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伴有增殖型糖尿病视网膜病变的1型糖尿病孕妇的不良结局(英文)

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国际眼科杂志 2011年第9期11卷 1504-1507页

作者： c c t helen I tajunisah S c Reddy 马来亚大学医学院眼科马来西亚吉兰丹国际医药大学临床医学院眼科马来西亚森美兰

目的:报道伴有增殖型糖尿病视网膜病变的糖尿病孕妇,在给予适当的治疗与随访后,产妇和胎儿的不良结局。方法:对患有 1 型糖尿病及增殖型糖尿病视网膜病变的四位年轻的糖尿病孕妇( 年龄 20 ～25 岁) ,进行随访观察。结果:孕妇的不良后果:... 详细信息

目的:报道伴有增殖型糖尿病视网膜病变的糖尿病孕妇,在给予适当的治疗与随访后,产妇和胎儿的不良结局。方法:对患有 1 型糖尿病及增殖型糖尿病视网膜病变的四位年轻的糖尿病孕妇( 年龄 20 ～25 岁) ,进行随访观察。结果:孕妇的不良后果: 流产 1 例,先兆子痫及早产 1 例,肾功能衰竭需要透析 1 例; 胎儿的不良后果: 新生儿死亡1 例,早产婴儿 1 例。结论:对于糖尿病孕妇出现增殖型视网膜病变时,妇产科医生应该给予紧密的随访。对于患有糖尿病的妇女,在其妊娠期间的产前检查与随访中,增殖型糖尿病视网膜病变应当作为疾病的评估之一。

关键词：妊娠 1型糖尿病增殖型糖尿病视网膜病变玻璃体积血

Energy principle of ferroelectric ceramics and single domain mechanical model

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Acta Mechanica Sinica 2007年第5期23卷 531-543页

作者： t.c.Wang LNM Institute of MechanicsChinese Academy of SciencesBeijing 100080China

Many physical experiments have shown that the domain switching in a ferroelectric material is a complicated evolution process of the domain wall with the variation of stress and electric field. According to this mechanism, the volume fraction of the domain switching is introduced in the constitutive law of ferroelectric ceramic and used to study the nonlinear constitutive behavior of ferroelectric body in this paper. the principle of stationary total energy is put forward in which the basic unknown quantities are the displacement ui, electric displacement Di and volume fraction pI of the domain switching for the variant I. Mechanical field equation and a new domain switching criterion are obtained from the principle of stationary total energy. the domain switching criterion proposed in this paper is an expansion and development of the energy criterion. On the basis of the domain switching criterion, a set of linear algebraic equations for the volume fraction PI of domain switching is obtained, in which the coefficients of the linear algebraic equations only contain the unknown strain and electric fields. then a single domain mechanical model is proposed in this paper. the poled ferroelectric specimen is considered as a transversely isotropic single domain. By using the partial experimental results, the hardening relation between the driving force of domain switching and the volume fraction of domain switching can be calibrated. then the electromechanical response can be calculated on the basis of the calibrated hardening relation. the results involve the electric butterfly shaped curves of axial strain versus axial electric field, the hysteresis loops of electric displacement versus electric filed and the evo- lution process of the domain switching in the ferroelectric specimens under uniaxial coupled stress and electric field loading. the present theoretic prediction agrees reasonably with the experimental results given by Lynch.

关键词： Ferroelectric ceramic Domain switching the volume fraction of domain switching Single domain mechanical model

New discovery rarely runs smooth： an update on progranulin/tNFR interactions

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Protein & cell 2015年第11期6卷 792-803页

作者： Betty c. Wang helen Liu Ankoor talwar Jinlong Jian Stony Brook University School of Medicine 101 Nicolls Road Stony Brook NY 11794 USA New'York University School of Medicine 301 East 17th Street New York NY 10003 USA Union college 807Union Street Schenectady NY 12308 USA

Progranulin （PGRN） is a growth factor implicated in various pathophysiological processes, including wound healing, inflammation, tumorigenesis, and neurodegeneration. It was previously reported that PGRN binds to tumor necrosis factor receptors （tNFR） and has thera- peutic effects in inflammatory arthritis （tang et. al, in Science 332：478-484, 2011）; however, chen et al. reported their inability to demonstrate the PGRN-tNFR interactions under their own conditions （chert et. al, in J Neurosci 33：9202-9213, 2013）. A letter-to-editor was then published by the original group in response to the chen et al. paper that discussed the reasons for the latter＇s inability to recapitulate the interactions. In addition, the group published follow-up studies that further reinforced and dissected the interactions of PGRN- tNFR. Recently, the dispute about the legitimacy of PGRN-tNFR interactions appears to be finally settled with independent confirmations of these interactions in various conditions by numerous laboratories. this review presents a chronological update on the story of PGRN-tNFR interactions, highlighting the independent confirmations of these interactions in various diseases and conditions.

关键词： progranulin Atsttrin tNFR DR3 tNF-α tL1A

Equivalent series system to model a multiple friction pendulum system with numerous sliding interfaces for seismic analyses

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Earthquake Engineering and Engineering Vibration 2014年第1期13卷 85-99页

作者： c.S.tsai H.c.Su t.c.chiang Department of civil Engineering Feng Chia University Department of Water Resources Engineering and conservation Feng Chia University Earthquake Proof Systems Inc.

current structural analysis software programs offer few if any applicable device-specifi c hysteresis rules or nonlinear elements to simulate the precise mechanical behavior of a multiple friction pendulum system(MFPS) with numerous sliding *** on the concept of subsystems,an equivalent series system that adopts existing nonlinear elements with parameters systematically calculated and mathematically proven through rigorous derivations is *** aim is to simulate the characteristics of sliding motions for an MFPS isolation system with numerous concave sliding interfaces without prior knowledge of detailed information on the mobilized forces at various sliding *** MFPS with numerous concave sliding interfaces and one articulated or rigid slider located between these interfaces is divided into two subsystems: the fi rst represents the concave sliding interfaces above the slider,and the second represents those below the *** equivalent series system for the entire system is then obtained by connecting those for each subsystem in *** equivalent series system is validated by comparing numerical results for an MFPS with four sliding interfaces obtained from the proposed method with those from a previous study by Fenz and ***,these numerical results demonstrate that an MFPS isolator with numerous concave sliding interfaces,which may have any number of sliding interfaces,is a good isolation device to protect structures from earthquake damage through appropriate designs with controllable mechanisms.

关键词： seismic isolation base isolation earthquake engineering multiple friction pendulum system structural control mathematical modeling equivalent series system

MULtI-FAcILItY ORDERED MEDIAN PROBLEMS IN DIREctED NEtWORKS

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Journal of Systems Science & complexity 2011年第1期24卷 61-67页

作者： Huajun tANG t. c. Edwin cHENG c. t. NG Faculty of Management and Administration Macao University of Science and Technology Macao China Department of Logistics and Maritime Studies The Hong Kong Polytechnic University Hong Kong China

this paper uses a finite dominating set （FDS） to investigate the multi-facility ordered median problem （OMP） in a strongly connected directed network. the authors first prove that the multi-facility OMP has an FDS in the node set, which not only generalizes the FDS result provided by Kalcsics, et al. （2002）, but also extends the FDS result from the single-facility case to the multiple case, filling an important gap. then, based on this FDS result, the authors develop an exact algorithm to solve the problem. However, if the number of facilities is large, it is not practical to find the optimal solution, because the multi-facility OMP in directed networks is NP-hard. Hence, we present a constant-approximation algorithm for the p-median problem in directed networks. Finally, we pose an open problem for future research.

关键词： Algorithms finite dominating sets multi-facility ordered median problem pseudoequilibria.

Pushover analysis of reinforced concrete frames considering shear failure at beam-column joints

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Earthquake Engineering and Engineering Vibration 2013年第3期12卷 373-383页

作者： Y.c.Sung t.K.Lin c.c.Hsiao M.c.Lai Bridge Division Center for Research on Earthquake EngineeringTaipei University of Technology (NTUT) chiao tung University taipei University of technology (NtUt)

Since most current seismic capacity evaluations of reinforced concrete （Rc） frame structures are implemented by either static pushover analysis （PA） or dynamic time history analysis, with diverse settings of the plastic hinges （PHs） on such main structural components as columns, beams and walls, the complex behavior of shear failure at beam-column joints （BcJs） during major earthquakes is commonly neglected. this study proposes new nonlinear PA procedures that consider shear failure at BcJs and seek to assess the actual damage to Rc structures. Based on the specifications of FEMA-356, a simplified joint model composed of two nonlinear cross struts placed diagonally over the location of the plastic hinge is established, allowing a sophisticated PA to be performed. to verify the validity of this method, the analytical results for the capacity curves and the failure mechanism derived from three different full-size Rc frames are compared with the experimental measurements. By considering shear failure at BcJs, the proposed nonlinear analytical procedures can be used to estimate the structural behavior of Rc frames, including seismic capacity and the progressive failure sequence of joints, in a precise and effective manner.

关键词： Rc frame beam-column joint pushover analysis capacity curve plastic hinge performance-based seismic evaluation

Survival outcomes in early-onset oesophageal adenocarcinoma patients:A systematic review and meta-analyses

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World Journal of Gastroenterology 2024年第38期30卷 4221-4231页

作者： Ashleigh Russell Shauna Mitchell Richard c turkington helen G coleman centre for Public Health Queen's University BelfastBelfast BT126BAUnited Kingdom Patrick G Johnston centre for cancer Research Queen's University BelfastBelfast BT71NNUnited Kingdom

BAcKGROUND the incidence of oesophageal adenocarcinoma(OAc)has been reported to be increasing in many *** this trend,an increase in incidence of early-onset OAc,defined as OAc in adults aged under 50 years,has been *** is unclear whether survival outcomes for early-onset OAc patients differ from older age *** to investigate survival outcomes in early-onset OAc *** Ovid Medline and Embase were searched from inception to January 2022 for relevant studies relating to early-onset OAc and survival *** regarding the overall five-year survival and risk of death of younger and older patients with OAc were extracted and pooled using meta-analyses to produce pooled estimates and 95%cIs where *** Eleven studies which compared survival of early-onset OAc,defined as age at diagnosis ofth older patients were included.A narrative review of median and mean survival demonstrated conflicting results,with studies showing early-onset OAc patients having both better and worse outcomes compared to older age groups.A meta-analysis of five-year survival demonstrated similar outcomes across age groups,with 22%-25%of patients in the young,middle and older age groups alive after five years.A meta-analysis of four studies demon-strated that early-onset OAc patients did not have a significantly increased risk of death compared to middle-aged patients(hazard ratio 1.12,95%cI:0.85-1.47).INtRODUctION there is concern that the incidence of oesophageal adenocarcinoma(OAc)in patients under 50,described as early-onset OAc,is ***,data regarding survival of younger patients with OAc is ***,while increasing age remains a major non-modifiable risk factor for cancer,the incidence of early-onset cancers,largely accepted to be in adults aged under 50 years,is increasing[1].this includes an observed increase in the incidence of gastrointestinal malignancies such as colorectal,oesophageal,gastric and he

关键词： Early-onset cancer Early-onset oesophageal adenocarcinoma Survival cancer epidemiology Systematic review Meta-analysis

comparative Study of three High Order Schemes for LES of temporally Evolving Mixing Layers

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communications in computational Physics 2012年第10期12卷 1603-1622页

作者： helen c.Yee Bjorn Sjögreen Abdellah Hadjadj NASA-Ames Research center Moffett FieldCA94035USA Lawrence Livermore National Laboratory LivermoreCA94551USA cORIA UMR 6614&INSA de Rouen 76800 St-Etienne du RouvrayFrance

three high order shock-capturing schemes are compared for large eddy simulations(LES)of temporally evolving mixing layers for different convective Mach numbers ranging from the quasi-incompressible regime to highly compressible supersonic *** considered high order schemes are fifth-order WENO(WENO5),seventh-order WENO(WENO7)and the associated eighth-order central spatial base scheme with the dissipative portion of WENO7 as a nonlinear post-processing filter step(WENO7fi).this high order nonlinear filter method of Yee&Sjogreen is designed for accurate and efficient simulations of shock-free compressible turbulence,turbulence with shocklets and turbulence with strong shocks with minimum tuning of scheme *** LES results by WENO7fi using the same scheme parameter agree well with experimental results compiled by Barone et al.,and published direct numerical simulations(DNS)work of Rogers&Moser and Pantano&Sarkar,whereas results by WENO5 andWENO7 compare poorly with experimental data and DNS computations.

关键词： High order numerical methods numerical methods for turbulencewith shocks DNS LES mixing layer

A correlation between pulse diagnosis of human body and health monitoring of structures

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Earthquake Engineering and Engineering Vibration 2004年第1期3卷 117-125页

作者： c.c.chang Henry t.Y.Yang Department of civil Engineering Hong Kong University of Science and TechnologyHong Kong Department of Mechanical and Environmental EngineeringUniversity of California Department of Mechanical and Environmental Engineering University of California

the concept of health monitoring is a key aspect of the field of medicine that has been practiced for a long time. A commonly used diagnostic and health monitoring practice is pulse diagnosis, which can be traced back approximately five thousand years in the recorded history of china. With advances in the development of modern technology, the concept of health monitoring of a variety of engineering structures in several applications has begun to attract widespread attention. Of particular interest in this study is the health monitoring of civil structures. It seem natural, and even beneficial, that these two health-monitoring methods, one as applies to the human body and the other to civil structures, should be analyzed and compared. In this paper, the basic concepts and theories of the two monitoring methods are first discussed. Similarities are then summarized and commented upon. It is hoped that this correlation analysis may help provide structural engineers with some insights into the intrinsic concept of using pulse diagnosis in human health monitoring, which may of be some benefit in the development of modern structural health monitoring methods.

关键词： human health monitoring pulse diagnosis structural health monitoring vibration-based techniques local detection techniques