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Epidemiological and Paraclinical Aspects of Helicobacter pylori Infection among Hepatitis B Virus carriers in the Republic of congo

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Open Journal of Gastroenterology 2024年第5期14卷 184-191页

作者： Jile Florient Mimiesse Monamou Nuptia Kanoha Elenga Ngala Itoua Ngaporo clausina Ahoui Apendi Marlyse Ngalessami Mouakosso Arnaud Mongo Onkouo Mauria Ibobi Rody Stéphane Ngami Mardoché Motoula Latou Hostaud Atipo Ibara céline sandra adoua Déby Gassaye Blaise Irénée Atipo Ibara Department of Gastroenterology and Internal Medicine Brazzaville University Hospital Brazzaville The Republic of Congo Faculty of Health Sciences Marien Ngouabi University Brazzaville The Republic of Congo

Objective: Describe the epidemiological and paraclinical aspects of HP infection in hepatitis B virus carriers. Population and Method: This was a descriptive cross-sectional study running from January 1 to August 30, 2019, a period of 8 months. It took place in the Hospital centers of the two major cities of congo (Brazzaville and Pointe-Noire). The target population of our study consists of patients carrying HBV under antiviral treatment or not. Patients aged at least 18 years and consenting with a biological and morphological assessment were included. We did not include in our study patients taking or having taken antibiotics and/or PPIs less than 4 weeks ago. We excluded all patients who did not deposit fresh stools and those in whom stool extraction could not be done manually. The variables studied covered sociodemographic, clinical and paraclinical aspects. Data entry was done using Excel 8.0 software. Statistical analysis was carried out with SPSS 20.0 software. Results: During our study, we included 169 patients. The frequency of HPAG in the stools of HBV carriers in our study population was 63.9% (n = 109). Male patients represented 69% (n = 75) and female patients represented 31% (n = 34). The average age of the patients is 43.92 ± 13.51 years with extremes of 18 years and 80 years. concerning profession, unemployed patients and those working in the private sector were the most represented in respectively 28.4% (n = 31) and 22.9% (n = 25) without statistical link. Households comprising between 4 - 10 people and the use of public latrines were the risk factors most represented in respectively 69% (n = 75) and 88% (n = 96) without statistical link. clinically, hepatomegaly and signs of portal hypertension were most represented in 53% (n = 58) and 47% (n = 51). Biologically, HBV DNA was detectable in 60.5% of cases (n = 66).

关键词： Helicobacter pylori Hepatitis B Virus congo

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Knowledge Attitude and Practice of Viral Hepatitis B and c Screening by General Practitioners in Brazzaville

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Open Journal of Gastroenterology 2020年第12期10卷 311-316页

作者： Rody Stéphane Ngami Sonia Opomba Philestine clausina Mikolele Ahoui Apendi Arnaud Mongo-Onkouo Jile Florient Mimiesse Ngala Akoa Itoua-Ngaporo Marlyse Ngalessami céline sandra adoua Deby Gassaye Blaise Irénée Atipo Ibara Jean-Rosaire Ibara Department of Gastroenterology and Internal Medicine Brazzaville University Hospital Brazzaville Republic of the Congo Faculty of Health Sciences Marien Ngouabi University Brazzaville Republic of the Congo

The involvement of general practitioners in the early detection of viral hepatitis B and c must be paramount. The objectives of this work were to assess GPs’ knowledge, attitude and practice with regard to screening ... 详细信息

The involvement of general practitioners in the early detection of viral hepatitis B and C must be paramount. The objectives of this work were to assess GPs’ knowledge, attitude and practice with regard to screening for viral hepatitis B and C. We carried out a cross-sectional analytical study among GPs recruited by simple random sampling from the list of GPs in the city of Brazzaville. The judgement criteria were knowledge and practice of screening for viral hepatitis B and C, assessed according to a Likert scale divided into 3 categories: very good, good and bad. One hundred and twenty-one general practitioners were included, including 48 women and 73 men, with a sex ratio of 1.52;the average age was 33 years;52.89% of them worked in the private sector with an average period of activity of 4 years. The majority of the doctors had a good knowledge (69.42%) and a bad practice (56.20%) of screening for viral hepatitis B and C. The duration of activity was the factor linked to knowledge of viral hepatitis B and C (p = 0.006) while age was the factor linked to the practice of screening for viral hepatitis B and C (p = 0.0366). In conclusion, in Brazzaville, general practitioners’ knowledge of screening for viral hepatitis B and C is good in general, but the practices are poor and require targeted in-service training.

关键词： Viral Hepatitis B and c Screening General Practitioners Brazzaville

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Viral Hepatitis B: Seroprevalence and Genetic Diversity in Blood Donors North of congo

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Open Journal of Gastroenterology 2019年第12期9卷 239-245页

作者： Arnaud Mongo-Onkouo Amelia Dzia Lepfoundzou Dinghat Ornela Marlyne Yvonne Ahoui Apendi clausina Philestine Jile Florent Mimiesse Monamou Ngala Akoa Itoua-Ngaporo Rody Stéphane Ngami Mouakosso Marlyse Ngalessami céline sandra adoua Deby Gassaye Blaise Irénée Atipo Ibara Jean-Rosaire Ibara Department of Hepatogastroenterology and Internal Medicine Of Brazzaville Universty Hospital center Brazzaville Congo Faculty of Health Sciences Marien Ngouabi University Brazzaville Cong Department of Metabolic Diseases of Brazzaville University Hospital center Brazzaville Congo

Introduction: Viral hepatitis B is the most formidable and confusing of all viral hepatitis, given its cirrhogenic and carcinogenic potential. The objective of the study is to characterize the molecular profile of hepatitis virus B in northern congo. Materials and Methods: This was a descriptive and cross-sectional study that was carried out between January and September 2014, that is 9 months, in the establishments of the National center for Blood Transfusion (cNTS) of the 4 departments of the north of the congo. Epidemiological, serological and molecular variables (HBsAg, HBV DNA, genotypes and subtypes) were studied. The HBs antigen was searched by rapid test and confirmed by ELISA. For all positive donors, conventional and specific gene extraction and amplification techniques were performed for the identification of genotypes and subtypes from the serum. Results: A total of 892 donors were included. The average age was 35.36 ± 12.36 years with extremes ranging from 18 to 65 years old. The sex ratio (M/F) was 3.3. The prevalence of HBV was 8.6%. The viral DNA of HBV was amplified in 83.1%. Four genotypes were found: E (40.6%), A (3.1%), B (3.1%) and c (1.6%). Two cases of co-infection were identified: E/A (15.6%) and B/c (1.6%). Subgenotypes A1, B2 and c1 were highlighted. conclusion: The prevalence of HBV is high, HBV infection remains a major public health problem for blood donors in congo. Genotypes E, A, B, c as well as subtypes A1, B2, c1 have been identified in northern congo.

关键词： HBV Molecular Biodiversity Subgenotypes North congo

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Risk Factors for Mortality Upper Digestive Haemorrhages at the University Hospital centre of Brazzaville

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Open Journal of Gastroenterology 2020年第12期10卷 341-348页

作者： Rody Stéphane Ngami Pétula Moulene Jile Florient Mimiesse Arnaud Mongo-Onkouo Ngala Akoa Itoua-Ngaporo Marlyse Ngalessami Péres Mardochée Motoula Latou céline sandra adoua Philestine clausina Mikolele Ahoui Apendi Deby Gassaye Blaise Irénée Atipo Ibara Jean-Rosaire Ibara Department of Gastroenterology and Internal Medicine Brazzaville University Hospital Brazzaville Congo Faculty of Health Sciences Marien Ngouabi University Brazzaville Congo

In the absence of interventional endoscopy, the treatment of upper digestive haemorrhages (HDH) at Brazzaville University Hospital is essentially medicinal. The objective of this work was to identify the risk factors for HDH mortality at Brazzaville University Hospital by conducting a retrospective prognostic case-control study over a period of 2 years, from January 2017 to December 2018. The 180 patients included in the study for an HDH were divided into 2 groups according to their evolutionary modality: deceased patients (cases) and non deceased patients (controls). The mortality risk factors were studied by logistic regression. Mortality related to upper digestive haemorrhages was 36.6%;the risk factors for death were age between 30 and 60 years with a (OR: 9.79;95% cI [1.24 - 76.83];p = 0.003);male sex (OR: 2.03;95% cI [1.03 - 4];p = 0.0393);late consultation beyond 24 hours (OR: 6.30;95% cI [2.12 - 18.72];p = 0.0009), blood transfusions (OR: 3.5;95% cI [1.66 - 7.40];p = 0.0001). Protective factors were haemoglobin greater than 7 g/dL (OR: 0.28;95% cI [0.14 - 0.54];p = 0.0001);treatment with proton pump inhibitors (OR: 0.36;95% cI [0.15 - 0.84];p = 0.0191). In conclusion, the reduction of the still high mortality rate in our country requires taking into account the identified risk factors and the acquisition of endoscopic haemostasis equipment.

关键词： Upper Digestive Haemorrhage Mortality Haemostasis Brazzaville

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Depression and Suicidal Risk in HIV-Infected Adults at Brazzaville University Hospital: Prevalence and Associated Factors

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Advances in Infectious Diseases 2024年第1期14卷 24-33页

作者： Bienvenu Rolland Ossibi Ibara Tatia adoua Doukaga Alain M. Mouanga André Moukouma Martin Ekat Parfait Bintsindou Ella Angonga Pabota Princesse Benet Lebaho Bebene Damba Banzuzi Department of Infectious Diseases Brazzaville University Hospital Brazzaville Republic of the Congo Faculty of Health Sciences Marien Ngouabi University Brazzaville Republic of the Congo Department of Neurolgy Brazzaville University Hospital Brazzaville Republic of the Congo

Introduction: Highly active antiretroviral tritherapies have improved the quality of life of people living with HIV (PVVIH) and extended their life expectancy. However, the nervous system is faced with a neurotropic virus that evolves chronically, sometimes creating neurological disorders directly or indirectly linked to stigmatization or therapeutic effects. Objective: to determine the prevalence of depression associated with suicidal risk (SR) and identify associated factors. Patients and method: This was a prospective descriptive and analytical study from January 1 to November 30, 2022, including all HIV-positive patients receiving or not receiving antiretroviral therapy. The study took place in the infectious diseases department of Brazzaville University Hospital. This department has an inpatient capacity of 36 beds, and an outpatient capacity of 25 patients per day, three times a week. This is the largest center for PVVIH in Brazzaville. The Patient Heath Questionnaire 9 (PHQ-9) was used to assess the degree of depression and suicidal risk. Therapeutic adherence was assessed using the Morisky questionnaire. Data were analyzed using SPSS version 23 software. Qualitative variables were expressed as numbers and percentages, and quantitative variables as means and standard deviations. Statistical tests were used according to their applicability criteria. For all tests, the significance threshold was set at 0.05. Results: A total of 150 patients were consulted, constituting the sample size. The prevalence of depression and suicidal risk was 32%. These patients had an average age of 42.83 ± 10.24 years, were female (n = 101;67.3%), christian (n = 97;64%), single (n = 68;45.3%). Stigmatization (n = 75;50%) was the reason for attempted suicide. HIV was perceived as treatable (n = 103;68.7%), unlucky (n = 62;41.3%). Patients were WHO stage 1 (n = 105;70%). RS was present in 47 cases (31.3%). Factors associated with depression and suicidal risk were age (p = 0.000), resi

关键词： Depression Suicidal Risk HIV/AIDS Prevalence Associated Factors

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Antiretroviral Therpay Induced Liver Toxicity among Immunecompromised HIV Patients at chu Brazzaville

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Open Journal of Gastroenterology 2019年第8期9卷 135-140页

作者： Florient Jile Mimiesse clausina Ahoui-Apendi Ngala Akoa Itoua-Ngaporo Ursula Ingride Koukha Lucie charlotte Atipo Ibara Ollandzobo Arnaud Mongo-Onkouo Marlyse Ngalessami-Mouakosso céline adoua Jean Bruno Mokoko Rody Stéphane Ngami Deby-Gassaye Eric Rutaganda Blaise Irénée Atipo Ibara Ibara Jean-Rosaire Faculty of Health Sciences Marien Ngouabi University Brazzaville Congo Gastroenterolgy service University Hospital of Brazzaville Brazzaville Congo Infant pediatric service University Hospital of Brazzaville Brazzaville Congo Medical Depertment University Teaching Hospital Kigali Rwanda college of Medicine and Health Sciences University of Rwanda Kigali Rwanda

Introduction: Human immunodeficiency virus (HIV) infection is a public health problem of concern. Anti-retroviral therapy (ART) is associated with multiple side effects. This study aimed at identifying the different hepatic manifestations of antiretroviral therapy and the responsible molecules. Patients and Methods: This was an eight months period prospective descriptive study, from January 1st to August 31st, 2015, conducted in the Department of Gastroenterology and Internal Medicine at the Brazzaville University Teaching Hospital. Study participants were treatment-na?ve HIV patients who were initiated on ART treatment during the study period. Patients with liver disease, liver cytolysis prior to initiation of therapy, and those with alternative therapy that may cause hepatotoxicity were excluded. The sample size was 110 patients. Results: The age was ranging from 25 to 70 years with a mean age of 47.5 ± 7.5 years. During the six months of follow-up, the alarming hepatic signs were observed in 26.36% of cases (n = 29) in the 3rd month of treatment. There was no observed alarming sign in the 6th month of follow-up. The cytolytic pattern was observed in 54.55% of cases (n = 60) in the 3rd month. The cholestatic pattern was observed in 6.36% of cases (n = 7) in the 3rd month. Triple therapy combination of Zidovudine, Lamivudine and Nevirapine (AZT + 3Tc + NVP) was the most used in 57.27% (n = 63) with a statistically significant p value to the occurrence of cytolytic pattern (p conclusion: Drug induced liver toxicity occurs in a significant number of patients starting ART. The prevalence of hepatic events was high at the third month of treatment and the triple therapy of Zidovudine, Lamivudine and Nevirapine (AZT + 3Tc + NVP) was the most incriminated.

关键词： Drug Induced Liver Toxicity HIV Anti-Retroviral Therapy Brazzaville

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Recurrent Iron Deficiency Anemia Revealing chronic Gastritis with <i>Helicobacter pylori</i>

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Open Journal of Gastroenterology 2021年第2期11卷 47-51页

作者： Jile Florient Mimiesse Ngala Itoua-Ngaporo Arnaud Mongo Onkouo clausina Ahoui Apendi Lucie Atipo Ibara Ollandzobo Marlyse Ngalessami Mouakosso Mardoché Perez Motoula Rody Stéphane Ngami sandra celine adoua Firmin Bossali Deby Gassaye Blaise Irénée Atipo Ibara Jean-Rosaire Ibara Faculty of Health Sciences Marien Ngouabi University Brazzaville Congo Department of Gastroenterology and Internal Medicine University Hospital of Brazzaville Brazzaville Congo

We report a clinical case of a 21-year-old patient with iron deficiency anemia related to Helicobacter pylori (H. pylori) infection. The pan gastritis due to H. pylori and an unexplained iron deficiency anemia has recently been proposed although still discussed. Among the possible causes the role played by this bacterium remains controversial. The diagnosis had been mentioned in view of the recurrence of anemia and confirmed by endoscopic biopsy. Anemia was corrected by iron supplementation associated with a specific treatment of this germ.

关键词： Iron Deficiency Anemia Helicobacter pylori Pangastritis

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Assessment of Practice of colonoscopy in Pediatrics in Brazzaville, congo

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Open Journal of Pediatrics 2022年第3期12卷 577-581页

作者： A. Mongo-Onkouo L. c. Atipo-Ibara Ollandzobo Ikobo c. P. Ahoui Apendi J. F. Mimiesse Monamou N. A. Itoua-N Gaporo Deby Gassaye M. Ngalessami Mouakosso c. S. adoua B. I. Atipo Ibara J. R. Ibara Gastro-Enterology and Internal Medicine CHU of Brazzaville Brazzaville Congo Faculty of Health Sciences Ngouabi Marien University Brazzaville Congo Infant Pediatric Service CHU of Brazzaville Brazzaville Congo

Background: In congo, there is no pediatric gastroenterology department and the activity of colonoscopy has never been evaluated. The aim of this study is to report the indications and the results of pediatric colonoscopy in Brazzaville. Methods: A retrospective study was conducted from January 2016 to August 2017 by analyzing reports of colonoscopy performed in the gastroenterology department in Brazzaville. Sex, prescribers, indications and results of colonoscopy were the variables study. Results: over the 19-month period, 489 colonoscopies have been performed, in which 13 (2.7%) colonoscopies were performed in children under 17 years, with an average age of 9.8 ± 4.6 (8 males and 6 females) and the extreme ranging from 1 - 17 years. The sex ratio (H/F) was 1.6. The prescribers were gastroenterologist (n = 4), pediatrician (n = 4), surgeons (n = 2), general practitioners (n = 2), pediatric students (n = 1). chronic bowel inflammatory diseases and polypectomy was the most frequent conditions for colonoscopy indication. Seven (7) colonoscopies were normal. 4 cases were recto-polyps, and 2 cases were ulcerative colitis. conclusion: pediatric colonoscopy is a powerful diagnostic and therapeutic means. The pediatricians should think about it to improve the management of children with digestive symptoms that meet the indications of pediatric colonoscopy.

关键词： Pediatric colonoscopy Practice Brazzaville

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Seroprevalence and Molecular Biodiversity of Hepatitis B and Delta Virus Infections in the Republic of congo

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Open Journal of Gastroenterology 2018年第12期8卷 448-454页

作者： A. Mongo-Onkouo R. Itoko Okombi A. Boumba F. R. Niama c. P. Ahoui-Apendi J. F. Mimiesse Monamou N. A. Itoua-Ngaporo L. c. Atipo-Ibara Ollandzobo Ikobo Deby Gassaye M. Ngalessami Mouakosso c. S. adoua B. I. Atipo-Ibara J.-R. Ibara Gastro-Enterology and Internal Medicine CHU of Brazzaville Brazzaville Congo Faculty of Health Sciences Ngouabi Marien University Brazzaville Congo Laboratory Service Hospital General of Louandjili Pointe-Noire Congo National Public Health Laboratory Brazzaville Congo Infant Pediatric Service CHU of Brazzaville Brazzaville Congo

Hepatitis B virus (HBV) infection is a major public health problem in the world. In congo, studies on the prevalence of HBV infection are common but HDV infection is rare. Objective: contribute to improve the management and prevention of HBV and HDV infections. Patients and Methods: This was a descriptive and cross-sectional study conducted from January to August 2016 in the health services of the various departments of congo and at the national public health laboratory in Brazzaville. All patients with HBsAg surface antigen who were at least 18 years old and who consented to the study were included. The HBs antigen was first tested by a rapid test then confirmed by ELISA. All HBsAg positive patients were subsequently subjected to a second ELISA test for Delta antibody. The techniques of extraction and conventional and specific gene amplification were carried out on plasma for the identification of the genotypes of the two viruses. The data analysis was done with EpiInfo V7 software. The proportions were compared using the chi-square test or the Fisher test at the significance level of 5%. Results: 1618 subjects were included, of whom 180 were positive for HBsAg, a frequency of 11.12%. The sex ratio (M/F) was 0.77%, the mean age was 40.2 ± 15.6 years with extremes ranging from 18 to 88 years. Of the 180 HBsAg positive, 22 were anti-VHD positive, a frequency of 12.22%. HBV DNA was amplified in 83.8% (151/180), HDV RNA in 63.6% (14/22). For HBV, three genotypes were identified: E (46.9%), A (43.7%) and D (9.4%), however for VHD three genotypes D1, D5, D8 were identified. conclusion: co-infection of hepatitis B and Delta viruses is common in congo. The management and prevention of hepatitis B must take into account the reality of this co-infection.

关键词： Seroprevalence Molecular Biodiversity Hepatitis B Virus and Delta congo

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