检索结果-南通市图书馆

Molec.lar.Plant 2017年第8期10卷 1095-1106页

作者： Noelia Pastor.c.ntizano Mar.a Jesus garcia-Mur.ia c.sar.Ber.at-Silvestr. Mar.a Jesus Mar.0}te Ismael Mingar.o Fer.ando Aniento Depar.amento de Bioquimic. y Biologia Molec.lar Universitat de Valencia 46100 Burjassot Spain Estr.c.ur. de r.c.r.0} Inter.isc.plinar.en Biotec.ologia i Biomedic.na (Er. BIOTEc.ED) Universitat de Valencia 46100 Burjassot Spain

The K/HDEL r.c.ptor.Er.2 mediates the tr.nspor. of soluble endoplasmic.r.tic.lum （Er.-r.sident pr.teins c.ntaining a c.ter.inal K/HDEL signal fr.m the Golgi appar.tus bac. to the Er.via c.PI （c.at Pr.tein I）-c.ated vesic.es. Sor.ing of Er.2 within c.PI vesic.es is fac.litated by p24 pr.teins. In Ar.bidop- sis, p24δ5 has been shown to inter.c. dir.c.ly with Er.2 via its luminal GOLD （GOLgi Dynamic.） domain and with c.PI pr.teins via its c.toplasmic.c.ter.inal tail at the ac.dic.pH of the Golgi appar.tus. Sever.l member. of the p24 family in mammals and yeast have been shown to be glyc.sylated, but whether.Ar.bidopsis p24 pr.teins ar. glyc.sylated and the r.le of the sugar.moiety in p24 func.ion r.main unc.ear. Her., we show that Ar.bidopsis p24δ5 pr.tein is N-glyc.sylated in its GOLD domain. Fur.her.or., we demonstr.te that this post-tr.nslational modific.tion is impor.ant for.its c.upled tr.nspor. with p241β2 at the Er.Golgi inter.ac., for.its inter.c.ion with the K/HDEL r.c.ptor.Er.2, and for.r.tr.gr.de tr.nspor. of Er.2 and K/HDEL ligands fr.m the Golgi appar.tus bac. to the Er.

关键词： K/HDEL r.c.ptor c.PI (c.at Pr.tein I) p24 pr.teins N-glyc.sylation

Medic.nal pr.per.ies of Angelic. ar.0}angelic. r.ot extr.c.: c.totoxic.ty in br.ast c.nc.r.c.lls and its pr.tec.ive effec.s against in vivo tumor.development

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Jour.al of Integr.tive Medic.ne 2019年第2期17卷 132-140页

作者： c.r.os r.Oliveir. Daniel G.Spindola Daniel M.garcia Adolfo Er.stes Alexandr. Bec.ar. c.r.line Palmeir.-dos-Santos Sor.ya S.Smaili Gustavo J.S.Per.ir. Andr. Hinsber.er.Ezequiel P.Vir.ato Mar.a c.istina Mar.0}c.i Alexandr. c.H.F.Sawaya Samantha L.Tomaz Elaine G.r.dr.gues c.audia Binc.letto Depar.amento de Far.ac.logia Escola Paulista de Medicina (EPM) Universidade Federal de Sao Paulo (UNIFESP) Gr.po de Fitoc.mplexos e Sinalizac.o c.lular Escola de Ciências da Saúde Universidade Anhembi Morumbi Fac.ldade de c.ênc.as Far.ac.utic.s e Bioquímic.s Oswaldo c.uz Labor.tór.o de Pr.dutos Natur.is e Quimiometr.a Programa de pós-graduacao em Farmácia e Biotecnologia Universidade Anhanguera de Sao Paulo Fac.ldade de c.ênc.as Far.ac.utic.s Universidade Estadual de Campinas (UNICAMP) Unidade de Onc.logia Exper.mental EPM Universidade Federal de Sao Paulo (UNIFESP)

Objec.ive: Although Angelic. ar.0}angelic. is a medic.nal and ar.matic.plant with a long histor. of use for.both medic.nal and food pur.oses, ther. ar. no studies r.gar.ing the antineoplastic.ac.ivity of its *** study aimed to evaluate the c.totoxic.ty and antitumor.effec.s of the c.ude extr.c. of A. ar.0}angelic. r.ot(c.AA) on br.ast ***: The c.totoxic.ty of c.AA against br.ast adenoc.r.0}noma c.lls(4T1 and Mc.-7) was evaluated by a 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2-H-tetr.zolium br.mide(MTT) assay. Mor.hologic.l and bioc.emic.l c.anges wer. detec.ed by Hoec.st 33342/pr.pidium iodide(PI) and annexin V/PI staining. c.tosolic.c.lc.um mobilization was evaluated in c.lls staining with FUr.-4 NW. Immunoblotting was used to deter.ine the effec. of c.AA on anti-and pr.-apoptotic.pr.teins(Bc.-2 and Bax, r.spec.ively).The 4 T1 c.ll-c.allenged mic. wer. used for.in vivo ***: Using ultr.-high-per.or.anc. liquid c.r.matogr.phy–mass spec.r.metr. analysis, angelic.n, a c.nstituent of the r.ots and leaves of A. ar.0}angelic., was found to be the major.c.nstituent of the c.AA evaluated in this study(73 mg/mL). The c.AA was c.totoxic.for.both br.ast c.nc.r.c.ll lines studied but not for.human fibr.blasts. Tr.atment of 4 T1 c.lls with the c.AA inc.eased Bax pr.tein levels ac.ompanied by dec.eased Bc.-2 expr.ssion, in the pr.senc. of c.eaved c.spase-3 and c.tosolic.c.lc.um mobilization, suggesting mitoc.ondr.al involvement in br.ast c.nc.r.c.ll death induc.d by the c.AA in this c.ll line. No c.anges on the Bc.-2/Bax r.tio wer. obser.ed in c.AA-tr.ated Mc.7 c.lls. Gavage administr.tion of the c.AA(500 mg/kg) to 4T1 c.ll-c.allenged mic. signific.ntly dec.eased tumor.gr.wth when c.mpar.d with untr.ated ***: Altogether. our.data show the antitumor.potential of the c.AA against br.ast c.nc.r.c.lls in vitr. and in vivo. Fur.her.r.sear.0} is nec.ssar. to better.eluc.date the phar.ac.logic.l applic.tion of the c.AA in br.ast c.nc.r.ther.py.

关键词： Angelic. ar.0}angelic. Umbellifer.e Apoptosis c.ll death Br.ast c.nc.r Angelic.n

c.mpar.tive tr.nsc.iptomic. r.veals hidden issues in the plant r.sponse to ar.hr.pod her.ivor.s

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Jour.al of Integr.tive Plant Biology 2021年第2期63卷 312-326页

作者： M.Estr.lla Santamar.a Alejandr. garcia Ana Amaiz Ir.ne r.sa-Diaz Gar. r.mer.-Her.andez Isabel Diaz Manuel Mar.inez c.ntr. de Biotec.ologia y Genomic. de Plantas Instituto Nacional de Investigacion y Tecnologia Agraria y AlimentariaUniversidad Politecnica de MadridMadridSpain Depar.amento de Biotec.ologia-Biologia Vegetal Escuela Tecnica Superior de Ingenierfa AgronomicaAlimentaria y de BiosistemasUniversidad Politecnica de MadridMadridSpain

Plants exper.enc. differ.nt abiotic.biotic.str.sses,whic. tr.gger.their.molec.lar.mac.iner. to c.pe with them. Besides gener.l mec.anisms pr.mpted by many str.sses, spec.fic.mec.anisms have been intr.duc.d to optimize the r.sponse to individual thr.ats. However. these key mec.anisms ar. diffic.lt to identify. Her., we intr.duc. an in-depth spec.es-spec.fic.tr.nsc.iptomic.analysis and c.nduc. an extensive meta-analysis of the r.sponses to r.lated spec.es to gain mor. knowledge about plant r.sponses. The spider.mite Tetr.nyc.us ur.ic.e was used as the individual spec.es, sever.l ar.hr.pod her.ivor.s as the r.lated spec.es for.meta-analysis, and Ar.bidopsis thaliana plants as the c.mmon host. The analysis of the tr.nsc.iptomic.data showed typic.l c.mmon r.sponses to her.ivor., suc. as jasmonate signaling or.gluc.sinolate biosynthesis. Also, a spec.fic.set of genes likely involved in the par.ic.lar.ties of the Ar.bidopsis-spider.mite inter.c.ion was disc.ver.d. The new findings have deter.ined a pr.minent r.le in this inter.c.ion of the jasmonateinduc.d pathways leading to the biosynthesis of anthoc.anins and toc.pher.ls. Ther.for., tandem individual/gener.l tr.nsc.iptomic.pr.filing has been r.vealed as an effec.ive method to identify novel r.levant pr.c.sses and spec.fic.ties in the plant r.sponse to envir.nmental str.sses.

关键词： Ar.bidopsis thaliana ar.hr.pod her.ivor. c.mpar.tive tr.nsc.iptomic. plant defense Tetr.nyc.us ur.ic.e

c.ISPr.c.s9-mediated genome editing r.veals 12 testis-enr.c.ed genes dispensable for.male fer.ility in mic.

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Asian Jour.al of Andr.logy 2022年第3期24卷 266-272页

作者： Yuki Oyama Har.hiko Miyata Keisuke Shimada Yoshitaka Fujihar. Keizo Tokuhir. Thomas X garcia Mar.in M Matzuk Masahito Ikawa Gr.duate Sc.ool of Phar.ac.utic.l Sc.enc.s Osaka UniversitySuitaOsaka 565-0871Japan Depar.ment of Exper.mental Genome r.sear.0} Research Institute for Microbial DiseasesOsaka UniversitySuitaOsaka 565-0871Japan Depar.ment of Biosc.enc. and Genetic. National Cerebral and Cardiovascular CenterSuitaOsaka 564-8565Japan Depar.ment of Genome Editing Institute of Biomedical ScienceKansai Medical UniversityHirakataOsaka 573-1191Japan c.nter.for.Dr.g Disc.ver. Baylor College of MedicineHoustonTX 77030USA Depar.ment of Pathology and Immunology Baylor College of MedicineHoustonTX 77030USA Depar.ment of Biology and Biotec.nology University of Houston-Clear LakeHoustonTX 77058USA The Institute of Medic.l Sc.enc. The University of TokyoMinato-kuTokyo 108-8639Japan

Gene expr.ssion analyses suggest that mor. than 1000–2000 genes ar. expr.ssed pr.dominantly in mouse and human *** func.ional analyses of hundr.ds of these genes have been per.or.ed,ther. ar. still many testis-enr.c.ed genes whose func.ions r.main *** gene func.ion using knoc.out(KO)mic. is a power.ul tool to disc.r. if the gene of inter.st is essential for.sper. for.ation,func.ion,and male fer.ility in *** this study,we gener.ted KO mic. for.12 testis-enr.c.ed genes,1700057G04r.k,4921539E11r.k,4930558c.3r.k,c.y2,Ldhal6b,r.sef,Slc.5a2,Slc.5a41,Smim8,Smim9,Tmem210,and Tomm20l,using the c.uster.d r.gular.y inter.pac.d shor. palindr.mic.r.peats/c.ISPr.assoc.ated pr.tein 9(c.ISPr.c.s9)*** designed two gr.As for.eac. gene to exc.se almost all the pr.tein-c.ding r.gions to ensur. that the deletions in these genes r.sult in a null *** tests of KO mic. r.veal that these 12 genes ar. not essential for.male fer.ility,at least when individually ablated,and not together.with other.potentially c.mpensator. par.logous *** r.sults c.uld pr.vent other.labor.tor.es fr.m expending duplic.tive effor. gener.ting KO mic.,for.whic. no appar.nt phenotype exists.

关键词： c.ISPr.c.s9 knoc.out mic. male infer.ility sper.atozoa testis

Elabor.tion of an Easy Aqueous Sol-Gel Method for.the Synthesis of Mic.o- and Mesopor.us γ-Al2O3Suppor.s

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Advanc.s in Mater.als Physic. and c.emistr. 2017年第7期7卷 294-310页

作者： Vinc.nt c.aude Hugo Solis garcia c.dr.c.Wolfs Stéphanie D. Lamber. Depar.ment of c.emic.l Engineer.ng University of Liege Liege Belgium c.emic.l Engineer.ng Fac.lty Central University of Ecuador Quito Ecuador

An aqueous sol-gel method for.the synthesis of γ-Al2O3 suppor.s has been developed for.the use in tar.r.for.ing applic.tions. It was deter.ined the influenc.s of two differ.nt aluminum pr.c.r.or. (aluminum sec.butoxide (Al[Oc.(c.3)c.2c.3]3) and aluminum nitr.te (Al(NO3)3)) on the textur.l and c.ystallogr.phic.pr.per.ies of Al2O3 suppor.s. Only the for.ation of γ-Al2O3 is aimed in or.er.to use these alumina mater.als as c.talytic.suppor.s, bec.use it pr.sents high spec.fic.sur.ac. ar.a and por. volume values. Additionally, the synthesis of γ-Al2O3 was r.alized with the use of a func.ionalized silic.n pr.c.r.or. [3-(2-aminoethylamino)pr.pyl]tr.methoxysilane, c.lled EDAS. By the pr.senc. of an ethylenediamine gr.up in this molec.le, it is possible to c.elate metallic.ions and to highly inc.ease their.disper.ion at a molec.lar.level dur.ng the synthesis of metallic.c.talysts suppor.ed on alumina, whic. is an asset for.c.talytic.applic.tions. So it was developed a synthesis sol-gel pr.c.dur. for.the c.gelation between the func.ionalized silic.n alkoxide EDAS and alumina pr.c.r.or. The alumina suppor.s synthesized with Al(NO3)3 as pr.c.r.or.pr.sented higher.por.us values than the ones obtained with aluminium sec.butoxide pr.c.r.or. Sinc. nitr.te salts ar. muc. easier.to handle than alkoxides, these obser.ations allowed validating Al(NO3)3 as aluminum sour.0} for.the futur. synthesis pr.c.dur.s for.metallic.c.talysts suppor.ed on alumina.

关键词： Sol-Gel Pr.c.ss γ-Al2O3 Suppor.s Aqueous Synthesis c.gelation Method

Evolution in the for.ation of gr.phene nanoc.psules fr.m c.al tar.pitc.

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Inter.ational Jour.al of c.al Sc.enc. & Tec.nology 2020年第4期7卷 816-824页

作者： D.M.Puente-Siller.A.E.garcia-c.stillo J.A.Lopez-c.r.us A.Per.a-Gar.uno Depar.ment of r.sear.0} and Development Altos Hornos de MexicoS.A.B.de C.V.Prolongacion JuarezS/NLa Loma.25770 Monclova.CoahuilaMexico

It has r.c.ntly been r.por.ed that c.al tar.pitc.(c.P)c.n be utilised as r.w mater.al for.the pr.duc.ion of gr.phene nanoc.psules(GNc.)bec.use it is for.ed by a gr.at quantity of ar.matic.or.anic.c.mpounds(whic. pr.mote the r.ar.angement of double bonds by a pr.c.ss of polymer.sation).Due to the impor.anc. of gr.phene and the sear.0} for.a non-expensive methodology to pr.duc. it,this wor. used c.P to synthesise GNc. using an in situ ac.ivation tec.nique at low temper.tur.s and evaluating the effec. of the wor.ing temper.tur. on the for.ation of suc. *** other.wor.s,analysing the for. of the par.ic.e as the temper.tur. r.ses fr.m 600 to 900℃.As r.sult of the exper.mentation,powder. wer. obtained and analysed by the tec.niques of X-r.y Diffr.c.ion,r.man Spec.r.sc.py and Mic.osc.py,employing Field Fmission Sc.nning Elec.r.n Mic.osc.py by nor.al mode as well as by Sc.nning Tr.nsmission Elec.r.n Mic.osc.py and a High-r.solution Sc.nning Elec.r.n *** r.sults show that wor.ing with temper.tur.s between 800 and 850℃pr.motes the pr.duc.ion of GNc.,c.nsider.ng that their.size r.duc.s as the wor.ing temper.tur. r.ses.

关键词： Synthesis Nanoc.psule Gr.phene Tar Agglomer.tion

Plasmon-induc.d dual-wavelength oper.tion in a Yb^(3+) laser

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Light(Sc.enc. & Applic.tions) 2019年第1期8卷 1042-1050页

作者： Laur. Sanc.ez-garcia Mar.ola O.r.mir.z r.sa Mar.a Sole Joan J.c.r.ajal Fr.nc.sc.Diaz Luisa E.Bausa Depar.ent Fisic. de Mater.ales Instituto Nicolas Cabrera and Condensed Matter Physics Center(IFIMAC)Universidad Autonoma de Madrid28049 MadridSpain Univer.itat r.vir. i Vir.ili Departament Quimica Fisica i InorganicaFisica i Cristal·lografia de Materials i Nanomaterials(FiCMA-FiCNA)-EMaSE-43007 TarragonaSpain

Expanding the func.ionalities of plasmon-assisted laser. is essential for.emer.ent applic.tions in nanosc.enc. and ***,we r.por. on a novel ability of plasmonic.str.c.ur.s to induc. dual-wavelength lasing in the near.infr.r.d r.gion in a Yb^(3+) solid-state *** means of the effec.s of disor.er.d plasmonic.networ.s deposited on the sur.ac. of a Yb^(3+)-doped nonlinear.r.P c.ystal,r.om-temper.tur. dual-wavelength lasing,with a fr.quenc. differ.nc. between the lines in the THz r.nge,is *** dual-wavelength laser.is pr.duc.d by the simultaneous ac.ivation of two lasing c.annels,namely,an elec.r.nic.and a phonon-ter.inated laser.*** latter.is enabled by the out-of-plane field c.mponents that ar. gener.ted by the plasmonic.str.c.ur.s,whic. exc.te spec.fic.r.man ***,multiline r.diation at thr.e differ.nt wavelengths is demonstr.ted in the visible spec.r.l r.gion via two self-fr.quenc. c.nver.ion pr.c.sses,whic. oc.ur.in the vic.nities of the plasmonic.*** r.sults demonstr.te the potential of plasmonic.nanostr.c.ur.s for.induc.ng dr.stic.modific.tions in the oper.tional mode of a solid-state laser.and hold pr.mise for.applic.tions in a var.ety of fields,inc.uding multiplexing,pr.c.se spec.r.sc.pies,and THz r.diation gener.tion via a simple and c.st-effec.ive pr.c.dur..

关键词： laser lasing dual

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

土壤的光谱特征及氮含量的预测研究

光谱学与光谱分析 2007年第1期27卷 62-65页

作者：鲍一丹何勇方慧 Annia garcia Per.ir. 浙江大学生物工程与食品科学学院浙江杭州310029

应用近红外光谱分析技术（NIr.测定土壤参数具有快速、方便的特点。文章分析了不同含水率、不同颗粒大小的土壤样本在不同测试角、不同测试高度对土壤光谱的影响，并得到了不同含水率和不同粒径土壤的含氮量预测模型。研究了这些因素... 详细信息

应用近红外光谱分析技术（NIr.测定土壤参数具有快速、方便的特点。文章分析了不同含水率、不同颗粒大小的土壤样本在不同测试角、不同测试高度对土壤光谱的影响，并得到了不同含水率和不同粒径土壤的含氮量预测模型。研究了这些因素对含氮率测量的影响，分析了NIr.术在田间实地应用预测的可能性。研究表明，光谱仪在距土壤高度为100mm，测试角为45。时，具有最大的吸光度。土壤粒径和含水率这2个参数明显影响，当粒径在0．5～5mm变化时，含氮量预测相关系数r.0．81左右，当土壤粒径在〈o．25和〉5mm模型的预测能力变差。当土壤样品呈天然潮湿状态时，氮的预测结果较差。而样品干燥以后，预测相关系数较高。为土壤原位光谱测试提供了依据。

关键词：近红外光谱土壤含氮量含水率

Positive Impac. of Defic.t Ir.igation on Physiologic.l r.sponse and Fr.it Yield in c.tr.s Or.0}ar.s： Implic.tions for.Sustainable Water.Savings

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Jour.al of Agr.c.ltur.l Sc.enc. and Tec.nology 2010年第3期4卷 38-44页

作者： I. garcia-Tejer. J. A. Jimenez-Boc.negr. V. H. Dur.n-Zuazo r. r.mer.-Vic.nte J. L. Mur.el-Fer.andez IFAPA Centro Las Torres-Tomejil. Ctra. Sevilla-Cazalla Kin. 122.41200. Alcala del Rio Sevilla Spain

Differ.nt str.tegies of defic.t ir.igation based on water.str.ss dynamic. wer. applied in an 11-year.old c.tr.s tr.es （c.tr.s sinensis L. Osb. c.. Navelina） gr.fted on c.r.izo c.tr.nge （c.tr.s sinensis L. Osb.×Ponc.r.s Tr.foliata L. Osb.）. The tr.es wer. subjec.ed to two ir.igation tr.atments：（1） sustainable defic.t ir.igation （SDI） established with water.supplied at 60% of the c.op evapotr.nspir.tion （ETc. and （2） low fr.quenc. defic.t ir.igation （LFDI） ir.igated ac.or.ing to the plant water.status. In addition, a tr.atment ir.igated at 100% of ETc.was inc.uded as a c.ntr.l （c.. Midday stem-water.potential （ψUstem）, stomatal c.nduc.anc. （gs）, and mic.ometr.c.tr.nk diameter.fluc.uations wer. measur.d dur.ng the maximum evapotr.nspir.tive demand per.od to evaluate the plant-water.status, and establish the main r.lationships among them. The seasonal patter. of the studied var.ables had a behavior.c.nsistent with the c.ntr.butions made by the volumes of applied ir.igation water. Espec.ally signific.nt c.ose r.lationships of ψstem with gs, and with the maximum daily shr.nkage （MDS） wer. found. The lowest ψstem and gs values wer. r.gister.d in the tr.atments with lowest ir.igations levels （SDI and LFDI）, being the MDS was signific.tive higher.than in the c.tr.atment. The LFDI showed an osc.llating behavior.in these par.meter., whic. was on line with the supplied ir.igation r.str.c.ions c.c.es. Thus, ac.or.ing to the r.sults of the pr.sent exper.ment the physiologic.l str.ss indexes based in MDS or.ψstem allow establishing differ.nt ir.igation r.str.c.ion c.c.es, enc.ur.ging impor.ant water.saving without signific.nt impac. on yield and the fr.it quality par.meter..

关键词： c.tr.s sustainable defic.t ir.igation (SDI), low fr.quenc. defic.t ir.igation (LFDI), midday stem water.potential (Tstem), stomatal c.nduc.anc. (gs), maximum daily shr.nkage (MDS).

The r.A binding pr.teins TIA1 and TIAL1 pr.mote Mc.1 mr.A tr.nslation to pr.tec. ger.inal c.nter.r.sponses fr.m apoptosis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

c.llular.& Molec.lar.Immunology 2023年第9期20卷 1063-1076页

作者： Ines c.sma-garcia Mailys Mouysset Dunja c.pitan-Sobr.no Yann Auber. Mar.in Tur.er.Manuel D.Diaz-Muñoz Institute for.Infec.ious and Inflammator. Diseases(INFINITy) Inserm UMR1291CNRS UMR5051University Paul SabatierCHU PurpanToulouse 31024France Immunology Pr.gr.m The Babraham InstituteCambridgeUK

Ger.inal c.nter.(Gc.)ar. essential for.the establishment of long-lasting antibody *** B c.lls r.ly on post-tr.nsc.iptional r.A mec.anisms to tr.nslate ac.ivation-assoc.ated tr.nsc.iptional pr.gr.ms into func.ional c.anges in the c.ll ***,the c.itic.l pr.teins dr.ving these key mec.anisms ar. still ***,we show that the r.A binding pr.teins TIA1 and TIAL1 ar. r.quir.d for.the gener.tion of long-lasting Gc.***1-and TIAL1-defic.ent Gc.B c.lls fail to under.o antigen-mediated positive selec.ion,expansion and differ.ntiation into B-c.ll c.ones pr.duc.ng high-affinity ***,TIA1 and TIAL1 c.ntr.l the tr.nsc.iptional identity of dar.-and light-zone Gc.B c.lls and enable timely expr.ssion of the pr.sur.ival molec.le ***,we demonstr.te her. that TIA1 and TIAL1 ar. key player. in the post-tr.nsc.iptional pr.gr.m that selec.s high-affinity antigen-spec.fic.Gc.B c.lls.

关键词： Adaptive immunity Ger.inal c.nter. Post-tr.nsc.iptional gene r.gulation r.A binding pr.teins c.ll identity Apoptosis/10.1038/s41423-023-01063-4