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Esophagogastric Reconstruction in cobra-Head Shape with Toupet-Like Partial Anti-Reflux Technique for Resection of Proximal Gastric Tumors. Experience with Three cases from a Non-Asian Population

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Open Journal of Gastroenterology 2023年第4期13卷 149-160页

作者： Alberto M. León-Takahashi Ana P. Meléndez-Fernández Leonardo S. Lino-Silva Horacio N. López-Basave Rosa Angelica Salcedo Hernandez césar zepeda-najar Ángel Herrera-Gómez Surgical Oncology National Cancer Institute (México) Mexico City Mexico Surgical Pathology National Cancer Institute (México) Mexico City Mexico Surgical Oncology ángeles Hospital Tijuana Mexico

Background: Proximal gastrectomy is a rarely performed procedure but a feasible option in benign tumors and malignant neoplasms in the proximal third of the stomach since novel options of reconstructions are available nowadays with fewer long-term sequels. Methods: Report of three cases of proximal gastric gastrointestinal stromal tumors (GIST), with a description of its presentation, histological characteristics, and follow-up after being treated with proximal gastrectomy with cobra head reconstruction. Results: case 1: A 62-year-old woman with epigastric pain of four months with endoscopic evidence of a cardia GIST. The surgery was performed without complications. The histopathological report confirmed a fusiform GIST of 3.2 × 3 × 2.5 cm, stage IA. No adjuvant treatment was considered. An esophagogram showed no evidence of reflux and no stenosis, and no disease recurrence after 40-months follow-up. case 2: A 66-year-old woman with dyspepsia and a palpable tumor in the epigastrium. The surgery was performed without complications. The pathology report confirmed a proximal gastric GIST of 13 × 8 × 7 cm, staged II. She received adjuvant treatment with imatinib for 36 months without recurrence and no reflux or stenosis. case 3: A 55-year-old woman with intermittent hematemesis and right subscapular pain. The surgery was performed without complications. The histopathological report concluded that a GIST tumor of the cardia, 1.4 × 1.2 cm, staged IA. She was left in observation. At a 6-month follow-up, she does not report dysphagia, reflux, or stenosis, and no locoregional recurrence. conclusions: Open and laparoscopic proximal gastrectomy is a safe therapeutic option for GIST. Furthermore, the reconstruction of the esophagus-gastro anastomosis in the cobra head after proximal gastrectomy is feasible and secure in our population, with good functional results in a short follow-up.

关键词： GIST Gastric cancer Laparoscopy Proximal Gastrectomy cobra Head Reconstruction

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Effect of outplanting time on commercial cultivation of kelp Laminaria saccharina at the southern limit in the Atlantic coast,***

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chinese Journal of Oceanology and Limnology 2009年第1期27卷 54-60页

作者： césar PETEIRO óscar FREIRE Instituto Espaíol de Oceanografía (IEO) Centro Oceanográfico de Santander Promontorio de San Martin s/n. Apdo. 240 39080 Santander Spain Universidad de A corua (UDc) Facultad de Ciencias 15071 A Corua Spain

The aim of the study is to examine the influence of the outplanting time on the cultivation of the kelp Laminaria saccharina in the northwestern Spain, close to its southern limit of distribution in the North Atlantic coast. We compared two L. saccharina cultures outplanted in February and December. We found that the starting time of outplanting affects to the yield and the substantiality value, as well as the growth rate. The yield, the substantiality value and the growth rates of L. saccharina sporophytes obtained for the trial outplanted in December were significantly higher than those in February. These results can be mainly explained by the effect of temperature on the growth of L. saccharina sporophytes during cultivation. On the other hand, our results show that even in the southern limit of distribution of L. saccharina, the cultivation of this species was very profitable in high yield and quality.

关键词： outplanting kelp farming Laminaria substantiality value yield

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cyst fluid glucose: An alternative to carcinoembryonic antigen for pancreatic mucinous cysts

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World Journal of Gastroenterology 2019年第19期25卷 2271-2278页

作者： césar Vivian Lopes Department of Gastroenterology and Digestive Endoscopy Santa Casa Hospital

Pancreatic cystic lesions(PcLs) have been increasingly recognized in clinical practice. Although inflammatory cysts(pseudocysts) are the most common PcLs detected by cross-sectional imaging modalities in symptomatic patients in a setting of acute or chronic pancreatitis, incidental pancreatic cysts with no symptoms or history of pancreatitis are usually neoplastic cysts. For these lesions,it is imperative to identify mucinous cysts(intraductal papillary mucinous neoplasms and mucinous cystic neoplasms) due to the risk of their progression to malignancy. However, no single imaging modality alone is sufficient for a definitive diagnosis of all PcLs. The cyst fluid obtained by endoscopic ultrasound-guided fine needle aspiration provides additional information for the differential diagnosis of PcLs. current recommendations suggest sending cyst fluid for cytology evaluation and measurement of carcinoembryonic antigen(cEA) levels. Unfortunately, the sensitivity of cytology is greatly limited, and cyst fluid cEA has demonstrated insufficient accuracy as a predictor of mucinous cysts. More recently, cyst fluid glucose has emerged as an alternative to cEA for distinguishing between mucinous and nonmucinous lesions. Herein, the clinical utility of cyst fluid glucose and cEA for the differential diagnosis of PcLs was evaluated.

关键词： carcinoembryonic antigen Differential diagnosis Fine-needle biopsy Glucose Pancreatic cyst Tumor marker

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Status and prospects for symmetric organic redox flow batteries

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Journal of Energy chemistry 2025年第1期100卷 125-143页

作者： Md Al Raihan c.Adam Dyker Department of chemistry University of New Brunswick

As environmental concerns from fossil fuel consumption intensify, large-scale energy storage becomes imperative for the integration of renewable sources like wind, hydro, and solar with the electrical *** flow batteries, particularly those employing organic molecules, are positioned as a key technology for this purpose. This review explores the growing field of symmetric organic redox flow batteries(ORFBs) within this context. Unlike traditional asymmetric designs based on unique active materials for each electrode, symmetric ORFBs involve a single bipolar species for both electrodes. This review highlights the benefits of a symmetric design, and categorizes five distinct classes of organic bipolar molecules used in both aqueous and non-aqueous solvents. By providing a comprehensive overview of their cell cycling and performance characteristics, the strengths and weaknesses of the diverse categories of bipolar molecules are highlighted for both solvent systems, as are opportunities for future development. This should guide new research directions and advance the development of practical symmetric ORFBs.

关键词： Redox flow battery Symmetric battery Organic battery Aqueous electrolyte Non-aqueous electrolyte

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Acquired sensorineural hearing loss,oxidative stress,and microRNAs

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Neural Regeneration Research 2025年第9期20卷 2513-2519页

作者： Desmond A.Nunez Ru c.Guo Division of Otolaryngology–Head&Neck Surgery Department of SurgeryFaculty of MedicineThe University of British ColumbiaVancouverBCCanada Division of Otolaryngology–Head&Neck Surgery Gordon&Leslie Diamond Health Care CentreVancouver General HospitalVancouverBCCanada Faculty of Medicine–The University of British columbia VancouverBCCanada

Hearing loss is the third leading cause of human ***-related hearing loss,one type of acquired sensorineural hearing loss,is largely responsible for this escalating global health ***-induced,ototoxic,and idiopathic sudden sensorineural are other less common types of acquired hearing *** etiology of these conditions is complex and multi-fa ctorial involving an interplay of genetic and environmental *** stress has recently been proposed as a likely linking cause in most types of acquired sensorineural hearing *** non-coding RNA sequences known as microRNAs(miRNAs)have increasingly been shown to play a role in cellular hypoxia and oxidative stress responses including promoting an apoptotic *** hair cell death is a central histopathological finding in sensorineural hearing *** these cells do not regenerate in humans,it underlies the irreversibility of human age-related hearing *** EMBASE,Ovid MEDLINE,Web of Science core collection,and *** databases over the period August 1,2018 to July 31,2023 were searched with"hearing loss,""hypoxamiRs,""hypoxia,""microRNAs,""ischemia,"and"oxidative stress"text words for English language primary study publications or registered clinical *** red clinical trials known to the senior author we re also assessed.A total of 222studies were thus *** excluding duplicates,editorials,retra ctions,secondary research studies,and non-English language articles,39 primary studies and clinical trials underwent full-text *** resulted in 11 animal,in vitro,and/or human subject journal articles and 8 registered clinical trial database entries which form the basis of this narrative *** miR-34a and miR-29b levels increase with age in *** miRNAs were demonstrated in human neuroblastoma and murine cochlear cell lines to target Sirtuin 1/peroxisome proliferato r-activated receptor gamma coactivator-1-alpha(SIRT1/P Gc-1α),SIRT

关键词： hearing loss hypoxia microRNAs oxidative stress sensorineural

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Adsorption of dyes onto activated carbon prepared from olive stones

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Journal of Environmental Sciences 2005年第6期17卷 998-1003页

作者： Souad najar-SOUISSI Abdelmottaleb OUEDERNI Abdelhamid RATEL chemical Reactors and Process control National School of Engineers of Gabes Medenine Street 6029 Tunisia Chemical Reactors and Process Control National School of Engineers of Gabes Medenine Street 6029 Tunisia Chemical Reactors and Process Control National School of Engineers of Gabes Medenine Street 6029 Tunisia

Activated carbon was produced from olive stones（OSAc） by a physical process in two steps. The adsorption character of this activated carbon was tested on three colour dyes molecules in aqueous solution： Methylene blue（MB）, Rhodamine B（RB） and congo Red（cR）. The adsorption equilibrium was studied through isotherms construction at 30℃, which were well described by Langmuir model. The adsorption capacity on the OSAc was estimated to be 303 mg/g, 217 mg/g and 167 mg/g respectively for MB, RB and cR. This activated carbon has a similar adsorption properties to that of commercial ones and show the same adsorption performances. The adsorption kinetics of the MB molecule in aqueous solution at different initial concentrations by OSAc was also studied. Kinetic experiments were well fitted by a simple intra-particle diffusion model. The measured kinetics constant was influenced by the initial concentration and we found the following correlation： Kid = 1.55 c0^0.51.

关键词： activated carbon olive stones adsorption dyes isotherms kinetic

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Port Integration in china: Temporal Pathways, Spatial Patterns and Dynamics

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chinese Geographical Science 2015年第5期25卷 612-628页

作者： WANG chengjin césar DUcRUET WANG Wei Key Laboratory of Regional Sustainable Development Modeling Institute of Geographical Sciences and Natural Resources Research Chinese Academy of Sciences French National centre for Scientific Research (cNRS) UMR 8504 Géographie-citésParis F-75006 France University of chinese Academy of Sciences

Over the past two decades, numerous ports located in china have participated in port integration strategies, thus influencing the entire port system. The current research is initiated in order to examine the nature of port integration in china, including associated temporal pathways, spatial patterns and dynamics. Results indicate that port integration in china has been characterized by a significant increase at the turn of the 21 st century, comprising thirteen distinguishable pathways typified by differing dynamics, particularly between the northern and southern ports. Pathways were found to include 44 seaports and river ports, chiefly concentrated in the Bohai Rim, Yangtze(changjiang) River Delta, Beibu Gulf and the southeastern Fujian, thus representing significant spatial regions. categorically larger seaports have become the primary beneficiaries of port integration. Integration cases were divided into four categories based upon quantified dynamic magnitude including the government-driven mode, market-driven mode, government/market-driven mode and strategic alliance, and into five further categories based upon spatial extent including port internal integration, jurisdictional port integration, port integration across neighbor region, regional port integration and hub-feeder port integration. Results suggest that several factors have effectively driven port integration in china, including legislative tools and spatial planning, optimization of shoreline resources and port functionality, and port competition with the same hinterland.

关键词： port integration integration mode integration pathway integration dynamics china

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Artificial intelligence and liver transplantation:Looking for the best donor-recipient pairing

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Hepatobiliary & Pancreatic Diseases International 2022年第4期21卷 347-353页

作者： Javier Briceno Rafael calleja césar Hervás Unit of Liver Transplantation Department of General SurgeryHospital Universitario Reina SofíaCórdobaSpain Maimónides Institute of Biomedical Research of córdoba(IMIBIc) CórdobaSpain Department of computer Sciences and Numerical Analysis Universidad de CórdobaCórdobaSpain

Decision-making based on artificial intelligence(AI)methodology is increasingly present in all areas of modern *** recent years,models based on deep-learning have begun to be used in organ *** into account the huge number of factors and variables involved in donor-recipient(DR)matching,AI models may be well suited to improve organ ***-based models should provide two solutions:complement decision-making with current metrics based on logistic regression and improve their *** of classifiers could be used to address this ***,not all of them are really useful for D-R ***,in the decision to assign a given donor to a candidate in waiting list,a multitude of variables are handled,including donor,recipient,logistic and perioperative *** these last two,some of them can be inferred indirectly from the team’s previous *** groups of AI models have been used in the D-R matching:artificial neural networks(ANN)and random forest(RF).The former mimics the functional architecture of neurons,with input layers and output *** algorithms can be uni-or *** general,ANNs can be used with large databases,where their generalizability is ***,they are models that are very sensitive to the quality of the databases and,in essence,they are black-box models in which all variables are ***,these models do not allow to know safely the weight of each *** the other hand,RF builds decision trees and works well with small *** addition,they can select top variables as with logistic ***,they are not useful with large databases,due to the extreme number of decision trees that they would generate,making them *** ANN and RF allow a successful donor allocation in over 80%of D-R pairing,a number much higher than that obtained with the best statistical metrics such as model for end-stage liver disease,balance of risk

关键词： Donor-recipient matching Artificial intelligence Deep learning Artificial neural networks Random forest Liver transplantation outcome

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Oxygen-vacancy induced magnetic phase transitions in multiferroic thin films

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npj computational Materials 2020年第1期6卷 1047-1055页

作者： césar Menéndez Dewei chu claudio cazorla School of Materials Science and Engineering UNSW SydneySydneyNSW 2052Australia

Multiferroics in which giant ferroelectric polarization and magnetism coexist are of tremendous potential for engineering disruptive applications in information storage and energy *** the functional properties of multiferroics are thought to be affected detrimentally by the presence of point defects,which may be abundant due to the volatile nature of some constituent atoms and the high temperatures involved in the synthesis of ***,we demonstrate with theoretical methods that oxygen vacancies may enhance the functionality of multiferroics by radically changing their magnetic interactions in thin ***,oxygen vacancies may restore missing magnetic super-exchange interactions in large axial ratio phases,leading to full antiferromagnetic spin ordering,and induce the stabilization of ferrimagnetic states with considerable net *** theoretical study should help to clarify the origins of long-standing controversies in bismuth ferrite and improve the design of technological applications based on multiferroics.

关键词： magnetic Oxygen transitions

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Multiple sclerosis is at a checkpoint: advancing the program

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Neural Regeneration Research 2025年第3期20卷 811-812页

作者： Brandon c.Smith Jessica L.Williams Department of Neurosciences Lerner Research InstituteCleveland ClinicClevelandOHUSA Department of Biological Geologicaland Environmental SciencesCleveland State UniversityClevelandOHUSA

Multiple sclerosis(MS) is a chronic inflammatory and demyelinating disease of the central nervous system(cNS). Patients with MS experience sensory and motor function loss due to myelin and/or axon damage perpetuated b... 详细信息

关键词： Hauser sclerosis damage

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