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超高真空泵

真空 1980年第1期 76-106+62页

作者： c.F.weston 翁国屏

WONcA研究论文摘要汇编——英国全科医生接诊的慢性病患者疾病负担情况:基于应用三项指标调查的横断面研究

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中国全科医学 2017年第2期20卷 126-126页

作者： weston c GILKES A DURBABA S 本刊编辑部

背景全科医生接诊的慢性病患者的疾病负担有很大的不同。本研究旨在调查全科医生接诊有重度疾病负担的慢性病患者的特点。方法回顾性调查2014—2015年英国全科医生的执业情况,3项指标用来量化全科医生接诊的慢性病患者患病率情况,影响... 详细信息

背景全科医生接诊的慢性病患者的疾病负担有很大的不同。本研究旨在调查全科医生接诊有重度疾病负担的慢性病患者的特点。方法回顾性调查2014—2015年英国全科医生的执业情况,3项指标用来量化全科医生接诊的慢性病患者患病率情况,影响因素包括全科医生接诊次数、患者例数、全科医生的执业特点、患者人口学因素、二级保健机构利用情况。结果 3项指标的结果:(57.7±22.3)%的患者患有在英国全科医疗按质计酬体系中登记的20种慢性病;(22.8±8.2)%的患者患有9种疾病中的1种或1种以上疾病;(63.5±11.7)%的患者患有全科医生列出的15种慢性病中的1种或1种以上疾病。高龄患者比例和二级保健机构利用情况是该3项指标最强预测因素。结论英国全科医生接诊的慢性病患者的疾病负担因人而异。这种差异主要由人口学因素而不是全科医生执业特点造成的。由于患者的疾病负担较重,全科医生在执业中高度利用二级保健机构对医疗资源配置及资金预算有很大的启示。

关键词：全科医生执业疾病负担 WONcA 慢性病慢性疾病疾病患者英国大不列颠及北爱尔兰联合王国

急性冠脉综合征中的高血糖：风险标记还是治疗靶点？

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英国医学杂志中文版 2010年第2期13卷 110-111页

作者： R Anantharaman M Heatley c weston 赵振燕(译) 李崇剑(校) 吴永健(校) Department of cardiology Singleton Hospital Swansea SA2 8QA Swansea University Singleton ParkSwansea Wales. SA2 8PP 北京阜外心血管病医院心内科

急性冠脉综合征患者入院时经常伴随高血糖现象；这种现象是一个预后不良的标志。使血糖迅速正常化的干预措施不能恰当应用并且疗效也不确切。在此，我们对高血糖与预后之间的关系进行了综述，对高血糖不仅仅反映了糖尿病前期状态的看法... 详细信息

急性冠脉综合征患者入院时经常伴随高血糖现象；这种现象是一个预后不良的标志。使血糖迅速正常化的干预措施不能恰当应用并且疗效也不确切。在此，我们对高血糖与预后之间的关系进行了综述，对高血糖不仅仅反映了糖尿病前期状态的看法提供依据，并且我们还讨论了高血糖可能对急性心肌梗死过程产生不利影响的机制。最后，我们寻求胰岛素强化治疗改善预后的依据。

关键词：急性冠脉综合征高血糖治疗靶点胰岛素强化治疗风险预后不良急性心肌梗死糖尿病前期

Bayesian inference for dynamical systems

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Infectious Disease Modelling 2020年第1期5卷 221-232页

作者： weston c.Roda Department of Mathematical and Statistical Sciences University of AlbertaEdmontonAB T6G 2G1Canada

Bayesian inference is a common method for conducting parameter estimation for dynamical *** the prevalent use of Bayesian inference for performing parameter estimation for dynamical systems,there is a need for a formalized and detailed *** paper presents a comprehensive methodology for dynamical system parameter estimation using Bayesian inference and it covers utilizing different distributions,Markov chain Monte carlo(McMc)sampling,obtaining credible intervals for parameters,and prediction intervals for solutions.A logistic growth example is given to illustrate the methodology.

关键词： Bayesian Inference Model fitting Data Dynamical system Mathematical model

Dynamic characteristics of a switch and crossing on the West coast main line in the UK

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Railway Engineering Science 2022年第2期30卷 183-203页

作者： Jou-Yi Shih Paul weston Mani Entezami clive Roberts Birmingham centre for Railway Research and Education University of BirminghamBirmingham B152TTUK ZynaMic Engineering AB 12070 StockholmSweden

Railway switches and crossings constitute a small fraction of linear track length but consume a large proportion of the railway track system maintenance *** switch and crossing(S&c)faults rarely prevent trains from running,switches and crossings are the source of many faults and need continual *** the rare occasions when trains are prevented from running the cost of the disruption is very *** monitoring of the point operating equipment that moves the switchblades has been in use for many years but condition monitoring of the state of the switch in terms of the support and mechanical damage as trains pass over has only recently started to become *** this end,it is important to understand the correlation between S&c faults and sensor data that can detect those *** paper assesses some of the data collected from multiple sensors variously positioned on and around a switch and crossing on the UK mainline for a few days of normal train ***,geophones,and strain gauges were installed at the locations where they were anticipated to be most *** at the load transfer point on the crossing nose were estimated from two separate strain gauge bridges and possible use of acceleration on the crossing is *** between different data are analysed and assessed and correlation between peak estimated load transfer forces and accelerations is *** on the analysis,conclusions are drawn about the different types of dynamic information around S&cs that can be obtained from a variety of sensor types.

关键词： Railway Accelerometer condition monitoring Impact force Switch and crossing Strain gauge

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Why is it difficult to accurately predict the cOVID-19 epidemic?

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Infectious Disease Modelling 2020年第1期5卷 271-281页

作者： weston c.Roda Marie B.Varughese Donglin Han Michael Y.Li Department of Mathematical and Statistical Sciences University of AlbertaEdmontonAlbertaT6G 2G1 Canada Analytics and Performance Reporting Branch Alberta HealthEdmontonAlbertaT5J 2N3Canada

Since the cOVID-19 outbreak in Wuhan city in December of 2019,numerous model predictions on the cOVID-19 epidemics in Wuhan and other parts of china have been *** model predictions have shown a wide range of *** our study,we demonstrate that nonidentifiability in model calibrations using the confirmed-case data is the main reason for such wide *** the Akaike Information criterion(AIc)for model selection,we show that an SIR model performs much better than an SEIR model in representing the information contained in the confirmed-case *** indicates that predictions using more complex models may not be more reliable compared to using a simpler *** present our model predictions for the cOVID-19 epidemic in Wuhan after the lockdown and quarantine of the city on January 23,*** also report our results of modeling the impacts of the strict quarantine measures undertaken in the city after February 7 on the time course of the epidemic,and modeling the potential of a second outbreak after the return-to-work in the city.

关键词： cOVID-19 epidemic in Wuhan SIR and SEIR models Bayesian inference Model selection Nonidentifiability Quarantine Peak time of epidemic

Abscisic Acid Receptors:Past,Present and Future

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Journal of Integrative Plant Biology 2011年第6期53卷 469-479页

作者： Jianjun Guo Xiaohan Yang David J. weston Jin-Gui chen Department of Genetics Harvard Medical School Boston Massachusetts 02114-2790 USA Department of Molecular Biology Massachusetts General Hospital Boston Massachusetts 02114-2790 USA Biosciences Division Oak Ridge National Laboratory Oak Ridge TN 37831-6422 USA

acid （ABA） is the key plant stress hormone. consistent with the earlier studies in support of the presence of both membrane- and cytoplasm-localized ABA receptors, recent studies have identified multi- ple ABA receptors located in various subcellular locations. These include a chloroplast envelope-localized receptor （the H subunit of chloro- plast Mg2＋-chelatase/ABA Receptor）, two plasma membrane-localized receptors （G-protein coupled Receptor 2 and GPcR-type G proteins）, and one cytosol/nucleus-localized Pyrabactin Resistant （PYR）/PYR-Like （PYL）/Regulatory component of ABA Receptor 1 （RcAR）. Although the downstream molecular events for most of the identified ABA receptors are currently unknown, one of them, PYR/PYL/RcAR was found to directly bind and regulate the activity of a long-known central regulator of ABA signaling, the A-group protein phosphatase 2c （PP2c）. Together with the Sucrose Non-fermentation Kinase Subfamily 2 （SnRK2s） protein kinases, a central signaling complex （ABA-PYR-PP2cs-SnRK2s） that is responsible for ABA signal perception and transduction is supported by abundant genetic, physiological, biochemical and structural evidence. The identification of multiple ABA receptors has advanced our understanding of ABA signal perception and transduction while adding an extra layer of complexity.

关键词： ABA chlH/ABAPJccH/GUN5 FcA GcR2 GTGIlGTG2 PYLIPYL/RcAR.

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Mathematical modeling of the dynamics of cOVID-19 variants of concern:Asymptotic and finite-time perspectives

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Infectious Disease Modelling 2022年第4期7卷 581-596页

作者： Adriana-Stefania ciupeanu Marie Varughese weston c.Roda Donglin Han Qun cheng Michael Y.Li Department of Mathematics and Department of Statistics University of ManitobaWinnipegManitobaR3T 2N2Canada Analytics and Performance Reporting Branch Alberta HealthEdmontonAlbertaCanada Department of Mathematical and Statistical Sciences University of AlbertaEdmontonAlbertaT6G 2G1Canada

The cOVID-19 pandemic has seen multiple waves,in part due to the implementation and relaxation of social distancing measures by the public health authorities around the world,and also caused by the emergence of new variants of concern(VOcs)of the SARS-cov-2 *** the cOVID-19 pandemic is expected to transition into an endemic state,how to manage outbreaks caused by newly emerging VOcs has become one of the primary public health *** mathematical modeling tools,we investigated the dynamics of VOcs,both in a general theoretical framework and based on observations from public health data of past cOVID-19 waves,with the objective of understanding key factors that determine the dominance and coexistence of *** results show that the transmissibility advantage of a new VOc is a main factor for it to become ***,our modeling study indicates that the initial number of people infected with the new VOc plays an important role in determining the size of the *** results also support the evidence that public health measures targeting the newly emerging VOc taken in the early phase of its spread can limit the size of the epidemic caused by the new VOc(Wu et al.,2139Wu,Scarabel,Majeed,Bragazzi,&Orbinski,Wu et al.,2021).

关键词： cOVID-19 pandemic Variants of concern Mathematical modeling coexistence and replacement of variants Public health measures

Finite-size correction for slab supercell calculations of materials with spontaneous polarization

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npj computational Materials 2021年第1期7卷 520-528页

作者： Su-Hyun Yoo Mira Todorova Darshana Wickramaratne Leigh weston chris GVan de Walle Jörg Neugebauer Department of computational Materials Design Max-Planck-Institut für Eisenforschung GmbHDüsseldorfGermany Materials Department University of California Santa BarbaraSanta BarbaraCAUSA center for computational Materials Science US Naval Research LaboratoryWashingtonDCUSA

The repeated slab approach has become a de facto standard to accurately describe surface properties of materials by density functional theory calculations with periodic boundary *** materials exhibiting spontaneous polarization,we show that the conventional scheme of passivation with pseudo hydrogen is unable to realize a charge-neutral *** presence of a net surface charge induces via Gauss’s law a macroscopic electric field through the slab and results in poor size convergence with respect to the thickness of the *** propose a modified passivation method that accounts for the effect of spontaneous polarization,describes the correct bulk limits and boosts convergence with respect to slab *** robustness,reliability,and superior convergence of energetics and electronic structure achieved by the proposed method are demonstrated using the example of polar ZnO surfaces.

关键词： surface convergence size