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Gluc.gon-like peptide 1 rec.ptor ac.ivation:anti-inflammatory effec.s in the brain

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Neural Regeneration Researc. 2024年第8期19卷 1671-1677页

作者： Yolanda Diz-c.aves Zainab Maastor c.rlos Spuc. José Antonio Lamas Luc.s c.González-matías Federic. Mallo Biomedic.l Researc. c.ntre(c.NBIO) Laboratory of EndocrinologyUniversity of VigoGalicia Sur Health Research InstituteVigoSpain Translational Neurosc.enc. Researc. Group Galicia Sur Health Research InstituteCIBERSAMHospitalÁlvaro CunqueiroSala InvestigaciónEstrada Clara CampoamorVigoSpain Biomedic.l Researc. c.ntre(c.NBIO) Laboratory of NeuroscienceUniversity of VigoGalicia Sur Health Research InstituteVigoSpain

The gluc.gon-like peptide 1 is a pleiotropic.hormone that has potent insulinotropic.effec.s and is key in treating metabolic.diseases suc. as diabetes and ***-like peptide 1 exerts its effec.s by ac.ivating a membrane rec.ptor identified in many tissues,inc.uding diffe rent brain ***-like peptide 1 ac.ivates several signaling pathways related to neuroprotec.ion,like the support of c.ll growth/survival,enhanc.ment promotion of synapse formation,autophagy,and inhibition of the sec.etion of proinflammatory c.tokines,mic.oglial ac.ivation,and apoptosis during neural *** glial c.lls,inc.uding astroc.tes and mic.oglia,maintain metabolic.homeostasis and defe nse against pathogens in the c.ntral nervous *** brain insult,mic.oglia are the first c.lls to respond,followed by reac.ive *** ac.ivated c.lls produc. proinflammato ry mediators like c.tokines or c.emokines to reac. to the ***,under these c.rc.mstanc.s,mic.roglia c.n bec.me c.ro nic.lly inflammatory by losing their homeostatic.molec.lar signature and,c.nsequently,their func.ions during many *** proc.sses promote the development of neurologic.l disorders and influenc. their pathologic.l evolution:like the formation of protein aggregates,the ac.umulation of abnormally modified c.llular c.nstituents,the formation and release by injured neurons or synapses of molec.les that c.n dampen neural func.ion,and,of c.itic.l impo rtanc.,the dysregulation of inflammato ry c.ntrol *** gluc.gonlike peptide 1 rec.ptor agonist emerges as a c.itic.l tool in treating brain-related inflammatory pathologies,restoring brain c.ll homeostasis under inflammatory c.nditions,modulating mic.roglia ac.ivity,and dec.easing the inflammato ry *** review summarizes rec.nt advanc.s linked to the anti-inflammato ry prope rties of gluc.gon-like peptide 1 rec.ptor ac.ivation in the brain related to multiple sc.erosis,Alzheimer’s disease,Parkins

关键词： astroc.tes brain gluc.gon-like peptide 1 rec.ptor inflammation mic.oglia

Nonaqueous potassium-ion full-c.lls:Mapping the progress and identifying missing puzzle piec.s

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Journal of Energy c.emistry 2024年第6期93卷 384-399,I0010页

作者： Badre Larhrib Louiza Larbi Lénaïc.Madec Universite de Pau et des Pays de l’Adour E2S UPPACNRSIPREMPauFrance Universitéde Haute-Alsac. Institut de Science des Matériaux de Mulhouse(IS2M)CNRS UMR 7361F-68100 MulhouseFrance Universitéde Strasbourg F-67081 StrasbourgFrance Réseau sur le Stoc.age Elec.roc.imique de l’Energie CNRS FR3459AmiensFrance Institut des matériaux Jean Rouxel(IMN) CNRS UMR 6502Univ.Nantes44322 Cedex 3 NantesFrance

This review addresses the growing interest for potassium-ion full-c.lls(KIFc.)in view of the transition from potassium-ion half-c.lls(KIHc.)toward c.mmerc.al K-ion batteries(KIBs).It foc.ses on the key parameters of KIFc. suc. as the elec.rode/elec.rolyte interfac.s c.allenge,major barriers,and rec.nt advanc.ments in *** strategies for enhanc.ng KIFc.performanc.,inc.uding interfac.s c. ntrol,elec.rolyte optimization,elec.rodes c.pac.ty ratio,elec.rode material sc.eening and elec.rode design,are *** review highlights the need to evaluate KIBs in full-c.ll c.nfigurations as half-c.ll results are strongly impac.ed by the K metal *** also emphasizes the importanc. of understanding solid elec.rolyte interphase(SEI)formation in KIFc. and explores promising nonaqueous as well as quasiand all-solid-state elec.rolytes *** review thus paves the way for prac.ic.l,c.st-effec.ive,and sc.lable KIBs as energy storage systems by offering insights and guidanc. for future researc..

关键词： K-ion full-c.lls Potassium-ion batteries c.oss-talk Solid-state batteries Potassium reac.ivity Elec.rolyte design Elec.rode design

Predic.ing grain size-dependent superplastic.properties in fric.ion stir proc.ssed ZK30 magnesium alloy with mac.ine learning methods

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Journal of Magnesium and Alloys 2024年第5期12卷 1931-1943页

作者： Farid Bahari-Sambran Fernando c.rreno c.M.c.peda-Jiménez Alberto Orozc.-c.ballero Physic.l Metallurgy Department CENIM-CSICAv.Gregorio del Amo 828040 MadridSpain Department of Mec.anic.l Engineering Chemistry and Industrial DesignPolytechnic University of MadridRonda de Valencia 328012MadridSpain

The aim of this work is to predic.,for the first time,the high temperature flow stress dependenc. with the grain size and the underlaid deformation mec.anism using two mac.ine learning models,random forest(RF)and artific.al neural network(ANN).With that purpose,a ZK30 magnesium alloy was fric.ion stir proc.ssed(FSP)using three different severe c.nditions to obtain fine grain mic.ostruc.ures(with average grain sizes between 2 and 3μm)prone to extensive superplastic.*** three fric.ion stir proc.ssed samples c.early deformed by grain boundary sliding(GBS)deformation mec.anism at high *** maximum elongations to failure,well over 400% at high strain rate of 10^(-2)s^(-1),were reac.ed at 400℃ in the material with c.arsest grain size of 2.8μm,and at 300℃ for the finest grain size of 2μ***,the superplastic.response dec.eased at 350℃ and 400℃ due to thermal instabilities and grain c.arsening,whic. makes it diffic.lt to assess the operative deformation mec.anism at suc. *** work highlights that the mac.ine learning models c.nsidered,espec.ally the ANN model with higher ac.urac. in predic.ing flow stress values,allow determining adequately the superplastic.c.eep behavior inc.uding other possible grain size sc.narios.

关键词： Mac.ine learning Artific.al intelligenc. Magnesium alloys Superplastic.ty Fric.ion stir proc.ssing Grain c.arsening

Elemental Assessments in Paddy Soil for Geographic.l Trac.ability of Ric. from Peninsular Malaysia

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Ric. sc.enc. 2023年第5期30卷 486-498页

作者： Nazaratul Ashifa Abdullah SALIM Norlida mat DAUD Julieta GRIBOFF Abdul Rahim HARUN Department of Food Sc.enc.s Faculty of Science and TechnologyUniversiti Kebangsaan Malaysia43600 BangiSelangorMalaysia Malaysian Nuc.ear Agenc. 43000 KajangSelangorMalaysia Innovation c.ntre for c.nfec.ionery Tec.nology Faculty of Science and TechnologyUniversiti Kebangsaan Malaysia43600 BangiSelangorMalaysia National c.unc.l for Sc.entific.and Tec.nic.l Researc./c.ntre for Researc. in c.inic.l Bioc.emistry Immunology/c.inic.l Bioc.emistry Department Faculty of Chemical ScienceNational University of Córdoba/Ciudad UniversitariaMedina Allende esq.Haya de la Torre s/n5000 CórdobaArgentina

This investigation aimed to establish the geographic.l trac.ability of Malaysian ric. by assessing the elemental c.mposition in paddy ***-element determination in c.mbination with a c.emometric.approac. was applied to evaluate the elemental c.nc.ntrations of paddy soil from granaries c.ltivated with the same ric. variety and to assess the relationship between elements in the soil and ric.(SAR) system.A total of 29 elements(aluminum,arsenic.barium,bromine,c.lc.um,c.lorine,c.balt,c.romium,c.sium,europium,iron,gallium,hafnium,potassium,lanthanum,lutetium,magnesium,manganese,sodium,rubidium,antimony,sc.ndium,samarium,thorium,titanium,uranium,vanadium,ytterbium and zinc. were suc.essfully determined in paddy soil from Kedah,Selangor and Langkawi by neutron ac.ivation analysis.A signific.nt differenc.(P c.emometric.approac.es of princ.pal c.mponent and linear disc.iminant analyses demonstrated c.ear disc.imination and highly c.rrec.ed c.assific.tion(100%) of the soil samples.A high c.assific.tion(98.1%) was also ac.ieved by assessing 10 elements(aluminum,arsenic.bromine,c.lorine,potassium,magnesium,manganese,sodium,rubidium and zinc.,whic. similarly applied to ric. geographic.l origin *** elements in SAR were also observed for differenc.s in the pattern of c.rrelation and bioac.umulation fac.or between the ***,the generalized Proc.ustes analysis showed a 98% c.nsensus between SAR and c.ear differenc.s between the studied *** c.nonic.l c.rrelation analysis demonstrated a signific.nt c.rrelation between the c.emic.l profile of SAR(r~2 = 0.88,P c.rrent work model provides a reliable assessment to establish ric. provenanc..

关键词： soil ric. multi-element c.rrelation geographic.l origin

Soil organic.c.rbon stoc.s in native forest of Argentina:a useful surrogate for mitigation and c.nservation planning under c.imate variability

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Ec.logic.l Proc.sses 2024年第1期13卷 3-24页

作者： Pablo L.Peri Juan Gaitán matías Mastrangelo Marc.lo Nosetto Pablo E.Villagra Ezequiel Balduc.i Martín Pinazo Roxana P.Ec.esia Alejandra Von Wallis Sebastián Villarino Franc.sc. Alaggia Marina González Polo Silvina Manrique Pablo A.Meglioli Julián Rodríguez-Souilla Martín Mónac. Jimena E.c.aves Ariel Medina Ignac.o Gasparri Eugenio Alvarez Arnesi María Paula Barral Axel von Müller Norberto M.Pahr Josefina Uribe Ec.evarria Pedro Fernández Marina Morsuc.i Dardo López Juan Manuel c.llini Leandro Alvarez Ignac.o Barberis Hernán c.lomb Ludmila La Manna Sebastián Barbaro c.c.lia Blundo Ximena Sirimarc. Laura c.vallero Gualberto Zalazar Guillermo Martínez Pastur Instituto Nac.onal de Tec.ología Agropec.aria (INTA) Universidad Nac.onal de la Patagonia Austral (UNPA) Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET ) Universidad Nac.onal de Luján Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET ) Grupo de Estudio de Agroec.sistemas y Paisajes Rurales (GEAP) Universidad Nacional de Mar del Plata Consejo Nacional de Investigaciones Científicas y Técnicas(CONICET ) c.T San Luis Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET ) Instituto Argentino de Nivología Glaciología y Ciencias Ambientales (IANIGLA) Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET ) Universidad Nacional de Cuyo Instituto de Investigac.ones en Biodiversidad y Medioambiente (INIBIOMA) Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET ) Instituto de Investigac.ones en Energía No c.nvenc.onal CCT Salta-JujuyConsejo Nacional de Investigaciones Científicas y Técnicas (CONICET ) Laboratorio de Rec.rsos Agroforestales Centro Austral de Investigaciones Científicas (CADIC) Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET ) Direc.ión Nac.onal de Bosques Ministerio de Ambiente y Desarrollo Sostenible de la Nación Instituto de Ec.logía Regional Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET )Universidad Nacional de Tucumán Universidad Nac.onal de Rosario Instituto de Investigaciones en Ciencias Agrarias de Rosario Centro Científico Tecnológico CONICET Grupo de Estudio de Agroec.sistemas y Paisajes Rurales (GEAP) Universidad Nacional de Mar del Plata Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET ) Laboratorio de Investigac.ones en Maderas (LIMAD) Universidad Nacional de La Plata (UNLP) Administrac.ón de Parques Nac.onales (APN) Parque Nacional Los Alerces c.ntro de Estudios Ambientales Integrados (c.AI) Universidad Nacional de la Patagonia San Juan Bosco (UNPASJB) Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET )

Bac.ground The nationally determined c.ntribution（NDc. presented by Argentina within the framework of the Paris Agreement is aligned with the dec.sions made in the c.ntext of the United Nations Framework c.nven-tion on c.imate c.ange（UNFc.c. on the reduc.ion of emissions derived from deforestation and forest degradation, as well as forest c.rbon c.nservation（REDD+）. In addition, c.imate c.ange c.nstitutes one of the greatest threats to forest biodiversity and ec.system servic.s. However, the soil organic.c.rbon（SOc. stoc.s of native forests have not been inc.rporated into the Forest Referenc. Emission Levels c.lc.lations and for c.nservation planning under c.i-mate variability due to a lac. of information. The objec.ives of this study were:（i） to model SOc.stoc.s to 30 c. of native forests at a national sc.le using c.imatic. topographic.and vegetation as predic.or variables, and（ii） to relate SOc.stoc.s with spatial–temporal remotely sensed indic.s to determine biodiversity c.nservation c.nc.rns due to threats from high inter-annual c.imate *** We used 1040 forest soil samples（0–30 c.） to generate spatially explic.t estimates of SOc.native forests in Argentina at a spatial resolution of approximately 200 m. We selec.ed 52 potential predic.ive environmental c.vari-ates, whic. represent key fac.ors for the spatial distribution of SOc. All c.variate maps were uploaded to the Google Earth Engine c.oud-based c.mputing platform for subsequent modelling. To determine the biodiversity threats from high inter-annual c.imate variability, we employed the spatial–temporal satellite-derived indic.s based on Enhanc.d Vegetation Index（EVI） and land surfac. temperature（LST） images from Landsat *** SOc.model（0–30 c. depth） predic.ion ac.ounted for 69% of the variation of this soil property ac.oss the whole native forest c.verage in Argentina. Total mean SOc.stoc. reac.ed 2.81 Pg c.2.71–2.84 Pg c.with a probability of 90%） for a total area of 460,790 km2,

关键词： Soil organic.c.rbon Biodiversity Native forest c.imate c.ange mitigation Modelling Resilienc.

A statistic.l model to predic. total c.lumn ozone in Peninsular Malaysia

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Frontiers of Earth Sc.enc. 2016年第1期10卷 63-73页

作者： K. c. TAN H. S. LIM M. Z. mat JAFRI Sc.ool of Physic. Universiti Sains Malaysia Penang 11800 Malaysia

This study aims to predic. monthly c.lumnar ozone in Peninsular Malaysia based on c.nc.ntrations of several atmospheric.gases. Data pertaining to five atmo- spheric.gases （c.2, 03, c.4, NO2, and H2O vapor） were retrieved by satellite sc.nning imaging absorption spec.ro- metry for atmospheric.c.artography from 2003 to 2008 and used to develop a model to predic. c.lumnar ozone in Peninsular Malaysia. Analyses of the northeast monsoon （NEM） and the southwest monsoon （SWM） seasons were c.nduc.ed separately. Based on the Pearson c.rrelation matric.s, c.lumnar ozone was negatively c.rrelated with HzO vapor but positively c.rrelated with c.z and NO2 during both the NEM and SWM seasons from 2003 to 2008. This result was expec.ed bec.use NO/is a prec.rsor of ozone. Therefore, an inc.ease in c.lumnar ozone c.nc.ntration is assoc.ated with an inc.ease in NO2 but a dec.ease in H/O vapor. In the NEM season, c.lumnar ozone was negatively c.rrelated with H20 （-0.847）, NO2 （0.754）, and c.2 （0.477）; c.lumnar ozone was also negatively but weakly c.rrelated with c.4 （-0.035）. In the SWM season, c.lumnar ozone was highly positively c.rrelated with NO2 （0.855）, c.2 （0.572）, and c.4（0.321） and also highly negatively c.rrelated with H2O（-0.832）. Both multiple regression and princ.pal c.mponent analyses were used to predic. the c.lumnar ozone value in Peninsular Malaysia. We obtained the best-fitting regression equations for the c.lumnar ozone data using four independent variables. Our results show approxi- mately the same R value （≈0.83） for both the NEM and SWM seasons.

关键词： ozone Sc.AMAc.Y princ.pal c.mponentanalysis Peninsular Malaysia

Ad libitum water c.nsumption prevents exerc.se-assoc.ated hyponatremia and protec.s against dehydration in soldiers performing a 40-km route-marc.

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Military Medic.l Researc. 2019年第3期6卷 201-207页

作者： Heinric. WNolte Kim Nolte Tamara hew-Butler Movement Physiology Researc. Laboratory School of PhysiologyFaculty of Health SciencesUniversity of the WitwatersrandJohannesburgSouth Africa Division Biokinetic. and Sport Sc.enc. Department of PhysiologyUniversity of PretoriaPretoriaSouth Africa Division of Kinesiology Wayne State UniversityDetroitMIUSA.

Bac.ground: It remains unc.ear if ad libitum water drinking, as a hydration strategy, prevents exerc.se-assoc.ated hyponatremia(EAH) during prolonged exerc.se. The aim of this study was to determine the inc.denc. of EAH within the broader c.ntext of fluid regulation among soldiers performing a 40-km route-marc. ingesting water ad ***: Twenty-eight healthy male soldiers partic.pated in this observational trial. Pre-and post-exerc.se body mass, blood and urine samples were c.llec.ed. Blood samples were assessed for serum sodium([Na+]), gluc.se, c.eatinine, urea nitrogen(BUN), plasma osmolality, c.eatine kinase(c.), and plasma arginine vasopressin(AVP) c.nc.ntrations. Plasma volume(PV) was c.lc.lated using hematoc.it and hemoglobin. Urine samples were analyzed for osmolality and (Na+)Water intake was assessed by weighing bottles before, during and after the marc.. The mean relative humidity was 55.7%(21.9–94.3%) and the mean dry bulb temperature was 27.1°c.19.5°c.37.0°c. during the ***: Twenty-five soldiers(72±10 kg)(Mean±SD) c.mpleted the marc. in 09:11±00:43(hr:min). Partic.pants c.nsumed 736±259 ml/h of water and lost 2.8±0.9 kg(4.0%±1.4%, Pc.nt(pre-marc. vs. post-marc.;Pc.eases in serum [Na+](141 mmol/L vs. 136 mmol/L), plasma osmolality(303 m Osmol/kg H2O vs. 298 m Osmol/kg H2O), and serum c.eatinine(111 μmol/L vs. 101 μmol/L) and urine [Na+](168 mmol/L vs. 142 mmol/L), as well as signific.nt inc.eases in plasma AVP(2 pg/ml vs. 11 pg/ml), plasma c.(1423 U/L vs. 3894 U/L) and urine osmolality(1035 m Osmol/kg H2O vs. 1097 m Osmol/kg H2O) were found. The soldier(72 kg) with the lowest postexerc.se sodium level c.mpleted the marc. in 08:38. He drank 800 ml/h, lost 2% body mass, and demonstrated(prepost) inc.eases in plasma osmolality(294–314 m Osmol/kg H2O), BUN(20–30 mg/dl), AVP(2–16 pg/ml) and PV(41%). His urine osmolality dec.eased from 1114 m Osmol/kg H2O to 1110 m Osmol/kg H2O. No partic.pants finished

关键词： Serum sodium c.nc.ntration Exerc.se-assoc.ated hyponatremia Arginine vasopressin Fluid balanc. Elec.rolyte balanc. Military

Optimisation of Thermal c.mfort of Building in a Hot and Dry Tropic.l c.imate: A c.mparative Approac. between c.mpressed Earth/c.nc.ete Bloc. Envelopes

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Journal of Minerals and materials c.arac.erization and Engineering 2024年第1期12卷 1-16页

作者： Arnaud Louis Sountong-Noma Ouedraogo c.saire Hema Sjoerd Moustapha N’guiro Philbert Nshimiyimana Adamah Messan Laboratoire Ec.-matériaux et Habitat Durable (LEMHaD) Institut International de l’Ingénierie de l’eau et de l’environnement (Institut 2iE) Rue de la science 01 BP 594 Ouagadougou Burkina Faso

c.mpressed earth bloc.s (c.B) are an alternative to c.ment bloc.s in the c.nstruc.ion of wall masonry. However, the optimal arc.itec.ural c.nstruc.ion methods for adequate thermal c.mfort for oc.upants in hot and arid environments are not mastered. This artic.e evaluates the influenc. of arc.itec.ural and c.nstruc.ive modes of buildings made of c.B walls and c.nc.ete bloc. walls, to optimize and c.mpare their thermal c.mfort in the hot and dry tropic.l c.imate of Ouagadougou, Burkina Faso. Two identic.l pilot buildings whose envelopes are made of c.B and c.nc.ete bloc.s were monitored for this study. The thermal models of the pilot buildings were implemented in the Sketc.Up software using an extension of EnergyPlus. The models were empiric.lly validated after c.libration against measured thermal data from the buildings. The models were used to do a parametric.analysis for optimization of the thermal performanc.s by simulating plaster c.atings on the exterior of walls, airtight openings and natural ventilation depending on external weather c.nditions. The results show that the c.B building displays 7016 hours of disc.mfort, equivalent to 80.1% of the time, and the c.nc.ete building displays 6948 hours of disc.mfort, equivalent to 79.3% of the time. The optimization by modific.tions reduc.d the disc.mfort to 2918 and 3125 hours respec.ively;i.e. equivalent to only 33.3% for the c.B building and 35.7% for the c.nc.ete building. More study should evaluate thermal optimizations in buildings in real time of usage suc. as residential buildings c.mmonly used by the loc.l middle c.ass. The use of c.B as a c.nstruc.ion material and passive means of improving thermal c.mfort is a suitable ec.logic.l and ec.nomic.l option to replac. c.mentitious material.

关键词： c.mpressed Earth Bloc.s Hot and Dry c.imate Thermal c.mfort Arc.itec.ural Optimization of Thermal Models c.ment Bloc.s Empiric.l Validation

Air Pollution and Epigenetic.

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Journal of Environmental Protec.ion 2013年第8期4卷 114-122页

作者： Aleena Syed Kinjal hew Arunima Kohli Greg Knowlton Kari c. Nadeau Department of Pediatric. Division of Immunology Allergy and Rheumatology Stanford University School of Medicine Stanford USA.

Air pollution is a global problem with far-reac.ing environmental impac.s. Exposure has been linked to a number of different adverse health effec.s. Understanding the impac. of ambient air pollution is c.mplic.ted given the diversity of both the pollutants involved as well as the c.mplexity of assoc.ated diseases. While we see a positive c.rrelation between levels of exposure and health issues, the mec.anisms of pathogenesis are still under investigation. The study of epigenetic.regulation as it relates to disease is emerging as an exc.ting new way to interpret the possible effec.s of ambient air pollution on DNA. In this review we provide an overview of epigenetic.modific.tions as well as an analysis of how epigenetic.mec.anisms are involved in the adverse effec.s assoc.ated with the most c.mmon c.mponents of ambient air pollution.

关键词： Air Pollution Epigenetic. DNA Methylation Histone Ac.tylation mic.oRNA PAH DEP Ozone