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Refining pathological evaluation of neoadjuvant therapy for adenocarcinoma of the esophagus

World Journal of Gastroenterology 2013年第48期19卷 9282-9293页

作者： Fergus Noble Luke Nolan Adrian c Bateman James P Byrne Jamie J Kelly Ian S bailey Donna M Sharland charlotte N Rees Timothy J Iveson Tim J Underwood Andrew R Bateman cancer Sciences Unit Faculty of Medicine University of Southampton Southampton SO16 6YD United Kingdom Department of Surgery University Hospital Southampton NHS Foundation Trust Southampton SO16 6YD United Kingdom Department of cellular Pathology University Hospital Southampton NHS Foundation Trust Southampton SO16 6YD United Kingdom cancer care University Hospital Southampton NHS Foundation Trust Southampton SO16 6YD United Kingdom

AIM:To assess tumour regression grade(TRG)and lymph node downstaging to help define patients who benefit from neoadjuvant ***:Two hundred and eighteen consecutive patients with adenocarcinoma of the esophagus or gastro-esophageal junction treated with surgery alone or neoadjuvant chemotherapy and surgery between 2005and 2011 at a single institution were *** neoadjuvant chemotherapy consisting of platinum,fluoropyrimidine and anthracycline was considered for operable patients(World Health Organization performance status≤2)with clinical stage T2-4 *** to neoadjuvant chemotherapy(NAc)was assessed using TRG,as described by Mandard et *** addition lymph node downstaging was also *** node downstaging was defined by cN1 at diagnosis:assessed radiologically(computed tomography,positron emission tomography,endoscopic ultrasonography),then pathologically recorded as N0 after surgery;ypN0 if NAc given prior to surgery,or pN0if surgery *** were followed up for 5 years post *** was defined radiologically,with or without pathological *** association was examined between t TRG and lymph node downstaging with disease free survival(DFS)and a comprehensive range of clinicopathological ***:Two hundred and eighteen patients underwent esophageal resection during the study interval with a mean follow up of 3 years(median follow up:2.552,95%cI:2.022-3.081).There was a 1.8%(n=4)inpatient mortality *** hundred and thirty-six(62.4%)patients received NAc,with 74.3%(n=101)of patients demonstrating some signs of pathological tumour regression(TRG 1-4)and 5.9%(n=8)having a complete pathological *** four point one percent(n=60)had downstaging of their nodal disease(cN1 to ypN0),compared to only 15.9%(n=13)that underwent surgery alone(pre-operatively overstaged:cN1 to pN0),(Pc was associated with significantly increased DFS(mean DFS;TRG 1-2:5.1years,

关键词： Esophageal cancer Gastro-esophageal cancer Neoadjuvant Regression

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SHAKEN UP Traveling in Post-Quake Hualien

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城市漫步（GBA版） 2018年第5期 22-22,24页

作者： bailey Hu 不详

On arrival,Hualien,Taiwan,does not seem like a city recently hit by a 6.4-magnitude ***,the train the station is bustling and the town serene,almost exactly as we remember from our last visit four years mgo.

关键词： Taiwan remember exactly

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Functionalized, carbon nanotube material for the catalytic degradation of organophosphate nerve agents

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Nano Research 2014年第3期7卷 390-398页

作者： Mark M. bailey John M. Heddleston Jeffrey Davis Jessica L. Staymates Angela R. Hight Walker National Institute of Standards and Technology (NIST) Semiconductor and Dimensional Metrology Division Gaithersburg MD USA National Institute of Standards and Technology (NIST) Materials Measurement Science Division Gaithersburg MD USA Present Address: United States Army Medical Research Institute of Infectious Diseases (USAMRIID) Center for Aerobiological Sciences Fort Detrick MD USA

Recent world events have emphasized the need to develop innovative, functional materials that will safely neutralize chemical warfare （cW） agents in situ to protect military personnel and civilians from dermal exposure. Here, we demonstrate the efficacy of a novel, proof-of-concept design for a cu-containing catalyst, chemically bonded to a single-wall carbon nanotube （SWcNT） structural support, to effectively degrade an organophosphate simulant. SWcNTs have high tensile strength and are flexible and light-weight, which make them a desirable structural component for unique, fabric-like materials. This study aims to develop a self-decontaminating, carbon nanotube-derived material that can ultimately be incorporated into a wearable fabric or protective material to minimize dermal exposure to organophosphate nerve agents and to prevent accidental exposure during decontamination procedures. carboxylated SWcNTs were functionalized with a polymer, which contained cu-chelating bipyridine groups, and their catalytic activity against an organophosphate simulant was measured over time. The catalytically active, functionalized nanomaterial was characterized using X-ray fluorescence and Raman spectroscopy. Assuming zeroth-order reaction kinetics, the hydrolysis rate of the organophosphate simulant, as monitored by UV-vis absorption in the presence of the catalytically active nanomaterial, was 63 times faster than the uncatalyzed hydrolysis rate for a sample containing only carboxylated SWcNTs or a control sample containing no added nanotube materials.

关键词： single-wall carbonnanotubefunctionalization catalytically-activenanomaterial chemical warfare agent

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Oxygen-vacancy-rich phenanthroline/TiO_(2) nanocomposites: An integrated adsorption, detection and photocatalytic material for complex pollutants remediation

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chinese chemical Letters 2022年第2期33卷 907-911页

作者： Pinghua chen Huitao Zheng Hualin Jiang Jun Liu Xinman Tu Weibo Zhang bailey Phillips Lei Fang Jian-Ping Zou Key Laboratory of Jiangxi Province for Persistent Pollutants control and Resources Recycle Nanchang Hangkong UniversityNanchang 330063China Department of Applied chemistry College of Environmental and Chemical EngineeringNanchang Hangkong UniversityNanchang 330063China Department of chemistry Texas A&M UniversityCollege StationTexas 77843United States School of Resources Environmental and Chemical EngineeringNanchang UniversityNanchang 330031China

To address the challenge of treating complex pollutants containing heavy metals and organic compounds,a phenanthroline/TiO_(2)nanocomposite with rich oxygen vacancy defects was synthesized to integrate the functions of pollutant detection, adsorption, and photocatalytic degradation. The results showed that the nanocomposite could adsorb cr^(3+)and the process could be transduced into a colorimetric signal for qualitative and quantitative detection. The adsorbed heavy metal also exhibited a synergistically enhanced photocatalytic degradation of a model organic pollutant under visible light. The simultaneous adsorption, detection, and photocatalysis could reduce the multifarious operations and high cost of traditional environmental remediation methods, indicating a strong application potential for the nanocomposite.

关键词： Heavy metals Organic contaminants Adsorption Detection Photocatalytic degradation Oxygen vacancy

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ESMO 2023 pancreatic cancer guidelines signal stepwise progress

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Hepatobiliary Surgery and Nutrition 2024年第2期13卷 362-365页

作者： christoph Springfeld Peter bailey Markus W.Büchler John P.Neoptolemos Medical Oncology National Center for Tumor DiseasesHeidelberg University HospitalHeidelbergGermany Division of Applied Bioinformatics The German Cancer Research Center(DKFZ)HeidelbergGermany Department of General Visceral and Transplantation SurgeryHeidelberg University HospitalHeidelbergGermany

Pancreatic ductal adenocarcinoma(PDAc)is still a devastating disease,and for those who treat PDAc patients it sometimes seems that there is little to no relevant *** excellent new ESMO clinical practice guideline by conroy et al.(1)points to important advances in pancreatic cancer therapy that were made since the previous edition from 2015(2).According to the American cancer Society the overall five-year survival for all stages of PDAc has improved from 5%some 30 years ago to 13%in the present *** major thrust lies in greatly improved outcomes for resectable pancreatic cancer with 5-year survival increasing from 5-10%at the beginning of this period to 30-50%due to technical improvements in surgery along with combination adjuvant chemotherapy.

关键词： Resectable borderline adjuvant neoadjuvant persister cells

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Electroplating for high aspect ratio vias in PcB manufacturing:enhancement capabilities of acoustic streaming

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Advances in Manufacturing 2013年第3期1卷 211-217页

作者： Nadezhda Strusevich Marc P.Y.Desmulliez Eitan Abraham David Fiynn Thomas Jones Mayur Patel christopher bailey School of computing and Mathematical Sciences Old Royal Naval CollegeUniversity of Greenwich School of Engineering&Physical Sciences.Heriot-Watt University

This paper considers the copper electrodeposit ion processes in microvias and investigates whether the quality of the electroplating process can be improved by acoustic streaming using megasonic transducers placed into a plating cell. The theoretical results show that acoustic streaming does not take place within the micro-via （either through or blind-via＇ s）, however it does help improve cupric ion transport in the area close to the mouth of a via. This replenishment of cupric ions at the mouth of micro-via leads to better quality filling of the micro-via through diffusion compared to basic conditions. Experiments showing the improved quality of the filling of vias are also presented.

关键词： Electronics manufacturing Numericalmodelling High aspect ratio microvia Electroplating Megasonic agitation Acousticstreaming

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Pancreatic stromal Gremlin 1 expression during pancreatic tumorigenesis

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Genes & Diseases 2022年第1期9卷 108-115页

作者： Joy M.Davis Binglu cheng Madeline M.Drake Qiang Yu Baibing Yang Jing Li chunhui Liu Mamoun Younes Xiurong Zhao Jennifer M.bailey Qiang Shen Tien c.Ko Yanna cao Department of Surgery The University of Texas Health Science Center at HoustonHoustonTX 77030USA Department of Pathology&Laboratory Medicine The University of Texas Health Science Center at HoustonHoustonTX 77030USA Department of Neurology The University of Texas Health Science Center at HoustonHoustonTX 77030USA Department of Internal Medicine The University of Texas Health Science Center at HoustonHoustonTX 77030USA Department of Genetics Louisiana State University Health Sciences CenterNew OrleansLA 70112USA

chronic pancreatitis(cP)is a major risk factor of pancreatic ductal adenocarcinoma(PDAc).How cP promotes pancreatic oncogenesis remains unclear.A characteristic feature of PDAc is its prominent desmoplasia in the tumor microenvironment,composed of activated fibroblasts and *** can be characterized as M1 or M2,with tumor-inhibiting or-promoting functions,*** reported that Gremlin 1(GREM1),a key pro-fibrogenic factor,is upregulated in the stroma of *** current study aimed to investigate the expression of GREM1 and correlation between GREM1 and macrophages within the pancreas during chronic inflammation and the development of *** mRNA in situ hybridization,we detected GREM1 mRNA expression withinα-smooth muscle actin(SMA)-positive fibroblasts of the pancreatic *** designated FibroblastsGrem1+marginally increased from cP to pancreatic intraepithelial neoplasia(PanIN)and *** PDAc,FibroblastsGrem1+increased with higher pathological tumor stages and in a majority of PDAc subtypes ***,FibroblastsGrem1+positively correlated with total macrophages(MaccD68+)and M2 macrophages(M2cD163+)in *** begin exploring potential molecular links between FibroblastsGrem1+and macrophages in PDAc,we examined the expression of macrophage migration inhibitory factor(MIF),an endogenous counteracting molecule of GREM1 and an M1 macrophage promoting *** IHc staining of MIF,we found MIF to be expressed by tumor cells,positively correlated with GREM1;by IHc co-staining,we found MIF to be negatively correlated with M2cD163+*** findings suggest that GREM1 expression by activated fibroblasts may promote PDAc development,and GREM1/MIF may play an important role in macrophage phenotype.

关键词： Fibroblasts Gremlin 1 Macrophage migration inhibitory factor Macrophages

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学术写作指南

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作者： (英)斯蒂芬·贝利(Stephen bailey)

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应用集成BP神经网络进行田间土壤空间变异研究

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农业工程学报 2004年第3期20卷 35-39页

作者：沈掌泉施洁斌王珂 John S.bailey 浙江大学农业遥感与信息技术应用研究所浙江大学图书馆杭州310029 .Department of Agriculture for Northern Ireland Agricultural and Environmental Science Division

以英国北爱尔兰Hayes的一块牧草地为研究区,将所有样点分为独立的训练和检验数据集,并在训练样点集的基础上设计了其他4种样点布局方案,以研究神经网络集成技术应用于田间土壤性质空间变异性的可能性。与广泛应用的克里格法的试验结果相... 详细信息

以英国北爱尔兰Hayes的一块牧草地为研究区,将所有样点分为独立的训练和检验数据集,并在训练样点集的基础上设计了其他4种样点布局方案,以研究神经网络集成技术应用于田间土壤性质空间变异性的可能性。与广泛应用的克里格法的试验结果相比,集成BP神经网络的插值结果精度与之基本相当,尤其是在样点分布较稀疏和样点数较少的情况下,集成BP网络表现出明显的优势;由于神经网络集成方法对样本数据的分布没有任何要求,因此具有较广泛的应用前景和潜力,并在不符合克里格法对样本数据分布要求的情况下是一种可行的替代方法。

关键词：神经网络集成 BP网络土壤性质空间变异克里格插值法

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Trace elements migrating from tailings to rock varnish laminated sediments in an old mining region from Nelson,Nevada,USA

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International Journal of Sediment Research 2022年第2期37卷 202-213页

作者： Douglas B.Sims Amanda c.Hudson John E.Keller Michael Strange Andressa cristhy Buch David Ferrari Giavanna M.Fernandez Juan Garcia-Hernandez bailey D.Kesl Sean Torres Department of Physical Sciences College of Southern Nevada University of Nevada Fluminense Federal University

The dispersion and influence of soluble and particulate trace elements(TEs) present in the materials from abandoned mines is an imminent problem on terrestrial and aquatic *** goal of this research is to provide a broader view of such transport,assessing particle size distribution and TE interactions(e.g.,scavenging) with mine tailings and locally derived sediments transported by water in arid *** grains from wash sediment were collected from a dry ephemeral wash in Nelson,Nevada where the Techatticup Mine and Mill worked between 1850 and *** were evaluated to determine the association and behavior of certain metals and metalloids including aluminum,arsenic,barium,cadmium,copper,chromium,iron,manganese,lead,selenium,vanadium,and zinc to rock varnish laminated *** show that some metals and metalloids were more concentrated on larger particles whereas others indicated the opposite *** example,As was greatest on silt fractions and least on coarse fractions,while Se was detected only on ***,cu,Fe,Mn,Pb,and Zn concentrations all increased with decreasing particle size(silt> sand> coarse),whereas Al,Ba,and V showed the opposite trend(silt coarse).The enrichment factor(EF) of cu,Zn,Pb,As,and Se were lower in mine tailing sediment treated with wash than those obtained for source *** in treated wash sediment samples,the high EFs of Ba,cr,V,and Mn suggested a possible greater affinity of these metals to the Al,Fe,and Mn oxides from the RV *** data found in this study show that transport of contaminated sediments in arid regions could lead to the enrichment of some TEs in downgradient areas from source materials.

关键词： Adsorption Metals Metalloids Mine tailings Particle size Transport

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