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Mechanical properties of microcrystalline branching selenite gypsum samples and influence of constituting factors

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Journal of Rock Mechanics and Geotechnical Engineering 2019年第2期11卷 228-241页

作者： c.caselle S.Bonetto c.colombero c.comina Department of Earth Sciences (DST) Università degli Studi di Torino Department of Environment Land and Infrastructure Engineering (DIATI)Politecnico di Torino

The high sedimentological variability of gypsum rocks has the effect that a univocal characterization of this material is not easy to establish. This is particularly true from the geomechanical point of view: when the mechanical properties of gypsum rocks are requested, it is therefore necessary to undertake detailed characterization analyses. common facies of gypsum was observed in the Upper Miocene evaporitic succession(Messinian Salinity crisis) within the whole Mediterranean Basin. In this work, mechanical tests were conducted on a site-specific facies, represented by the microcrystalline branching selenite. The tested samples came from the Monferrato area(northwestern Italy). Uniaxial compressive strength(UcS)tests were performed in order to obtain reference mechanical parameters. More rapid and economic point load test(PLT) and ultrasonic pulse velocity(UPV) measurements were additionally performed to verify their applicability as complementary/alternative methods for site characterization. Rock-type specific PLT-UcS and UPV-UcS relationships were established. A wide dispersion of the mechanical parameters was observed due to the heterogeneities of the studied material. consequently, compositional, textural and microstructural observations on selected samples were performed. Two main material classes were recognized based on average grain size and total gypsum content, underlining the significant influence of the grain sorting on the measured mechanical properties.

关键词： Gypsum Uniaxial compressive strength(UcS) Point load test(PLT) Mechanical properties Geological heterogeneity

Design of a Very Small Residual Dispersion Fiber System for DWDM Operation Over the Entire c -&L-Bands of EDFA

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光学学报 2003年第S1期23卷 9-10页

作者： Ravi K. Varshney I.c. Goyal A.K. Ghatak Siny Antony c. Department of Physics Indian Institute of Technology Delhi New Delhi 110016 IndiaDepartment of Physics Indian Institute of Technology Delhi New Delhi 110016 IndiaDepartment of Physics Indian Institute of Technology Delhi New Delhi 110016 IndiaDepartment of Physics Indian Institute of Technology Delhi New Delhi 110016 India

We have given design of a very small residual dispersion fiber system consisting of a small dispersion fiber (SDF) with flat modal field and a corresponding dual core coaxial dispersion compensating fiber (DcF).

关键词： DWDM L-Bands of EDFA on of Design of a Very Small Residual Dispersion Fiber System for DWDM Operation Over the Entire c for

combining material characterization with single and multi-oxyanion adsorption for mechanistic study of chromate removal by cationic hydrogel

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Journal of Environmental Sciences 2011年第6期23卷 1004-1010页

作者： Irene M.c.Lo Samuel c.N.Tang Department of civil and Environmental Engineering The Hong Kong University of Science and TechnologyHong KongChina

cationic hydrogel with magnetic property was synthesized via radical polymerization and its removal capacity of chromate from contaminated water was found to be 200 mg/*** Fourier transform infrared spectroscopy（FT-IR） study,the mechanism of chromate removal by hydrogel was found to be non-specific adsorption,mainly due to ion exchange,as evidenced by the positively charged functional group,trimethyl ammonium-N＋（cH3）3,in the *** were accordingly determined by testing di？erent oxyanion adsorption onto the *** results of the chromate adsorption experiments illustrated that the amount of chromate adsorbed was nearly equal to that of the chloride released from the hydrogel,which is part of the evidence for ion *** and multi-oxyanion adsorption experiments were also performed,and it was demonstrated that ion removal was species independent,but charge dependent,another characteristic of the ion exchange *** was found that the same Langmuir model can be applied to best fit the findings of single and multi-oxyanion adsorption,which further indicates the mechanism of chromate removal is attributed to ion *** view of the above,the background anions compete for adsorption sites with chromate,evidenced by inhibitive chromate removal in the presence of background electrolytes in the batch studies,further echoing the ion exchange mechanism.

关键词： adsorption magnetic hydrogel mechanism ion exchange oxyanion

Genomic analysis uncovers functional variation in the c-terminus of anthocyanin-activating MYB transcription factors

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Horticulture Research 2021年第1期8卷 885-898页

作者： Jessica A.Rodrigues Richard V.Espley Andrew c.Allan The New Zealand Institute for Plant and Food Research Limited 120 Mount Albert RoadSandringhamAuckland 1025New Zealand School of Biological Sciences University of Auckland3A Symonds StAuckland 1010New Zealand

MYB transcription factors regulate diverse aspects of plant development and secondary metabolism,often by partnering in transcriptional regulatory ***,we harness genomic resources to identify novel MYBs,thereby producing an updated eudicot MYB phylogeny with revised relationships among subgroups as well as new information on sequence variation in the disordered c-terminus of anthocyanin-activating ***®and hidden Markov model scans of gene annotations identified a total of 714 MYB transcription factors across the genomes of four crops that span the eudicots:apple,grape,kiwifruit and *** model-based phylogenetic inference identified novel members of previously defined subgroups,and the function of specific anthocyanin-activating subgroup 6 members was assayed transiently in tobacco *** conservation within subgroup 6 highlighted one previously described and two novel short linear motifs in the disordered c-terminal *** novel motifs have a mix of hydrophobic and acidic residues and are predicted to be relatively ordered compared with flanking protein *** of motifs with the Eukaryotic Linear Motif database suggests roles in protein–protein *** of motifs and their flanking regions from strong anthocyanin activators into weak activators,and vice versa,affected *** conclude that,although the MYB c-terminal sequence diverges greatly even within MYB clades,variation within the c-terminus at and near relatively ordered regions offers opportunities for exploring MYB function and developing superior alleles for plant breeding.

关键词： phylogeny metabolism thereby

SIRT3-mediated inhibition of FOS through histone H3 deacetylation prevents cardiac fibrosis and inflammation

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Signal Transduction and Targeted Therapy 2020年第1期5卷 2322-2331页

作者： Xavier Palomer MSilvia Román-Azcona Javier Pizarro-Delgado Ana Planavila Francesc Villarroya Brenda Valenzuela-Alcaraz Fátima crispi Álvaro Sepúlveda-Martínez Irene Miguel-Escalada Jorge Ferrer JFrancisco Nistal Raquel García Mercy MDavidson Emma Barroso Manuel Vázquez-carrera Department of Pharmacology Toxicology and Therapeutic ChemistryIBUB(Institut de Biomedicina de la Universitat de Barcelona)Research Institute-Pediatric Research InstituteHospital Sant Joan de Déuand CIBER de Diabetes y Enfermedades Metabólicas Asociadas(CIBERDEM)Faculty of Pharmacy and Food SciencesUniversity of BarcelonaBarcelonaSpain Department of Biochemistry and Molecular Biomedicine IBUB and CIBER Fisiopatología de la Obesidad y Nutrición(CIBEROBN)Faculty of BiologyUniversity of BarcelonaBarcelonaSpain aBcNatal-Barcelona center for Maternal–Fetal and Neonatal Medicine(Hospital clínic and Hospital Sant Joan de Deu) Institut d’Investigacions Biomèdiques August Pi i SunyerUniversitat de Barcelonaand Center for Biomedical Research on Rare Diseases(CIBER-ER)BarcelonaSpain Genomic Programming of Betacells Laboratory Institut d’Investigacions August Pi i Sunyer(IDIBAPS)and CIBERDEMBarcelonaSpain Section of Epigenomics and Disease Department of Medicineand National Institute for Health Research(NIHR)Imperial Biomedical Research CentreImperial College LondonLondonUK Servicio de cirugía cardiovascular Hospital Universitario Marqués de ValdecillaDepartamento de Ciencias Médicas y QuirúrgicasFacultad de MedicinaUniversidad de CantabriaInstituto de Investigación Marqués de Valdecilla(IDIVAL)Centro de Investigación Biomédica en Red Cardiovascular(CIBERCV)Instituto de Salud Carlos IIISantanderSpain Departamento de Fisiología y Farmacología Facultad de MedicinaUniversidad de CantabriaInstituto de Investigación Marqués de Valdecilla(IDIVAL)SantanderSpain Department of Radiation Oncology Columbia UniversityNew YorkNYUSA

Sirtuin 3(SIRT3)is a deacetylase that modulates proteins that control metabolism and protects against oxidative *** of SIRT3 activity has been proposed as a promising therapeutic target for ameliorating metabolic diseases and associated cardiac *** this study,we investigated the role of SIRT3 in inflammation and fibrosis in the heart using male mice with constitutive and systemic deletion of SIRT3 and human cardiac Ac16 ***3 knockout mice showed cardiac fibrosis and inflammation that was characterized by augmented transcriptional activity of *** with this,SIRT3 overexpression in human and neonatal rat cardiomyocytes partially prevented the inflammatory and profibrotic response induced by TNF-α.Notably,these effects were associated with a decrease in the mRNA and protein levels of FOS and the DNA-binding activity of ***,we demonstrated that SIRT3 inhibits FOS transcription through specific histone H3 lysine K27 deacetylation at its *** findings highlight an important function of SIRT3 in mediating the often intricate profibrotic and proinflammatory responses of cardiac cells through the modulation of the FOS/AP-1 *** fibrosis and inflammation are crucial in the progression of cardiac hypertrophy,heart failure,and diabetic cardiomyopathy,our results point to SIRT3 as a potential target for treating these diseases.

关键词： SIRT3 inflammation cardiac

Air quality control in the ART laboratory is a major determinant of IVF success

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Asian Journal of Andrology 2016年第4期18卷 596-599页

作者： Sandro c Esteves Fabiola c Bento ANDROFERT Center for Male Reproduction Av. Dr. Heitor Penteado 1464 Campinas SP 13075-460 Brazil.

Arecently published article described how a fertility center in the UnitedStates implemented air quality control to newly designed in vitro fertilization （IVF） laboratory.1 A highly-efficient air filtration was achieved by installing a centered system supplying filtered air to the IVF laboratory and related critical areas, combining air particulate and volatile organic compound （VOc） filtration. As a consequence, live birth rates were increased by improvements in air quality. This article highlights the key aspects of air contamination in the IVF context. The topic is important not only to IVF specialists but also to Andrologists due to the great number of male infertility patients referred to assisted reproductive technology （ART） treatments. The evidence is growing that laboratory air quality is paramount importance for improved IVF outcome.

关键词： @@

Unveiling the inner structure of electron pulses generated from a laser-wakefield accelerator

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Light(Science & Applications) 2023年第10期12卷 1992-1994页

作者： Malte c.Kaluza Institute of Optics and Quantum Electronics Max-Wien-Platz 107743JenaGermany Helmholtz-Institute Jena Fröbelstieg 307743JenaGermany

A novel diagnostic method has been used to gain deeper insight into the transverse structure and its evolution of electron pulses generated from a laser-wakefield accelerator.

关键词： structure field laser

Structural features of substituted triazole-linked chalcone derivatives as antimalarial activities against D_(10) strains of Plasmodium falciparum: A QSAR approach

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Journal of central South University 2015年第10期22卷 3738-3744页

作者： Mukesh c.Sharma Division of Drug Design & Medicinal chemistry Research Lab School of Pharmacy Devi Ahilya University Takshila Campus

A quantitative structure–activity relationship(QSAR) was performed to analyze antimalarial activities against the D10 strains of Plasmodium falciparum of triazole-linked chalcone and dienone hybrid derivatives using partial least squares regression coupled with stepwise forward–backward variable selection method. QSAR analyses were performed on the available Ic50 D10 strains of Plasmodium falciparum data based on theoretical molecular descriptors. The QSAR model developed gave good predictive correlation coefficient(r2) of 0.8994, significant cross validated correlation coefficient(q2) of 0.7689, r2 for external test set)(2predr of 0.8256, coefficient of correlation of predicted data set)(2sepred,r of 0.3276. The model shows that antimalarial activity is greatly affected by donor and electron-withdrawing substituents. The study implicates that chalcone and dienone rings should have strong donor and electron-withdrawing substituents as they increase the activity of chalcone. Results show that the predictive ability of the model is satisfactory, and it can be used for designing similar group of antimalarial compounds. The findings derived from this analysis along with other molecular modeling studies will be helpful in designing of the new potent antimalarial activity of clinical utility.

关键词： quantitative structure–activity relationship(QSAR) chalcone antimalarial Plasmodium falciparum stepwise forward–backward partial least squares

cold plasma redistribution throughout geospace

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Science china(Technological Sciences) 2016年第9期59卷 1340-1345页

作者： Foster John c. Massachusetts Institute of Technology Haystack Observatory

The redistribution of the electrically charged cold plasma of ionospheric origin involves the equatorial,low,mid,auroral,and polar-latitude regions in a multi-step,system-wide process linking the regions of *** with ground and space-based instruments characterize the geospace plume-regularly occurring channels of enhanced plasma density flowing at both ionospheric and magnetospheric *** in the SAPS channel transports the eroded material to the noontime cusp in the ionosphere and to the dayside magnetopause at high *** the fluxes of cold plume plasma traverse the cusp and enter the polar cap,they form the polar tongue of *** the cusp the plume plasma provides a rich source of heavy ions for the magnetospheric injection and acceleration via the mechanisms operative on those field lines.

关键词： plasmasphere ionosphere geospace GPS TEc ionospheric electric field plume