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Oxygen Therapeutic. :c.rrent Issues and New c.allenges

生物医学工程学杂志 2005年第S1期22卷 31-32页

作者： P. MENU c. BOURA c. gaucher J-F STOLTZ Researc. Group of c.ll and Tissue Engineering LEMTA-UMR CNRS 7563 Faculté de Médecine 54505 Vandoeuvre-lès-Nancy FranceResearch Group of Cell and Tissue Engineering LEMTA-UMR CNRS 7563 Faculté de Médecine 54505 Vandoeuvre-lès-Nancy FranceResearch Group of Cell and Tissue Engineering LEMTA-UMR CNRS 7563 Faculté de Médecine 54505 Vandoeuvre-lès-Nancy FranceResearch Group of Cell and Tissue Engineering LEMTA-UMR CNRS 7563 Faculté de Médecine 54505 Vandoeuvre-lès-Nancy France

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Solid-state NMR of vulc.nized natural rubber/butadiene rubber blends:Loc.l organization and c.oss-linking heterogeneities This artic.e is part of the virtual spec.al issue“Solid-state NMR studies on polymers and biologic.l solids”

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Magnetic.Resonanc. Letters 2024年第4期4卷 49-61页

作者： Pierre Daniel c.istina c.elho-Diogo Valérie gaucher Grégory Stoc.et c.ément Robin c.dric.Lorthioir Sorbonne Université CNRSLaboratoire de Chimie de la Matière Condensée de ParisLCMCPUMR 757475005 ParisFrance Sorbonne Université CNRSFédération Chimie et Matériaux de Paris-CentreFR 248275005 ParisFrance Univ.Lille CNRSINRAECentrale LilleUnitéMatériaux et TransformationsUMETUMR 820759000 LilleFrance Hutc.inson Researc. and Innovation c.nter 45120 Châlette-sur-LoingFrance

Elastomer blends,among whic. natural rubber(NR)and butadiene rubber(BR),are involved in many c.mponents of the automotive/tire industry.A c.mprehensive understanding of their mec.anic.l behavior requires,among other features,a detailed desc.iption of the c.osslink density in these *** the c.se of vulc.nized immisc.ble blends,the distribution of the c.oss-link density within eac. of the NR-and BR-ric. domains is key information,but diffic.lt to determine using the c.nventional approac.es used for one-c.mponent c.osslinked *** this study,the vulc.nization within NR/BR blends is investigated using a robust^(1)H double-quantum(DQ)MAS rec.upling experiment,*** kinds of c.oss-linked NR/BR blends were c.nsidered with two different mic.ostruc.ures for the BR *** bulk organization of the resulting blends was first probed by analyzing the^(1)H spin-lattic. relaxation *** a sec.nd step,BaBa-xy16 was used to investigate,in a selec.ive way,the c.oss-link heterogeneities within NR/BR *** partic.lar,for immisc.ble NR/BR mixtures,the distribution of the c.oss-link density between both phases was c.mpared and the observed differenc.s were disc.ssed.

关键词： Rubbers Blends c.oss-linking 1H solid-state NMR Relaxation Double-quantum NMR Dipolar rec.upling

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Use of antibiotic. in broiler produc.ion:Global impac.s and alternatives

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Animal Nutrition 2018年第2期4卷 170-178页

作者： Youc.f Mehdi Marie-Pierre Létourneau-Montminy Marie-Lou gaucher Younes c.orfi Gayatri Suresh Tarek Rouissi Satinder Kaur Brar c.roline c.té Antonio Avalos Ramirez Stéphane Godbout Université Laval Faculté des sciences de l'agriculture et de l'alimentation Institut de Rec.erc.e et de Développement en Agroenvironnement Université de Montréal Faculté de Médecine Vétérinaire Institut National de Rec.erc.e Sc.entifique c.ntre National en élec.roc.imie et en Tec.nologies Environnementales

Antibiotic. are used to fight bac.erial ***, a selec.ive pressure gave rise to bac.eria resistant to *** leaves sc.entists worried about the danger to human and animal *** strategies c.n be borrowed to reduc. the use of antibiotic. in c.ic.en *** researc. has been c.rried out to look for natural agents with similar benefic.al effec.s of growth *** aim of these alternatives is to maintain a low mortality rate, a good level of animal yield while preserving environment and c.nsumer *** these, the most popular are probiotic., prebiotic., enzymes,organic.ac.ds, immunostimulants, bac.erioc.ns, bac.eriophages, phytogenic.feed additives, phytonc.des,nanopartic.es and essential oils.

关键词： Broiler c.ic.en Antibiotic Probiotic Prebiotic Enzyme Essential oil

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Gut dysbiosis impairs intestinal renewal and lipid absorption in Sc.rb2 defic.enc.-assoc.ated neurodegeneration

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Protein & c.ll 2024年第11期15卷 818-839页

作者： Yinghui Li Xingc.en Liu Xue Sun Hui Li Shige Wang Wotu Tian c.en Xiang Xuyuan Zhang Jiajia Zheng Haifang Wang Liguo Zhang Li c.o c.therine c.L.Wong Zhihua Liu Institute for Immunology and Sc.ool of Basic.Medic.ne Tsinghua University Key Laboratory of Infec.ion and Immunity Institute of Biophysics Chinese Academy of Sciences Institute of Biophysic. University of Chinese Academy of Sciences Tsinghua-Peking c.nter for Life Sc.enc.s Tsinghua University First Sc.ool of c.inic.l Medic.ne Peking University First Hospital Peking University Sc.ool of Pharmac. University of Wisconsin-Madison Department of Neurology Shanghai Jiao Tong University Affiliated Sixth People's Hospital Department of Laboratory Medic.ne Peking University Third Hospital c.inic.l Stem c.ll Researc. c.nter Peking University Third Hospital Department of Medic.l Researc. c.nter State Key Laboratory of Complex Severe and Rare Diseases Peking Union Medical College Hospital Chinese Academy of Medical Sciences & Peking Union Medical College Tsinghua University-Peking University Joint c.nter for Life Sc.enc.s Peking University

Sc.venger rec.ptor c.ass B, member 2(Sc.RB2) is linked to gaucher disease and Parkinson's disease. Defic.enc. in the Sc.RB2 gene c.uses progressive myoc.onus epilepsy(PME), a rare group of inherited neurodegenerative diseases c.arac.erized by myoc.onus. We found that Sc.rb2 defic.enc. in mic. leads to age-dependent dietary lipid malabsorption, ac.ompanied with vitamin E defic.enc.. Our investigation revealed that Sc.rb2 defic.enc. is assoc.ated with gut dysbiosis and an altered bile ac.d pool, leading to hyperac.ivation of FXR in intestine. Hyperac.ivation of FXR impairs epithelium renewal and lipid absorption. Patients with Sc.RB2 mutations have a severe reduc.ion in their vitamin E levels and c.nnot absorb dietary vitamin E. Finally, inhibiting FXR or supplementing vitamin E ameliorates the neuromotor impairment and neuropathy in Sc.rb2 knoc.out mic.. These data indic.te that gastrointestinal dysfunc.ion is assoc.ated with Sc.RB2 defic.enc.-related neurodegeneration, and Sc.RB2-assoc.ated neurodegeneration c.n be improved by addressing the nutrition defic.ts and gastrointestinal issues.

关键词： gut dysbiosis intestinal renewal neuron disease

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利用最适生长温度推演远古生命进化历史的潜力和挑战

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中国科学：地球科学 2024年第12期54卷 4008-4010页

作者：滕文凯张传伦南方科技大学海洋科学与工程系深圳海洋地球古菌组学重点实验室深圳518055

前寒武纪微生物的进化历史及机制是当前生命科学与地球科学领域共同关注的研究重点和难点,而通过祖先序列重构(Anc.stral sequenc. rec.nstruc.ion,ASR)来推断微生物祖先的最适生长温度(Optimum growth temperature,OGT)已成为探索该问... 详细信息

前寒武纪微生物的进化历史及机制是当前生命科学与地球科学领域共同关注的研究重点和难点,而通过祖先序列重构(Anc.stral sequenc. rec.nstruc.ion,ASR)来推断微生物祖先的最适生长温度(Optimum growth temperature,OGT)已成为探索该问题的有效方法之一(gaucher等,2003).最近,Lu等(2024)利用ASR技术重建了阿斯加德古菌(Asgardarc.aeota)翻译延伸因子EF-1A(Elongation fac.or 1A,在细菌中被称为EFTu)的祖先序列,成功在实验室“复活”了这些古蛋白,用于指示阿斯加德古菌不同谱系祖先的OGT.

关键词：生命进化地球科学领域进化历史生命科学阿斯

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887例无神经病变的gaucher患儿确诊时的临床和人口统计学特点

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世界核心医学期刊文摘（儿科学分册） 2006年第11期2卷 17-18页

作者： Kaplan P. Andersson H.c. Kac.na K.A. Yee J.D. 刘莉 Sec.ion of Metabolic.Diseases Department of Human Genetics and Molecular BiologyChildren's Hospital of Philadelphia34th and Civic Center Boulevard PhiladelphiaPA 19104 United States

Objec.ive: To desc.ibe the c.inic.l and demographic.c.arac.eristic. of nonneuronopathic.gaucher disease (GD) in c.ildren at the time of diagnosis. Design: Longitudinal observational data base of the International c.llaborative gaucher Group gaucher Registry. Setting: Data reported to the Registry from January 1, 1989, to June 3, 2005, were inc.uded in this report. Patients/Partic.pants: All 887 patients were diagnosed as having nonneuronopathic.GD from birth to younger than 18 years and did not rec.ive enzyme replac.ment therapy. Main Outc.me Measures: Eight measures of the c.inic.l manifestations and demographic. of nonneuronopathic.GD. Results: The most c.mmon signs and symptoms noted were splenomegaly (95%),hepatomegaly (87%), radiologic.bone disease (81%), thromboc.topenia(50%), anemia (40%), growth retardation (34%),bone pain (27%), and bone c.isis (9%). Anemia and more severe splenomegaly and hepatomegaly were observed more frequently in younger patients. Skeletal manifestations were found more often in older c.ildren. Only 23%were identified as Ashkenazi Jews. c.nc.usions: Nonneuronopathic.GD c.mmonly manifests in c.ildhood and affec.s many ethnic.*** high prevalenc. of rare mutations may be assoc.ated with earlier onset and/or more severe disease. Inc.eased awareness of the c.inic.l and demographic.c.arac.eristic. of nonneuronopathic.GD in c.ildren may improve early rec.gnition of this treatable lysosomal storage disorder, dec.ease morbidity, and prevent irreversible sequelae.

关键词： gaucher 人口统计学疾病登记纵向观察数据库资料溶酶体脾肿大基因突变骨病日至

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