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Phosphorus Use Efficiency of Bio-Based Fertilizers:Bioavailability and Fractionation

Pedosphere 2016年第3期26卷 310-325页

作者： céline VANEEcKHAUTE Joery JANDA Peter A.VANROLLEGHEM Filip M.G.TAcK Erik MEERS Laboratory for Analytical and Applied Ecochemistry Faculty of Bioscience EngineeringGhent University model EAU Département de Génie Civil et de Génie des EauxFaculté des Sciences et de GénieUniversité Laval

Although to date some technologies producing bio-based phosphorus(P) fertilizers have been proposed and implemented, the efficient use of the recovered products is still limited due to legislative constraints and lack of insights in the P release with time and in the corresponding mechanisms. The aim of this work was to evaluate the fertilizer performance in terms of P release and use efficiency of recovered struvite, FePO_4-sludge, digestate, and animal manure as compared to fossil reserve-based mineral triple superphosphate(TSP). First, product physicochemical characteristics and P fractions in the context of European fertilizer legislation were assessed. Next, a controlled greenhouse experiment was set up to evaluate plant reactions as well as changes of P availability in a sandy soil with high P status and a Rheinsand soil with low P status. Soil P fractions were determined in the extracts with water, ammonium lactate and cacl_2, and in soil solution sampled with Rhizon soil moisture samplers. Based on all results, it is worth conducting long-term field trials to evaluate the P release effect of struvite and digestate as compared to animal manure and TSP on different soil types with varying P status. These products showed promise as sustainable substitutes for conventional P fertilizers and could contribute to a more efficient use of P in agriculture. A refined classification of P application standards/recommendations in terms of soil P status, soil texture, and fertilizer characteristics, next to the crop P demand, is recommended. Moreover, the additional use of Rhizon samplers for determination of direct available P, including dissolved organic P, is proposed for better understanding and categorization of different P fertilizers in environmental and fertilizer legislations.

关键词： chemical soil analysis digestate nutrient recovery Rhizon samplers struvite

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Recurrent clostridium difficile infections:The importance of the intestinal microbiota

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World Journal of Gastroenterology 2014年第23期20卷 7416-7423页

作者： Marie céline Zanella Terrier Martine Louis Simonet Philippe Bichard Jean Louis Frossard Service of General Internal Medicine Geneva University Hospital1211 GenevaSwitzerland Service of Gastroenterology and Hepatology Geneva University Hospital1211 GenevaSwitzerland

clostridium difficile infections(cDI)are a leading cause of antibiotic-associated and nosocomial *** effective antibiotic treatments,recurrent infections are *** the recent emergence of hypervirulent isolates of ***,cDI is a growing epidemic with higher rates of recurrence,increasing severity and *** microbiota transplantation(FMT)is an alternative treatment for recurrent cDI.A better understanding of intestinal microbiota and its role in cDI has opened the door to this promising therapeutic *** is thought to resolve dysbiosis by restoring gut microbiota diversity thereby breaking the cycle of recurrent *** the first reported use of FMT for recurrent cDI in 1958,systematic reviews of case series and case report have shown its effectiveness with high resolution rates compared to standard antibiotic *** article focuses on current guidelines for cDI treatment,the role of intestinal microbiota in cDI recurrence and current evidence about FMT efficacy,adverse effects and acceptability.

关键词： clostridium difficile infection clostridium difficile recurrence Fecal microbiota transplantation Stool transplantation Microbiota

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Ultra‑Transparent and Multifunctional IZVO Mesh Electrodes for Next‑Generation Flexible Optoelectronics

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Nano-Micro Letters 2025年第1期17卷 293-309页

作者： Kiran A.Nirmal Tukaram D.Dongale Atul c.Khot chenjie Yao Nahyun Kim Tae Geun Kim School of Electrical Engineering Korea UniversityAnam‑ro 145Seongbuk‑guSeoulRepublic of Korea computational Electronics and Nanoscience Research Laboratory School of Nanoscience and BiotechnologyShivaji UniversityKolhapur 416004India

Mechanically durable transparent electrodes are essential for achieving long-term stability in flexible optoelectronic ***,they are crucial for applications in the fields of energy,display,healthcare,and soft *** meshes represent a promising alternative to traditional,brittle,metal oxide conductors due to their high electrical conductivity,optical transparency,and enhanced mechanical *** this paper,we present a simple method for fabricating an ultra-transparent conducting metal oxide mesh electrode using selfcracking-assisted *** this method,we produced an electrode with ultra-transparency(97.39%),high conductance(Rs=21.24Ωsq^(−1)),elevated work function(5.16 eV),and good mechanical *** also evaluated the effectiveness of the fabricated electrodes by integrating them into organic photovoltaics,organic light-emitting diodes,and flexible transparent memristor devices for neuromorphic computing,resulting in exceptional device *** addition,the unique porous structure of the vanadium-doped indium zinc oxide mesh electrodes provided excellent flexibility,rendering them a promising option for application in flexible optoelectronics.

关键词： Self-cracking template Vanadium-doped indium zinc oxide mesh Organic solar cells Organic light-emitting diodes Flexible transparent memory

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Evaluation of the colorectal cancer risk conferred by rare UNc5c alleles

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World Journal of Gastroenterology 2014年第1期20卷 204-213页

作者： Sébastien Küry céline Garrec Fabrice Airaud Flora Breheret Virginie Guibert cécile Frenard Shuo Jiao Dominique Bonneau Pascaline Berthet céline Bossard Olivier Ingster Estelle cauchin Stéphane Bezieau cHU Nantes Service de Génétique Médicale44093 Nantes CEDEX 1France Public Health Sciences Division Fred Hutchinson Cancer Research CenterSeattleWA 98109United States cHU Angers Service de Génétique Médicale4 rue Larrey49933 AngersFrance centre de Lutte contre le cancer Fran?ois Baclesse 3 avenue du Général Harris14076 Caen Cedex 5France Université de Nantes Faculté de Médecine de NantesEA 4273 NantesFrance cHU Nantes Institut des Maladies de l’Appareil Digestif et Service d’Hépato-Gastroentérologie44093 Nantes Cedex 1France

AIM: To evaluate the risk associated with variants of the UNc5c gene recently suspected to predispose to familial colorectal cancer (cRc).

关键词： colorectal cancer UNc5c Genetic predisposition Familial study Association study Low risk

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Machine learning empowers efficient design of ternary organic solar cells with PM6 donor

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Journal of Energy chemistry 2025年第1期100卷 337-347页

作者： Kiran A.Nirmal Tukaram D.Dongale Santosh S.Sutar Atul c.Khot Tae Geun Kim School of Electrical Engineering Korea University computational Electronics and Nanoscience Research Laboratory School of Nanoscience and Biotechnology Shivaji University Yashwantrao chavan School of Rural Development Shivaji University

Organic solar cells(OScs) hold great potential as a photovoltaic technology for practical ***, the traditional experimental trial-and-error method for designing and engineering OScs can be complex, expensive, and time-consuming. Machine learning(ML) techniques enable the proficient extraction of information from datasets, allowing the development of realistic models that are capable of predicting the efficacy of materials with commendable accuracy. The PM6 donor has great potential for high-performance OScs. However, it is crucial for the rational design of a ternary blend to accurately forecast the power conversion efficiency(PcE) of ternary OScs(TOScs) based on a PM6 ***, we collected the device parameters of PM6-based TOScs and evaluated the feature importance of their molecule descriptors to develop predictive models. In this study, we used five different ML algorithms for analysis and prediction. For the analysis, the classification and regression tree provided different rules, heuristics, and patterns from the heterogeneous dataset. The random forest algorithm outperforms other prediction ML algorithms in predicting the output performance of PM6-based TOScs. Finally, we validated the ML outcomes by fabricating PM6-based TOScs. Our study presents a rapid strategy for assessing a high PcE while elucidating the substantial influence of diverse descriptors.

关键词： Random forests

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continuous flow synthesis of PbS/cdS quantum dots using substituted thioureas

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Nano Research 2024年第12期17卷 10677-10684页

作者： Pierre Machut Anna Karina Antonini céline Rivaux Marina Gromova Harinderbir Kaur Wai Li Ling Gabriel Mugny Peter Reiss STMicroelectronics Grenoble 12 Rue Jules HorowitzGrenoble 38019France Univ.Grenoble Alpes CEA GrenobleCNRSGrenoble INPIRIG/SyMMES/STEPGrenoble 38000France Univ.Grenoble Alpes CEA Grenoble/IRIG/MEMGrenoble 38000France Univ.Grenoble Alpes CEACNRSIBSGrenoble 38000France

To enhance the reproducibility and scale up the synthesis of colloidal quantum dots(QDs),continuous flow synthesis is an appealing alternative to the widely used batch *** other advantages,the strongly enhanced heat and mass transfer in small tubular reactors combined with controlled pressure can be ***,the widespread use of this technique is hampered by special requirements such as the absence of solid or gaseous products and the room-temperature solubility of ***,the transfer of established reaction conditions from batch to flow is not straightforward and in most reported works the optical properties of the obtained QDs lag behind those prepared in batch *** is also the case for PbS-based QDs,which are established near infrared(NIR)absorbers/*** we identified experimental conditions giving access to high-quality PbS core and PbS/cdS core/shell QDs obtained in an automated,easily scalable continuous flow *** particular,substituted thioureas have been selected as the sulfur source and ex-situ synthesized lead and cadmium oleate as the metal precursors,and appropriate solvent mixtures have been identified for each *** luminescent PbS/cdS QDs emitting at the target wavelengths 940 and 1130 nm of special interest for NIR light-emitting diodes have been prepared,exhibiting a photoluminescence quantum yield up to 91%.

关键词： quantum dots continuous flow synthesis thioureas PbS/cdS core/shell nanocrystals quantum dots based light-emittingdiodes(QLEDs)

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Rationale for the potential use of mesenchymal stromal cells in liver transplantation

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World Journal of Gastroenterology 2014年第44期20卷 16418-16432页

作者： Morgan Vandermeulen céline Grégoire Alexandra Briquet chantal Lechanteur Yves Beguin Olivier Detry Department of Abdominal Surgery and Transplantation CHU Liege University of Liege Department of Hematology CHU Liege University of Liege Laboratory of cell and Gene Therapy CHU Liege University of Liege

Mesenchymal stromal cells (MScs) are multipotent and self-renewing cells that reside essentially in the bone marrow as a non-hematopoietic cell population, but may also be isolated from the connective tissues of most organs. MScs represent a heterogeneous population of adult, fibroblast-like cells characterized by their ability to differentiate into tissues of mesodermal lineages including adipocytes, chondrocytes and osteocytes. For several years now, MScs have been evaluated for their in vivo and in vitro immunomodulatory and ‘tissue reconstruction’ properties, which could make them interesting in various clinical settings, and particularly in organ transplantation. This paper aims to review current knowledge on the properties of MScs and their use in pre-clinical and clinical studies in solid organ transplantation, and particularly in the field of liver transplantation. The first available clinical data seem to show that MScs are safe to use, at least in the medium-term, but more time is needed to evaluate the potential adverse effects of long-term use. Many issues must be resolved on the correct use of MScs. Intensive in vitro and pre-clinical research are the keys to a better understanding of the way that MScs act, and to eventually lead to clinical success.

关键词： Mesenchymal stem cells Organ transplantation complication Immunosuppression Tolerance

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Functional responses to deforestation in fish communities inhabiting neotropical streams and rivers

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Ecological Processes 2023年第1期12卷 716-732页

作者： Isabel cantera céline Jézéquel Tony Dejean Jérôme Murienne Régis Vigouroux Alice Valentini Sébastien Brosse Department of Environmental Science and Policy Universitàdegli Studi di MilanoVia Celoria 2620133 MilanItaly Laboratoire Evolution et DiversitéBiologique UMR5174-UniversitéPaul SabatierCNRSIRD118 Route de Narbonne31062 ToulouseFrance SPYGEN Savoie Technolac-BP 27417 Rue du Lac Saint-André73375 Le Bourget-du-Lac CedexFrance HYDREcO Laboratoire Environnement de Petit SautB.P 82397388 Kourou CedexFrench GuianaFrance

Background Deforestation is a widespread disturbance for neotropical freshwater *** biodiversity declines have been associated with deforestation,its functional consequences for stream and river fish faunas remain poorly *** this study,we explored how deforestation affects the different facets of the functional structure of fish communities inventoried using environmental DNA metabarcoding in 64 river and 35 stream sites of French ***,we investigated how functional richness,divergence,evenness and identity of fish faunas are affected by *** We showed that anthropogenic disturbances in French Guiana are modifying the functional diversity of freshwater fish *** disturbances not only affected the amount of functional traits held by the communities but also the identity of the traits and the internal structure of the functional ***,different facets of the functional diversity supported by fish assemblages were *** streams,deforestation did not affect the overall diversity of traits but reduced functional redundancy,underlined by a shift in functional identity towards assemblages dominated by pelagic *** contrast,river fish faunas experienced a decline in functional richness,paired with shifts in functional identity and a loss of fish species with extreme *** The response to deforestation differed between streams and rivers,but it supports the hypothesis that deforestation is linked to functional changes in fish *** diminishing the range of the functions in rivers or by jeopardizing the redundancy of functions in streams,deforestation could severely hamper the functioning and stability of neotropical freshwater ecosystems.

关键词： eDNA Traits Functional space Richness Divergence Evenness Identity Gold mining

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Stem cell treatment and cerebral palsy: Systemic review and meta-analysis

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World Journal of Stem cells 2019年第10期11卷 891-903页

作者： Simone Eggenberger céline Boucard Andreina Schoeberlein Raphael Guzman Andreas Limacher Daniel Surbek Martin Mueller Department of Obstetrics and Gynaecology InselspitalUniversity Hospital BernBern 3010Switzerland Department for BioMedical Research University of BernBern 3008Switzerland Department of Neurosurgery University Hospital of BaselBasel 4056Switzerland cTU Bern University of BernBern 3012Switzerland

BAcKGROUND Perinatal complications may result in life-long morbidities,among which cerebral palsy(cP)is the most severe motor *** developed,cP is a nonprogressive disease with a prevalence of 1-2 per 1000 live births in developed *** demands an extensive and multidisciplinary ***,it is a challenge for our health system and a burden for patients and their ***,stem cell therapy emerged as a promising treatment option and raised hope in patients and their *** The aim is to evaluate the efficacy and safety of stem cell treatment in children with cP using a systematic review and meta-analysis METHODS We performed a systematic literature search on PubMed and EMBASE to find randomized controlled clinical trials(RcT)investigating the effect of stem cell transplantation in children with *** the review,we performed a randomeffects meta-analysis focusing on the change in gross motor function,which was quantified using the gross motor function *** calculated the pooled standardized mean differences of the 6-and/or 12-mo-outcome by the method of *** quantified the heterogeneity using the I-squared *** We identified a total of 8 RcT for a qualitative *** the initially selected trials,5 met the criteria and were included in the ***’population ranged from 0.5 up to 35 years(n=282).We detected a significant improvement in the gross motor function with a pooled standard mean difference of 0.95(95%confidence interval:0.13-1.76)favoring the stem cell group and a high heterogeneity(I2=90.1%).Serious adverse events were rare and equally distributed among both intervention and control *** Stem cell therapy for cP compared with symptomatic standard care only,shows a significant positive effect on the gross motor function,although the magnitude of the improvement is ***-term safety is present and further highquality RcTs are needed.

关键词： cerebral palsy Perinatal brain injury Stem cells Umbilical cord blood Mesenchymal stem/stromal cells Gross motor function Meta-analysis

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S1P: the elixir of life for naive T cells

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cellular & Molecular Immunology 2018年第7期15卷 657-659页

作者： Michaël Pérès Anne Montfort Nathalie Andrieu-Abadie céline colacios Bruno Ségui INSERM UMR1037 Centre de Recherches en Cancérologie de ToulouseToulouse 31037France Facultéde pharmacie UniversitéToulouse III Paul-SabatierToulouse 31062France Laboratoire d’hématologie CHU de ToulouseToulouse 31059France Equipe Labellisée Ligue contre Le cancer Toulouse 31037France Correspondence:Professor B SéguiPhDINSERMUMR1037 CRCTCentre de Recherches en Cancérologie de Toulouse2 avenue Hubert CurienToulouse 31037France

During their life,T cells are constantly circulating throughout the ***-1-phosphate(S1P),a sphingolipid metabolite,triggers T cell egress from the thymus and secondary lymphoid organs(SLO)into the lymph and the *** phenomenon is dependent on the S1P gradient between lymphoid organs(including thymus and SLO)and the lymphatic and blood vessels,which exhibit low,intermediate and high S1P levels,respectively.T cells follow the S1P gradient via the engagement of the G-protein-coupled receptor S1P receptor 1(S1P1)expressed on T cells.1 S1P production is regulated by various sphingolipid-metabolizing *** sphingosine kinases 1 and 2(SKs),encoded by Sphk1 and Sphk2,phosphorylate the sphingosine(Sph)into ***,S1P can be dephosphorylated to Sph by S1P phosphatases 1 and 2,encoded by Sgpp1 and ***,S1P can be irreversibly degraded by the S1P Lyase(SPL),encoded by Sgpl1,into phosphoethanolamine and hexadecenal.

关键词： organs al. lymphoid

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