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NeCAB family of neuronal calcium-binding proteins in health and disease

Neural Regeneration Research 2025年第5期20卷 1236-1243页

作者： Diones Bueno Michael K.e.Schafer Sudena Wang Michael J.Schmeisser Axel Methner Institute for Molecular Medicine University Medical Center of the Johannes Gutenberg-UniversityMainzGermany Department of Anesthesiology University Medical Center of the Johannes Gutenberg-UniversityMainzGermany Institute of Anatomy University Medical Center of the Johannes Gutenberg-UniversityMainzGermany

The N-terminal.eF-hand calcium-binding proteins 1–3(NeCAB1–3) constitute a family of predominantly neuronal proteins characterized by the presence of at least one eF-hand calcium-binding domain and a functionally less well characterized C-terminal antibiotic biosynthesis monooxygenase domain. All three family members were initially discovered due to their interactions with other proteins. NeCAB1 associates with synaptotagmin-1, a critical neuronal protein invol.ed in membrane trafficking and synaptic vesicle exocytosis. NeCAB2 interacts with predominantly striatal G-protein-coupled receptors, while NeCAB3 partners with amyloid-β A4 precursor protein-binding family A members 2 and 3, key regulators of amyloid-β production. This demonstrates the capacity of the family for interactions with various classes of proteins. NeCAB proteins exhibit distinct subcellular localizations: NeCAB1 is found in the nucleus and cytosol, NeCAB2 resides in endosomes and the plasma membrane, and NeCAB3 is present in the endoplasmic reticulum and Golgi apparatus. The antibiotic biosynthesis monooxygenase domain, an evolutionarily ancient component, is akin to atypical heme oxygenases in prokaryotes but is not wellcharacterized in vertebrates. Prokaryotic antibiotic biosynthesis monooxygenase domains typically form dimers, suggesting that calcium-mediated conformational changes in NeCAB proteins may induce antibiotic biosynthesis monooxygenase domain dimerization, potentially activating some enzymatic properties. However, the substrate for this enzymatic activity remains uncertain. Al.ernatively, calcium-mediated conformational changes might infl.ence protein interactions or the subcellular localization of NeCAB proteins by controlling the availability of protein–protein interaction domains situated between the eF hands and the antibiotic biosynthesis monooxygenase domain. This review summarizes what is known about genomic organization, tissue expression, intracellular localization, interac

关键词： calcium eF hand mitochondria nervous system signal transduction

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Monte Carlo generator photon jets used for luminosity at e^+e^- colliders

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Chinese Physics C 2010年第6期34卷 877-882页

作者： G.V.Fedotovich e.A.Kuraev A.l.Sibidanov Budker Institute of Nuclear Physics Novosibirsk State University Joint Institute of Nuclear Research

A Monte-Carlo Generator Photon Jets （MCGPJ） to simulate Bhabha scattering as well as production of two charged muons and two photons events is discussed. The theoretical precision of the cross sections with radiative corrections （RC） is estimated to be smal.er than 0.2%. The Next leading Order （NlO） radiative corrections proportional to α are treated exactly, whereas the all logarithmically enhanced contributions, related to photon jets emitted in the collinear region, are taken into account in frame of the Structure Function approach. Numerous tests of the MCGPJ as well as a detailed comparison with other MC generators are presented.

关键词： luminosity e^+e^- hadrons detectors

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Recent Advancements in the Optimization Capacity Configuration and Coordination Operation Strategy of Wind-Solar Hybrid Storage System

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energy engineering 2025年第1期122卷 285-306页

作者： Hongliang Hao Caifeng Wen Feifei Xue HaoQiu Ning Yang Yuwen Zhang Chaoyu Wang edwin e.Nyakilla Department of New energy Storage Peking University Ordos Research Institute of EnergyOrdos017010China School of energy and Power engineering Inner Mongolia University of TechnologyHohhot010080China Key laboratory of Wind energy and Solar energy Utilization Technology Inner Mongolia University of TechnologyHohhot010051China

Present of wind power is sporadically and cannot be utilized as the only fundamental load of energy *** paper proposes a wind-solar hybrid energy storage system(HeSS)to ensure a stable supply grid for a longer period.A multi-objective genetic algorithm(MOGA)and state of charge(SOC)region division for the batteries are introduced to sol.e the objective function and configuration of the system capacity,***/Simulink was used for simulation *** optimization results show that for a 0.5 MW wind power and 0.5 MW photovoltaic system,with a combination of a 300 Ah lithium battery,a 200 Ah lead-acid battery,and a water storage tank,the proposed strategy reduces the system construction cost by approximately 18,000 ***,the cycle count of the electrochemical.energy storage systemincreases from4515 to 4660,while the depth of discharge decreases from 55.37%to 53.65%,achieving shallow charging and discharging,thereby extending battery life and reducing grid voltage fluctuations *** proposed strategy is a guide for stabilizing the grid connection of wind and solar power generation,capability allocation,and energy management of energy conservation systems.

关键词： electric-thermal hybrid storage modal decomposition multi-objective genetic algorithm capacity optimization allocation operation strategy

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Merging bound states in the continuum in an open acoustic resonator

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 124-131页

作者： lujun Huang Bin Jia Artem S.Pilipchuk Sibo Huang Chen Shen Almas F.Sadreev Yong li Andrey e.Miroshnichenko School of Physics and electronic Sciences East China Normal University Institute of Acoustics Tongji University l.V.Kirensky Institute of Physics Department of Mechanical.engineering Rowan University School of engineering and Technology University of New South Wales at Canberra

Bound states in the continuum （BICs） are perfectly localized resonances despite embedding in the continuum ***,an isolated BIC is very sensitive to the structure ***,we report merging acoustic BICs in a single open resonator,robust against the structure *** find that both symmetry-protected BIC and Friedrich-Wintgen BIC are sustained in a single coupled waveguide-resonator *** varying the height and length of the resonator,these two BICs move toward each other and merge into a single one at a critical *** to an individual BIC,the merged BIC is robust against fabrication error because its Q-factor is proportional to Δl-4,whereΔl.embodies the structure *** essence of this extraordinary phenomenon is perfectly explained by the two-and three-level approximations of the effective nonHermitian ***,we present direct experimental demonstrations of the moving and merging of BICs in a coupled 3D waveguide-resonator,which are evidenced by the vanishing of the linewidth of Fano resonance in the transmission *** results may find exciting applications in designing high-quality acoustic sources,sensors and fil.ers.

关键词： acoustic resonances bound state in the continuum high-Q resonances

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enhancing perianal disease management with integrated physical and psychological approaches

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World Journal of Clinical Cases 2025年第2期13卷 59-63页

作者： Uchenna e Okpete Haewon Byeon Department of Digital Anti-aging Healthcare(BK21) Inje UniversityGimhae 50834South Korea

This article provides a comprehensive analysis of the study by Hou et al,focusing on the complex interplay between psychological and physical factors in the postoperative recovery(POR)of patients with perianal *** study sheds light on how ill.ess perception,anxiety,and depression significantly infl.ence recovery *** et al developed a predictive model that demonstrated high accuracy in identifying patients at risk of poor *** article explores the critical role of pre-operative psychological assessment,highlighting the need for mental health support and personalized recovery plans in enhancing POR quality.A multidisciplinary approach,integrating mental health professionals with surgeons,anesthesiologists,and other specialists,is emphasized to ensure comprehensive care for *** study’s findings serve as a call to integrate psychological care into surgical practice to optimize outcomes for patients with perianal diseases.

关键词： Perianal disease Post-operative recovery Anxiety Depression Pain management emotional well-being Multidisciplinary approach

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An efficient Boron Source Activation Strategy for the low‑Temperature Synthesis of Boron Nitride Nanotubes

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Nano-Micro letters 2025年第1期17卷 548-558页

作者： Ying Wang Kai Zhang liping Ding liyun Wu Songfeng e Qian He Nanyang Wang Hui Zuo Zhengyang Zhou Feng Ding Yue Hu Jin Zhang Yagang Yao National laboratory of Solid State Microstructures College of Engineering and Applied SciencesJiangsu Key Laboratory of Artificial Functional Materialsand Collaborative Innovation Center of Advanced MicrostructuresNanjing UniversityNanjing 210093People’s Republic of China School of electronic Information and Artificial Intelligence Shaanxi University of Science&TechnologyXian 710000People’s Republic of China Col.ege of Bioresources Chemical and Materials engineering Shaanxi University of Science&TechnologyXian 710000People’s Republic of China Key laboratory of Carbon Materials of Zhejiang Province College of Chemistry and Materials EngineeringWenzhou UniversityWenzhou 325000People’s Republic of China Shenzhen Institutes of Advanced Technology Chinese Academy of SciencesShenzhen 518000People’s Republic of China Col.ege of Chemical and Molecular engineering Peking UniversityBeijing 100871People’s Republic of China

lowering the synthesis temperature of boron nitride nanotubes(BNNTs)is crucial for their *** primary reason for adopting a high temperature is to enable the effective activation of highmelting-point solid *** this study,we developed a novel approach for efficiently activating boron by introducing alkali metal compounds into the conventional MgO–B *** approach can be adopted to form various low-melting-point AM–Mg–B–O growth *** growth systems have improved catalytic capability and reactivity even under low-temperature conditions,facilitating the synthesis of BNNTs at temperatures as low as 850℃.In addition,molecular dynamics simulations based on density functional theory theoretically demonstrate that the systems maintain a liquid state at low temperatures and interact with N atoms to form BN *** findings offer novel insights into the design of boron activation and are expected to facilitate research on the low-temperature synthesis of BNNTs.

关键词： Boron nitride nanotubes low-temperature Boron activation Density functional theory

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Optimization of Pul.e laser Annealing to Increase Sharpness of Implanted-junction Rectifier in Semiconductor Heterostructure

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Nano-Micro letters 2010年第4期2卷 256-267页

作者： e.l.Pankratov Nizhny Novgorod State University of Architecture and Civil.engineering

It has been recently shown that inhomogeneity of a semiconductor heterostructure leads to increasing of sharpness of diffusion-junction and implanted-junction rectifiers,which are formed in the semiconductor *** has been also shown that together with increasing of the sharpness,homogeneity of impurity distribution in doped area *** both effect could be increased by formation of an inhomogeneous distribution of temperature(for example,by laser annealing).Some conditions on correlation between inhomogeneities of the semiconductor heterostructure and temperature distribution have been *** time has been optimized for pul.e laser annealing.

关键词： Pul.e laser Implanted-juction rectifier Heterostructure

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Fish embryo and juvenile size under hypoxia in the mouth- brooding African cichlid Pseudocrenilabrus multicolor

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Current Zoology 2012年第3期58卷 401-412页

作者： e.e. ReARDON l.J. CHAPMAN Department of Biology McGill University 1205 Dr. Penfield Ave Montreal Quebec H3A 1B 1 Canada Wildlife Conservation Society 2300 Southern Boulevard Bronx NY 10460 USA

We used a field survey and a laboratory rearing experiment to （a） examine response （size and survival） to life-long hypoxia in offspring of the African maternal mouth-brooding cichlid Pseudocrenilabrus multicolor victoriae （Seegers） and （b） explore the degree to which developmental response can be environmentaUy-induced. embryo size metrics were quantified in 9 field populations across a range of dissol.ed oxygen （DO） concentrations. In the laboratory, first generation （F1） broods of low-DO origin were reared under high or low DO. Brooding period was quantified for the mothers; and egg size, egg metabolic rate and juvenile size-at-release were quantified in their （F2） offspring. The F2 offspring were split and grown for 3 months post-release under high or low DO, and juvenile size and survival were quantified. In the field survey, across stages, embryos from low-DO field populations were shorter and weighed less than embryos from high-DO populations. In the laboratory experi- ment, F2 eggs and juveniles-at-release from mother＇s mouth did not differ in mass, length, survival regardless of development DO environment. However, juveniles diverged in size after leaving mother＇s mouth, exhibiting smal.er size when grown under low DO. Size differences in embryo size across field populations and divergence in embryo size after release from the mother＇s mouth support predictions for smal.er body size under hypoxia. There was no evidence for negative effects on survival of juveniles after 3 months. Brooding period was 16% shorter in females reared under low DO suggesting that hypoxia may accelerate embryo de- velopment. This work provides insights into how bearer fishes respond to hypoxic stress relative to fishes with no post-spawning parental care; a shorter brooding interval and smal.er body size may provide an optimal solution to parent and embryo survival under hypoxia in brooding fishes [Current Zoology 58 （3）： 401-412, 2012].

关键词： African cichlid lake Victoria life-history Parental care Dissol.ed oxygen

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Faddeev calculations on lambda hypertriton with potentials from Gel'fand–levitan–Marchenko theory

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Communications in Theoretical Physics 2020年第10期72卷 119-124页

作者： e F Meoto M l lekala Department of Physics University of South AfricaPrivate Bag X61710 JohannesburgSouth Africa

effective lambda-proton and lambda-neutron potentials,restored from theoretical scattering phases through Gel'fand–levitan–Marchenko theory,are tested on a lambda hypertriton through three-body *** lambda hypertriton is treated as a three-body system consisting of lambda-proton,lambda-neutron and proton–neutron *** energy and root mean square radius are computed for the ground state of lambda hypertriton(Jp=12+).In coordinate space,the dynamics of the system is described using a set of coupled hyperradial.equations obtained from the differential Faddeev *** solving the eigenval.e problem derived from this set of coupled hyperradial.equations,the binding energy and root mean square matter radius computed are found to be-2.462 MeV and 7.00 fm,*** potentials are also shown to display a satisfactory convergence behaviour.

关键词： lambda-nucleon potential lambda-proton potential lambda-neutron potential lambda hypertriton Faddeev equations hyperspherical method

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Changes in phototactic behavior of Daphnia magna clone C_1242 in response to copper, cadmium and pentachlorophenol

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Journal of environmental Sciences 2003年第6期15卷 841-847页

作者： YUANling e.Michels l.DeMeester CallaveofResoureesandenvironment.SouthwestAmriculturalUniversity Chongcling400716China. laboratoryofecologyandAquaculture KatholiekeUniversiteitLeuvenBelgium

In order to develop a sound biotechnique for monitoring water quality that builds on the previous experiments carried out in our laboratory, a specific D. magna clone C 1242 was used to study the effects of pollutants on phototactic behavior. In all.experiments, the animals showed a stable and repeatable phototactic index approximated 0.2 in the presence and 0.4 in the absence of fish kairomones, which decreased significantly in response to pollutants. There existed no pollutant×fish kairomone interaction, indicating the changes in phototactic behavior of animals imposed by pollutants were independent of the presence of fish kairomones. The detection limits for changes in phototactic behavior of D. magna clone C 1242 are 0.04 mg/l for copper, 0.02 mg/l for cadmium, and 0.80 mg/l for PCP, respectively, quite lower than lC 50(48 h). The changes in phototactic behavior in presence to pollutants occurred quickly(3 h) compared to the period over whole acute toxicity tests. Therefore, D. magna clone C 1242 could be potentially used to monitor water quality. Moreover, the phototactic behavior did not decrease further in the pollutant mixtures employed in our experiments compared to individual pollutants, except in the Cd-PCP treatment. This fact suggests that the formation of water quality criteria must be based upon pollutant mixture tests.

关键词： Daphnia phototactic behavior copper cadmium pentachlorophenol fish kairomones

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