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Interactions of complement proteins c1q and factor H with lipid A and Escherichia coli:further evidence that factor H regulates the classical complement pathway

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Protein & cell 2011年第4期2卷 320-332页

作者： Lee Aun Tan Andrew c.Yang Uday Kishore Robert B.Sim Medical Research council Immunochemistry Unit Department of BiochemistryUniversity of OxfordSouth Parks RoadOxford OX13QUUK Present address:Department of Immunology Faculty of MedicineImperial College LondonHammersmith HospitalDu Cane RoadLondon W120NNUK St Peter’s college New Inn Hall St.Oxford OX12DLUK Present address:SUNY Downstate college of Medicine 450 Clarkson Avenue BrooklynNY 11203USA Weatherall Institute of Molecular Medicine John Radcliffe HospitalUniversity of OxfordHeadingtonOxford OX39DSUK Present address:center for Infection Immunity and Disease MechanismsBiosciencesSchool of Health Sciences and Social CareBrunel UniversityUxbridge UB83PH West LondonUK Present address:Department of Pharmacology University of OxfordMansfield RoadOxford OX13QTUK

Proteins of the complement system are known to interact with many charged *** recently characterized binding of c1q and factor H to immobilized and liposomal anionic *** H inhibited c1q binding to anionic phospholipids,suggesting a role for factor H in regulating activation of the complement classical pathway by anionic *** extend this finding,we examined interactions of c1q and factor H with lipid A,a well-characterized activator of the classical *** report that c1q and factor H both bind to immobilized lipid A,lipid A liposomes and intact Escherichia coli *** H competes with c1q for binding to these ***,increasing the factor H:c1q molar ratio in serum diminished c4b fixation,indicating that factor H diminishes classical pathway *** recombinant forms of the cterminal,globular heads of c1q A,B and c chains bound to lipid A and *** in a manner qualitatively similar to native c1q,confirming that c1q interacts with these targets via its globular head *** observations reinforce our proposal that factor H has an additional complement regulatory role of down-regulating classical pathway activation in response to certain *** is distinct from its role as an alternative pathway *** suggest that under physiological conditions,factor H may serve as a downregulator of bacterially-driven inflammatory responses,thereby finetuning and balancing the inflammatory response in infections with Gram-negative bacteria.

关键词： complement lipid A bacteria factor H c1q

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Influence of residual stress on the phase equilibrium of Ti(c_xN_y) thin films

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Journal of University of Science and Technology Beijing 2003年第6期10卷 76-79页

作者： YingJin changrongLi XiaoyanMa ZhenminDu WeijingZhang J.-c.Tedenac MaterialsScienceandEngineeringSchool UniversityofScienceandTechnologyBeijingBeijing100083China LaboratoryofPhysical-chemistryofcondensedMaterials UniversitydeMontpellierFrance

In order to provide a theoretic basis for the research of Ti(c_xN_y) thinfilms, the thermodynamic database of Ti-c-N ternary system is established and the phase diagramsections are calculated. In addition to the assessed thermodynamic properties of Ti-c-N system, theinfluence of the residual strain energy of Ti(c_xN_y) thin films on the phase equilibria isanalyzed. The classical formula for calculating the elastic strain energy is expressed into aRedlich-Kister form in order to perform the thermodynamic and equilibrium calculations using theThermo-calc software. Isothermal sections at 900 and 1100 K are calculated with this database andcompared with those calculated without considering the residual stress. As a result, with theaddition of strain energy delta-fcc Ti(c_xN_y) phase area shrinks. It is therefore concluded thatwith the influence of the residual stress in Ti(c_xN_y) thin solid film, the precipitation of puredelta film requires more precise control of composition.

关键词： titanium carbonitride coating thin films phase equilibrium residual stress

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córdoba乳腺断层融合筛查试验（cBTST）乳腺筛查间期癌：乳腺断层融合联合数字乳腺摄影与单纯数字乳腺断层成像的比较

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国际医学放射学杂志 2024年第5期 627-628页

作者： c.Pulido carmona S.Romero Martín J.L.Raya Povedano M.cara García P.Font Ugalde E.Elías cabot 张昕怡

目的比较数字乳腺断层摄影（DBT）+数字乳腺摄影（DM）与单纯DM筛查女性的乳腺筛查间期癌发病率及其特征的差异。方法比较córdoba乳腺断层融合筛查试验

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current Transport in copper Schottky contacts to a−Plane/ c−Plane n-Type MoSe_(2)

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chinese Physics Letters 2011年第8期28卷 254-257页

作者： c.K.Sumesh K.D.Patel V.M.Pathak R.Srivastav Department of Physics Faculty of Technology and EngineeringCharotar University of Science and TechnologyCHANGA 388421GujaratIndia Department of Physics Sardar Patel UniversityVallabh Vidyanagar 388120GujatatIndia

We identically prepared cu-nMoSe_(2)(a−plane)and cu-nMoSe_(2)(c−plane)Schottky barrier diodes(SBDs)on the same n-type MoSe_(2) single *** effective Schottky barrier heights(SBHs)and ideality factors were obtained from the current−voltage-temperature(I–V–T)*** barrier height and ideality factor,estimated from the conventional thermionic emission model by assuming a Gaussian barrier distribution,are highly dependent on temperature.A notable deviation from the theoretical Richardson constant value is also observed in the conventional Richardson *** decrease in the experimental barrier heightΦB0 and an increase in the ideality factor n with a decrease in temperature have been explained on the basis of barrier height inhomogeneities at the metal−semiconductor *** is proven that the presence of a distribution of barrier heights is responsible for the apparent decrease of the zero bias barrier *** voltage dependence of the standard deviation causes the increase of the ideality factor at low *** value of the Richardson constant obtained without considering the inhomogeneous barrier heights is much closer than the theoretical *** cu-nMoSe_(2)(a−plane)Schottky diode shows better results in comparison with the nMoSe_(2)(c-plane)Schottky diode.

关键词： Schottky temperature ideality

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Is chronic hepatitis c virus infection a risk factor for breast cancer?

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World Journal of Gastroenterology 2010年第29期16卷 3687-3691页

作者： Dominique Larrey Marie-cécile Bozonnat Ihab Kain Georges-Philippe Pageaux Eric Assenat Liver Unit and INSERM Unit 632 Saint-Eloi HospitalMontpellier University Department of Biostatistics Intitut Universitaire de Recherche CliniqueMontpellier University Liver Unit Saint-Eloi HospitalMontpellier University Medical Oncology Unit Saint-Eloi HospitalMontpellier University

AIM:To evaluate the prevalence of breast tumors in adult females with chronic hepatitis c virus(HcV) ***:Prospective,single-center study,based on female outpatients consulting in a liver unit,for 1 *** study group included females with present and/or past history of chronic infection by *** with spontaneous recovery were *** hepatitis had been proved by liver biopsy in the majority of cases and/or biological markers of inflammation and *** control group included female patients with other well documented chronic liver diseases:chronic hepatitis B,alcoholic liver disease,autoimmune hepatitis,hemochromatosis,non alcoholic liver disease,chronic *** patients were prospectively questioned during consultation about past breast history and follow-up by ***:Breast carcinoma was recorded in 17/294 patients with HcV infection(5.8%,95% cI:3.1-8.4) vs 5/107 control patients(4.7%,95% cI:0.67-8.67).Benign tumors of the breast(mastosis,nodules,cysts) were recorded in 75/294 patients with HcV infection(25.5%,95% cI:20.5-30.5) vs 21/107(19.6%,95% cI:12.1-27.1) in the control *** lesion was noted in 202 patients with HcV(68.7%,95% cI:63.4-74) vs 81 control patients(75.7%,95% cI:67.6-83.8).Despite a trend to an increased prevalence in the group with HcV infection,the difference was not significant compared to the control group(P=NS).In patients over 40 years,the results were,respectively,as follows:breast cancer associated with HcV:17/266 patients(6.3%,95% cI:3.4-9.3) vs 5/95 patients(5.2%,95% cI:0.7-9.7) in the control group;benign breast tumors:72/266 patients with HcV infection(27%,95% cI:21.7-32.4) vs 18/95 patients(18.9%,95% cI:11-26.8) in the control group;no breast lesion 177/266(66.5%,95% cI:60.9-72.2) in patients with HcV infection vs 72/95(75.7%,95% cI:67.1-84.4) in the control *** differences were not significant(P=NS).cONcLUSION:These results suggest that chronic HcV infectio

关键词： Breast tumors Breast cancer Hepatitis c virus infection Risk factor

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On a Kind of Series Summation Utilizing c-Numbers

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Journal of Mathematical Research with Applications 2014年第1期34卷 1-11页

作者： Leetsch c.HSU Xinrong MA School of Mathematical Sciences Dalian University of Technology School of Mathematical Sciences Soochow University

This paper provides a pair of summation formulas for a kind of combinatorial series involvingak+b m as a factor of the *** construction of formulas is based on a certain series transformation formula[2,7,9]and by making use of the c-numbers[3].Various consequences and examples including several remarkable classic identities are presented to illustrate some applications of the formulas obtained.

关键词： combinatorial series summation formula diference operator generalized Stirling number c-number.

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c反应蛋白调节脂蛋白(a)相关冠心病风险:BiomarcaRE项目

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中华高血压杂志（中英文） 2024年第3期32卷 299-299页

作者： Arnold N Blaum c GoBling A Brunner FJ Bay B Ferrario MM Brambilla P cesana G Leoni V Palmieri L Donfrancesco c Padro T Andersson J Jousilahti P Ojeda F Zeller T Linneberg A Soderberg S Iacoviello L Gianfagna F Sans S Veronesi G Thorand B Peters A Tunstall-Pedoe H Kee F Salomaa V Schnabel RB Kuulasmaa K Blankenberg S Koenig W Waldeyer c 袁源(译) 郑武洪(审校) 不详

近期研究显示,脂蛋白(a)[lipoprotein(a),Lp(a)]相关心血管疾病风险与机体炎症负荷存在交互作用。本研究旨在探索一般人群中,高敏c反应蛋白(high-sensitive c-reactive protein,hscRP)能否调节Lp(a)相关冠心病风险。方法:纳入欧洲8项基... 详细信息

近期研究显示,脂蛋白(a)[lipoprotein(a),Lp(a)]相关心血管疾病风险与机体炎症负荷存在交互作用。本研究旨在探索一般人群中,高敏c反应蛋白(high-sensitive c-reactive protein,hscRP)能否调节Lp(a)相关冠心病风险。方法:纳入欧洲8项基于人群的前瞻性队列研究的71678例参与者数据(基线时65661例未患冠心病/6017例患有冠心病。

关键词：前瞻性队列研究高敏c反应蛋白心血管疾病风险机体炎症冠心病 reactive 交互作用

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A cLASS OF c^1 DIScRETE INTERPOLANTS OVERTETRAHEDRA

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Journal of computational Mathematics 1997年第2期15卷 149-158页

作者： X.c. Liu(Institute of Image Processing and Pattern Recognition, Shanghai Jiao Tong University,Shanghai, china) Institute of Image Processing and Pattern Recognition Shanghai Jiao Tong University Shanghai China

Smooth interpolants defined over tetrahedra are currently being developed for they have many applications in geography, solid modeling, finite element analysis, etc. In this paper, we will characterize a certain class of c-1 discrete tetrahedral interpolants with only c-1 data required. As special cases of the class characterized, we give two c-1 discrete tetrahedral interpolants which have concise expressions.

关键词： A cLASS OF c~1 DIScRETE INTERPOLANTS OVERTETRAHEDRA

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Influence of Fe Addition on Products of Self-Propagating High-Temperature Synthesis Reaction in 3Ti-Si-2c System

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稀有金属材料与工程 2009年第A3期38卷 113-118页

作者： Guan Q L Wang H Y Li S L Si W P Jiang Q c Key Laboratory of Automobile Materials of Ministry of Education Jilin University Changchun 130025 China

Influence of Fe addition on products of self-propagating high-temperature synthesis (SHS) reaction in 3Ti-Si-2c system was investigated in the present study. Without Fe addition, Ti5Si3 and Tic are the dominant phases along with a small amount of Ti3Sic2 phase and unreacted c left in the final products. As Fe content ranges from 10% to 30%, the products consist of Tic, Ti5Si3, Fe2Ti and unreacted c, but no trace of Ti3Sic2 phase is detected. Furthermore, the amounts of both Fe2Ti and c phases increase with Fe content increasing. Addition of Fe has a great effect on the reaction route and significantly restrains the formation of Ti3Sic2 during the combustion synthesis process, and therefore, the SHS is not an effective fabrication technique to synthesize the ternary Ti3Sic2 ceramic in either 3Ti-Si-2c or Fe-3Ti-Si-2c system. Besides, without Fe addition, Ti5Si3 presents as the coarse irregular appearance with an obviously sintered morphology. In contrast, the shape of Ti5Si3 exhibits more and more spherical (cobblestone-like) and the surface becomes increasingly smooth, because the amount of liquids formed during the SHS reaction increases with the increase of Fe content. On the other hand, with Fe content increasing from 0 to 30 wt.%, the particulate size of Tic decreases from more than 5 μm to 1 μm or less, mainly due to the fact that the combustion temperature decreases with the increase of Fe content in the preforms.

关键词：复合材料铁含量燃烧过程物理性能

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Precision measurements of strangeness photoproduction at threshold energies with the crystal Ball at MAMI-c

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chinese Physics c 2009年第12期33卷 1358-1361页

作者： T. c. Jude D. I Glazier D. P. Watts The University of Edinburgh Edinburgh EH9 3JZ UK

The photoproduction of K＋ mesons from the nucleon provides important constraints on the nucleon excitation spectrum and at threshold energies challenges effective field theories based on chiral perturbation in the strange quark sector. Preliminary cross-section measurements for γ（P, K＋）A are presented at an unprecedented beam energy resolution. The data was collected at the MAMI-c facility in Mainz using the crystal Ball Detector. A new method of K＋ detection was used in which the K＋ is tagged from its weak decay products in the detector crystals. This technique has application with other calorimeters at present and future hadron facilities.

关键词： crystal Ball Detector strange meson photoproduction

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