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A functional tacrolimus-releasing nerve wrap for enhancing nerve regeneration following surgical nerve repair

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Neural Regeneration Research 2025年第1期20卷 291-304页

作者： Simeon c.Daeschler Katelyn J.W.So Konstantin Feinberg Marina Manoraj Jenny cheung Jennifer Zhang Kaveh Mirmoeini JPaul Santerre Tessa Gordon Gregory HBorschel SickKids Research Institute Neuroscience and Mental Health ProgramTorontoONCanada Institute of Biomaterials and Biomedical Engineering University of TorontoTorontoONCanada Indiana University School of Medicine IndianapolisINUSA Division of Plastic and Reconstructive Surgery the Hospital for Sick ChildrenTorontoONCanada Translational Biology and Engineering Program Ted Rogers Centre for Heart ResearchInstitute of Biomedical EngineeringFaculty of DentistryUniversity of TorontoTorontoONCanada

Axonal regeneration following surgical nerve repair is slow and often incomplete,resulting in poor functional recovery which sometimes contributes to lifelong ***,there are no FDA-approved therapies available to promote nerve *** accelerates axonal regeneration,but systemic side effects presently outweigh its potential benefits for peripheral nerve *** authors describe herein a biodegradable polyurethane-based drug delivery system for the sustained local release of tacrolimus at the nerve repair site,with suitable properties for scalable production and clinical application,aiming to promote nerve regeneration and functional recovery with minimal systemic drug *** is encapsulated into co-axially electrospun polycarbonate-urethane nanofibers to generate an implantable nerve wrap that releases therapeutic doses of bioactive tacrolimus over 31 *** and drug loading are adjustable for applications in small and large caliber nerves,and the wrap degrades within 120 days into biocompatible *** released from the nerve wrap promotes axon elongation in vitro and accelerates nerve regeneration and functional recovery in preclinical nerve repair models while off-target systemic drug exposure is reduced by 80%compared with systemic *** its surgical suitability and preclinical efficacy and safety,this system may provide a readily translatable approach to support axonal regeneration and recovery in patients undergoing nerve surgery.

关键词： biodegradable local drug delivery nerve injury nerve regeneration nerve wrap tacrolimus

current needs, the future of adolescents and young adults having sustained a moderate or severe Traumatic Brain Injury (TBI) and the potential of their social participation

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Open Journal of Therapy and Rehabilitation 2014年第1期2卷 45-55页

作者： Sirois Katia Boucher Normand Lepage céline centre for Interdisciplinary Research on Rehabilitation and Social Integration (cIRRIS) Quebec City Canada Rehabilitation Institute of Quebec city (IRDPQ) Quebec City Canada

The general objective of this study is to identify the specific needs of youths who have suffered a moderate or severe traumatic brain injury (TBI) and their levels of life habit accomplishments. The secondary objective aims to identify how they view themselves in the future with regard to their life habits. Eighteen young persons with moderate or severe TBIs aged 14 to 20 completed questionnaires based on the Life-Habits questionnaire and elaborated on their current level of satisfaction and their visions of the future. Teenagers reported that maintaining good interpersonal relationships, being autonomous, fulfilling their responsibilities, warding off lone-liness, as well as being supported in their efforts to reach a satisfying response to their needs and concerns were their highest priorities. In order to increase their satisfaction related to life habits they suggest improving external factors, such as information concerning TBIs to their entourage. They see themselves as complete social participants in the future. Youths with moderate or severe TBIs identified their needs and envisioned their future to be like that of any other teenager and young adult. They hope to start a family and find a good job. They also identified strategies to improve their life habits.

关键词： Traumatic Brain Injury Adolescents Rehabilitation Social Participation

cyanido-bridged one-dimensional systems assembled from [Re~Ⅳcl_4(cN)_2]_(2-) and [M~Ⅱ(cyclam)]^(2+) (M=Ni,cu) precursors

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Science china chemistry 2012年第6期55卷 1004-1011,1192-1197页

作者： BHOWMIcK Indrani HARRIS T. David DEcHAMBENOIT Pierre HILLARD Elizabeth A. PIcHON cline JEON Ie-Rang cLéRAc Rodolphe cNRS CRPP UPR 8641 F-33600 Pessac France Univ. Bordeaux CRPP UPR 8641 F-33600 Pessac France Department of chemistry University of California Berkeley California 94720 USA

Three new cyanido-bridged heterometallic ReIVNin and ReIVcu one-dimensional systems were synthesized and extensively characterized both structurally and magnetically. Single-crystal X-ray diffraction analysis revealed that these compounds display a common topology, with chains composed of alternating [RetVc14（cN）2]2- and [Mn（cyclam）]2＋（M = Ni in 1, cu in 2） or [cull（N,N＇-dimethylcyclam）]2＋（in 3） building units. Two different chain orientations with a tilt angle of ca. 51° to 55° are present in the crystal packing of these compounds. The magnetic susceptibility measurements suggest the presence of intrachain ferromagnetic interactions between the S = 3/2 ReTM centers and the 3d metal ions： S = 1 Ni1I or S = 1/2 cuII. At low temperature, a three-dimensional ordered magnetic phase induced by interchain antiferromagnetic interactions （antiferromagnetic for 1 and 2; canted antiferromagnetic for 3） is detected for the three compounds.

关键词： molecular magnets cyanido-based materials crystal structure magnetic properties

Drug resistance in glioblastoma:are persisters the key to therapy

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cancer Drug Resistance 2020年第3期3卷 287-301页

作者： Lisa Oliver Lisenn Lalier céline Salaud Dominique Heymann Pierre François cartron François M.Zallette Universitéde Nantes INSERMCRCINANantes 44007France. cHU de Nantes Nantes 44093France. LaBcT ICOSaint Herblain 44805France.

Glioblastoma(GBM)represents the main form of brain tumors in adults,and one of the most aggressive cancers *** treatment of GBM is a combination of surgery(when possible),chemotherapy(usually Temozolomide,TMZ)and radiotherapy(RT).However,despite this heavy treatment,GBM invariably recur and the median length of survival following diagnosis is 12 to 15 months,with less than 10%of people surviving longer than five *** is extremely resistant to most treatments because of its heterogeneous nature,which is associated with extreme clonal plasticity and the presence of cancer stem cells,refractory to TMZ-and RT-induced cell *** this review,we explore the mechanisms by which cancer cells,and especially GBM,can acquire resistance to *** describe and discuss the concept of persister/tolerant cells that precede and/or accompany the acquisition of ***/tolerant cells are cancer cells that are not eliminated by treatment(s)because of different mechanisms ranging from dormancy/quiescence to *** discuss the possibility of targeting these mechanisms in new therapeutic regimen.

关键词： Drug resistance persisters tolerance chromatin remodeling metabolism tumor environment

IgH locus suicide recombination does not depend on NHEJ in contrast to cSR in B cells

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cellular & Molecular Immunology 2019年第2期16卷 201-202页

作者： Hend Boutouil François Boyer Jeanne cook-moreau Michel cogné Sophie Péron cRIBL UMR CNRS 7276 INSERM U126287000 LimogesFrance Institut Universitaire de France 75000 ParisFrance

IgH locus suicide recombination(LSR)occurs in activated Blymphocytes and may result in the death of the concerned B cell,justifying the name“locus suicide recombination”.1 LSR,as for immunoglobulin(Ig)class switch recombination(cSR),is an intrachromosomal recombination in the Ig heavy chain(IgH)***,LSR somehow appears to be the detrimental counterpart of cSR in activated B cells,since cSR intends for cells to actively participate in immune responses while LSR eliminates B ***,an important question to address is the regulation and the exact molecular mechanism of LSR.

关键词： cSR eliminate concerned

Mechanobiology and cartilage Tissue Engineering

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生物医学工程学杂志 2005年第S1期22卷 33-34页

作者： céline HUSELSTEIN Natalia de ISLA Jing-Wei YANG Yun WANG Sylvaine MULLER Jean-Fran·ois STOLTZ Research Group of cell and Tissue Engineering LEMTA-CNRS UMR 7563 et IFR 111 BioingénierieFacultéde Médecine54505 Vandoeuvre-lès-Nancy CedexFrance Unitéde Thérapie cellulaire et Tissulaire(UTcT)-cHRU-54500 Vandoeuvre-lès-Nancy cedex France

1 Introduction The cartilage i s a hydrated connective tissue in joint s that withstands and distributes mechanical *** utilize mechanical signals to maintain tissue *** regulate their metabolic activity through complex biological and biophysical interactions with the extracellular matrix(EcM).Although some of the mechanisms of mechanotransduction are known today,there are certainly many others left *** topics of chondrocytes mechanobiology have led to the development of tissue *** is the concept of substitute tissue developed in vitro,from bioresorbable or non2bioresorbable scaffolds and from cells harvested in a physiologic mechanical environment.

关键词： ca MScs Mechanobiology and cartilage Tissue Engineering

Evaluation and Examination of a Possible Shoe‑polish Trace in a Hold‑up case

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Journal of Forensic Science and Medicine 2016年第4期2卷 233-244页

作者： line Gueissaz Tacha Hicks cyril Muehlethaler Geneviève Massonnet Faculty of Law Criminal Justice and Public AdministrationSchool of Criminal JusticeUniversity of LausanneLausanne 1015Switzerland Fondation Pour la Formation continue Universitaire Lausannoise Lausanne1015Switzerland Department of chemistry City College of the City University of New YorkNew York 10031USA

In this article,we show how the Bayesian framework can be applied to a hold‑up case involving a possible shoe‑polish trace according to one of the *** article highlights the importance of interpreting data from the beginning of the examination through the preassessment *** a set of alternative propositions in agreement with the information provided by the parties is chosen,one can establish what is needed in the ***,limited data were available to assign factors such as transfer and rarity of the ***,we showed how specific case‑tailored experiments provide meaningful data for *** this case,the police had observed a trace on the jacket of a person who reported to have been pushed with the offender’s gun during the hold‑up *** the jacket was submitted to our laboratory,the exact nature of the trace was *** from this trace were collected and analyzed by stereomicroscopy,microscopy,and infrared *** obtained results supported that this trace was waxy *** literature dealing with the analysis of waxy materials generally uses solvent extraction‑based ***,as our analytical sequence allowed a good discrimination of different waxy products of known origin,we considered that this methodology was ***,it did not involve any extraction step that could lead to undesired compounds from the substrate(e.g.,dyes and additives).This article therefore suggests an alternative analytical sequence for the analysis of such material in casework.

关键词： Bayesian evaluation firearms trace evidence transfer

Bush, bugs, and birds;interdependency in a farming landscape

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Open Journal of Ecology 2011年第2期1卷 9-23页

作者： Philippe James Thomas Pamela Martin céline Boutin National Wildlife Research centre Science & Technology Branch Environment Canada Ottawa Ontario K1A 0H3 Canada

changes in farming practices over the second half of the twentieth century greatly reduced the extent of natural areas remaining within agricultural landscapes. Field margins and hedgerows have recently been recognized as important habitat in maintaining wildlife diversity and proper ecosystem functioning. Ecotones, defined as the transitionary area of vegetation between woody plant species and the arable crop, are an especially important landscape element for birds and arthropods. In this manuscript, we aimed to evaluate which hedgerow attribute was best at predicting avian densities in a conventional and organic farming landscape. Furthermore, we wished to investigate if these same hedgerow attributes could explain arthropod family density, richness and diversity, and how these were correlated to avian densities. An information theory-based multimodel inference method was used to identify which factors influenced variability in avian densities. Although not always significant, avian densities increased with arthropod richness at our study sites. Ecotone width is the best predictor of avian densities and arthropod richness while percent gap is the most important factor if a manager wishes to increase avian diversity (H’) in hedgerow habitats. Increasing ecotone width benefits both avian densities and arthropod richness that in turn further increases bird numbers in our farming landscape.

关键词： Abundance AIc Arthropod Avian Diversity Ecotone Farming Landscape Management Richness

Genome-wide differences in hepatitis c-vs alcoholism-associated hepatocellular carcinoma

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World Journal of Gastroenterology 2008年第11期14卷 1749-1758页

作者： céline Derambure cédric coulouarn Frédérique caillot Romain Daveau Martine Hiron Michel Scotte Arnaud Franois celia Duclos Odile Goria Marie Gueudin catherine cavard Benoit Terris Maryvonne Daveau Jean-Philippe Salier Inserm Unité519 and Institut Fédératif de Recherches Multidisciplinaires sur les Peptides Facultéde Médecine-PharmacieRouenFrance Inserm Unité519 and Institut Fédératif de Recherches Multidisciplinaires sur les Peptides Facultéde Médecine-PharmacieRouenFrance Service de Chirurgie Générale et DigestiveCentre Hospitalier UniversitaireRouenFrance Département de Pathologie Centre Hospitalier UniversitaireRouenFrance Inserm Unité519 and Institut Fédératif de Recherches Multidisciplinaires sur les Peptides Facultéde Médecine-PharmacieRouenFrance Service d'Hépato-gastro-enterologieCentre Hospitalier UniversitaireRouenFrance Laboratoire de Virologie and UPRES EA 2646 Centre Hospitalier UniversitaireRouenFrance Inserm Unité567 CNRS UMR 8104 UniversitéParis 5Département GDPMInstitut CochinParis France

AIM:To look at a comprehensive picture of etiology- dependent gene abnormalities in hepatocellular carcinoma in Western Europe. METHODS:With a liver-oriented microarray,transcript levels were compared in nodules and cirrhosis from a training set of patients with hepatocellular carcinoma (alcoholism,12;hepatitis c,10)and 5 *** or tight selection of informative transcripts with an abnormal abundance was statistically valid and the tightly selected transcripts were next quantified by qRTPcR in the nodules from our training set(12+10) and a test set(6+7). RESULTS:A selection of 475 transcripts pointed to significant gene over-representation on chromosome 8 (alcoholism)or-2(hepatitis c)and ontology indicated a predominant inflammatory response(alcoholism)or changes in cell cycle regulation,transcription factors and interferon responsiveness(hepatitis c).A stringent selection of 23 transcripts whose differences betweenetiologies were significant in nodules but not in cirrhotic tissue indicated that the above dysregulations take place in tumor but not in the surrounding *** 23 transcripts separated our test set according to etiologies. The inflammation-associated transcripts pointed to limited alterations of free iron metabolism in alcoholic vs hepatitis c tumors. cONcLUSION:Etiology-specific abnormalities(chromo- some preference;differences in transcriptomes and related functions)have been identified in hepatocellular carcinoma driven by alcoholism or hepatitis *** may open novel avenues for differential therapies in this disease.

关键词： Alcoholism chromosome cirrhosis Hepatitis c Transcriptomes Protein function