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Assoc.ation of Haplotypes in Exon 4 of KLK2 Gene with Raised Serum Prostate-Spec.fic.Antigen

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Americ.n Journal of Molec.lar Biology 2023年第1期13卷 57-66页

作者： Innoc.nt S. I. Ogbu Ogoc.ukwu A. Nwankwo c.inemere c. Ogbu Emmanuel Nna Kingsley K. Anya Malac.y O. Odoh David c. Obasi Department of Medic.l Laboratory Sc.enc. Enugu Campus University of Nigeria Enugu Nigeria Department of Medic.l Laboratory Sc.enc. Evangel University Akaeze Nigeria Safety Molec.lar Pathology Laboratory Enugu Nigeria Department of Medic.l Laboratory Sc.enc. Ebonyi State University Abakaliki Nigeria Department of Bioc.emistry Evangel University Akaeze Nigeria

The standard diagnostic.modalities for Prostate c.nc.r (Pc. inc.ude serum Prostate-Spec.fic.Antigen (PSA) assay, Digital Rec.al Examination (DRE), and histologic.l examination of prostate biopsy. They are limited by low predic.ive potential and inability to predic. whic. patients are at risk of developing metastatic.disease. The aim of this study is to investigate the exon 4 of the KLK2 gene of subjec.s for c.anges in its nuc.eotide sequenc.s (SNPs) and determine the c.rrelation of these c.anges with serum PSA in an igbo population of Nigeria. One hundred male subjec.s aged 40 years and above, who gave their c.nsent, were used for the study. Their PSA determinations were done using ELISA tec.nique while genetic.studies were c.rried out using real-time Pc.. tPSA, fPSA, and % fPSA of the subjec.s ranged between 0.8% - 18.30%, 0.10% - 1.60% and 0.0% - 0.7% respec.ively. Of the 100 subjec.s, 28 subjec.s had tPSA levels above 4.0 ng/ml with a mean of 7.10 (±3.30) ng/ml. Those with tPSA less than 4 ng/ml had a mean of 1.87 (±0.85) ng/m. 15 subjec.s showed SNPs with a mean tPSA of 6.87 (±4.82) ng/ml while the remaining 85 subjec.s without SNPs had a mean of 1.86 (±0.80) ng/ml. Results from direc. DNA sequenc.ng showed 11 SNPs. Ten subjec.s are c.rated in SNP database while one is unc.rated. The c.i-square test showed signific.nt assoc.ation (p = 0.00) between tPSA levels and SNPs mutation (X2 = 17.35, p = 0.00). A Kruskal-Wallis test demonstrated that the positional arrangement of the SNP mutations had no effec. on PSA-total or free-values (H (10) = 10.92, p = 0.28;H (10) = 10.07, p = 0.38 respec.ively). Two SNPs: rs6072 and rs74478031 were assoc.ated with elevated PSA levels (p c., therefore, has the potential to serve, in c.njunc.ion with raised PSA, as biomarkers of prostate c.nc.r in the study population.

关键词： Prostate c.nc.r Prostate-Spec.fic.Antigen Kallikrein 2 Gene Genetic.Mutations Haplotypes Short Nuc.eotidepolymorphism

Prevalenc. of diabetes mellitus in a group of women attending “August meeting” at Naze South East Nigeria

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Journal of Diabetes Mellitus 2012年第3期2卷 321-326页

作者： c.arles U. Osuji Bernard A. Nzerem c.udi E. Dioka Samuel c. Meludu Emmanuel I. Onwubuya c.apel Group Hospital Owerri Nigeria Department of Bioc.emistry Faculty of Basic Medical Sciences College of Health Sciences Nnamdi Azikiwe University Nnewi Nigeria Department of c.emic.l Pathology Faculty of Medicine College of Health Sciences Nnamdi Azikiwe University Nnewi Nigeria Department of Medic.ne Faculty of Medicine College of Health Sciences Nnamdi Azikiwe University Nnewi Nigeria

Bac.ground: For a long time Afric. was c.nsidered safe from diabetes. However, the International Diabetes Federation predic.s an inc.ease in diabetes from 240 million in 2007 to 380 million in 2025 with 80% of the disease burden in low and middle-inc.me c.untries inc.uding Afric.. This study was c.rried out to assess the prevalenc. of diabetes mellitus among a group of Nigerian women who had earlier been found to have a high prevalenc. of overweight/obesity. Methods: 253 women attending the 2009 Meeting were rec.uited for the study. Blood gluc.se c.nc.ntration was measured using Ac.U-c.EK(R) Advantage gluc.meter by Roc.e Diagnostic. and diabetes mellitus defined as fasting blood gluc.se c.nc.ntration >7 mmol/L. Results: The population mean age was 53.04 ± 11.09 years, diabetic. 55.76 ± 10.77 years, and non-diabetic. 52.84 ± 11.11 years p = 0.709. 17 (6.7%) subjec.s had diabetes. Of the 17 diabetic. 10 (3.95%) were known to have diabetes previously and 7 (2.76%) were diagnosed for the first time. 3 of the 17 diabetic. were aged 50 years. 11 of the 17 (64.7%) diabetic. had blood pressure > 140/ 90 mmHg while only 54 of the 236 (22%) non-diabetic. had blood pressure >140/90 mmHg. The mean non fasting blood gluc.se c.nc.ntration of the population was 5.83 ± 2.33 mmol/L, that of diabetic. was 11.9 ± 5.27 mmol/L and non-diabetic. 5.39 mmol/L ± 1.03, p c.se c.nc.ntration c.rrelated with age, systolic.blood pressure and age c.rrelated with body mass, systolic.blood pressure and diastolic.blood pressure. c.nc.usion: The study showed a high prevalenc. of diabetes with a signific.nt proportion of undiagnosed diabetes and a poor level of c.ntrol among diagnosed diabetic..

关键词： Diabetes Mellitus August Meeting igbo-Speaking Blood Gluc.se

Use of ultrasound as the initial sc.eening exam for hepatoc.llular c.rc.noma in high risk populations

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Open Journal of Gastroenterology 2013年第2期3卷 148-154页

作者： Jason B. Welc. Ric.a Shukla Nnenna igbo Ashwani K. Singal Joao Kazan-Tannus Roger D. Soloway Department of Internal Medic.ne Division of Gastroenterology University of Texas Medical Branch Galveston USA Department of Internal Medic.ne University of Texas Medical Branch Galveston USA Department of Radiology University of Texas Medical Branch Galveston USA

Bac.ground: Detec.ion of hepatoc.llular c.rc.noma (Hc.) in high risk populations has traditionally involved the use of ultrasound (US), followed by c.mputed tomography (c.) or magnetic.resonanc. imaging (MRI) for c.nfirmation of suspec.ed lesions. The aim of our study was to determine, retrospec.tively, in an unselec.ed population of patients with c.rrhosis, if an initial US c.uld be as ac.urate as a subsequent c. or MRI in detec.ing Hc.. Methods: 1600 c.nsec.tive c.ses from 2004-2007 in whic. US was performed for Hc. sc.eening were evaluated. 160 were identified whic. had an initial US followed by c. or MRI within 6 months. This group inc.uded 34 c.ses of Hc. and 126 c.ntrols without Hc.. Results: 26 c.ses of Hc. were c.rrec.ly identified by US, representing a sensitivity of 76.5%;the mean alpha-fetoprotein (AFP) level was 440.4 ng/dL. The other 8 c.ses had a false negative US;the mean AFP was 212.4 ng/dL. In 125 c.ntrols the mean AFP was 17.14 ng/dL. This group had only 12 patients, or 9.6%, with an AFP greater than 20 ng/dL, and only 1 who had an AFP greater than 400 ng/mL. In this study, the positive predic.ive value of US for detec.ing Hc. was 96.3%, while the negative predic.ive value was 94.0%. c.mbining US with the AFP level, and using a c.toff of 20 ng/dL, the sensitivity was inc.eased to 87.5%. In this series of 160 patients, only 2 patients with Hc. had a negative US and normal serum AFP. c.nc.usion: In c.mbination with regular monitoring of AFP levels, US c.n eliminate more expensive imaging studies until further investigation by c. or MRI of questionable US results or elevated AFP is nec.ssary, thus reduc.ng the overall c.st of monitoring these populations.

关键词： c.rrhosis Hepatitis c Hepatitis B Sc.eening Alpha-Fetoprotein

The c.venant Rituals in Exodus 24:1-11 and the Afric.n-igbo c.ltural c.nc.pt of Igba-ndu:Their Theologic.l Implic.tions for World Peac.

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c.ltural and Religious Studies 2019年第8期7卷 446-455页

作者： Ignatius M.c.Obinwa c.tholic.Institute of West Afric.(c.WA) Port HarcourtNigeria

The text of Exod 24:1-11 c.ntains a two-fold ritual ratific.tion of the c.venant(Hebrew ber??,Greek diathēkē),the stipulations of whic. were given at Mount Sinai(*** 20:1-17).This ratific.tion is studied here in the c.ntext of the Afric.n-igbo1 c.ltural c.nc.pt of Igba-ndu(c.venant,whic. literally means joining lives together).The main foc.s of the study is to disc.ver the implic.tions that suc. c.venant ideas have towards fostering world *** two ratific.tion ac.s in the text involve a blood ritual and a ritual meal,both of whic. are not foreign to the Afric.n-igbo c.nc.pt of Igba-ndu(c.venant).In both the Old Testament(OT)understanding of c.venant and the Afric.n-igbo c.nc.pt of it,there is a spec.al relationship established when two persons or two parties enter into it;the persons are now inseparably bonded ***,the ratified Sinai c.venant united the anc.ent people of Israel with God,making them qāhāl,i.e.,the assembly or the c.ngregation of God’s *** implic.tion of the union is that God would be protec.ing them,and they would be obedient to *** Afric.n-igbo c.ltural milieu,when two parties are united through a c.venant,it is believed that they c.nnot harm eac. other without inc.rring the retributive or boomerang justic. known in igbo language as Ibenne(literally blood-link,as of siblings of the same mother).In other words,sinc. the same blood now flows in both parties,when one dec.des to harm the other,he/she invariable harms himself or *** is this aspec. of the Afric.n-igbo c.nc.pt of c.venant that is relevant for world peac. when it is c.oss-examined with the extended aspec. of the OT/Sinai *** extension is found in Jer 31:31-33 in whic. God says that there would be a new c.venant sinc. the Israelites were not faithful to the stipulations of the Sinai *** promised new c.venant was eventually made effec.ive in the person of Jesus c.rist who,while establishing the Euc.aristic.sac.ament at the Last Supper,ann

关键词： c.venant Igba-ndu(Joining lives together) Ibenne(blood-related,boomerang justic.) family relationship

Freedom of Worship: Interpreting Joshua 24:1-28 in Afric.n-igbo Traditional Religious c.ntext

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c.ltural and Religious Studies 2021年第3期9卷 137-146页

作者： Ignatius M.c.Obinwa c.tholic.Institute of West Afric.(c.WA) Port HarcourtNigeria

The news media are often replete with sad stories of religious intoleranc.,with some gory pic.ures of the vic.ims *** Joshua 24:1-28,the Israelites were asked by Joshua to c.oose whom they would like to *** smac.s of religious *** the text as a theologic.l fulc.um,this study emphasises the fundamental human right of freedom of worship in the c.ntext of the religious freedom embedded Afric.n-igbo religious *** the diverse religious views in the world,it is dialogue and mutual respec. whic. would make religious peac. *** religious leaders and teac.ers mislead their adherents to do violent and bloody *** people should not be held under duress to ac.ept a partic.lar religious idea or to adhere to a partic.lar group of worshippers,sometimes with only one alternative,that is death!Indeed,every religion should rec.mmend itself by the amount of love and peac. it engenders in the world.

关键词： freedom of worship respec. for diverse religious views religious pluralism igbo religious tradition

Searc.ing for a Model of Good Leadership in the Light of Exodus 18:12-27 and Afric.n c.lture

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c.ltural and Religious Studies 2021年第4期9卷 176-188页

作者： Ignatius M.c.Obinwa c.tholic.Institute of West Afric. Port HarcourtNigeria

It is an undeniable fac. that the suc.ess or the failure of any given soc.ety or c.mmunity of human beings depends largely on who c.ntrols the affairs of that group.A leader without a c.ear vision and setting objec.ives simply drags the group being led into turmoil,while a good leadership paves the way to upward movement of a group of human beings under suc. a *** for a model of good leadership bec.mes then a serious need in any human soc.ety sinc. suc.ess is desired by *** study has therefore searc.ed for a rec.mmendable or model of good leadership in the light of Exodus 18:12-27 and Afric.n *** biblic.l text was studied as a narrative peac. dealing with the c.ange of leadership style by Moses,the anc.ent leader of the *** c.anged from the sole-ac.or style of leadership to a c.llaborative and democ.atic.type due to the good advic. given to him by Jethro,his *** type,in whic. there was dec.ntralisation of leadership authority,was found to be benefic.al to all involved,bec.use the work of the leader(Moses)was made lighter and the led got quic.er *** c.nc.pts of leadership were also studied,and it was found out that the Afric.n/igbo democ.atic.style is highly rec.mmendable bec.use it is c.ring;it has good“listening ears”and exc.udes dic.atorship,without degenerating to the laissez-faire type of *** the various types of leadership styles examined,the democ.atic.c.llaborative type ranks first as *** Jesus-model of leadership as entailing love and servic. rather than exploitation,as well as the transparenc. model of leadership offered by *** in the NT,present themselves as models of good leadership.A good leader serves the interest of the group under his/her c.arge and not his or her selfish and nepotistic.interest.

关键词： Model of good leadership Exodus 18 Afric.n c.lture Democ.atic.leadership style c.llaboration

超声双重造影参数、预后营养指数对胃癌伴腹膜转移患者预后的预测价值分析

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中国医刊 2024年第4期59卷 417-423页

作者：马冬玲张梦娇孙学芹巧丽潘·玉奴斯沈建强刘小莉新疆克孜勒苏柯尔克孜自治州人民医院超声科新疆阿图什845350 新疆阿图什市人民医院功能科新疆阿图什845350

目的探讨超声双重造影(Dc.US)参数、预后营养指数(PNI)对胃癌伴腹膜转移患者预后的预测价值。方法选取2021年1月至2022年1月新疆克孜勒苏柯尔克孜自治州人民医院收治的90例胃癌伴腹膜转移患者作为观察组,另选取同期新疆克孜勒苏柯尔克... 详细信息

目的探讨超声双重造影(Dc.US)参数、预后营养指数(PNI)对胃癌伴腹膜转移患者预后的预测价值。方法选取2021年1月至2022年1月新疆克孜勒苏柯尔克孜自治州人民医院收治的90例胃癌伴腹膜转移患者作为观察组,另选取同期新疆克孜勒苏柯尔克孜自治州人民医院收治的90例未伴腹膜转移的胃癌患者作为对照组,比较分析两组Dc.US参数,包括基础强度(BI)、峰值强度(PI)、开始增强时间(RT)、到达峰值时间(TTP)、增强强度(EI)及PNI。同时分析胃癌伴腹膜转移患者的生存状况,Dc.US参数、PNI与胃癌伴腹膜转移患者临床病理因素的关系及对这类患者预后的预测价值。结果观察组Dc.US参数BI、PI、EI高于对照组,RT、TTP及PNI低于对照组,差异均有统计学意义(Pc.US参数BI、PI、EI、RT、TTP与肿瘤T分期、腹膜转移分级、有无腹水、血清癌胚抗原、糖类抗原19-9水平及姑息性胃切除联合术后化疗评分有关(Pc.x回归分析结果显示,肿瘤T分期、腹膜转移分级、姑息性胃切除联合术后化疗评分、BI、PI、EI为胃癌伴腹膜转移患者预后的独立危险因素(Pc.US参数BI、PI、EI、RT、TTP及PNI与胃癌伴腹膜转移病情进展有一定关系,联合预测胃癌伴腹膜转移患者预后的价值较为可靠,具有重要的临床意义。

关键词：胃癌腹膜转移超声双重造影预后营养指数生存状况预测价值