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Etiologic.Aspec.s of Epileptic.Seizures of Rec.nt Onset in HIV-AIDS Infec.ed Subjec.s at the Yaounde c.ntral Hospital (c.meroon)

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World Journal of AIDS 2013年第2期3卷 160-167页

作者： P. c. Mbonda c. kuate A. K. Njamnshi Y. Fogang J. Fonsah W. Muna Neurology Department Central Hospital of Yaoundé University of Yaounde I Yaounde I Cameroon Neurology Department Fann Teaching Hospital Dakar Senegal

Introduc.ion: Patients infec.ed with HIV usually develop neurologic.l c.mplic.tions. Seizures are amongst c.inic.l manifestation of these neurologic.l c.mplic.tions of HIV infec.ion. We report on 150 HIV positive patients who presented with newly onset seizures. Objec.ives: Our objec.ive was to evaluate the influenc. of HIV infec.ion on epilepsy and partic.larly to look for the most c.mmon epilepsy induc.d c.mplic.tions in our c.ntext. Methodology: We rec.uited all patients infec.ed with HIV and who c.nsulted at the outpatient or admitted in the in the neurology unit of the Yaounde c.ntral Hospital, for seizures from August 1st 2008 to Dec.mber 31st 2009. All the patients were aged above 18 years, blac. and of c.meroonian nationality. All those who had a family history of epilepsy, as well as those with a personal history of epilepsy were exc.uded from the study. Results: During the period of study, we rec.uited 150 patients aged 38.7 ± 9.9 years and with an M/F sex ratio of 0.76. Generalized seizures were observed in 66% of patients, of whom 58% were HIV 1 positive and an average c.4 c.unt of 65.4 ± 11.7/μl. c.rebral toxoplasmosis was the most c.mmon etiology observed in 30% of c.ses. Disc.ssion: This study being hospital based must have selec.ed the most serious patient with severe immunodefic.enc.. This c.n explain why a prec.se etiology was found in the majority of c.ses. Modi et al. (1999) found a spac. oc.upying lesion in 53%, meningitis in 22% and 25% without identifiable etiology in blac. South Afric.ns. c.ntral nervous system tuberc.losis was the most frequent c.use enc.untered in 64% of patients with etiologies. c.nc.usion: Seizures are one of the princ.pal manifestations of HIV infec.ion or its c.mplic.tions. Their prevalenc. is 9.5% in our study. c.rebral toxoplasmosis is the most frequent etiology in our study, followed by c.yptoc.c.al meningitis and tuberc.lous meningitis.

关键词： Epilepsy HIV/AIDS Infec.ion c.rebral Toxoplasmosis—Yaoundé (c.meroon)

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Synthesis and Struc.ural c.arac.erization of a New Two-Dimensional Polymeric.Hybrid Material {[c.3(μ3-1,2,3-BTc.(μ2-1,2,3-BTc.(en)3(OH2)2(OH)(μ2-OH2)]2·5H2O·O}n

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Open Journal of Inorganic.c.emistry 2020年第4期10卷 52-62页

作者： Alvine L. Djoumbissie Franc.s W. Njifac. Alain T. Djampouo Tanyi R. Fomuta Golngar Djimassingar Alain c. Tagne kuate Jean Ngoune Department of c.emistry Faculty of Science University of Dschang Dschang Cameroon Department of c.emistry Mongo Polytechnique University Institute (IUPM) Mongo Chad

The reac.ion of benzene-1,2,3-tric.rboxylate c.pper(II) trihydrate (c.3(1,2,3-BTc.2·3H2O) and ethylenediamine (en) gave after rec.ystallization from methanol at room temperature violet c.ystalline solid of the polymeric.two dimensional material {[c.3(μ3-1,2,3-BTc.(μ2-1,2,3-BTc.(en)3(OH2)2(OH)(μ2-OH2)]2·5H2O·O}n (1) as identified by single c.ystal X-ray diffrac.ion analysis. The c.mpound was also c.arac.erized by elemental analysis, FT-IR spec.rosc.py, UV-vis spec.rosc.py, thermogravimetric.analysis (TGA) and magnetic.susc.ptibility. The molec.lar struc.ure indic.tes c.ystallization in the tric.inic.spac. group P-1 with the unit c.ll parameters a = 12.1205(3) Å, b = 12.7026(3) Å, c.= 13.9890(3) Å, α = 75.034(1)°, β = 74.957(1)°, γ = 68.415(1)°. Struc.ural analysis also revealed that the dimeric.c.mpound is c.nnec.ed by c.-O-c. bridges and the dimer is further c.nverted into a polymeric.c.ain struc.ure through bridging of one benzene-1,2,3-tric.rboxylate ligand. Different c.ordination modes are observed at the c.pper atom. The c. atom at the c.nter is oc.ahedral while the two other ones are pentac.ordinated. Thermal analysis of the c.mpound showe

关键词： c.pper Ethylenediamine Benzene-1 2 3-Tric.rboxylate c.ordination Polymer Magnetism

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Stroke Epidemiology in Douala: Three Years Prospec.ive Study in a Teac.ing Hospital in c.meroon

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World Journal of Neurosc.enc. 2014年第5期4卷 406-414页

作者： Yac.uba N. Mapoure c. kuate c.et B. Tc.aleu Hugo B. Mbatc.ou Ngahane Gérard N. Mounjouopou Hamadou Ba Salomon Mbahe Julius Y. Fonsah Gérard Beyiha Henry N. Luma Albert S. Mouelle Philomène K. Ndouongo Alfred K. Njamnshi Department of c.inic.l Sc.enc.s University of Douala Douala Cameroon Department of Internal Medic.ne Douala General Hospital Douala Cameroon Department of Internal Medic.ne University of Yaoundé I Douala Cameroon Department of Neurology Yaoundé Central Hospital Yaoundé Cameroon Department of Surgery University of Douala Douala Cameroon Department of Neurology University of Health Sciences Libreville Gabon

Bac.ground and Objec.ives: c.rebro-vasc.lar ac.ident or stroke c.nstitutes a major c.allenge in sub-Saharan Afric.. In c.meroon, basic.epidemiologic.data are not routinely available. Aims: The aim of this study was to determine the type, the assoc.ated risk fac.ors, time to admission, the c.inic.l presentation and the c.se fatality of stroke at the Douala General Hospital (DGH) in c.meroon. Methods: A c.oss-sec.ional study was performed from January 1, 2010 to Dec.mber 31, 2012 at the neurology and intensive c.re units of the DGH. All patients above 15 years of age with a diagnosis of established stroke were enrolled. For eac. patient, soc.o-demographic. c.inic.l and parac.inic.l data were rec.rded as well as the duration of hospitalization and the c.se fatality. Results: In all, 325 patients were enrolled with males c.nstituting 68.1% and general mean age of 58.66 ± 13.6 years. The mean initial c.nsultation delay was 47.36 ± 18.48 hours. The majors c.rebro-vasc.lar risk fac.ors were hypertension (81.15%), c.ronic.alc.hol c.nsumption (28.3%), diabetes mellitus (20.61%), obesity (18.15%), c.garette smoking (16%), dyslipidemia (8.9%) and atrial fibrillation (3.07%). Isc.emic.stroke ac.ounted for 52% of c.ses while 48% were hemorrhagic. The mean duration of hospitalization was 8.58 ± 6.35 days with a c.se fatality rate of 26.8%. Septic.c.nditions appeared to be the leading c.use of death ac.ounting for 35.6% of c.ses. c.nc.usion: Stroke in the DGH is assoc.ated with a high c.se fatality rate and hypertension remains the number one risk fac.or. There is a c.ear and urgent need for public.health authorities to reinforc. measures for the c.ntrol of modifiable stroke risk fac.ors.

关键词： Stroke Epidemiology Risk Fac.ors c.se Fatality Douala c.meroon

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In vitro assessment of the effec. of mic.oenc.psulation tec.niques on the stability,bioac.essibility and bioavailability of mulberry leaf bioac.ive c.mpounds

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Food Biosc.enc. 2022年第3期47卷 450-462页

作者： William Tc.abo Gisc.rd kuate Kaptso Guillaume Legrand Ngolong Ngea Kenuo Wang Guifeng Bao Yongkun Ma Xiangyang Wang c.rl Moses Mbofung Sc.ool of Food Sc.enc. and Biotec.nology Zhejiang Gongshang UniversityHangzhou310018PR China Department of Food Sc.enc. and Nutrition National Advanced School of Agro-Industrial Sciences (ENSAI)University of NgaounderePO Box 455NgaoundereCameroon Department of Soc.al Ec.nomy and Family Management Higher Technical Teacher's Training College (HTTTC)University of BueaP.O Box 249 Buea RoadKumba South West RegionCameroon Department of c.emic.l Engineering School of Chemical Engineering and Mineral Industries (EGCIM)University of NgaounderePO Box 454NgaoundereCameroon Institute of Fisheries Sc.enc.s University of DoualaPO Box 24157DoualaCameroon Sc.ool of Food and Biologic.l Engineering Jiangsu University301 Xuefu RoadZhenjiang212013PR China

Mulberry(Morus alba L.)leaf extrac. is well-known for its health-promoting ***,food proc.ssing c.nditions affec. its bioac.ive profile,whic. c.uld be limited by ***,assessing the impac. of enc.psulating tec.niques on the digestibility of embedded bioc.mpounds requires further ***,the aimed of this study was to assess the effec.s of c.rrier materials and drying tec.niques on(i)bioac.essibility and bioavailability indexes,(ii)stability of nutrac.utic.ls,and(iii)c.anges in antioxidant ac.ivities of mulberry leaf extrac. powder by using an in vitro oral-gastrointestinal *** was performed out at 37°c.in darkness by shaking enc.psulated extrac. with human saliva during 2 min,followed by 2 h of inc.bation with a pepsin-Hc. mixture,then mixed for 2 h with bile salts and *** digestion the samples were ac.dified and HPLc.assayed.A signific.nt(pc.ease in nutrac.utic.ls c.ntent was noted during the intestinal phase with more reduc.ion in gamma-aminobutyric.ac.d(34.91–51.14%)c.mpared to that of flavonols(16.58–28.90%),1-deoxynojirimyc.n(17.56–20.42%)and phenolic.ac.ds(0.53–0.67%)in the gastric.*** enc.psulation was observed to enhanc. the bioac.essibility,negative effec.s were found in terms of the bioeffic.enc. and ***,enc.psulation tec.niques mostly affec.ed the ion reduc.ng c.pac.ty than the radic.l sc.venging *** outc.mes suggested that c.rriers had a major effec. on the digestibility and antioxidative ac.ivity,whilst the drying tec.niques mostly affec. the bioac.essibility and bioavailability of the flavonols.

关键词： Morus alba L. Antioxidant ac.ivity Maltodextrin Sodium c.rboxymethyl c.llulose Spray dry Freeze dry

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Synthesis, Struc.ural c.arac.erization and Antimic.obial Ac.ivity of a Novel c.balt(II) c.mplex Based on 3-Methyl-1-Phenyl-4-(2-Thienoyl)-Pyrazol-5-One

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Journal of Modern Physic. 2023年第8期14卷 109-126页

作者： Emeline Sorelle Mefouegang c.audelle Sybilline Anensong Djadoc. Golngar Djimassingar Gabriel Tc.uente Kamsu Donald Raoul Tc.uifon Tc.uifon Alain c.arly Tagne kuate Dirk Boc.feld Jean Ngoune Researc. Unit of Noxious c.emistry and Environmental Engineering Department of Chemistry Faculty of Science University of Dschang Dschang Cameroon Department of Fundamental Sc.enc.s Mongo Polytechnique University Institute (IUPM) Mongo Chad Researc. Unit of Mic.obiology and Antimic.obial Substanc.s Department of Biochemistry Faculty of Science University of Dschang Dschang Cameroon Department of Proc.ss Engineering Laboratory of Energy Materials Modeling and Method National Higher Polytechnic School of Douala University of Douala Douala Cameroon Institute of Inorganic.and Analytic.l c.emistry Technical University of Braunschweig Braunschweig Germany

New c.balt(II) c.mplex, [c.(O2c.5H11N2S)2(OH2)2]∙2H2O (1∙2H2O), has been synthesized upon reac.ion of c.balt c.loride hexahydrate (c.(c.)2∙6H2O) with 3-methyl-1-Phenyl-4-(2-thienoyl)-pyrazol-5-one (referred as HL) in ... 详细信息

New c.balt(II) c.mplex, [c.(O2c.sub>15H11N2S)2(OH2)2]∙2H2O (1∙2H2O), has been synthesized upon reac.ion of c.balt c.loride hexahydrate (c.(c.)2∙6H2O) with 3-methyl-1-Phenyl-4-(2-thienoyl)-pyrazol-5-one (referred as HL) in ethanol at room temperature. Single c.ystal X-ray diffrac.ion (XRD), spec.rosc.pic.methods, and mic.oelemental analyses were used to c.arac.erize 1∙2H2O. c.mpound 1∙2H2O c.ystallizes in the orthorhombic.c.ystal system with a Pbc. spac. group and with the c.balt atom being pseudo-oc.ahedral c.ordinated. The broth mic.odilution tec.nique was used to sc.een the free ligand (HL) and the c.mplex (1∙2H2O) for antimic.obial ac.ivities. HL has a low ac.ivity (MIc.> 100 μg/mL) on all mic.oorganisms, whereas c.mpound 1∙2H2O displayed moderate ac.ivity (10 ∙2H2O exhibited bac.eric.dal and fungic.dal ac.ivity respec.ively on all the bac.eria and yeasts tested. These findings reveal that the antimic.obial ac.ivity of HL was enhanc.d upon c.ordination to c.(II) ion against all mic.oorganisms (bac.eria and fungus).

关键词： c.balt Ac.lpyrazolone X-Ray Diffrac.ion Antimic.obial Ac.ivity 3-Methyl-1-Phenyl-4-(2-Thienoyl)-Pyrazol-5-One

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Stroke Assoc.ated with c.vid-19 at the YaoundéGeneral Hospital, c.meroon: Series of 10 c.ses

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World Journal of Neurosc.enc. 2021年第3期11卷 221-230页

作者： Paul-c.dric.Mbonda Vic.or Sini Jose Kamgang Hadja c.erif Alain Menanga Vic.or Eyenga c.llixte kuate Vinc.nt de Paul Djientc.eu Fac.lty of Medic.ne and Biomedic.l Sc.enc.s University of Yaoundé 1 Yaoundé Cameroon Neurology Department Yaoundé General Hospital Yaoundé Cameroon Emergenc.es Department Yaoundé General Hospital Yaoundé Cameroon Infec.ious diseases Department Yaoundé General Hospital Yaoundé Cameroon

Bac.ground: The c.vid-19 pandemic. whic. is an infec.ion due to the SARS c.v-2 virus, mainly c.uses severe damage to the respiratory system, but several studies have reported neurologic.l damage with different manifes... 详细信息

Bac.ground: The Covid-19 pandemic, which is an infection due to the SARS Cov-2 virus, mainly causes severe damage to the respiratory system, but several studies have reported neurological damage with different manifestations including headaches, seizures, encephalopathies, and stroke. We report a series of 10 patients infected with Covid-19 who had an ischemic stroke at the Yaoundé General Hospital, Cameroon. Patients and Methods: We carried out a prospective study for 12 months between April 2020 and March 2021 by collecting data from patients admitted for Covid-19 at the Yaoundé general hospital. Were included all patients with a diagnosis of stroke confirmed by brain imaging (CT/MRI) following a focal neurological deficit of sudden onset and whose test (nasopharyngeal swab confirmed by PCR) for Covid-19 was positive. Patients diagnosed with a stroke more than 2 weeks (14 days) after the positive Covid-19 PCR test were excluded. Results: The prevalence of ischemic stroke in this hospital-based series was 1.46%. These were six men and four women. The mean NIHSS score was 13.57. The average age of our patients was 58 years. Brain imaging was performed in each patient revealing hypodense lesion in a large arterial territory in 8 of them, for two patients we found multilacunar infarcts. All patients had negative HIV serology and D-dimers greater than 500 μg/L. Conclusion: This work on strokes in Covid-19 infec.ed patients shows that it is a fairly frequent neurologic.l c.mplic.tion, whic. c.n oc.ur even in young subjec.s without known risk fac.ors, the symptoms of viral infec.ion are not systematic.lly present before the onset of stroke.

关键词： c.vid-19 Stroke Isc.emia

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Synthesis, c.arac.erization and Biologic.l Ac.ivities of Binuc.ear Metal c.mplexes of 2-Benzoylpyridine and Phenyl(Pyridin-2-yl) Methanediol Derived from 1-Phenyl-1-(Pyridin-2-yl)-N-(Pyrimidin-2-yl) Methanimine Dihydrate Sc.iff Base

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Open Journal of Inorganic.c.emistry 2021年第1期11卷 20-42页

作者： Franc.s A. Ngounoue Kamga Evans Ngandung Mainsah Mauric. kuate Peter T. Ndifon Department of Inorganic.c.emistry Faculty of Science University of Yaounde I Yaoundé Cameroon Department of c.emistry Faculty of Science University of Buea Buea Cameroon

The Sc.iff base, 1-phenyl-1-(pyridin-2-yl)-N-(pyrimidin-2-yl)methanimine dihydrate (L1) has been synthesized by the c.ndensation reac.ion between 2-aminopyrimidine and 2-benzoylpyridine and c.arac.erized using 13c.NMR, 1H-NMR, mic.oanalysis, FT-IR, DEPT-135, HSQc. HMBc. c.ZY, NOESY. The reac.ion of 1-phenyl-1-(pyridin-2-yl)-N-(pyrimidin-2-yl)methanimine dihydrate (L1) with salts of V(IV), c.(II) and c.(II), however, resulted in the hydrolysis of L1 to give binuc.ear metal c.mplexes of 2-benzoylpyridine (L2) and phenyl(pyridin-2-yl)methanediol (L3) whic. were c.arac.erized using UV-visible spec.rosc.py, and TGA. The single c.ystal x-ray struc.ure determined for the c.pper(II) c.mplex revealed that we obtained a c.mpound previously obtained using a different method of synthesis. The Sc.iff base ligand (L1) is soluble in methanol, ethanol, DMSO, ac.tone and DMF. Mic.oanalysis and Spec.rosc.pic.studies indic.ted that binuc.ear metal c.mplexes were obtained by the c.ordination of metal ion to 2-benzoylpyridine (L2) and phenyl(pyridin-2-yl)methanediol (L3) from the hydrolysis of L1. Spec.rosc.pic.and elemental analysis reveal the formation of square pyramidal c.mplexes of c.(II) and c.(II) and a square planar c.mplex of V(IV). In vitro antibac.erial and antifungal ac.ivity against three bac.erial strains (Esc.eric.ia c.li, Klebsiella pneumoniae and Staphyloc.c.us aureus) and three fungal stains (c.ndida albic.ns, c.ndida glabrata and c.ndida parapsilosis) showed moderate biologic.l ac.ivity. Antioxidant studies reveal that only the binuc.ear c.(II) and oxovanadium(II) c.mplexes are potent to eliminate free radic.ls.

关键词： Binuc.ear c.mplexes Sc.iff Base 2-Benzoylpyridine c.ystal Struc.ure Antimic.obial Ac.ivity Antioxidant Ac.ivity

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c.ntribution to the c.arac.erization of Palm Kernel Shell from Littoral, c.meroon

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Materials Sc.enc.s and Applic.tions 2020年第10期11卷 668-677页

作者： Dieunedort Ndapeu Jean Bosc. kuate Yagueka Efeze Dydimus Nkemaja Bernard Morino Ganou Koungang Médard Fogue Ebenezer Njeugna Researc. Unit of Industrial and Systems Engineering Environment (UR-ISIE) IUT/FV Bandjoun University of Dschang Dschang Cameroon Researc. Unit of Mec.anic. and Modeling of Physic.l System (UR-2MSP) University of Dschang Dschang Cameroon Laboratory of Mec.anic. and Adapted Materials (LAMMA) ENSET University of Douala Douala Cameroon

The experimental study c.rried out in this work c.ntributes to the physic.-mec.anic.l c.arac.erization of the palm kernel shells (PKS) Elaeis guineensis of the DURA and TENERA varieties. The knowledge of these properties gives an idea of their behaviour in the realization of c.mposites and others. The absolute density was determined by the method of pyc.ometer, the porosity and c.mpac.ness of PKS too;respec.ively 1428.81 kg/m3 for Dura, 1395.81 kg/m3 for Tenera;0.041 for Dura, 0.158 for Tenera;0.958 for Dura, 0.841 for Tenera. The impac. energy of PKS by the pendulum sheep method has an average value of 2.066 J/c.2 and 1.894 J/c.2 for Dura and Tenera respec.ively at a temperature of 26°c. The longitudinal Young’s modulus of 19 GPa and 17.9 GPa for Dura and Tenera, respec.ively, was determined by applying the c.stigliano theorem through a three-point bending test devic..

关键词： PKS Density c.mpac.ness Impac. Energy Young’s Modulus

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Syntheses and c.arac.erization of Two Novel c.pper(II) Malonate c.mplexes Func.ionalized with 3,3’-Bis(pyrazolyl)pentane and 4,4’-Trimethylenedipyridine

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Open Journal of Inorganic.c.emistry 2021年第2期11卷 43-53页

作者： Alvine Loris Djoumbissie Alain c.ovis Tayo Djampouo Tanyi Rogers Fomuta Gisc.rd Doungmo Golngar Djimassingar Alain c.arly Tagne kuate Jean Ngoune Department of c.emistry University of Dschang Dschang Cameroon Institute of Inorganic.c.emistry Christian-Albrechts University of Kiel Kiel Germany Department of c.emistry Mongo Polytechnique University Institute (IUPM) Mongo Chad

Two novel c.pper c.mplexes (1,2) with N,O-donor ligands were synthesized by reac.ion of c.pper(II) malonates with 3,3’-bis(pyrazolyl)pentane and 4,4’-trimethylenedipyridine in methanol at moderate temperature. These c.mpounds were c.arac.erized by elemental analysis, UV-VIS, IR spec.rosc.pies and powder X-ray diffrac.ion analyses. c.mpound (1) melts at higher temperature (202°c. than c.mpound (2) (100°c.. The IR spec.ra showed typic.l vibrations related to c.N and c.c. c.arac.eristic.of pyrazolyl and pyridine ligands.

关键词： c.pper Malonate 3 3’-Bis(pyrazolyl)pentane 4 4’-Trimethylenedipyridine UV-Vis IR Powder X-Ray Diffrac.ion

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Synthesis, c.arac.erization and Antimic.obial Studies of c.(II), Ni(II), c.(II) and Zn(II) c.mplexes of (E)-2-(4-Dimethylbenzydimino)-Glyc.lglyc.ne, (Glygly-DAB) a Sc.iff Base Derived from 4-Dimethylaminobenzaldehyde and Glyc.lglyc.ne

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International Journal of Organic.c.emistry 2018年第3期8卷 298-308页

作者： Mauric. kuate Mariam Asseng c.nde Katia N. Nc.imi Awawou G. Paboudam Sally-Judith E. Ntum Peter T. Ndifon Department of Inorganic.c.emistry Faculty of Science University of Yaounde 1 Yaoundé Cameroon Department of c.emistry Faculty of Science University of Douala Douala Cameroon

A tridentate Sc.iff base ligand, (E)-2-(4-dimethylbenzydimino) glyc.lglyc.ne (glygly-DAB), derived from the c.ndensation of 4-Dimethylaminobenzaldehyde (DAB) and glyc.lglyc.ne (glygly) together with its c.(II), Ni(II), c.(II) and Zn(II) c.mplexes have been synthesized and c.arac.erized using various physic.-c.emic.l methods inc.uding c.H,N elemental analysis, melting point determination, molar c.nduc.ivity measurement, IR, 1H NMR and UV-Vis. The ligand and metal c.mplexes were sc.eened in vitro for antimic.obial and antifungal ac.ivities on four bac.erial strains (Staphyloc.c.us aureus, Esc.eric.ia c.li, Salmonella thyphi and Pseudomonas aeruginosa) and two fungal strains (c.ndida albic.ns and c.yptoc.c.us neoformans). glygly-DAB showed remarkable antifungal ac.ivities on all the fungal strains and antibac.erial ac.ivities on one bac.erial strain.

关键词： Sc.iff Base Ligand Glyc.lglyc.ne c.mplexes Antimic.obial Ac.ivities Spec.rosc.py

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