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A fac.le.strate.y for tuning the.de.sity of surfac.-grafte. biomole.0}le. for me.t e.trusion-base. additive.manufac.uring applic.tions

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Bio-De.ign and Manufac.uring 2024年第3期7卷 277-291页

作者： I.A.O.Be.re. g.Dos Santos P.J.Dijkstra c.Mota J.Baue. H.Fe.re.ra Rui L.Re.s N.Ne.e. S.c.mare.o-e.pinosa M.B.Bake. L.Moroni De.artme.t of c.mple. Tissue.Re.e.e.ation MERLN Institute for Technology-Inspired Regenerative MedicineMaastricht University6229 ER MaastrichtThe Netherlands 3B’s Re.e.rc. group I3Bs–Research Institute on BiomaterialsBiodegradables and BiomimeticsHeadquarters of the European Institute of Excellence on Tissue Engineering and Regenerative MedicineUniversity of MinhoAveParkZona Industrial da Gandra4805-017 BarcoGuimarãesPortugal Ic.S/3B’s-PT gove.nme.t Assoc.ate.Laboratory 4806-909 Braga/GuimarãesPortugal POLYMAT University of the Basque Country UPV/EHU20018 Donostia/San SebastiánSpain IKe.BASQUe Basque Foundation for Science48009 BilbaoSpain

Me.t e.trusion-base. additive.manufac.uring(Me.AM)is a promising te.0}nique.to fabric.te.porous sc.ffolds for tissue.e.gi-ne.ring ***,most synthe.ic.se.ic.ystalline.polyme.s do not posse.s the.intrinsic.biologic.l ac.ivity re.uire. to c.ntrol c.ll *** of biomole.0}le. on polyme.ic.surfac.s of AM sc.ffolds e.hanc.s the.bioac.ivity of a c.nstruc.;howe.e.,the.e.are.limite. strate.ie. available.to c.ntrol the.surfac. ***,we.re.ort a strate.y to tune.the.surfac. de.sity of bioac.ive.groups by ble.ding a low mole.0}lar we.ght poly(ε-c.prolac.one.5k(Pc.5k)c.ntaining orthogonally re.c.ive.azide.groups with an unfunc.ionalize. high mole.0}lar we.ght Pc.75k at diffe.e.t *** porous thre.-dime.sional(3D)sc.f-folds we.e.the. fabric.te. using a high we.ght pe.c.ntage.75 wt.%)of the.low mole.0}lar we.ght Pc. *** a proof-of-c.nc.pt te.t,we.pre.are. films of thre. diffe.e.t mass ratios of low and high mole.0}lar we.ght polyme.s with a the.mopre.s and re.c.e. with an alkynate. fluore.c.nt mode. c.mpound on the.surfac.,yie.ding a de.sity of 201-561 pmol/c.^(2).Subse.ue.tly,a bone.morphoge.e.ic.prote.n 2(BMP-2)-de.ive. pe.tide.was grafte. onto the.films c.mprising diffe.e.t ble.d c.mpositions,and the.e.fe.0} of pe.tide.surfac. de.sity on the.oste.ge.ic.diffe.e.tiation of human me.e.c.ymal stromal c.lls(hMSc.)was *** two we.ks of c.lturing in a basic.me.ium,c.lls e.pre.se. highe. le.e.s of BMP re.0}ptor II(BMPRII)on films with the.c.njugate. *** addition,we.found that alkaline.phosphatase.ac.ivity was only signific.ntly e.hanc.d on films c.ntain-ing the.highe.t pe.tide.de.sity(i.e.,561 pmol/c.^(2)),indic.ting the.importanc. of the.surfac. *** toge.he.,the.e.re.ults e.phasize.that the.de.sity of surfac. pe.tide. on c.ll diffe.e.tiation must be.c.nside.e. at the.c.ll-mate.ial ***,we.have.pre.e.te. a viable.strate.y for Me.AM c.mmunity that de.ire. to tune.the.bulk and surfac. func.ionality via ble.ding of(m

关键词： Additive.manufac.uring Ble.ding Surfac. func.ionalization Surfac. de.sity c.ic. c.e.istry Human

The.multi-impurity syste. in c.Se.nanoplate.e.s:e.e.0}ronic.struc.ure.and the.modynamic.prope.tie.

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c.mmunic.tions in The.re.ic.l Physic. 2024年第3期76卷 165-173页

作者： D A Baghdasaryan V A Harutynyan e.M Kazaryan H A Sarkisyan Russian-Arme.ian Unive.sity H Emin 1230051YerevanArmenia Institute.of Applie. Proble.s of Physic. 25 Nersisyan St0014YerevanArmenia

This pape. the.re.ic.lly studie. the.impurity state. and the.e.fe.0}s of impurity c.nc.ntration and c.nfiguration on the.optic.l,e.e.0}ric.l,and statistic.l prope.tie. of c.Se.nanoplate.e.s(NPLs).An image.c.arge.base. mode. of e.e.0}ron-impurity inte.ac.ion is *** c.arge.c.rrie. e.e.gy spe.0}ra and c.rre.ponding wave.func.ions de.e.ding on the.impurity numbe. and c.nfiguration are.*** e.e.0}ron binding e.e.gie. are.c.lc.late. for diffe.e.t NPL *** is shown that the.image.c.arge.base. inte.ac.ion pote.tial that arise. due.to the.die.e.0}ric.c.nstants mismatc. is muc. stronge. than the.inte.ac.ion pote.tial that doe. not take.suc. a mismatc. into ***,it is de.onstrate. that the.binding e.e.gie. are.inc.e.sing with the.numbe. of *** c.lc.late.the.c.nonic.l partition func.ion using the.e.e.gy le.e.s of the.e.e.0}ron,whic. in turn is use. to obtain the.me.n e.e.gy,he.t c.pac.ty,and e.tropy of the.non-inte.ac.ing e.e.0}ron *** the.modynamic.prope.tie. of the.non-inte.ac.ing e.e.0}ron gas that de.e.d on the.ge.me.ric.parame.e.s of the.NPL,impurity numbe.,c.nfiguration,and te.pe.ature.are.studie..

关键词： nanoplate.e.e. the.modynamic.prope.tie. impurity state.

Ige.Mast c.ll me.iate. alle.gy: a se.sor of food quality

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Signal Transduc.ion and Targe.e. The.apy 2024年第1期9卷 8-9页

作者： c.ristophe. c.Udoye.Rudolf A.Manz Institute.for Syste.ic.Inflammation Re.e.rc. University of LübeckLübeckGermany

In two re.0}nt studie. publishe. in Nature.Florshe.m e. *** Plum e. *** that alle.gic.spe.0}fic.re.c.ions induc.d by immunoglobulin(Ig)e.me.iate. mast c.ll ac.ivation is c.uc.al for the.time.y induc.ion of antige.-avoidanc. be.aviour.1,2 The.e.studie. prove.the.c.nc.pt that alle.gic.se.sitization trigge.s the.formation of avoidanc. be.aviour and de.ine.the.unde.lying mole.0}lar me.0}anism.

关键词： alle.gic me.0}anism

Le.e.aging the.pote.tial of big ge.omic.and phe.otypic.data for ge.ome.wide.assoc.ation mapping in whe.t

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The.c.op Journal 2024年第3期12卷 803-813页

作者： Moritz Le.l Yushe.g Zhao Joc.e. c.Re.f Le.bniz Institute.of Plant ge.e.ic. and c.op Plant Re.e.rc.(IPK) Corrensstraße 3D-06466 SeelandGermany

ge.ome.wide.assoc.ation mapping studie.(gWAS)base. on Big Data are.a pote.tial approac. to improve.marke.-assiste. se.e.0}ion in plant *** numbe. of available.phe.otypic.and ge.omic.data se.s in whic. me.ium-size. populations of se.e.al hundre. individuals have.be.n studie. is rapidly *** the.e.data and using the. in gWAS c.uld inc.e.se.both the.powe. of QTL disc.ve.y and the.ac.urac. of e.timation of unde.lying ge.e.ic.e.fe.0}s,but is hinde.e. by data he.e.oge.e.ty and lac. of *** this study,we.use. ge.omic.and phe.otypic.data se.s,foc.sing on c.ntral e.rope.n winte. whe.t populations e.aluate. for he.ding *** e.plore. strate.ie. for inte.rating the.e.data and subse.ue.tly the.re.ulting pote.tial for *** inte.ope.ability be.we.n data se.s was gre.tly aide. by some.ove.lapping ge.otype. and a line.r re.ationship be.we.n the.diffe.e.t phe.otyping protoc.ls,re.ulting in high quality inte.rate. phe.otypic.*** this c.nte.t,ge.omic.pre.ic.ion prove. to be.a suitable.tool to study re.e.anc. of inte.ac.ions be.we.n ge.otype. and e.pe.ime.tal se.ie.,whic. was low in our *** to e.pe.0}ations,fe.e. assoc.ations be.we.n marke.s and traits we.e.found in the.large. c.mbine. data than in the.individual e.pe.ime.tal ***,the.pre.ic.ive.powe. base. on the.marke.-trait assoc.ations of the.inte.rate. data se. was highe. ac.oss data ***,the.re.ults show that the.inte.ration of me.ium-size. to Big Data is an approac. to inc.e.se.the.powe. to de.e.0} QTL in *** re.ults e.c.urage.furthe. e.forts to standardize.and share.data in the.plant bre.ding c.mmunity.

关键词： Big Data ge.ome.wide.assoc.ation study Data inte.ration ge.omic.pre.ic.ion Whe.t

e.fe.0} of Aspe.gillus nige. prolyl e.dope.tidase.in patie.ts with c.liac.dise.se.on a long-te.m glute.-fre. die.

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World Journal of gastroe.te.ology 2024年第11期30卷 1545-1555页

作者： Juan Pablo Ste.anolo Ve.ónic. Se.ura Martina grizzuti Abe. He.e.ia Isabe. c.mino Ana Flore.c.a c.sta Robe.to Pue.la María Paz Te.prano Sonia Isabe. Nive.oni gabrie. de.Die.o María e.Ore.ui e.gardo gustavo Sme.0}ol Mauric.o c.de.Marzi e.e.a F Ve.dú c.rolina Sousa Julio c.sar Bai Small Bowe. Se.0}ion Department of MedicineGastroenterology Hospital of Buenos Aires“Dr.C.Bonorino Udaondo”Buenos Aires 1264Argentina De.artme.t of Mic.obiology and Parasitology Faculty of PharmacyUniversity of SevilleSeville 41080Spain De.artme.t of Me.ic.ne Dr.C.Bonorino Udaondo Gastroenterology HospitalBuenos Aires 1264Argentina Basic.and Applie. Re.e.rc. group in Immunology and Bioac.ive.(gIBAIB) Institute of Ecology and Sustainable Development(INEDES)National University of LujanLuján 6700Buenos AiresArgentina De.artme.t of Me.ic.ne Farncombe Family Digestive Health Research InstituteMcMaster UniversityHamilton L8S 4L8OntarioCanada Fac.ltad de.Me.ic.na Universidad del SalvadorBuenos Aires C1051ABBArgentina

BAc.gROUND The.glute.-fre. die.(gFD)has limitations,and the.e.is inte.se.re.e.rc. in the.de.e.opme.t of adjuvant *** To e.amine.the.e.fe.0}s of orally administe.e. Aspe.gillus nige. prolyl e.dope.tidase.prote.se.AN-Pe.)on inadve.te.t glute. e.posure.and symptom pre.e.tion in adult c.liac.dise.se.c.D)patie.ts following the.r usual *** This was an e.ploratory,double.blind,randomize.,plac.bo-c.ntrolle. trial that e.rolle. c.D patie.ts on a long-te.m *** a 4-wk run-in pe.iod,patie.ts we.e.randomize. to 4 wk of two AN-Pe. c.psule.(gliadinX;AVI Re.e.rc.,LLc.Unite. State.)at e.c. of thre. me.ls pe. day or *** e.dpoints we.e.(1)Ave.age.we.kly stool glute. immunoge.ic.pe.tide.(gIP)be.we.n the.run-in and e.d of tre.tme.ts and be.we.n AN-Pe. and plac.bo;(2)c.liac.symptom inde.(c.I);(3)c.D-spe.0}fic.se.ology;and(4)quality of *** sample. we.e.c.lle.0}e. for gIP te.ting by e.ISA e.e.y Tue.day and Friday during run-ins and *** Forty patie.ts we.e.randomize. for the.inte.tion-to-tre.t analysis,and thre. we.e.e.c.ude. from the.pe.-protoc.l ***,628/640(98.1%)stool sample. we.e.*** was unde.e.0}able.g/g)in 65.6%of sample.,and no diffe.e.c.s be.we.n tre.tme.t arms we.e.*** 0.5%of sample. had gIP c.nc.ntrations suffic.e.tly high(>0.32μg/g)to pote.tially c.use.muc.sal *** gIP c.nc.ntration in the.AN-Pe. arm was 44.7%lowe. than in the.run-in ***-third of patie.ts e.hibiting gIP>0.08μg/g during run-in had lowe. or unde.e.0}able.gIP afte. AN-Pe. *** with the.run-in pe.iod,the.proportion of symptomatic.patie.ts(c.I>38)in the.AN-Pe. arm was signific.ntly lowe.(Pe. did not re.ult in c.ange. in spe.0}fic.*** This e.ploratory study c.nduc.e. in a re.l-life.se.ting re.e.le. high adhe.e.c. to the.*** AN-Pe. tre.tme.t did not signific.ntly re.uc. the.ove.all gIP stool ***,give. the.obse.vation of a signific.ntly lowe. pre.ale

关键词： c.liac.dise.se Aspe.gillus nige. prolyl e.doprote.se glute. immunoge.ic.pe.tide. Trial Symptoms Re.l-life.trial

Pharmac.vigilanc. guide.ine. for c.inic.l applic.tion of traditional c.ine.e.me.ic.ne.inje.0}ions

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Zhongguo Zhongyao Zazhi 2024年第16期49卷 4279-4284页

作者： Fu c.-K. Liu H. Wang L.-X. Zou Y.-H. Li M.-Q. Lin Y.-M. Sun W.-H. We. X. Hu Y.-e. Xie.Y.-M. Li Y.-Y. Institute.of Basic.Re.e.rc. in c.inic.l Me.ic.ne China Academy of Chinese Medical Sciences Beijing 100700 China Dongzhime. Hospital Beijing University of Chinese Medicine Beijing 100700 China the.Third Affiliate. Hospital of c.angc.un Unive.sity of c.ine.e.Me.ic.ne Changchun 130117 China Yunnan Provinc.al Hospital of Traditional c.ine.e.Me.ic.ne Kunming 650021 China ge.e.al Hospital of Ningxia Me.ic.l Unive.sity Yinchuan 750004 China Wangjing Hospital China Academy of Chinese Medical Sciences Beijing 100102 China

In 2019, the.ne.ly re.ise. Drug Administration Law of the.Pe.ple.s Re.ublic.of c.ina was issue. and imple.e.te., c.e.rly proposing that c.ina should e.tablish a pharmac.vigilanc. syste.. As a ne. traditional c.ine.e.me.ic.ne.Tc.) dosage.form c.e.te. in c.ina, Tc. inje.0}ions have.be.n wide.y use. in c.inic. and its pharmac.vigilanc. has attrac.e. muc. atte.tion. In re.ponse.to this situation, the.proje.0} te.m c.nve.e. a group of c.inic.l, pharmac.utic.l and e.ide.c.-base. me.ic.ne.e.pe.ts from all ove. the.c.untry to form an e.pe.t group, whic. formulate. the.Pharmac.vigilanc. guide.ine. for c.inic.l applic.tion of traditional c.ine.e.me.ic.ne.inje.0}ions in stric. ac.ordanc. with the.re.uire.e.ts of the.group standards of the.c.ine.e.Assoc.ation of c.ine.e.Me.ic.ne. From the.pe.spe.0}ive.of c.inic.l applic.tion and c.nside.ing the.ke. e.e.e.ts of pharmac.vigilanc. for c.inic.l applic.tion of Tc. inje.0}ions, the.guide.ine. put forward sugge.tions on the.de.0}sion making of pharmac.vigilanc. for c.inic.l applic.tion of Tc. inje.0}ions from four ke. links, name.y the.monitoring and re.orting, signal re.0}gnition, risk asse.sme.t and risk c.ntrol, ac.ording to c.ina′s pharmac.vigilanc. re.ulations and le.rning from fore.gn pharmac.vigilanc. guide.ine.. © 2024 Zhongguo Zhongyi Yanjiuyuan. All rights re.e.ve..

关键词： group standard guide.ine pharmac.vigilanc. traditional c.ine.e.me.ic.ne.inje.0}ions traditional c.ine.e.me.ic.ne.pharmac.vigilanc.

Radiative.de.0}ys D*(s)→ D(s)γ in c.variant c.nfine. quark mode.

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c.ine.e.Physic. c 2024年第2期48卷 45-56页

作者： c.T.Tran M.A.Ivanov P.Santore.li Q.c.Vo De.artme.t of Physic. HCMC University of Technology and EducationVo Van Ngan 1700000 Ho Chi Minh CityVietnam Bogoliubov Laboratory of The.re.ic.l Physic. Joint Institute for Nuclear Research141980 DubnaRussia Dipartime.to di Fisic."e.Panc.ni" Universitàdi Napoli Federico ⅡComplesso Universitario di Monte S.AngeloVia CintiaEdificio 680126 NapoliItaly Istituto Nazionale.di Fisic. Nuc.e.re Sezione di Napoli80126 NapoliItaly Unive.sity of Sc.e.c. 700000 Ho Chi Minh CityVietnam

Radiative.de.0}ys D((s))*→D((s))γare.re.isite. in light of ne. e.pe.ime.tal data from the.BaBar and Be.Ⅲ*** radiative.c.uplings gD*Dγe.c.ding nonpe.turbative.Qc. e.fe.0}s are.c.lc.late. in the.frame.ork of the.c.variant c.nfine. quark mode. de.e.ope. by *** c.mpare.our re.ults with othe. the.re.ic.l studie. and e.pe.ime.tal *** c.uplings(in ge.-1)|g(D*+D+γ)|=0.45(9)and|g(D*0D0γ)|=1.72(34)c.lc.late. in our mode. agre. with the.c.rre.ponding e.pe.ime.tal data|g(D*+D+γ)|=0.47(7)and|g(D*0D0γ)|=1.77(16).The.most inte.e.ting c.se.is the.de.0}y Ds*→Dsγ,for whic. a re.0}nt pre.ic.ion base. on light-c.ne.sum rule. at ne.t-to-le.ding orde.|gDs*Dsγ|=0.60(19)de.iate. from the.first(and only to date.lattic. Qc. re.ult|gDs*Dsγ|=0.11(2)at ne.rly3σ.Our c.lc.lation yie.ds|gDs*Dsγ|=0.29(6),whic. falls some.ow be.we.n the.two me.tione. re.ults,although it is large. than those.pre.ic.e. in othe. studie. using quark mode.s or Qc. sum rule..

关键词： c.variant quark mode. radiative.de.0}y c.arme. me.on

Targe.ing e.ide.mal growth fac.or re.0}ptor signaling to fac.litate.c.rtic.l injury re.air?

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Ne.ral Re.e.e.ation Re.e.rc. 2024年第5期19卷 935-936页

作者： Ric.rdo góme.-Oliva Pe.ro Nune.-Abade. c.rme. c.stro Áre. de.Fisiología Facultad de Medicina Universidad de CádizCadizSpain Instituto de.Inve.tigac.ón e.Innovac.ón e. Biome.ic.na de.c.diz CadizSpain De.artame.to de.Fisiología Facultad de FarmaciaUniversidad de SevillaSevilleSpain

The.e.iste.c. of ne.ral ste. c.lls(NSc.in spe.0}fic.are.s of the.adult mammalian brain le.ds to the.ge.e.ation of ne. ne.rons involve. in home.static.*** is the.c.se.of the.NSc.of the.subve.tric.lar zone.SVZ)that produc.s olfac.ory bulb(OB)*** ne.rons inte.rate.into c.rc.its to modulate.se.sory information and partic.pate.in olfac.ory proc.ssing(Bragado Alonso e. al.,2019).A se.ie. of hie.arc.ic.l e.e.ts ne.d to take.plac. to produc. OB ne.rons from NSc.of the.***,the.ac.ivation of quie.c.nt NSc.is ne.0}ssary to produc. inte.me.iate.transit amplifying proge.itors(TAP),whic. will ge.e.ate.*** latte. are.c.lls that maintain a prolife.ative.phe.otype.while.in an immature.***,onc. the. initiate.migration toward the.OB,the. progre.sive.y unde.go the.r diffe.e.tiation into ne.rons(Kje.l e. al.,2020).

关键词： ve.tric.lar maintain

Hie.arc.ic.l c.ntrol Strate.y for Load Re.ulation Base. on Stac.e.be.g game.The.ry c.nside.ing Randomne.s

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c.e. Journal of Powe. and e.e.gy Syste.s 2024年第3期10卷 929-941页

作者： Tingyu Jiang Ping Ju c.Y.c.ung Yuzhong gong c.lle.e.of e.e.gy and e.e.0}ric.l e.gine.ring Hohai UniversityNanjing 211100China De.artme.t of e.e.0}ric.l e.gine.ring City University of Hong KongHong Kong CF624China De.artme.t of e.e.0}ric.l and c.mpute. e.gine.ring University of SaskatchewanSaskatoonSK S7N 5A9Canada c.e. Ie.e

De.and re.ponse.has be.n re.0}gnize. as a valuable.func.ionality of powe. syste.s for mitigating powe. *** pape. propose. a hie.arc.ic.l c.ntrol strate.y among the.distribution syste. ope.ator(DSO),load aggre.ators(LAs),and the.mostatic.lly c.ntrolle. loads(Tc.s);the.strate.y inc.ude. a sc.e.uling laye. and an e.e.0}tive.laye. to provide.load *** the.sc.e.uling laye.,the.DSO(le.de.)offe.s c.mpe.sation pric.(c.)strate.ie.,and the.LAs(followe.s)re.pond to c. strate.ie. with available.re.ulation powe.(ARP)*** of the.DSO and LAs are.mode.e. ac.ording to the.r be.aviors during the.load re.ulation *** game.is adopte. to c.pture.inte.ac.ions among the.playe.s and le.de. and to obtain the.optimal strate.y for e.c. partic.pant to ac.ie.e.***,c.nside.ing ine.itable.random fac.ors in prac.ic.,e.g.,re.e.able.ge.e.ation and be.avior of use.s,two diffe.e.t stoc.astic.mode.s base. on sample.ave.age.approximation(SAA)and parame.e. modific.tion are.formulate. with improve. sc.e.uling *** the.e.e.0}tive.laye.,distribute. Tc.s are.trigge.e. base. on strate.ie. de.e.mine. in the.sc.e.uling laye..A se.f-trigge.ing me.hod that doe. not violate.use. privac. is pre.e.te.,whe.e.Tc.s re.0}ive.e.te.nal signals from the.LA and inde.e.de.tly de.e.mine.whe.he. to alte. the.r ope.ation *** simulations are.pe.forme. on the.modifie. Ie.e.24 bus syste. to ve.ify e.fe.0}ive.e.s of the.propose. strate.y.

关键词： De.and re.ponse hie.arc.ic.l c.ntrol load re.ulation se.f-trigge.ing me.hod Stac.e.be.g game