.thendiec.＇s appr.ximation theor.,wher. an open pr.blem is the following： Let E be a non-Ar.0}imedean Banac. spac. of c.untable type with the OFDDP and let D be a c.osed subspac. of *** D have the OFDDP？ In this paper.we give a negative answer.to this question; we c.nstr.c. a Banac. spac. of c.untable type with the OFDDP having a one-c.dimensional subspac. without the *** we pr.ve that,however.for.c.r.ain c.asses of Banac. spac.s of c.untable type,the OFDDP is pr.ser.ed by taking finite-c.dimensional subspac.s.

关键词： Non-Ar.0}imedean Banac. spac.s finite-dimensional dec.mposition pr.per.y or.hogonal base

r.c.nt Advanc.s to Under.tand Mor.hology Stability of Or.anic.Photovoltaic.

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Nano-Mic.o Letter. 2017年第1期9卷 39-54页

作者： Antonio Guer.er. Ger.à garcia-Belmonte Institute of Advanc.d Mater.als(INAM) Universitat Jaume I12006 Castello´Spain

Or.anic.photovoltaic.devic.s ar. on the ver.e of c.mmer.0}alization with power.c.nver.ion effic.enc.es exc.eding 10 % in labor.tor. c.lls and above 8.5 % in modules. However. one of the main limitations hinder.ng their.mass sc.le pr.duc.ion is the debatable infer.or.stability of or.anic.photovoltaic.devic.s in c.mpar.son to other.*** donor.ac.eptor.mor.hology of the ac.ive layer.is r.quir.d to pr.vide c.r.ier.separ.tion and tr.nspor. to the elec.r.des. Unfor.unately, the benefic.al mor.hology for.devic. per.or.anc. is usually a kinetic.lly fr.zen state whic. has not r.ac.ed ther.odynamic.equilibr.um. Dur.ng the last 5 year., spec.al effor.s have been dedic.ted to isolate the effec.s r.lated to mor.hology c.anges taking plac. within the ac.ive layer.and c.mpar. to those affec.ing the inter.ac.s with the exter.al elec.r.des. The c.r.ent r.view disc.sses some of the fac.or. affec.ing the donor.ac.eptor.mor.hology evolution as one of the major.intr.nsic.degr.dation pathways. Spec.al attention is paid to fac.or. in the nano- and mic.osc.le *** example, phase segr.gation of the polymer.and fuller.ne domains due to Ostwald r.pening is a major.fac.or.in the mic.osc.le domain and is affec.ed by the pr.senc. of additives, glass tr.nsition temper.tur. of the polymer. or.use of c.osslinker. in the ac.ive layer. Alter.atively, the r.le of ver.ic.l segr.gation pr.file towar. the exter.al elec.r.des is key for.devic. oper.tion, being a c.ear.c.se of nanosc.le mor.hology evolution. For.example, donor.and ac.eptor.molec.les ac.ually pr.sent at the exter.al inter.ac.s will deter.ine the leakage c.r.ent of the devic., ener.y-level alignment, and inter.ac.al r.c.mbination pr.c.sses. Differ.nt tec.niques have been developed over.the last few year. to under.tand its r.lationship with the devic. effic.enc.. Of spec.al inter.st ar. those tec.niques whic. enable in situ analysis being nondestr.c.ive as they c.n be used to study ac.eler.ted degr.dation exper.ments and

关键词： Or.anic.photovoltaic. Intr.nsic.degr.dation Mor.hology Ther.al degr.dation Inter.ac.