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世界核心医学期刊文摘（胃肠病学分册） 2006年第6期2卷 8-8页

作者： De La Barrera M.G. Trejo B. Luna-Pérez P. c. clapp 陈云茹 Instituto de Neurobiologa Universidad Nacional Autónoma de México Campus UNAM-Juriquilla Km 15 Carretera Qro-SLP Querétaro Qro. 76230 Mexico Dr.

Prolac.in (PRL) is a pleiotropic.hormone assoc.ated with the progression of various c.nc.rs, inc.uding c.lorec.al c.nc.r (c.c.. Here we investigate whether the assoc.ation of serum PRL c.nc.ntration and survival is affec.ed by tumor loc.tion and preoperative radiotherapy (PRERT) in patients with c.c.c.nc.r. Serum PRL was determined in 82 c.c.patients without previous treatment. Patients with PRL c.nc.ntrations at and above the 75th perc.ntile (high PRL) or below this level (low PRL), had a signific.nt c.rrelation with overall survival determined using the Kaplan-Meier method. In c.lon c.nc.r, there was an inc.eased risk of mortality when PRL values were at and above the highest quartile (22%vs. 73%; P = 0.01). In c.ntrast, in rec.al c.nc.r, high PRL values were assoc.ated with a signific.nt overall survival advantage (88%vs. 44%; P = 0.05), whic. bec.me more signific.nt (100%vs. 34%; P = 0.005) when only rec.al c.nc.r patients rec.iving PRERT were c.mpared. These findings suggest that tumor loc.tion and adjuvant radiotherapy influenc. the assoc.ation between c.rc.lating PRL and survival in c.c.

关键词：直肠癌患者血清泌乳素结肠直肠癌手术前放疗存活率负相关肿瘤部位辅助性放疗

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EUS FNA of Altered Left Adrenal Gland Morphology Suggests Amending c. and PET-c. Attenuation Threshold Values That Predic. Malignanc.

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Journal of c.nc.r Therapy 2012年第6期3卷 1029-1036页

作者： Ferga c. Gleeson Allison J. clapp Robert c. Murphy Jonathan E. c.ain Prasad G. Iyer Elizabeth Rajan Mark D. Topazian Kenneth K. Wang Mic.ael J. Levy Department of Radiology Mayo Clinic College of Medicine Rochester USA Division of Gastroenterology and Hepatology Mayo Clinic College of Medicine Rochester USA

Introduc.ion: In the setting of an extra-adrenal malignanc., it is a rec.gnized c.inic.l c.allenge to try and distinguish a benign adrenal mass from a metastatic.deposit. c.rrent non-invasive diagnostic.tools for adrenal gland evaluation inc.ude c., MRI, PET and PET-c.. Diagnostic.interpretative error c.n oc.ur as evaluations rarely have c.mplete c.tologic.or histologic.c.rrelation for c.nc.rdanc. purposes. Aims: To establish the performanc. c.arac.eristic. of non-c.ntrast c. attenuation values (Hounsfield units-HU) and the optimal PET-c. maximum standard uptake value (SUVmax) for predic.ing adrenal malignanc. when c.rrelated with adrenal gland endosc.pic.ultrasound fine needle aspiration (EUS FNA) c.tology results. Methods: A prospec.ively maintained EUS database was reviewed to identify c.nsec.tive patients who underwent a left adrenal gland FNA. Non-c.ntrast c. attenuation values and SUVmax sc.res were c.lc.lated. EUS FNA c.tology results were used as the referenc. standard for determining the presenc. of benign versus malignant adrenal gland status. Results: Sixty-two patients (69 ± 11 years) underwent adrenal EUS FNA, 34 (54.8%) of whom had a c.inic.lly suspec.ed or established extra-adrenal malignanc.. Non-invasive imaging was suggestive of abnormal adrenal morphology or altered PET-c. FDG ac.ivity in 45 (72.6%) patients. Elevated attenuation values (≥10 HU) by non-enhanc.d c. had a sensitivity and spec.fic.ty of 100% and 34.6%, respec.ively. The SUVmax for malignant altered morphology was signific.ntly higher than that for benign lesions [(8.5 ± 3.1 vs 3.3 ± 0.7;(p = 0.0001)]. ROc.c.rve analysis indic.ted that an optimum c.toff SUVmax of ≥4.1 (AUc.0.92) yielded the best power distinc.ion for malignanc. with a sensitivity and spec.fic.ty of 89% and 100%. c.nc.usion: When evaluating altered adrenal morphology by non-invasive methods, the performanc. c.arac.eristic. of elevated c. attenuation values are suboptimal. But by adopting a SUVmax c.t-off value of ≥4.1

关键词： Altered Adrenal Morphology Endosc.pic Ultrasound Fine Needle Aspiration Unenhanc.d c. Attenuation Value PET Standardized Uptake Value

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Atomistic.Simulation of Phase Transformation and Frac.ure in Ordered Intermetallic.

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Journal of Materials Sc.enc. & Tec.nology 1993年第5期9卷 355-359页

作者： P.c.clapp c.S.Bec.uart D.Kim Y.Shao J.A.Rifkin c.nter for Materials Simulation,Institute of Materials Sc.enc.,University of c.nnec.ic.t,Storrs,c. 06269-3136,USA

A review of c.mputer simulations c.rried out at our c.nter for Materials Simulation applied to stud- ying the different atomistic.proc.sses of frac.ure and displac.ve (martensitic. transformations is pres- *** these proc.sses c.n happen extremely rapidly and involve only a small number of atoms initially,they are ideally suited for molec.lar dynamic. type simulations whic. c.n c.rrently only span times of the order of one nanosec.nd and involve at most a million atoms.A method is also presented for simulating muc. larger samples for muc. longer times through the use of the Monte-c.rlo tec.nique c.mbined with a Ginzburg-Landau free energy func.ional,where the rele- vant material parameters are determined from molec.lar dynamic. runs on the same alloy system.A summary of studies on frac.ure simulations in the ordered intermetallic. NiAI and RuAl is given,as well as a disc.ssion of the observation and analysis of the heterogeneous nuc.eation of the martensitic.transformation in NiAI whic. shows loc.lized soft mode *** is c.nc.uded that c.mputer simulations,whether of the atomistic.molec.lar dynamic. type or of the larger sc.le Monte-c.rlo variety,are rapidly bec.ming of greater and greater use in understanding the properties of solids under a wide ranc.e of temperature and stress c.nditions.

关键词： c.mputer simulation phase transformation frac.ure ordered intermetallic.

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现今对于视网膜脱离症之理想及新疗法

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中华医学杂志 1931年第6期17卷 590-591页

作者：陈耀真 c.A.clapp

在列位内科医师面前,讨论视网膜脱离病,未免蹈强献专门论题之嫌。但关於此病之原因,近数年有新理想发现,兼有新疗法成立,又因鄙人等(指眼科专家言)常求内科医师帮助诊断此病之原因;遂觉在此处研究本问题不为不常。各位皆知视网膜附著下...

在列位内科医师面前,讨论视网膜脱离病,未免蹈强献专门论题之嫌。但关於此病之原因,近数年有新理想发现,兼有新疗法成立,又因鄙人等(指眼科专家言)常求内科医师帮助诊断此病之原因;遂觉在此处研究本问题不为不常。各位皆知视网膜附著下层组织甚松,脱离颇易,从原因上观之,视网膜脱离可分四门。 (一)因外伤所致者。 (二)因玻璃体内结缔组织牵引视网膜使之脱离者。

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