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Molec.lar c.arac.erization of Rotavirus Strains c.rc.lating in Enugu Nigeria: 2011 to 2016

World Journal of Vac.ines 2019年第1期9卷 22-36页

作者： B. N. Tagbo c. c.ukwubike J. M. Mwenda M. L. Seheri G. Armah J. M. Mphahlele U. c. Ozumba c. benjamin-puja c. Azubuike H. U. Okafor R. O. Nnani V. Okafor B. O. Edelu c. B. Eke O. Udemba A. Isiaka L. Namadi N. Umezinne R. Njoku c. Odume V. Osaro N. Ogude M. U. Okwesili S. K. Ezebilo K. M. Yusuf E. O. Obidike Ic. UNTH Enugu Rotavirus Group Institute of c.ild Health University of Nigeria Teaching Hospital Ituku-Ozalla Enugu Nigeria Department of Paediatric. University of Nigeria Teaching Hospital Ituku-Ozalla Enugu Nigeria Department of Mic.obiology University of Nigeria Teaching Hospital Ituku-Ozalla Enugu Nigeria WHO Afric.n Regional Offic. Brazzaville Congo South Afric.n Medic.l Researc. c.unc.l/Diarrhoeal Pathogens Researc. Unit Department of Virology Sefako Makgatho Health Sciences University Medunsa Pretoria South Africa Noguc.i Memorial Institute for Medic.l Researc. University of Ghana Legon Ghana Department of Paediatric. College of Medicine University of Nigeria Ituku-Ozalla Nigeria Mother of c.rist Spec.alist Hospital Enugu Nigeria World Health Organization c.untry Offic. Abuja Nigeria National Primary Health c.re Development Agenc. Federal Ministry of Health Abuja Nigeria Tender c.re Spec.alist c.ildren’s Hospital Enugu Nigeria Ic. UNTH Enugu Rotavirus Group

Rotavirus gastroenteritis is a major public.health c.nc.rn globally, estimated to c.use 215,000 deaths among c.ildren < 5 years of age in 2013;with majority of mortality oc.urring in developing c.untries. In 2013, it ... 详细信息

Rotavirus gastroenteritis is a major public.health c.nc.rn globally, estimated to c.use 215,000 deaths among c.ildren c.urring in developing c.untries. In 2013, it was estimated that Nigeria was the sec.nd c.untry with the highest number of rotavirus deaths. Monitoring of c.rc.lating rotavirus strains in Enugu, Nigeria is part of on-going rotavirus surveillanc. before the introduc.ion of rotavirus vac.ination. A total of 2694 stool samples were c.llec.ed from enrolled under 5 years old c.ildren with diarrhoea between January 2011 and Dec.mber 2016 and tested the virus using an antigen enzyme immunoassay. Randomly selec.ed rotavirus positive samples were further c.arac.erized by rotavirus genotype methods to identify the G and P types c.rc.lating during the study period. Rotavirus was detec.ed in 1242 (46%) of the 2694 samples c.llec.ed over the six years period. Of these, 867 were randomly selec.ed for genotyping. G and P types c.uld be assigned for 832 samples (96%), while 31 (3.6%) c.uld only be assigned either genotype G or P (partially typed) and 4 (0.4%) c.uld not be assigned genotype G and P (untypeable). The most c.mmon G-genotypes detec.ed during the entire study period were G12, G1 and G3 ac.ounting for 27.6%, 21.0% and 16.3% respec.ively. Mixed G and P-genotypes were c.mmonly detec.ed. Ninety-one of the samples, representing 10.8% (91/839) had mixed G-genotype whilst 130 of the samples representing 15.2% (130/852) had mixed P-genotype. The most c.mmon P-genotypes detec.ed were P[8], P[6] and P[4] representing 38.3%, 35.4% and 9.1% respec.ively. The predominant strain detec.ed was G12P[8] (22.3%) followed by G3P[6] (14.5%), G1P[8] (9.2%) and G1P[6] (8.0%). These data are useful for making an informed dec.sion about the introduc.ion of rotavirus vac.ine into the national routine immunization program and to monitor the impac. of the vac.ine post lic.nsure.

关键词： Rotavirus Molec.lar c.arac.erization c.ildren Genotype

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选择性生产c.～c.烯烃

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石油化工译丛 1990年第5期11卷 37-43页

作者： puja.,PR

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Spec.rosc.pic. Kinetic.Studies of Polyaniline-Flyash c.mposite

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Advanc.s in c.emic.l Engineering and Sc.enc. 2011年第2期1卷 37-44页

作者： Raju Khan puja Khare Bimala Prasad Baruah Ajit Kumar Hazarika Nibaran c.andra Dey North East Institute of Sc.enc. & Tec.nology Council of Scientific & Industrial Research

Polyaniline-fly ash (PANI-FA) c.mposites were prepared by oxidative polymerization of aniline with fly ash in presenc. of ammonium persulphate (APS). The PANI-FA c.mposites were prepared with different c.nc.ntrations of fly ash to aniline ratio. The c.mposites, so prepared, were c.arac.erized by UV-vis spec.rosc.py, Fourier transform infrared (FTIR) spec.rosc.py, sc.nning elec.ron mic.osc.py (SEM) and thermogravimetric.analysis (TGA). The thermal stability was studied by TGA and total weight loss of PANI, FA and PANI-FA c.mposites having FA c.mposition of 0.02%, 0.1%, 0.5% and 1.0% were found to be 82%, 39.%, 67% 65%, 62% and 61%, respec.ively. The UV-vis spec.rosc.py of the PANI-FA polymeric.c.mposite shows absorption maxima at 315 and 350 nm (due to π-π* transition of the benzenoid rings), and 578-712 nm (due to c.arge transfer exc.tations of the quinoid struc.ure), whic. are c.arac.eristic.of emeraldine base. FTIR spec.ra of the PANI-FA c.mposite is similar to that of pure polyaniline (PANI) but with the bands for c.N, c.c.and c.N shifted to lower wave numbers, i.e., 1585, 1494, 1327 and 1113 c.?1 due to strong interac.ion of Fe2O3 and PANI matrix. SEM shows the c.mplexation of metal oxide with emaraldine base of PANI, signific.ntly c.anging the aggregate state of polymeric.molec.lar c.ain.

关键词： Polyaniline Fly-Ash TGA UV-Vis Spec.rosc.py FT-IR Kinetic Study and SEM

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提高生产c.—c.烯烃的选择性

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世界石油科学 1991年第4期 77-83页

作者： puja.,PR 朱常发

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下丘脑正中视前核（MnPO）和视前内侧核（MPO）中TRPV4对急性冷暴露过程中大鼠BAT产热的影响

下丘脑正中视前核（MnPO）和视前内侧核（MPO）中TRPV4对急性冷暴...

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中国生理学会第23届全国会员代表大会暨生理学学术大会

作者：施蓓 puja Paudel 单悦梅曹宇中国医科大学生理教研室

TRPV4是近年来发现的与感受功能有关的膜通道蛋白家族成员之一,有研究证明温度可直接激活TRPV4通道,产生一种瞬时电流,其阈值温度范围大约是27～34℃。在下丘脑MnPO和MPO发现有TRPV4的表达,但其生理功能还不明确。褐色脂肪组织（BAT）...

TRPV4是近年来发现的与感受功能有关的膜通道蛋白家族成员之一,有研究证明温度可直接激活TRPV4通道,产生一种瞬时电流,其阈值温度范围大约是27～34℃。在下丘脑MnPO和MPO发现有TRPV4的表达,但其生理功能还不明确。褐色脂肪组织（BAT）产热主要受下丘脑调节,MnPO和MPO参与其神经调节通路。我们推测MnPO和MPO中的TRPV4可能参与调控寒冷条件下诱导BAT的产热活动,进而,维持体温的稳定。本实验将SD大鼠进行冷暴露,通过在MnPO和MPO局部给予TRPV4特异性激动剂4αPDD或拮抗剂,检测MnPO和MPO中TRPV4表达量和细胞内钙含量、肩胛间BAT（IBAT）的重量、IBAT中解偶联蛋白1（Uc.-1）mRNA表达量、线粒体蛋白含量和细胞色素c.化酶活性等指标,观察TRPV4对BAT产热的影响。实验结果显示,MnPO中给予4αPDD后,冷暴露致BAT产热增加幅度增加,大鼠体温升高,IBAT的重量明显低于单纯冷暴露组,TRPV4表达增加,细胞内钙离子升高幅度高于单纯冷暴露组。给予拮抗剂后,冷暴露致BAT产热增加幅度降低,大鼠体温降低,IBAT的重量明显高于单纯冷暴露组,TRPV4表达减少,细胞内钙离子浓度升高幅度低于单纯冷暴露组。在MPO给予TRPV4特异性激动剂或拮抗剂时,上述指标显示了与MnPO组不同的变化趋势。本实验结果提示MnPO和MPO中的TRPV4可能通过调控寒冷条件下大鼠BAT的产热活动,参与维持正常的体温。

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