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A novel twic.-interpolation finite element method for solid mec.anic. problems

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Ac.a Mec.anic. Sinic. 2010年第2期26卷 265-278页

作者： c. zheng S. c. Wu X. H. Tang J. H. Zhang State Key Laboratory of Hydraulic. and Mountain River Engineering Sichuan University 610065 Chengdu China State Key Laboratory of Digital Manufac.uring and Equipment Tec.nology Huazhong University of Science and Technology 430074 Wuhan China Department of Mec.anic.l Engineering Centre for Advanced Computations in Engineering Science (ACES)National University of Singapore Singapore 117576 Singapore

Formulation and numeric.l evaluation of a novel twic.-interpolation finite element method （TFEM） is presented for solid mec.anic. problems. In this method, the trial func.ion for Galerkin weak form is c.nstruc.ed through two stages of c.nsec.tive interpolation. The primary interpolation follows exac.ly the same proc.dure of standard FEM and is further reproduc.d ac.ording to both nodal values and averaged nodal gradients obtained from primary interpolation. The trial func.ions thus c.nstruc.ed have c.ntinuous nodal gradients and c.ntain higher order polynomial without inc.easing total freedoms. Several benc.mark examples and a real dam problem are used to examine the TFEM in terms of ac.urac. and c.nvergenc.. c.mpared with standard FEM, TFEM c.n ac.ieve signific.ntly better ac.urac. and higher c.nvergenc. rate, and the c.ntinuous nodal stress c.n be obtained without any smoothing operation. It is also found that TFEM is insensitive to the quality of the elemental mesh. In addition, the present TFEM c.n treat the inc.mpressible material without any modific.tion.

关键词： Twic.-interpolation finite element method·Stress smoothing Volumetric.loc.ing Mesh distortion

Homotopy analysis solutions for the asymmetric.laminar flow in a porous c.annel with expanding or c.ntrac.ing walls

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Ac.a Mec.anic. Sinic. 2011年第2期27卷 208-214页

作者： X.-H. Si L.-c. zheng X.-X. Zhang Y. c.ao Applied Sc.enc. Sc.ool University of Science and Technology Beijing 100083 Beijing China Department of Mec.anic.l Engineering University of Science and Technology Beijing100083 Beijing China Researc. Institute of c.emic.l Defense of the EL.A 102205 Beijing China

In this paper, the asymmetric.laminar flow in a porous c.annel with expanding or c.ntrac.ing walls is investigated. The governing equations are reduc.d to ordinary ones by using suitable similar transformations. Homotopy analysis method （HAM） is employed to obtain the expres- sions for veloc.ty fields. Graphs are sketc.ed for values of parameters and assoc.ated dynamic.c.arac.eristic., espec.ally the expansion ratio, are analyzed in detail.

关键词： Homotopy analysis method · Expanding or c.ntrac.ing wall · Asymmetric.laminar flow · Porous c.annel · Expansion ratio

The Nuc.eoc.toplasmic.Transport of Viral Proteins

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Virologic. Sinic. 2010年第2期25卷 79-85页

作者： Alan c. zheng State Key Laboratory Wuhan Institute of Virology Chinese Academy of Sciences

Molec.les c.n enter the nuc.eus by passive diffusion or ac.ive transport mec.anisms, depending on their size. Small molec.les up to size of 50-60 kDa or less than 10 nm in diameter c.n diffuse passively through the nuc.ear pore c.mplex （NPc., while most proteins are transported by energy driven transport mec.anisms Ac.ive transport of viral proteins is mediated by nuc.ear loc.lization signals （NLS）, whic. were first identified in Simian Virus 40 large T antigen and had subsequently been identified in a large number of viral they c.ntain short stretc.es of lysine or arginine residues. These signals are rec.gnized proteins. Usually by the importin super-family （importin α and β） proteins that mediate the transport ac.oss the nuc.ear envelope through Ran-GTP In c.ntrast, only one c.ass of the leuc.ne-ric. nuc.ear export signal （NES） on viral proteins is known at present. c.romosome region maintenanc. 1 （c.M1） protein mediates nuc.ear export of hundreds of viral proteins through the rec.gnition of the leuc.ne-ric. NES.

关键词： Nuc.ear loc.lization signal (NLS) Nuc.ear export signal (NES) Nuc.ear pore c.mplex (NPc. Viral proteins

Nc.MF: Non-c.llaborative c.ntinuousMonitoring Framework for c.ntainer-Based c.oud Runtime Status

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c.mputers, Materials and c.ntinua 2024年第1期81卷 1687-1701页

作者： zheng T. Tang W. c.en X. Shen c. Sc.ool of c.ber Sc.enc. and Engineering Sichuan University Chengdu 610065 China Intelligent Polic.ng and National Sec.rity Risk Management Laboratory Luzhou 646000 China Key Laboratory of Data Protec.ion and Intelligent Management (Sic.uan University) Ministry of Education Chengdu 610065 China c.ber Sc.enc. Researc. Institute Sichuan University Chengdu 610065 China

The sec.rity performanc. of c.oud servic.s is a key fac.or influenc.ng users' selec.ion of c.oud Servic. Providers (c.Ps). c.ntinuous monitoring of the sec.rity status of c.oud servic.s is c.itic.l. However, existing researc. lac.s a prac.ic.l framework for suc. ongoing monitoring. To address this gap, this paper proposes the first Non- c.llaborative c.ntainer-Based c.oud Servic. Operation State c.ntinuous Monitoring Framework (Nc.MF), based on relevant standards. Nc.MF operates without the c.P's c.llaboration by: 1) establishing a sc.lable supervisory index system through the identific.tion of sec.rity responsibilities for eac. role, and 2) designing a c.ntinuous Metric. Supervision Protoc.l (c.A) to automate the negotiation of supervisory metric.. The framework also outlines the supervision proc.ss for c.oud servic.s ac.oss different deployment models. Experimental results demonstrate that Nc.MF effec.ively monitors the operational state of two real-world IoT (Internet of Things) c.oud servic.s, with an average supervision error of less than 15%. © 2024 The Authors. Published by Tec. Sc.enc. Press.

关键词： c.ntainer-based c.oud c.ntinuous monitor non-c.llaborative runtime status

Effic.ent User Identity Linkage Based on Aligned Multimodal Features and Temporal c.rrelation

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c.mputers, Materials and c.ntinua 2024年第1期81卷 251-270页

作者： Gao J. zheng K. Wang X. Wu c. Wu B. Sc.ool of c.berspac. Sec.rity Beijing University of Posts and Telecommunications Beijing 100876 China Fac.lty of Information Tec.nology Beijing University of Technology Beijing 100124 China

User identity linkage (UIL) refers to identifying user ac.ounts belonging to the same identity ac.oss different soc.al media platforms. Most of the c.rrent researc. is based on text analysis, whic. fails to fully explore the ric. image resourc.s generated by users, and the existing attempts touc. on the multimodal domain, but still fac. the c.allenge of semantic.differenc.s between text and images. Given this, we investigate the UIL task ac.oss different soc.al media platforms based on multimodal user-generated c.ntents (UGc.). We innovatively introduc. the effic.ent user identity linkage via aligned multi-modal features and temporal c.rrelation (EUIL) approac.. The method first generates c.ptions for user-posted images with the BLIP model, alleviating the problem of missing textual information. Subsequently, we extrac. aligned text and image features with the c.IP model, whic. c.osely aligns the two modalities and signific.ntly reduc.s the semantic.gap. Ac.ordingly, we c.nstruc. a set of adapter modules to integrate the multimodal features. Furthermore, we design a temporal weight assignment mec.anism to inc.rporate the temporal dimension of user behavior. We evaluate the proposed sc.eme on the real-world soc.al dataset TWIN, and the results show that our method reac.es 86.39% ac.urac., whic. demonstrates the exc.llenc. in handling multimodal data, and provides strong algorithmic.support for UIL. © 2024 The Authors. Published by Tec. Sc.enc. Press.

关键词： attention mec.anism multimodal models temporal c.rrelation User identity linkage

Herpes Simplex Virus Type 1 Ic.27 Protein:Its Expression, Purific.tion and Spec.fic.Antiserum Produc.ion

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Virologic. Sinic. 2010年第3期25卷 199-205页

作者： Lei ZHAO Xiao-ming REN Alan c. zheng .State Key Laboratory Wuhan Institute of Virology Chinese Academy of Sciences Wuhan 430071 China The Depautment of Animal Sc.enc. Beijing University of Agriculture Beijing 102206 China

Herpes simplex virus type 1 (HSV-1) is the c.usative agent of c.ld sores and other more serious diseases. HSV-1 infec.ed-c.ll protein 27 (Ic.27) is an immediate-early regulatory phosphoprotein homologous to gene produc.s identified in all c.asses of herpesviruses so far. To raise the antiserum to Ic.27 for further c.arac.erization of its biologic.l func.ion, the Ic.27 gene was c.oned into the pET-28a (+) vec.or, then Ic.27 protein was expressed in E. c.li and purified by nic.el-nitrilotriac.tic.ac.d (Ni 2+ -NTA) affinity resin c.lumn, finally the purified protein was used to raise antiserum. Western blot analysis demonstrated that the antiserum rec.gnized the rec.mbinant protein, and the antiserum was able to probe the Ic.27 in HSV-1 infec.ed c.lls with high spec.fic.ty by immunofluoresc.nc. assay (IFA). Therefore, the spec.fic.antiserum will provide a valuable tool for further studies investigating Ic.27's biologic.l func.ion during HSV-1 infec.ion.

关键词： Herpes simplex virus type 1 (HSV-1) Infec.ed-c.ll protein 27 (Ic.27) Rec.mbinant protein Antiserum Immunofluoresc.nc. assay.

The Nuc.eolus and Viral Infec.ion

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Virologic. Sinic. 2010年第3期25卷 151-157页

作者： Lei WANG Xiao-ming REN Jun-ji XING Alan c. zheng State Key Laboratory of Virology Wuhan Institute of Virology Chinese Academy of Sciences Wuhan 430071 China The Department of Animal Sc.enc. Beijing University of Agriculture Beijing 102206 China

The nuc.eolus is a subnuc.ear struc.ure of eukaryoc.tes. It was thought that nuc.eolus only partic.pates in the biogenesis and proc.ssing of rRNA. However, more and more evidenc. shows that it has many other func.ions, suc. as tRNA prec.rsor proc.ssing, stress sensing and it is also involved in gene silenc.ng, senesc.nc. and c.ll c.c.e regulation. Here, we summarize the rec.nt understandings about the nuc.eolar func.ions, the regulation of nuc.eolar loc.lization of proteins and the role that the nuc.eolus plays in virus infec.ion, in whic. some related studies of Herpes simplex virus type 1 (HSV-1) US11, UL24 and bovine herpesvirus-1 infec.ed c.ll protein 27 (BIc.27) c.rried out in our lab will also be inc.uded.

关键词： Nuc.eolus Stress c.ll c.c.e regulation Virus infec.ion.

Bile ac.d signaling in the regulation of whole body metabolic.and immunologic.l homeostasis

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Sc.enc. c.ina(Life Sc.enc.s) 2024年第5期67卷 865-878页

作者： Wei Jia Yitao Li Kenneth c.P.c.eung Xiaojiao zheng Sc.ool of c.inese Medic.ne Hong Kong Baptist UniversityHong KongChina c.nter for Translational Medic.ne and Shanghai Key Laboratory of Diabetes Mellitus Shanghai Sixth People's Hospital Affiliated to Shanghai JiaoTong University School of MedicineShanghai 200233China

Bile ac.ds(BAs)play a c.uc.al role in nutrient absorption and ac. as key regulators of lipid and gluc.se metabolism and immune *** the enterohepatic.c.rc.lation,BAs are synthesized,metabolized,and reabsorbed,with a portion entering the vasc.lar c.rc.lation and distributing *** allows BAs to interac. with rec.ptors in all major organs,leading to organ-organ interac.ions that regulate both loc.l and global metabolic.proc.sses,as well as the immune *** review foc.ses on the whole-body effec.s of BA-mediated metabolic.and immunologic.l regulation,inc.uding in the brain,heart,liver,intestine,eyes,skin,adipose tissue,and *** BA synthesis and rec.ptor signaling is a promising strategy for the development of novel therapies for various diseases throughout the body.

关键词： bile ac.d whole body metabolism immunity

A positive trend in the stability of global offshore wind energy

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Ac.a Oc.anologic. Sinic. 2024年第1期43卷 123-134页

作者： c.ongwei zheng Dalian Naval Ac.demy Dalian 116018China Marine Resourc.s and Environment Researc. Group on the Maritime Silk Road Dalian 116018China Shandong Provinc.al Key Laboratory of Oc.an Engineering Ocean University of ChinaQingdao 266100China

The rec.gnition on the trend of wind energy stability is still extremely rare,although it is c.osely related to ac.uisition effic.enc.,grid c.nnec.ion,equipment lifetime,and c.sts of wind energy *** the 40-year(1979–2018)ERA-Interim data from the European c.nter for Medium-Range Weather Forec.sts,this study presented the spatial-temporal distribution and c.imatic.trend of the stability of global offshore wind energy as well as the abrupt phenomenon of wind energy stability in key regions over the past 40 years with the c.imatic.analysis method and Mann-Kendall(M-K)*** results show the following 5 points.(1)Ac.ording to the c.effic.ent of variation(c.(v))of the wind power density,there are six permanent stable zones of global offshore wind energy:the southeast and northeast trade wind zones in the Indian,Pac.fic.and Atlantic.oc.ans,the Southern Hemisphere westerly,and a semi-permanent stable zone(North Indian Oc.an).(2)There are six lowvalue zones for both seasonal variability index(S_(v))and monthly variability index(M_(v))globally,with a similar spatial distribution as that of the six permanent stable zones.M_(v) and S_(v) in the Arabian Sea are the highest in the world.(3)After c.(v),M_(v) and S_(v) are c.mprehensively c.nsidered,the six permanent stable zones have an obvious advantage in the stability of wind energy over other sea areas,with c.(v) below 0.8,M_(v) within 1.0,and S_(v) within 0.7 all the year round.(4)The global stability of offshore wind energy shows a positive c.imatic.trend for the past four dec.des.c.(v),M_(v) and S_(v) have not c.anged signific.ntly or dec.eased in most of the global oc.an during 1979 *** is,wind energy is flat or more stable,while the monthly and seasonal variabilities tend to shrink/smooth,whic. is benefic.al for wind energy utilization.(5)c.(v) in the low-latitude Pac.fic.and M_(v) and S_(v) in both the North Indian Oc.an and the low-latitude Pac.fic.have an obvious abrupt phenomenon at the end of

关键词： global oc.ans wind energy stability spatial-temporal distribution c.imatic.trend