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人肥大细胞系白细胞介素4的产生及药物对其的影响

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中华耳鼻咽喉头颈外科杂志 2005年第2期40卷 124-127页

作者：赵宇 c.andrew van hasselt 吴港生黄约爱梁传余梁秉中香港中文大学威尔斯亲王医院耳鼻咽喉科香港中文大学中医中药研究所四川大学华西医院耳鼻咽喉科

目的了解人肥大细胞系(humanmastcellline,HMc1)在佛波醇酯(phorbol12myristate13acetate,PMA)+钙离子通道(A23187)激发下能否产生白介素(Interleukin,IL)4,并且观察布地奈得、地氯雷他定和地塞米松等药物对IL4的产生和表达的影响。方法HMc1在10-6~10-10mol/L浓度的药物中孵育1h后,以25ng/mlPMA+25×10-7mol/LA23187激发细胞因子生成,再分别孵育6、12或24h,提取上清液,采用酶联免疫吸附法(enzymelinkedimmunosorbentassays,ELISA)测定IL4水平,并采用半定量逆转录聚合酶链反应(reversetranscriptionpolymerasechainreaction,RTPcR)观察药物对IL4mRNA表达水平的影响。结果HMc1在激发后可产生IL4,IL4mRNA的表达也很明显。布地奈得、地氯雷他定和地塞米松在各时间点和浓度下,均对HMc1IL4的产生有明显的抑制作用(同未加药物的对照组比较,P值均c1经激发可表达和产生IL4,布地奈得、地氯雷他定和地塞米松能显著抑制IL4的产生,地氯雷他定还能抑制IL4mRNA的表达。

关键词：肥大细胞系白细胞介素4 地氯雷他定地塞米松

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卵白蛋白经鼻致敏建立变应性鼻炎动物模型

中华耳鼻咽喉头颈外科杂志 2005年第3期40卷 176-180页

作者：赵宇 c.andrew vanhasselt 吴港生黄约爱梁传余梁秉中香港中文大学威尔斯亲王医院耳鼻咽喉科香港中文大学中医中药研究所四川大学华西医院耳鼻咽喉科

目的　建立豚鼠变应性鼻炎动物模型,并对其速发和迟发症状、病理学和免疫学指标进行观察。方法　实验豚鼠分为模型组、治疗组和阴性对照组,每组 12只。阴性对照组未予致敏和激发,模型组和地氯雷他定治疗组由卵白蛋白经鼻反复致敏和激发... 详细信息

目的　建立豚鼠变应性鼻炎动物模型,并对其速发和迟发症状、病理学和免疫学指标进行观察。方法　实验豚鼠分为模型组、治疗组和阴性对照组,每组 12只。阴性对照组未予致敏和激发,模型组和地氯雷他定治疗组由卵白蛋白经鼻反复致敏和激发后,对其喷嚏、抓鼻、鼻腔分泌物及鼻塞做动态症状学观察;通过被动皮肤过敏实验,测定血清IgG1和IgE水平;计量鼻腔灌洗液中白细胞总数、嗜酸粒细胞数及组胺水平;并且观察鼻腔组织的病理改变。结果　经抗原激发后,模型组出现典型的喷嚏、抓鼻、鼻塞和分泌物增多的表现;鼻腔灌洗液中炎性细胞和嗜酸粒细胞增多、组胺水平升高、血清IgG1和IgE滴度升高。上述表现与阴性对照组比较差异有统计学意义 (P<0.05或<0.01),也比治疗组明显增高(P<0.05或<0.01)。模型组的鼻腔黏膜嗜酸粒细胞浸润明显,小血管扩张,杯状细胞扩大。此外,模型组还可观察到迟发相鼻塞。结论　此模型能良好地反映变应性鼻炎的各项表现,方法简易,建模时间短,亦能观察迟发性鼻塞,且对组胺H1受体拮抗剂的治疗反应明确,是研究变应性鼻炎的良好工具。

关键词：变应性鼻炎动物模型卵白蛋白致敏经鼻组胺H1受体拮抗剂嗜酸粒细胞增多鼻腔灌洗液皮肤过敏实验 IgG1 0.05 免疫学指标地氯雷他定症状学观察鼻腔分泌物 IgE水平白细胞总数抗原激发后分泌物增多粒细胞浸润

construction of a novel six-gene signature to predict tumour response to induction chemotherapy and overall survival in locoregionally advanced laryngeal and hypopharyngeal carcinoma

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Genes & Diseases 2024年第3期11卷 148-150页

作者： chen Tan Lingwa Wang Yifan Yang Shizhi He George G.chen Jason YK.chan Michael cF.Tong c.A.van hasselt Wenbin Xu Ling Feng Ru Wang Jugao Fang Department of Otolaryngology Head and Neck Surgery Beijing Tongren HospitalCapital Medical UniversityBeijing 100730China Key Laboratory of Otolaryngology Head and Neck Surgery(Ministry of Education of china) Beijing Institute of OtolaryngologyBeijing 100730China Department of Otorhinolaryngology Head and Neck SurgeryThe Chinese University of Hong KongPrince of Wales HospitalHongKong SAR999077China Department of Medical Genetics Institute of Basic Medical ScienceChinese Academy of Medical Science&Peking Union Medical CollageBeijing 100730China

Locoregionally advanced laryngeal and hypopharyngeal cancers(LA-LHcs)are traditionally treated with surgery followed by postoperative radiotherapy,which impairs speech and swallowing functions and reduces the quality of life.^(1,2)The use of induction chemotherapy(Ic)as a larynxpreserving approach for LA-LHcs has been verified and refined.^(3)However,the short-term tumor response to Ic varies,non-responders usually show poor survival and little benefit.

关键词： chemotherapy laryngeal surgery

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鼻咽癌

BAHA在鼻咽癌放疗术后伴中耳流脓患者中的应用

2002年

作者：尹怀信（c.andrew van hasselt）叶伟霖（Alan G.Gibb）王荣光郭宝煌主译

本书共有19章约50万字，内容涵盖了对鼻咽癌应有的认识、对解剖学、组织病理学、流行病学、实验研究、临床表现、临床和实验室的诊断方法、最新近的治疗方式以及鼻咽癌有关的耳部问题的详细阐述。

ISBN: (纸本)7810723146

关键词：鼻咽肿瘤

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BAHA在鼻咽癌放疗术后伴中耳流脓患者中的应用

内镜检查：早期喉部和下咽部癌的NBI，AFI，和SMR诊断技术

中华医学会第十次全国耳鼻咽喉-头颈外科学术会议

作者： Gordon Soo Tsang SS Wong KT To KF Leung SF John KS Woo c andrew van hasselt Michael cFTong Department of Otorhinolaryngology Head & Neck SurgeryThe Chinese University of Hong Kong Prince of Wales HospitalHong Kong SAR Departmentof Anawmical and cellular Pathology The Chinese University of Hong Kong Prince of Wales HospitalHong Kong SAR Departmentof clinical Oncology The Chinese University of Hong Kong Prince of Wales HospitalHong Kong SAR

背景鼻咽癌(Nasopharyngeal cancer,NPc)患者的主要治疗方法是放疗。但放疗后的中耳并发症及颞骨放射性骨坏死(ORN)所造成的听力损伤是摆在 NPc 患者面前的大难题。而传统的助听器可能加重耳漏和感染,并且耳模会对 ORN 患者的外耳道溃...

背景鼻咽癌(Nasopharyngeal cancer,NPc)患者的主要治疗方法是放疗。但放疗后的中耳并发症及颞骨放射性骨坏死(ORN)所造成的听力损伤是摆在 NPc 患者面前的大难题。而传统的助听器可能加重耳漏和感染,并且耳模会对 ORN 患者的外耳道溃疡造成直接的创伤。目的探讨 Baha 对 NPc 患者放疗后听觉损伤的治疗是否有益。病例对13例 NPc 放疗后伴听力损伤的患者分两个阶段,观察两年。疗效评定一期手术时的骨钻标本做组织切片。同时进行听力学评估、植入固定度观察、邻近皮肤分级及满意度问卷调查分析。结果尽管组织切片显示53．8％(n=7)植入部位未建立骨性连接,但到目前所有 BaHa 植入均在位(平均 FU=14．8月;跨度=12-26月),80％的 BaHa 使用者每天开机时间＞8小时,平均满意主为85％。所有病例反映转用 Baha 后耳漏减少。讨论对所选择 NPc 病要而言,BaHa 是一种理想的声音处理器。我们的结果显示所有入选病人的骨整合成功,主观听觉清晰度增高、耳漏减少,使用 BaHa 时间越长,患者的满意度越高。结论 Baha 对 NPc 伴有听力损伤的患者是一种非常有效的助听器。骨整合成功率与未放疗病人无明显差异。

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内镜检查：早期喉部和下咽部癌的NBI，AFI，和SMR诊断技术

Editorial for Multiscale&Multifield coupling in Geomechanics

中华医学会第十次全国耳鼻咽喉-头颈外科学术会议

作者： Hing-sang chan Philip W.Y.chiu Alexander Vlantis Raymond K.Y.Tsang c andrew van hasselt Siu-Kwan Ng Michael c.F.Tong Department of Otorhinolaryngology Head and Neck Surgerythe Chinese University of Hong Kong Department of Surgery The Chinese University of Hong KongHong Kong SAR

前言大部分头颈部鳞状上皮细胞癌(HNScc)表现为处于进展期，大范围的手术切除会造成严重的功能障碍和美容上的畸形，总存活数常让人失望。除了局部病变，同期或不同期Scc(短程化疗，小细胞癌)的发生对病死率产生显著影响。

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第6期16卷 1919-1921页

作者： Min Wang Pengzhi Pan andrew H.c.chan Y.T.Feng T-3 Fluid Dynamics and Solid Mechanics Theoretical DivisionLos Alamos National LaboratoryNew MexicoUSA Institute of Rock and Soil Mechanics Chinese Academy of SciencesWuhanChina School of Engineering University of TasmaniaTasmaniaAustralia college of Engineering Swansea UniversityWalesUK

We are delighted to serve as guest editors for this special issue in the Journal of Rock Mechanics and Geotechnical *** purpose of this special issue is dedicated to gathering the latest research work on Multiscale&Multifield coupling in Geomechanics,where we delve into the intricate interplay of various fields and scales that govern the behavior of *** total,30 manuscripts from USA,china,UK,Germany,canada,India and United Arab Emirates are selected to be included in this issue.

关键词： materials. gathering mechanics

Mshpy23:a user-friendly,parameterized model of magnetosheath conditions

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Earth and Planetary Physics 2024年第1期8卷 89-104页

作者： Jaewoong Jung Hyunju connor andrew Dimmock Steve Sembay andrew Read Jan Soucek NASA Goddard Space Flight center GreenbeltMDUSA Department of Astronomy University of MarylandCollege ParkMDUSA Swedish Institude of Space Physics UppsalaSweden University of Leicester LeicesterUK Institute of Atmospheric Physics Academy of Sciences of the Czech Republic

Lunar Environment heliospheric X-ray Imager(LEXI)and Solar wind−Magnetosphere−Ionosphere Link Explorer(SMILE)will observe magnetosheath and its boundary motion in soft X-rays for understanding magnetopause reconnection modes under various solar wind conditions after their respective launches in 2024 and *** conditions,namely,plasma density,velocity,and temperature,are key parameters for predicting and analyzing soft X-ray images from the LEXI and SMILE *** developed a userfriendly model of magnetosheath that parameterizes number density,velocity,temperature,and magnetic field by utilizing the global Magnetohydrodynamics(MHD)model as well as the pre-existing gas-dynamic and analytic *** this parameterized magnetosheath model,scientists can easily reconstruct expected soft X-ray images and utilize them for analysis of observed images of LEXI and SMILE without simulating the complicated global magnetosphere ***,we created an MHD-based magnetosheath model by running a total of 14 OpenGGcM global MHD simulations under 7 solar wind densities(1,5,10,15,20,25,and 30 cm)and 2 interplanetary magnetic field Bz components(±4 nT),and then parameterizing the results in new magnetosheath *** compared the magnetosheath model result with THEMIS statistical data and it showed good agreement with a weighted Pearson correlation coefficient greater than 0.77,especially for plasma density and plasma ***,we compiled a suite of magnetosheath models incorporating previous magnetosheath models(gas-dynamic,analytic),and did two case studies to test the *** MHD-based model was comparable to or better than the previous models while providing self-consistency among the magnetosheath ***,we constructed a tool to calculate a soft X-ray image from any given vantage point,which can support the planning and data analysis of the aforementioned LEXI and SMILE missions.A release of the code has been uploaded to a Git

关键词： magnetosheath python modeling

Effects of improved amino acid balance diet on lysine mammary utilization, whole body protein turnover and muscle protein breakdown on lactating sows

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Journal of Animal Science and Biotechnology 2024年第5期15卷 2031-2043页

作者： Sai Zhang Juan c.Marini Vengai Mavangira andrew claude Julie Moore Mahmoud A.Mohammad Nathalie L.Trottier Department of Animal Science Michigan State UniversityEast Lansing 48824USA State Key Laboratory of Swine and Poultry Breeding Industry Key Laboratory of Animal Nutrition and Feed Science in South ChinaMinistry of Agriculture and Rural AffairsGuangdong Provincial Key Laboratory of Animal Breeding and NutritionInstitute of Animal ScienceGuangdong Academy of Agricultural SciencesGuangzhou 510640PR China USDA/ARS children’s Nutrition Research center and Pediatric critical care Medicine Department of PediatricsBaylor College of MedicineHoustonTX 77030USA Department of Large Animal clinical Sciences Michigan State UniversityEast LansingMI 48824USA Present address:Department of Animal Science Cornell UniversityFrank Morrison Hall507 Tower RoadIthacaNY 14853‑4801USA

Background The study objective was to test the hypothesis that low crude protein(cP)diet with crystalline amino acids(cAA)supplementation improves Lys utilization efficiency for milk production and reduces protein turnover and muscle protein *** lactating multiparous Yorkshire sows were allotted to 1 of 2 isocaloric diets(10.80 MJ/kg net energy):control(cON;19.24%cP)and reduced cP with“optimal”AA profile(OPT;14.00%cP).Sow body weight and backfat were recorded on d 1 and 21 of lactation and piglets were weighed on d 1,14,18,and 21 of *** d 14 and 18,a subset of 9 sows(cON=4,OPT=5)was infused with a mixed solution of 3-[methyl-2H3]histidine(bolus injection)and[13c]bicarbonate(priming dose)first,then a constant 2-h[13c]bicarbonate infusion followed by a 6-h primed constant[1-13c]lysine *** blood and milk sampling were performed to determine plasma and milk Lys enrichment,Lys oxidation rate,whole body protein turnover,and muscle protein *** Over the 21-d lactation period,compared to cON,sows fed OPT had greater litter growth rate(Pcompared to cON,sows fed OPT had greater efficiency of Lys(Pciency(Pcompared to cON,sows fed OPT tended to have lower whole body protein breakdown rate(P=0.069).Muscle protein breakdown rate did not differ between OPT and cON(P=0.197).conclusion Feeding an improved AA balance diet increased efficiency of Lys and reduced whole-body protein turnover and protein *** results imply that the lower maternal N retention observed in lactating sows fed improved AA balance diets in previous studies may be a result of greater partitioning of AA towards milk rather than greater body protein breakdown.

关键词： Amino acid Efficiency Lactating sows Protein breakdown Protein turnover Reduced protein diet