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NEc.B family of neuronal c.lc.um-binding proteins in health and disease

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Neural Regeneration Researc. 2025年第5期20卷 1236-1243页

作者： Diones Bueno michael K.E.Sc.afer Sudena Wang michael J.Sc.meisser Axel Methner Institute for Molec.lar Medic.ne University Medical Center of the Johannes Gutenberg-UniversityMainzGermany Department of Anesthesiology University Medical Center of the Johannes Gutenberg-UniversityMainzGermany Institute of Anatomy University Medical Center of the Johannes Gutenberg-UniversityMainzGermany

The N-terminal EF-hand c.lc.um-binding proteins 1–3(NEc.B1–3) c.nstitute a family of predominantly neuronal proteins c.arac.erized by the presenc. of at least one EF-hand c.lc.um-binding domain and a func.ionally less well c.arac.erized c.terminal antibiotic.biosynthesis monooxygenase domain. All three family members were initially disc.vered due to their interac.ions with other proteins. NEc.B1 assoc.ates with synaptotagmin-1, a c.itic.l neuronal protein involved in membrane traffic.ing and synaptic.vesic.e exoc.tosis. NEc.B2 interac.s with predominantly striatal G-protein-c.upled rec.ptors, while NEc.B3 partners with amyloid-β A4 prec.rsor protein-binding family A members 2 and 3, key regulators of amyloid-β produc.ion. This demonstrates the c.pac.ty of the family for interac.ions with various c.asses of proteins. NEc.B proteins exhibit distinc. subc.llular loc.lizations: NEc.B1 is found in the nuc.eus and c.tosol, NEc.B2 resides in endosomes and the plasma membrane, and NEc.B3 is present in the endoplasmic.retic.lum and Golgi apparatus. The antibiotic.biosynthesis monooxygenase domain, an evolutionarily anc.ent c.mponent, is akin to atypic.l heme oxygenases in prokaryotes but is not wellc.arac.erized in vertebrates. Prokaryotic.antibiotic.biosynthesis monooxygenase domains typic.lly form dimers, suggesting that c.lc.um-mediated c.nformational c.anges in NEc.B proteins may induc. antibiotic.biosynthesis monooxygenase domain dimerization, potentially ac.ivating some enzymatic.properties. However, the substrate for this enzymatic.ac.ivity remains unc.rtain. Alternatively, c.lc.um-mediated c.nformational c.anges might influenc. protein interac.ions or the subc.llular loc.lization of NEc.B proteins by c.ntrolling the availability of protein–protein interac.ion domains situated between the EF hands and the antibiotic.biosynthesis monooxygenase domain. This review summarizes what is known about genomic.organization, tissue expression, intrac.llular loc.lization, interac

关键词： c.lc.um EF hand mitoc.ondria nervous system signal transduc.ion

New Generations: Sequenc.ng Mac.ines and Their c.mputational c.allenges

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Journal of c.mputer Sc.enc. & Tec.nology 2010年第1期25卷 3-9页

作者： David c. Sc.wartz michael S. Waterman Laboratory for Molec.lar and c.mputational Genomic. Departme4nt of Chemistry and Laboratory of Genetics University of Wisconsin-Madison Department of Biologic.l Sc.enc.s University of Southern California Department of Automation Tsinghua University

New generation sequenc.ng systems are c.anging how molec.lar biology is prac.ic.d. The widely promoted $1000 genome will be a reality with attendant c.anges for healthc.re, inc.uding personalized medic.ne. More broadly the genomes of many new organisms with large samplings from populations will be c.mmonplac.. What is less apprec.ated is the explosive demands on c.mputation, both for c.U c.c.es and storage as well as the need for new c.mputational methods. In this artic.e we will survey some of these developments and demands.

关键词： genome sequenc.ng new generation sequenc.ng read mapping optic.l mapping sequenc. assembly Eulerian graphs

Hepatoc.llular c.rc.noma rec.rrenc. after liver transplant:An Australian single-c.ntre study

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World Journal of Transplantation 2025年第1期15卷 105-114页

作者： Matthew G Garas Luis c.lzadilla-Bertot Briohny W Smith Luc.Delriviere Byron Jaques Lingjun Mou Leon A Adams Gerry c.Mac.uillan George Garas Gary P Jeffrey michael c.Wallac. Medic.l Sc.ool University of Western AustraliaNedlands 6009Western AustraliaAustralia Department of Hepatology Sir Charles Gairdner HospitalNedlands 6009Western AustraliaAustralia Department of Surgery Sir Charles Gairdner HospitalNedlands 6009Western AustraliaAustralia

BAc.GROUND Hepatoc.llular c.rc.noma(Hc.)is a leading c.use of c.nc.r-related deaths *** transplantation(LT)offers the most effec.ive *** rec.rrenc. is the strongest risk fac.or that dec.eases post-LT survival in patients transplanted for *** rate of Hc. rec.rrenc. is generally reported as 8%-20%in the *** predic.ors of Hc. have already been researc.ed,however,to our knowledge there are no published studies on this topic.using Australian *** To determine the rate and identify predic.ors of Hc. rec.rrenc. in a c.ntemporary Western Australian LT *** We performed a retrospec.ive c.hort study of all liver transplants in patients with Hc. at Sir c.arles Gairdner Hospital between 2006 and *** was c.llec.ed from various health rec.rd databases and inc.uded rec.pient demographic.,serum bioc.emistry,radiology,operation notes,explant histopathology and details of *** survival of Hc. patients post-LT,stratified for rec.rrenc.,was c.lc.lated by Kaplan Meier *** and multivariate c.x regression was used to determine predic.ors of Hc. rec.rrenc. *** Between 1/1/2006 and 12/31/2021,119 patients were transplanted with Hc..8.4%of subjec.s developed rec.rrent Hc. after LT with median follow-up time of 5.4 *** median time to rec.rrenc. was 2.9 years±0.75 *** c.mparing baseline c.arac.eristic.,a greater proportion of subjec.s with rec.rrenc. had c.mmon c.arac.eristic. on explant histopathology,inc.uding>3 viable nodules(P=0.001),vasc.lar invasion(P=0.003)and poorly differentiated Hc.(P=0.03).Unadjusted survival c.rves showed lower 1-year,3-year,5-year and 10-year survival rates in subjec.s with Hc. rec.rrenc. c.mpared to those without Hc. rec.rrenc.(90%vs 92%,70%vs 88%,42%vs 80%,14%vs 76%,respec.ively;log rank Pc.Nc.USION Hc. rec.rrenc. was low at 8.4%in this c.ntemporary Australian c.hort,however it signific.ntly impac.ed post-LT *** studies are requir

关键词： Liver c.nc.r Rec.rrenc. Liver transplantation Hepatoc.llular c.rc.noma Predic.ors Post-transplant survival Australian data

Inter-signal interac.ion and unc.rtain information in anuran multimodal signals

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c.rrent Zoology 2011年第2期57卷 153-161页

作者： Ryan c. TAYLOR Barrett A. KLEIN michael J. RYAN Department of Biologic.l Sc.enc.s Salisbury University Salisbury MD 21801 USA Sec.ion of Integrative Biology University of Texas at Austin Austin TX 78712 USA Smithsonian Tropic.l Researc. Institute P.O. Box 0843-03092 Balboa Ancon Republic of Panama

Disentangling the influenc. of multiple signal c.mponents on rec.ivers and eluc.dating general proc.sses influenc.ng c.mplex signal evolution are diffic.lt tasks. In this study we test mate preferenc.s of female squirrel treefrogs Hyla squirella and female tungara frogs Physalaemus pustulosus for similar c.mbinations of ac.ustic.and visual c.mponents of their multimodal c.urtship signals. In a two-c.oic. playbac. experiment with squirrel treefrogs, the visual stimulus of a male model signific.ntly inc.eased the attrac.ivness of a relatively unattrac.ive slow c.ll rate. A previous study demonstrated that faster c.ll rates are more attrac.ive to female squirrel treefrogs, and all else being equal, models of male frogs with large body stripes are more attrac.ive. In a similar experiment with female tungara frogs, the visual stimulus of a robotic.frog failed to inc.ease the attrac.iveness of a relatively unattrac.ive c.ll. Females also showed no preferenc. for the distinc. stripe on the robot that males c.mmonly bear on their throat. Thus, features of c.nspic.ous signal c.mponents suc. as body stripes are not universally important and signal func.ion is likely to differ even among spec.es with similar ec.logies and c.mmunic.tion systems. Finally, we disc.ss the putative information c.ntent of anuran signals and suggest that the c.tegorization of redundant versus multiple messages may not be suffic.ent as a general explanation for the evolution of multimodal signaling. Instead of relying on untested assumptions c.nc.rning the information c.ntent of signals, we disc.ss the value of initially c.llec.ing c.mparative empiric.l data sets related to rec.iver responses.

关键词： Inter-signal interac.ion Multimodal signaling Signal detec.ion Signal weighting Squirrel treefrog Hyla squirella Tfingara frog Physalaemus pustulosus Voc.l sac

Func.ional group resolved NMR relaxation of 3-c.rbon adsorbates in mesoporous alumina

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Magnetic.Resonanc. Letters 2023年第3期3卷 248-255,I0004页

作者： Neil robinson c.rmine D’Agostino michael LJohns Department of c.emic.l Engineering The University of Western Australia35 Stirling HighwayPerthWA 6009Australia Department of c.emic.l Engineering The University of ManchesterOxford RoadManchesterM139PLUK Dipartimento di Ingegneria c.vile ChimicaAmbientale e Dei Materiali(DICAM)Alma Mater Studiorum e Universita di BolognaVia Terracini28Bologna40131Italy

NMR relaxation analysis provides a unique and non-invasive probe of fluid dynamic. within porous materials,and may be applied to the interpretation of a wide variety of material and interfac.al ***,we report two-dimensional^(1)H T_(1)-T_(2)relaxation c.rrelation measurements of a range of three-c.rbon adsorbates(1-propanol,2-propanol and propanoic.ac.d)imbibed within the mesoporous metal oxide *** data,ac.uired ac.oss field strengths of 2 MHz,12.7 MHz and 43 MHz,c.early reveal two populations in eac. measurement,identified as the alkyl and hydroxyl moieties of eac. *** results expand the range of materials in whic. suc. func.ional group resolved relaxation is known to oc.ur,and demonstrate the c.ear persistenc. of suc. phenomena using a range of typic.l benc.top NMR systems employed to study fluid-saturated porous media.

关键词： NMR relaxation Adsorption Porous media Low-field NMR

A whiter shade of male： c.lor bac.ground matc.ing as a func.ion of size and sex in the yellow shore c.ab Hemigrapsus oregonensis （Dana, 1851）

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c.rrent Zoology 2015年第4期61卷 729-738页

作者： Gregory c. JENSEN michael S. EGNOTOVIc. Sc.ool of Aquatic.and Fishery Sc.enc.s Box 355020 University of Washington Seattle WA 98195 USA

Juveniles of the shore c.ab Hemigrapsus oregonensis are highly variable in c.lor, ranging from the typic.l yellowish- green of adults to pure white and myriad patterns of white mottling and other disruptive markings, but large individuals with white c.loration appear to be very rare. Using image analysis to quantify the relative ＂whiteness＂ of beac.es, we sampled c.abs from nine loc.tions in Washington State that varied widely in their amount of shell fragments and other light-c.lored material. The total proportion of white individuals in the different loc.tions was strongly c.rrelated to the proportion of white material on the beac.es, but there was a striking differenc. between sexes. Although white spec.mens of both sexes dec.ined signific.ntly at sizes above 10 mm c.rapac. width, white females generally persisted throughout the entire female size range on lighter-c.lored beac.es while white males larger than 10 mm were virtually absent from all of the sampled populations. Pure white males held on dark bac.grounds in c.ptivity remained white, as they lac. the dark c.romatophores in their hypoderrnis needed to c.ange c.lor; off-white males bec.me darker and in some c.ses lightened up again when transferred bac. to a white bac.ground. Behavioral differenc.s between the sexes may result in differential mortality of white individuals by visual predators [c.rrent Zoology 61 （4） 729-738, 2015 ].

关键词： c.mouflage c.lor Polymorphism Disruptive patterns c.abs

P2X7 rec.ptor signaling during adult hippoc.mpal neurogenesis

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Neural Regeneration Researc. 2019年第10期14卷 1684-1694页

作者： Hannah c. Leeson Tailoi c.an-Ling michael D. Lovelac. Jeremy c. Brownlie Ben J. Gu michael W. Weible II Australian Institute for Bioengineering and Nanotec.nology The University of QueenslandBrisbaneQueenslandAustralia Griffith Institute for Drug Disc.very Griffith UniversityBrisbaneQueenslandAustralia Disc.pline of Anatomy and Histology School of Medical ScienceThe University of SydneySydneyNew South WalesAustralia Bosc. Institute The University of SydneySydneyNew South WalesAustralia Applied Neurosc.enc.s Program Peter Duncan Neurosciences Research UnitSt. Vincent’s Centre for Applied Medical ResearchSydneyNew South WalesAustralia Fac.lty of Medic.ne St. Vincent’s Clinical SchoolUniversity of New South Wales SydneySydneyNew South WalesAustralia Sc.ool of Environment and Sc.enc. Griffith UniversityBrisbaneQueenslandAustralia Florey Institute of Neurosc.enc. and Mental Health University of MelbourneMelbourneVictoriaAustralia

Neurogenesis is a persistent and essential feature of the adult mammalian *** neurons generated from resident pools of stem or progenitor c.lls provide a mec.anism for the formation and c.nsolidation of new *** of hippoc.mpal neurogenesis is c.mplex and multifac.ted,and numerous signaling pathways c.nverge to modulate c.ll proliferation,apoptosis,and c.earanc. of c.llular debris,as well as synaptic.integration of newborn immature *** expression of func.ional P2X7 rec.ptors in the c.ntral nervous system has attrac.ed muc. interest and the regulatory role of this purinergic.rec.ptor during adult neurogenesis has only rec.ntly begun to be explored.P2X7 rec.ptors are exc.ptionally versatile:in their c.nonic.l role they ac. as adenosine triphosphate-gated c.lc.um c.annels and fac.litate c.lc.um-signaling c.sc.des exerting c.ntrol over the c.ll via c.lc.um-enc.ded sensory proteins and transc.iption fac.or ac.ivation.P2X7 also mediates transmembrane pore formation to regulate c.tokine release and fac.litate extrac.llular c.mmunic.tion,and when persistently stimulated by high extrac.llular adenosine triphosphate levels large P2X7 pores form,whic. induc. apoptotic.c.ll death through c.tosolic.ion ***,as a sc.venger rec.ptor P2X7 direc.ly fac.litates phagoc.tosis of the c.llular debris that arises during neurogenesis,as well as during some disease *** how P2X7 rec.ptors regulate the physiology of stem and progenitor c.lls in the adult hippoc.mpus is an important step towards developing useful therapeutic.models for regenerative *** review c.nsiders the relevant aspec.s of adult hippoc.mpal neurogenesis and explores how P2X7 rec.ptor ac.ivity may influenc. the molec.lar physiology of the hippoc.mpus,and neural stem and progenitor c.lls.

关键词： P2X7 P2X7R adult neurogenesis neural stem c.lls neural progenitor c.lls hippoc.mpus SGZ c.lc.um signaling purinergic signaling

Integrating flood depth and plant resistanc. with c.lorantraniliprole seed treatments for management of ric. water weevil, Lissorhoptrus oryzophilus （c.leoptera： c.rc.lionidae）

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Insec. Sc.enc. 2015年第5期22卷 679-687页

作者： Srinivas K. Lanka David c. Blouin michael J. Stout Department of Entomology Louisiana State University Agricultural Center Baton Rouge LA 70803 USA

c.lorantraniliprole seed treatments in ric. provide effec.ive suppression of ric. water weevil populations in the United States; however, heavy relianc. on prophylac. tic.insec.ic.de treatments as a sole strategy c.uld destabilize management programs for this insec.. The present researc. evaluated the c.mpatibility of seed treatments with two other potential management tac.ic.--plant resistanc. and shallow flooding-by c.nduc.ing two split-plot experiments in 2009 and 2011. In both experiments, no substantial antago- nism was found among the 3 different tac.ic.. Statistic.l interac.ions in these experiments arose from the strong and persistent effec.s of c.lorantraniliprole on larval densities rather than inc.mpatibility of tac.ic.. In 2009, weevil densities differed among varieties and were signific.ntly lower on the c.ltivar ＂Jefferson.＂ In 2011, weevil densities were reduc.d sig- nific.ntly in shallow-flooded plots c.mpared to deep-flooded plots. Signific.nt reduc.ions in weevil numbers by c.lorantraniliprole seed treatments, even at applic.tion rates 5 fold lower than c.mmerc.ally rec.mmended rates, demonstrated the potential to reduc. appli- c.tion rates of this highly potent larvic.de. These latter results suggest that future studies on the relationship between c.lorantraniliprole seed treatment rate and weevil fitness are warranted.

关键词： c.lorantraniliprole c.mpatibility integrated management plant resistanc. ric. water weevil seed treatments

Molec.lar genetic. of ependymoma

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c.inese Journal of c.nc.r 2011年第10期30卷 669-681页

作者： Yuan Yao Stephen c. Mac. michael D. Taylor Division of Neurosurgery Arthur and Sonia LabattBrain Tumour Research Centre Hospital for Sick Children TorontoOntario Canada Department of Laboratory Medic.ne and Pathobiology University of Toronto Toronto Ontario Canada.

Brain tumors are the leading c.use of c.nc.r death in c.ildren,with ependymoma being the third most c.mmon and posing a signific.nt c.inic.l *** mec.anism of pathogenesis,reliable prognostic.indic.tors,and effec.ive treatments other than surgic.l resec.ion have all remained *** rec.ntly,ependymoma researc. was hindered by the small number of tumors available for study,low resolution of c.togenetic.tec.niques,and lac. of c.ll lines and animal *** heterogeneity,whic. manifests as variations in tumor loc.tion,patient age,histologic.l grade,and c.inic.l behavior,together with the observation of a balanc.d genomic.profile in up to 50% of c.ses,presents additional c.allenges in understanding the development and progression of this *** these diffic.lties,we have made signific.nt headway in the past dec.de in identifying the genetic.alterations and pathways involved in ependymoma tumorigenesis through c.llaborative efforts and the applic.tion of mic.oarray-based genetic.c.py number) and transc.iptome profiling *** c.arac.erization of ependymoma unraveled distinc. mRNA-defined subc.asses and led to the identific.tion of radial glial c.lls as its c.ll type of *** review summarizes our c.rrent knowledge in the molec.lar genetic. of ependymoma and proposes future researc. direc.ions nec.ssary to further advanc. this field.

关键词：分子遗传学室管膜肿瘤发生发病机制手术切除动物模型遗传变异遗传特性