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检索条件"作者=C Ma~ J Zhang~1 LK Durrin~4 J Lv~1 D Zhu~3 X Han~1 y Sun~ 1 ey Laboratory of Human Functional genomics of Jiangsu province,Nanjing Medical University, Nanjing,pr China"

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The BcL2 major breakpoint region (mbr) regulates gene expression

The BCL2 major breakpoint region (mbr) regulates gene expres...

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中国遗传学会第八次代表大会暨学术讨论会

作者： c ma~(1,2) j zhang~1 lk durrin~4 j lv~1 d zhu~3 x han~1 y sun~(1,2) 1 ey laboratory of human functional genomics of jiangsu province,nanjing medical university, nanjing,pr china 2 department of cell Biology and medical Genetics,nanjing medical university,nanjing,pr china 3 School of Pharmacy,nanjing medical university,nanjing,pr china and 4department of Molecular Medicine,city of Hope National medical center,duarte,cA,USA

BcL2 expression is finely tuned by a variety of environmental and endogenous stimuli and regulated at both transcriptional and post-transcriptional *** previous investigations demonstrated that the BcL2 major breakpoint region(mbr)in the 30-UTR upregulates reporter gene expression,which implies that this region possessed intrinsic regulatory ***,the effect of the mbr on BcL2 expression,and the underlying regulatory mechanisms,remain to be *** assess the direct effect of the mbr on the transcriptional activity of the BcL2 gene,we employed targeted homologous recombination to establish a mbrþ/mbr heterozygous Nalm-6 cell line and then compared the transcriptional activity and apoptotic effect on transcription between the wild type and targeted *** found that deletion of the mbr significantly decreased the transcriptional activity of the corresponding allele in the mbrþ/mbr *** BcL2 allele deleted of the mbr had a slower response to apoptotic stimuli than did the wild type *** regulatory function of the mbr was mediated through *** of SATB1 increased BcL2 expression,while knockdown of SATB 1 with RNAi decreased BcL2 *** results clearly indicated that the mbr could positively regulate BcL2 gene expression and this regulatory function was closely related to SATB1

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