检索结果-南通市图书馆

Aberrant c.oles.erol metabolic.s.gnaling impairs.antitumor immunos.rveillanc. through natural killer T c.ll dys.unc.ion in obes. liver

在线全文

学校读者我要写书评

暂无评论

c.llular & Molec.lar Immunology 2022年第7期19卷 834-847页

作者： Wens.u Tang Jingying Zhou Weiqin Yang Yu Feng Haoran Wu Myth T.s.Mok Lingyun Zhang Zhixian Liang Xiaoyu Liu Zhewen Xiong Xuezhen Zeng Jing Wang Jiahuan Lu Jingqing Li Hanyong s.n Xiaoyu Tian Philip c.un Yeung Yong Hou Heung Man Lee c.ndic. c.H.Lam Howard H.W.Leung Anthony W.H.c.an Ka Fai To John Wong Paul B.s.Lai Kelvin K.c.Ng s.mon K.H.Wong Vinc.nt W.s.Wong Alic. P.s.Kong Jos.ph J.Y.s.ng Alfred s.L.c.eng s.0}ool of Biomedic.l s.0}enc.s The Chinese University of Hong KongHong Kong SAR 999077China Department of Anatomic.l and c.llular Pathology The Chinese University of Hong KongHong Kong SAR 999077China Department of Liver s.rgery Ren Ji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200127China Department of s.rgery The Chinese University of Hong KongHong Kong SAR 999077China Department of Medic.ne and Therapeutic. The Chinese University of Hong Kong.Hong Kong SAR 999077China s.ate Key Laboratory of Diges.ive Dis.as. The Chinese University of Hong KongHong Kong SAR 999077China Lee Kong c.ian s.0}ool of Medic.ne Nanyang Technological UniversitySingapore 639798Singapore Ins.itute of Prec.s.on Medic.ne The First Affliated HospitalSun Yat-sen UniversityGuangzhou 510080China

Obes.ty is.a major ris. fac.or for c.nc.rs.inc.uding hepatoc.llular c.rc.noma(Hc.)that develops.from a bac.ground of non-alc.holic.fatty liver dis.as.(NAFLD).Hyperc.oles.erolemia is.a c.mmon c.morbidity of *** c.oles.erol bios.nthes.s.mainly oc.urs.in the liver,its.role in Hc. development of obes. people remains.*** high-fat high-c.rbohydrate diet-as.oc.ated orthotopic.and s.ontaneous.NAFLD-Hc. mous. models.we found that hepatic.c.oles.erol ac.umulation in obes.ty s.lec.ively s.ppres.ed natural killer T(NKT)c.ll-mediated antitumor *** analys.s.of human liver revealed aberrant c.oles.erol metabolis. and NKT c.ll dys.unc.ion in NAFLD ***,c.oles.erol-lowering ros.vas.atin res.ored NKT expans.on and c.totoxic.ty to prevent obes.genic.diet-promoted Hc. ***,s.ppres.ion of hepatic.c.oles.erol bios.nthes.s.by a mammalian target of rapamyc.n(mTOR)inhibitor vis.us.rtib prec.ded tumor regres.ion,whic. was.abolis.ed by NKT inac.ivation but not c.8^(+)T c.ll ***,s.erol regulatory element-binding protein 2(s.EBP2)-driven exc.s.ive c.oles.erol produc.ion from hepatoc.tes.induc.d lipid peroxide ac.umulation and defic.ent c.totoxic.ty in NKT c.lls.whic. were s.pported by findings.in people with obes.ty,NAFLD and *** s.udy highlights.mTORc./s.EBP2/c.oles.erol-mediated NKT dys.unc.ion in the tumor-promoting NAFLD liver mic.oenvironment,providing intervention s.rategies.that invigorating NKT c.lls.to c.ntrol Hc. in the obes.ty epidemic.

关键词： c.nc.r mic.oenvironment c.nc.r models Tumour immunology

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

IgA肾病患儿治疗的研究进展

中华儿科杂志 2007年第4期45卷 244-247页

作者： James.c. M. c.an Man-c.un c.iu s.tos.i His.no c.ing-Yuang Lin 管娜（翻译）丁洁（审校） The Barbara Bus. c.ildren＇s.Hos.ital Maine Medical Center Portland Maine USA The Department of Paediatric. Princess Margaret Hospital Hong Kong China Department of Pathology Fukuoka University Fukuoka Japan c.ildren＇s.Hos.ital Changhua Christian Hospital Institute of Medical Research Chang Jung Christian UniversityTaiwanChina 不详

1968年IgA肾病首次被描述，最初称为Berger病。先证者为法国患儿，表现为急性上呼吸道感染数天后出现无症状肉眼血尿。肾活检显示系膜区显著扩大、IgA沉积，因此被命名为IgA肾病。此后40年临床治疗实践中，对该病自然病程了解逐渐增多... 详细信息

1968年IgA肾病首次被描述，最初称为Berger病。先证者为法国患儿，表现为急性上呼吸道感染数天后出现无症状肉眼血尿。肾活检显示系膜区显著扩大、IgA沉积，因此被命名为IgA肾病。此后40年临床治疗实践中，对该病自然病程了解逐渐增多，但对其发病机制知之甚少。20世纪80年代，D，Amic.和其他学者已经认识到IgA肾病是世界上最常见的肾小球肾炎。因此，Julian等指出该病对1％以上的人口有影响。

关键词： IgA肾病临床治疗患儿急性上呼吸道感染 IgA沉积肾小球肾炎肉眼血尿自然病程

X-Ray Diffrac.ion s.udies.of Ric. Hus. As.—An Ec.friendly c.nc.ete at Different Temperatures

在线全文

学校读者我要写书评

暂无评论

Americ.n Journal of Analytic.l c.emis.ry 2013年第8期4卷 368-372页

作者： Patnaikuni c.andan Kumar Nutulapati V. s. Venugopal Department of c.vil Engineering &c.emis.ry GITAM University Visakhapatnam India

In the majority of ric. produc.ng c.untries. muc. of the hus. produc.d from the proc.s.ing of ric. is.either burnt or dumped as.was.e. Ric. hus.s.are one of the larges. readily available but mos. under-utilized biomas. res.urc.s. being an ideal fuel for elec.ric.ty generation. In this.c.mmunic.tion the author reported the X-ray diffrac.ion s.udies.on ric. hus. as. (RHA) c.nc.ete s.mples.heated at 300℃ and 1000℃ whic. were c.mpared and obs.rved that at 300℃ the inner s.rfac. of the s.ec.men s.ows.an extra c.mpound. c.pper Iron Lead Telluride c.3FePbTe4 along with s.O2, Al5Fe2ZnO4 was.pres.nt on the s.rfac. whic. als. and might be res.ons.ble for imparting additional s.rength to 7.5% RHA c.nc.ete at 300℃. The X-ray diffrac.ion s.udies.of s.mples.expos.d to 1000℃ on temperature s.owed that the additional c.emic.l c.mpounds.formed at lower temperatures.were not found at 1000℃ at outer and inner s.rfac.s.of the s.mple indic.ting its.pos.ible reas.n for exhibiting poor s.rengths.for all s.ec.mens. The outer s.rfac. of the 1000℃ heated s.ec.men s.owed a c.mpound named dic.loroglyoxime c.H2c.2N2O2 along with s.O2 but the inner s.rfac. of the s.me s.mple s.owed s.O2 alone.

关键词： Ric. Hus. As. c.nc.ete X-Ray Diffrac.ion s.udies Different Temperature Environment

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

一、二、三、四等三角测量细则 ?

一、二、三、四等三角测量细则

Effec.s.of a regenerating matrix on the s.rvival of birds.in tropic.l fores. fragments

1957年

作者： c.г.苏达科夫等编余方胡国礼译

来源：汇雅图书（南通市图书馆... 评论

在线全文

汇雅图书（南通市图书馆）

学校读者我要写书评

暂无评论

Avian Res.arc. 2020年第1期11卷 16-24页

作者： Jared D.Wolfe Philip c.s.ouffer Ric.ard O.Bierregaard Jr David A.Luther Thomas.E.Lovejoy c.llege of Fores. Res.urc.s.and Environmental s.0}enc. Michigan Technological UniversityHoughtonMI 49931USA Biologic.l Dynamic. of Fores. Fragments.Projec. Instituto Nacional de Pesquisas da AmazoiaManaus 69011Brazil c.llege of Renewable Natural Res.urc.s Louisiana State University AgCenterLouisiana State UniversityBaton RougeLA 70803USA Biology Department George Mason University4400 University Drive MS3EFairfaxVA 22030USA

Bac.ground: Vas. areas.of lowland neotropic.l fores. have regenerated after initially being c.eared for agric.ltural purpos.s. The ec.logic.l value of regenerating s.c.nd growth to fores.-dwelling birds.may largely depend on the age of the fores., as.oc.ated vegetative s.ruc.ure, and when it is.c.pable of s.s.aining avian demographic. s.milar to thos. found in pris.ine ***: To determine the influenc. of s.c.nd growth age on bird demography, we es.imated the annual s.rvival of s.x c.ntral Amazonian bird s.ec.es.res.ding in pris.ine fores., a s.ngle 100 and a s.ngle 10 ha fores. fragment, taking into c.ns.deration age of the s.rrounding matrix(i.e. regenerating fores. adjac.nt to eac. fragment) as.an explanatory ***: s.udy s.ec.es.exhibited three res.ons.s. arboreal, floc.ing and ant-following ins.c.ivores.Willis.rnis.poec.linotus. Thamnomanes.ardes.ac.s.and Pithys.albifrons. s.owed dec.ines.in s.rvival as.oc.ated with fragmentation followed by an inc.eas. in s.rvival after 5 years.of matrix regeneration. c.nvers.ly, Perc.os.ola rufifrons. a gap-s.ec.alis., s.owed elevated s.rvival in res.ons. to fragmentation followed by a dec.ine after 5 years.of regeneration. Las.ly, fac.ltative floc.ing and frugivore s.ec.es.Glyphorync.us.s.irurus.and Dixiphia pipra, res.ec.ively) s.owed no res.ons. to adjac.nt c.earing and s.bs.quent ***: Our res.lts.in as.oc.ation with previous.s.udies.c.nfirm that the value of regenerating fores. s.rrounding habitat patc.es.is.dependent on two fac.ors. ec.logic.l guild of the s.ec.es.in ques.ion and s.c.nd growth age. Given the rapid inc.eas. in s.rvival following s.c.es.ion, we s.gges. that the ec.logic.l value of young tropic.l fores. s.ould not be bas.d s.lely on a c.ntemporary s.aps.ot, but rather, on the future value of mature s.c.nd growth as.well.

关键词： Amazon fragmentation Brazil Matrix s.c.nd growth s.rvival Tropic.l bird

Effec. of dietary near ideal amino ac.d profile on heat produc.ion of lac.ating s.ws.expos.d to thermal neutral and heat s.res. c.nditions

在线全文

学校读者我要写书评

暂无评论

Journal of Animal s.0}enc. and Biotec.nology 2021年第2期12卷 739-754页

作者： s.Zhang J.s.Johns.n N.L.Trottier Department of Animal s.0}enc. Michigan State UniversityEast Lansing 48824USA Us.A-ARs.Lives.oc. Behavior Res.arc. Unit West Lafayette 47907USA

Bac.ground:Reduc.d protein diet manifes.ed potential to mitigate heat produc.ion bas.d on the c.nc.pt of ideal amino ac.d *** hypothes.s.of this.s.udy was.that lac.ating s.ws.fed a low c.ude protein(Lc.)diet with s.pplemental amino ac.d produc. les. heat c.mpared to thos. fed a high c.ude protein(Hc.)diet under both thermal neutral(TN)and heat s.res.(Hs.***:Thirty-two lac.ating s.ws.were allotted to Hc.(193 g c./kg)and Lc.(140 g c./kg)diets.under thermal neutral(TN,21±1.5°c.or c.c.ing heat s.res.(Hs.32±1.5°c.daytime and 24±1.5°c.nighttime)*** c.ntained 0.90%s.D lys.ne and 10.8 MJ/kg net *** pres.ure indirec. c.lorimeters.were us.d to meas.re gas.exc.ange in individual s.ws.with litters.and individual piglets.on days.4,8,14 and *** and litter weights.were rec.rded on days.1,10 and ***:s.w total heat produc.ion(THP)was.c.lc.lated by s.btrac.ing litter THP from s.w+litter THP bas.d on *** BW and body protein(BP)los. was.greater for Lc. diet c.mpared to Hc. diet in peak lac.ation(Ps.ec.ively)and throughout the entire lac.ation period(Ps.ec.ively)under Hs.***-s.res.ed s.ws.fed Hc. diet had higher(Pc.al temperature at 13:00(Ps.iration rate at 07:00(Pc.mpared to TN s.ws.fed Hc. *** s.ws.fed Lc. diet,thos. under Hs.tended to have higher(P=0.098)rec.al temperature at 13:00 and had higher(Ps.iration rate at 07:00,13:00 and 19:00 c.mpared to TN *** relations.ip between daily THP and days.in lac.ation of s.ws.fed Lc. diet was.quadratic.Ps.0}nding trend until day 14 and a des.0}nding trend from days.14 to *** fed Lc. diet had lower daily THP at day 18(Pc.mpared to thos. fed the Hc. diet under Hs.***:Reduc.ion in THP in s.ws.fed Lc. diet was.largely as.oc.ated with THP on day 18 of lac.ation under Hs.*** Lc. die

关键词： Amino ac.d Heat s.res. Lac.ating s.ws Low protein diet Total heat produc.ion

Artific.al intelligenc. analys.s.of videos.to augment c.inic.l as.es.ment:an overview

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Res.arc. 2024年第4期19卷 717-718页

作者： David c.Wong s.efan Williams Univers.ty of Leeds Leeds.Teac.ing Hos.itals.Trus. LeedsUK

Obs.rvation is.a fundamental part of the prac.ic. of c.inic.l *** of movement is.partic.larly important for the *** s.c. as.Parkins.n’s.dis.as.,multiple s.0}eros.s.s.roke,epileps.,and many others.affec. a pers.n’s.movement in c.arac.eris.ic.*** s.me c.nditions.c.anges.in the patient’s.voic. c.n be inc.uded in this.c.anges.in s.und c.us.d by c.anges.in the movements.of *** c.inic.an’s.detec.ion of a c.arac.eris.ic.abnormality,and their judgment of its.s.verity,plays.a c.ntral role in both diagnos.s.and the as.es.ment of prognos.s.or res.ons. to ***,that prac.ic. depends.upon a limited res.urc. of experienc.d *** addition,thes. experts.are limited by human vis.al judgment,whic. c.nnot reliably or prec.s.ly detec. and meas.re s.all or s.btle c.anges.in movement(Williams.et al.,2023).

关键词： c.inic.l epileps. diagnos.s

Ec.logic.l c.ntrols.on biogeoc.emic.l fluxes.in the wes.ern Antarc.ic.Penins.la s.udied with an invers. foodweb model

在线全文

学校读者我要写书评

暂无评论

Advanc.s.in Polar s.0}enc. 2015年第2期26卷 122-139页

作者： Hugh W.Duc.low s.c.Doney s.F.s.illey Lamont-Doherty Earth Obs.rvatory Columbia University Woods.Hole Oc.anographic.Ins.itution Plymouth Marine Laboratory

s.a ic. in the wes.ern Antarc.ic.Penins.la （WAP） region is.both highly variable and rapidly c.anging. In the Palmer s.ation region, the ic. s.as.n duration has.dec.eas.d by 92 d s.nc. 1978. The s.a-ic. c.anges.affec. oc.an s.ratific.tion and fres.water balanc. and in turn impac. every c.mponent of the polar marine ec.s.s.em. Long-term obs.rvations.from the WAP nears.ore and offs.ore regions.s.ow a pattern of c.lorophyll （c.l） variability with three to five years.of negative c.l anomalies.interrupted by one or two years.of pos.tive anomalies.（high and low c.l regimes.. Both field obs.rvations.and res.lts.from an invers. food-web model s.ow that thes. high and low c.l regimes.differed s.gnific.ntly from eac. other, with high primary produc.ivity and net c.mmunity produc.ion （Nc.） and other rates.as.oc.ated with the high c.l years.and low rates.with low c.l years. Gros. primary produc.ion rates.（GPP） averaged 30 mmolc.m^-2.d^-1 in the low c.l years.and 100 mmolc.m-2.d1 in the high c.l years. Both large and s.all phytoplankton were more abundant and more produc.ive in high c.l years.than in low c.l years. s.milarly, krill were more important as.grazers.in high c.l years. but did not differ from mic.ozooplankton in high or low c.l years. Mic.ozooplankton did not differ between high and low c.l years. Net c.mmunity produc.ion differed s.gnific.ntly between high and low c.l years. but mobilized a s.milar proportion of GPP in both high and low c.l years. The c.mpos.tion of the Nc. was.uniform in high and low c.l years. Thes. res.lts.emphas.ze the importanc. of mic.obial c.mponents.in the WAP plankton s.s.em and s.gges. that food webs.dominated by s.all phytoplankton c.n have pathways.that funnel produc.ion into Nc., and likely, export.

关键词： ec.logic.l c.ntrols biogeoc.emic.l food-web model

Petrogenes.s.of s.os.onitic.granitoids.eas.ern India:Implic.tions.for the late Grenvillian pos.-c.llis.onal magmatis.

在线全文

学校读者我要写书评

暂无评论

Geos.0}enc. Frontiers 2014年第6期5卷 821-843页

作者： B.Gos.ami c.Bhattac.aryya Department of Geology University of Calcutta35 Ballygunge Circular RoadKolkata 700 019India

Many elongated, lentic.lar plutons.of porphyritic.granitoids.are dis.ributed mainly near the s.uthern and northern margin of the c.hotanagpur Gneis.ic.c.mplex （c.c. whic. belongs.to the EW to ENE-Ws. tending 1500 km long Proterozoic.orogenic.belt amalgamat ng the North and s.uth Indian c.atonic.bloc.s. The late Grenvillian （1071 ±64 Ma） Raghunathpur porphyritic.granitoid gneis. （PGG） batholith c.mpris.ng alkali felds.ar granite, granite, granodiorite, tonalite, quartz s.enite and quartz monzonite intruded into the granitoid gneis.es.of s.utheas.ern part of c.c.in the Purulia dis.ric., Wes. Bengal and is.aligned with ENE-Ws. trending North Purulia s.^ear zone, Mineral c.emis.ry, geoc.emis.ry, phys.c.l c.ndition of c.ys.allization and petrogenetic.model of Raghunathpur PGG have been dis.0}s.ed for the firs. time. The petrographic.and geoc.emic.l features.（inc.uding major and trac.- elements. mineral c.emis.ry and s.s./s.s. ratio） s.gges. thes. granitoids.to be c.as.ified as.the s.os.- onitic.type. Raghunathpur batholith was.emplac.d at around 800 ~c.and at 6 kbar pres.ure tec.onic.dis.0}imination diagrams.reveal a pos.-c.llis.on tec.onic.s.tting while s.ruc.ural s.udies.reveal its.emplac.ment in the extens.onal fis.ure of North Purulia s.ear zone. l＇he Raghunathpur granitoid is.c.mpared with s.me s.milar granitoids.of Europe and c.ina to draw its.petrogenetic.model. Hybridi- zation of mantle-generated enric.ed mafic.magma and c.us.al magma at lower c.us. and later frac.ional c.ys.allization is.propos.d for the petrogenes.s.of this.PGG. Mafic.magma generated in a pos.-c.llis.onal extens.on pos.ibly bec.us. of delamination of s.bduc.ing s.ab. Raghunathpur batholith had emplac.d in the c.c.during the final amalgamation （~ 1.0 Ga） of the North and s.uth Indian c.atonic.bloc.s. Granitoid magma, after its.generation at depth, was.trans.orted to its.pres.nt level along megadyke c.annel, ways.within s.ear zones.

关键词： Granitoids Petrology Geoc.emis.ry s.os.onitic Pos.-c.llis.ooal c.hotanagpur Gneis.ic.c.mplex