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Prognostic Significance of Pigment Epithelium-Derived Factor Expression in Patients with Non-Small-cell-Lung cancer

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Advances in Lung cancer 2016年第3期5卷 30-38页

作者： Alexander Emmert Angelika Oellerich Laszlo Füzesi Regina Waldmann-Beushausen Friedrich A. Schöndube Hanibal Bohnenberger bernhard c. Danner Department of Thoracic and cardiovascular Surgery University Medical Center Gottingen Gottingen Germany Institute of Pathology University Medical Center Gottingen Gottingen Germany

The aims of this study were to examine prognostic significance of pigment epithelium-derived factor (PEDF) in patients with stage IA-IIIB non-small cell lung cancer (NScLc). Using immunohistochemistry and multivariate analysis, we set out to investigate whether PEDF expression could provide prognostic information in NScLc in a cohort of 69 patients who had undergone radical resection for NScLc. The correlation between PEDF and the clinical pathological features of stage I-III NScLc after radical surgery were analyzed as well as influence on long term survival. No correlation between PEDF intensity, PEDF area or PEDF area index and clinic opathologic parameters was seen. PEDF values showed a slight correlation to the tumor stage. There was a significant negative correlation (T = -0.288, p = 0.002) between pathologic T-stage and median PEDF area and vice versa a positive correlation (T = 0.227, p = 0.016) with median PEDF intensity. We could not detect any correlation between PEDF and long term survival. For PEDF analysis, there was only a slight correlation between expression and T-stage of the tumor.

关键词： NScLc PEDF Neoangiogenesis

Solution viscosity of charged and of uncharged polymers: Effects of extra salt and of solute concentration

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Solution viscosity of charged and of uncharged polymers: Eff...

2015年全国高分子学术论文报告会

作者： bernhard A.Wolf Xiaopeng Xiong Institut für Physikalische chemie der Johannes Gutenberg-Universit?t Mainz Department of Materials Science and Engineering College of Materials Xiamen University

The flow behavior of polymer solutions is by and large well understood. There are, however, two areas in which our knowledge is still poor. One(i) concerns the behavior of polyelectrolyte solutions in the absence of extra salt. Another field of deficiency(ii) lies in a consistent description of the influences of polymer concentration form infinite dilution to the pure melt. The present lecture deals with these two subjects. Ad(i): This part[1, 2] describes the effects of the salinity of the solvent on the flow behavior in terms of viscosities and of intrinsic viscosities [ ]. Particular attention is being paid to the valency of the counterion of extra salt and on the establishment of predictive master curves. Ad(ii): This part[3] presents a thermodynamically inspired approach. Instead of polymer concentrations c(mass per volume) it uses the dimensionless reduced polymer concentration c [ ]= c. The following relation ln η=c/(1+pc+qc), in which rel stands for the relative viscosity as compared with that of the pure solvent, is capable of describing the behavior in the entire compositon range by means of the two paremters p and q. A better description of the phenomena addressed above should help an improved understanding of the performance of complex systems, like the biologically important joint solutions of chain molecules and proteins in saline solvents.

关键词： polyelectrolyte solutions intrinsic viscosities extra salt composition dependent viscosities

考尔雅典女神,雅典卫城682——一尊希腊古典晚期雕塑的重建工作(英文)

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文博 2009年第6期 111-117页

作者： bernhard Schmaltz 基尔大学考古艺术研究所德国

在15世纪的意大利,人们发现了大量的古代雕塑遗存,基本上都是大理石雕塑残片。出于对大理石的迷恋、对雕刻工艺的欣赏、对人体雕塑生动表现的着迷,当时的贵族热衷于收集这些残片并试图拼对与重建这些残破的雕塑。但是几乎没有发现任何... 详细信息

在15世纪的意大利,人们发现了大量的古代雕塑遗存,基本上都是大理石雕塑残片。出于对大理石的迷恋、对雕刻工艺的欣赏、对人体雕塑生动表现的着迷,当时的贵族热衷于收集这些残片并试图拼对与重建这些残破的雕塑。但是几乎没有发现任何颜色的残存,他们甚至不会去探究彩绘他们更赞赏大理石洁白无瑕的表面。19世纪早期,建筑学家们考察了西西里一些古代庙宇的彩绘残存,随后有关一些著名希腊神庙(如帕台农神庙)彩绘的重构工作在全欧洲引发了热烈的讨论。但是对于这些雕塑涂施彩绘的强烈质疑声一直持续到十九世纪八十年代,直到雅典卫城发掘工作的开展才证实了古代大理石雕塑彩绘的事实。出土时,很多破碎的雕塑残片上都残存有鲜亮的彩绘,但通常在出土几个小时后就由于干燥而剥落了,只有依稀的彩绘痕迹残存,以及工作人员的描述和水彩模画。今天,翻开现代有关古代雕塑的书籍,你会发现大量彩色照片,但总是显现白色大理石表面。有关雕塑的工艺、功能和历史发展的意义的讨论已经很多了,但是很难得到一个完整的古代雕塑彩绘的例子。不仅仅是雅典卫城的雕塑曾经涂饰彩绘,经过重建工作这一时期有大量彩绘的例子。本次工作即是采用古代颜料与模具,尽可能完整的重建了一尊古代雕塑。

关键词：彩绘考尔雅典女神雅典卫城682 艺术雕像

Spatial Distribution of Soil Organic Matter and Soil Organic carbon Stocks in Semi-Arid Area of Northeastern Syria

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Natural Resources 2019年第12期10卷 415-432页

作者： Hussam Hag Husein Mohammsd Mousa Wahib Sahwan Rupert Baeumler bernhard Lucke Institute of Geography and Soil Science FAU Erlangen Nuremberg University Erlangen Germany General commission for Scientific Agriculture Research Al Raqqa Syria

Although soil organic matter (SOM) forms a small portion of the soil body. Nevertheless, it is the most important component of the soil ecosystem, as well as of the carbon global cycle. In the semi-arid environment, there has been little research on the spatial distribution of SOM and soil organic carbon (SOc) stock. In this study, stratified random samples of total 30 soils were collected from two different soil depth (topsoil, subsoil) of Al Balikh plain and used for mapping the spatial variability of SOc and to estimating the SOc stock. The result showed that the values were relatively homogenate, with the normal decreasing trend with increasing the depth. The standard deviation (Std. D) for both SOc and SOc stock indicates homogeneous and absence of outliers values, whereas the coefficient of variation (c.V) indicates non-dispersion and clustering of values around the average. SOc was 0.38%, 0.17% in topsoil and subsoil respectively;the corresponding averages of SOc stock were 1.23 kg·m-2? and 1.14 kg·m-2 respectively, these values reflecting typical characteristics of poor SOc semi-arid soil. The correlation between SOc and SOc stock was (R2 = 0.996, p 2 = 0.941, p cated that both SOc and SOc stock were best fitted to the exponential model. Nugget, range, and sill were equal to 0.002, 0.036, and 0.044, respectively for SOc in topsoil, and 0.014, 0.071, and 0.081, for SOc in the subsoil. For SOc stock, it was 0.0, 0.036, and 0.0508, respectively in topsoil. In the subsoil, the values were 0.1899, 0.086, and 4.159, respectively. SOc and ScO stock in both two layers are shown a strong spatial dependence, for which were 4.3, 17.2 for SOc in topsoil and subsoil respectively, and 0.0, 4.5 for SOc stock in topsoil and subsoil respectively, thus, which can be attributed to intrinsic factors.

关键词： Soil Organic carbon Stock Semi-Arid Semivariogram Exponential Model Flood Plain

Encyclopedia of Materials: Science and Technology (v. 10) 1st

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EcDI-fixed donor SPs infusion based combination treatment for induction of tolerance in porcine to mouse islet xenotransplant model

2001年

作者： K.H.J. Buschow Ph.D. Robert cahn Merton c Flemings bernhard Ilschner Edward J Kramer Subhash Mahajan Patrick Veyssiere

来源：畅想之星图书光盘版（南... 评论

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ECDI-fixed donor SPs infusion based combination treatment fo...

2013中国器官移植大会

作者： Shusen Wang Stephen Miller bernhard Hering Xunrong Luo Tianjin Union Medical center Nankai University Affiliated Hospital Northwestern University Feinberg School of Medicine Department of Microbiology and Immunology University of Minnesota Schulze Diabetes InstituteDepartment of Surgery Northwestern University Feinberg Shcool of Medicine Division of Nephrology and Hypertension

Body:Background Previously we demonstrated that transient B cell depletion combined with donor EcDI—SPs is a robust strategy for induction of xenodonor—specific T and B cell tolerance in a rat to mouse islet xenotransplant *** combinatorial therapy may be a promising strategy for tolerance induction for clinical xenogeneic islet *** aim of this study was to further determine whether this combinatorial therapy could induce tolerance to porcine islet xenografts in murine recipients. Methods EcDI-treated porcine splenocytes(SP)were infused to c57BL/6(B6)mice at day-7 and day 1.250 ug of Anti-cD20 was administered on day-10 and 1.2500 IEQ of porcine islets were transplanted into the renal subcapsular space of streptozotocin-

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Human Gingiva-Derived Mesenchymal Stem cells regulated the balance of osteoclasts and osteoblasts by cD39 in treatment of osteoporosis

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Human Gingiva-Derived Mesenchymal Stem Cells regulated the b...

第十三届全国免疫学学术大会

作者： Wenbin Wu Julie Wang bernhard Ryffel Song Guo Zheng Sun Yat-sen University Penn State University France cNRS

The cytokines such as RANKL, TNF-α and the immune cells such as Treg and Th17 play an important role in the incidence of *** existing treatment failed to reduce the risk of fractures in ***, we need to find more effective *** evaluated the therapeutic potential of GMSc inhibition in osteoporosis induced by estrogen deficiency, the most prevalent cause of osteoporosis worldwide, using the ovariectomy(OVX)-induced osteopenia *** explore therapeutic potential, OVX was performed in adult c57 BL/6 J mice after complete skeletal remodeling, and GMSc therapy initiated 2 weeks after *** 8 weeks of treatment, the distal femoral trabecular bone was sparse and discontinuous in OVX group, and GMSc showed a clear therapeutic effect in bone density, trabecular BV/TV, trabecular *** identify the mechanism of GMSc function in osteoporosis in vivo, we analyzed the role of cD39 signals, since we found that GMScs inhibited osteoclast differentiation through cD39 signals and cD39 inhibitors(POM-1) inhibited the osteogenic potential of GMScs in ***, POM-1 almost completely abolished the therapeutic effect of GMScs on *** results highlight the key role of cD39 in the GMScs function.

关键词： GMSc osteoclast osteoporosis cD39

Density may alter diversity-productivity relationships in experimental plant communities

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Density may alter diversity-productivity relationships in ex...

“全国第五届青年植物生态学学术研讨会”暨“第二届植物生理生态学学术研讨会”

作者： Kelly S.Wolfe-Bellin bernhard Schmid F.A.Bazzaz Department of Organismic and Evolutionary Biology Harvard UniversityCambridgeMassachusetts 02138 USA Institute of Environmental Sciences Zurich University Winterthurerstrasse 190 CH-8057 Zurich Switzerland

contemporary biodiversity experiments, in which plant species richness is manipulated and aboveground productivity of the system measured, generally demonstrate that greater plant species diversity leads to greater productivity. However, we propose that varying community density may alter the shape of the diversity-productivity relationship. Furthermore, the response of the relationship to changing density may provide insight as to which of the two primary hypotheses postulated to explain the relationship-sampling effects and niche complementarity-contributes more strongly to the relationship. The slope of the diversity-productivity relationship is predicted to increase with increasing density under the sampling-effects hypothesis, and decrease under the niche-complementarity hypothesis. We conducted a factorial experiment in which we manipulated diversity, by increasing species richness from 3 to 6 to 12 plant species, and community density from 440 to 1050 to 2525 seedlings m-2. As response variables we measured plant above- and belowground biomass, plant density and plant evenness at harvest. The species pool used to construct the experimental communities consisted of annuals from the flora of the Midwestern United States representing the c3, c4, and nitrogen-fixing functional groups. Total biomass increased significantly with species richness and community density, and species evenness decreased with increasing density. A significant interaction between species richness and community density occurred for both total and aboveground biomass: the diversity-productivity relationship was more positive at low density and decreased in strength with increasing density. This indicates that density can alter the diversity-productivity relationship in experimental plant communities. In addition, the results support the niche-complementarity hypothesis as the primary mechanism operating in this experimental system, since species richness had the largest positive effect on p

关键词： biodiversity species richness density productivity community biomass ecosystem functioning plant functional groups constant final yield

天然气初期裂解过程的同位素分馏模型:反应动力学探讨

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天然气地球科学 1999年第5期10卷 28-37页

作者： bernhard cramer bernhard M.Kroos Ralf Littke 刘全有德国

已有一些模型把^(13)cH_4和^(12)cH_4的生成当作初期裂解的一系列平行初级反应来计算天然气(甲烷)稳定碳同位素组成的变化。本项研究的目的是把同位素分馏的类型和已建立的天然气生成的动力学模型结合起来。沉积有机物形成的甲烷稳定碳... 详细信息

已有一些模型把^(13)cH_4和^(12)cH_4的生成当作初期裂解的一系列平行初级反应来计算天然气(甲烷)稳定碳同位素组成的变化。本项研究的目的是把同位素分馏的类型和已建立的天然气生成的动力学模型结合起来。沉积有机物形成的甲烷稳定碳同位素比值取决于有机质中甲烷母质的初始碳同位素比值和来自相应母质中^(12)c和^(13)c甲烷之间活化能的内在差异。在开放体系的裂解实验中,新模型对于δ^(13)c观察值的变化能给予理论解释和数学描述,能模拟出任何地温下热成因气中甲烷的碳同位素值。对西伯利亚西北部的Pokur组中的2个含煤岩样进行模拟实验,得到了与Pokur组气藏天然气接近的甲烷碳同位素值(δ^(13)c_1=-42‰～-54‰)。这一发现支持了在成熟阶段早期的天然气热解成因。

关键词：甲烷天然气同位素分馏反应动力学初期裂解