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Impact of high glucose on metastasis of colon cancer cells

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World Journal of Gastroenterology 2015年第7期21卷 2047-2057页

作者： Cheng-Yao Lin Chih-Hui lee Chien-Cheng Huang Song-Tay lee How-Ran Guo Shih-Bin su Division of Hematology-Oncology Department of Internal Medicine Chi Mei Medical Center Department of Dental Laboratory Technology Min-Hwei College of Health Care Management Department of Public Health National Cheng Kung University Department of Emergency Medicine Chi-Mei Medical Center Department of Child Care and Education Southern Taiwan University of Science and Technology Department of Biotechnology Southern Taiwan University of Science and Technology Department of Environmental and Occupational Health National Cheng Kung University Department of Occupational Medicine Chi-Mei Medical Center Department of Medical Research Chi Mei Medical Center

AIM:To investigate the possible mechanism of how glucose promotes invasion and metastasis of colon cancer ***:CT-26 rat colorectal cancer cells were cultured in different concentrations of glucose environments(10,20,and 30 mmol/L).Wound healing assay and transwell chamber invasion assay were utilized to test the migration and invasion,*** order to understand the role of signal transducer and activator of transcription 3(STAT3)in the process,STAT3 inhibitors,including Stattic(an STAT3 specific inhibitor)and small interfering RNA targeting STAT3,were used to block STAT3 function to evaluate their impact on CT-26 cell *** verify whether STAT3 and matrix metalloproteinase-9(MMP-9)protein expression is associated with glucose-induced cell movement,Western blot was used to compare the differences in the expression of MMP-9 and STAT3 in cells incubated with and without STAT3 inhibitors in high glucose ***:In both wound healing and invasion assays,the migration and invasion of CT-26 cells increased gradually with the increase in glucose ***,the glucose-induced migration and invasion were obviously inhibited by STAT3 inhibitors(P0.05).When STAT3inhibitors were added in the 30 m M glucose group,not only STAT3 but also MMP-9 expression decreased significantly(P<0.05).CONCLUSION:Our study provides evidence that glucose can promote both migration and invasion of CT-26 cells,and that the STAT3-induced MMP-9 signal pathway is involved in this process.

关键词： Colorectal cancer Glucose Signal transducer and ac

Clinicopathological characteristics in the differential diagnosis of hepatoid adenocarcinoma:A literature review

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World Journal of Gastroenterology 2013年第3期19卷 321-327页

作者： Jiann-Sheng su Yu-Tso Chen Ren-Ching Wang Chun-Ying Wu Shou-Wu lee Teng-Yu lee Division of Gastroenterology and Hepatology Kuang Tien General Hospital Division of Gastroenterology and Hepatology Taichung VeteransGeneral Hospital Department of Pathology and LaboratoryMedicine Taichung Veterans General Hospital Graduate Institute of Clinical Medical Science China Medical University Department of Medicine Chung Shan Medical University Division of Gastroenterology and Hepatology Taichung Veterans General Hospital

Hepatoid adenocarcinoma (HAC) is a rare but important special type of extrahepatic adenocarcinoma with clinicopathological presentation mimicking hepatocellular carcinoma (HCC), and prompt and correct diagnosis can be a challenge, especially in endemic areas with a high incidence of HCC. To date, HAC has only been reported in case series or single case reports, so we aimed to review the clinicopathological characteristics of HAC to obtain a more complete picture of this rare form of extrahepatic adenocarcinoma. All the articles about HAC published from 2001 to 2011 were reviewed, and clinicopathological findings were extracted for analysis. A late middle-aged male with high serum α-fetoprotein and atypical image finding of HCC should raise the suspicion of HAC, and characteristic pathological immunohistochemical stains can help with the differential diagnosis. Novel immunohistochemical markers may be useful to clearly differentiate HAC from HCC. Once metastatic HAC is diagnosed, the primary tumor origin should be identified for adequate treatment. The majority of HAC originates from the stomach, so panendoscopy should be arranged first.

关键词： Hepatocellular carcinoma Alpha-fetopro-tein-producing tumor Alpha fetoprotein Gastric adeno-carcinoma Pathology

Fabrication of Transparent Conducting Electrode Pattern by Metal Mesh Method on Stretchable Film substrate

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Materials Sciences and Applications 2019年第5期10卷 393-405页

作者： Gun-Woo lee Dock Young lee byung Chan lee Kyungha Baek Genggongwo Shi Jeseob Kim lee Soon Park su Yong Nam Green Ind. Co. Ltd. Changwon South Korea ELK Corporation Daejeon South Korea Daegu Technopark Daegu South Korea School of Materials Science and Engineering Ulsan National Institute of Science and Technology (UNIST) Ulsan South Korea CCTech Inc. Hwaseong South Korea Department of Graphic Arts Information Engineering Pukyong National University Busan South Korea

Smart phones have become one of major electronic devices for human being. The easy and rapid exchange of information between man and machine is carried out by the touch screen panel (TSP) installed in the smart phones. Currently the smart phones are widely spread out while displays for automobiles are in the initial stage of developments. Since the automobile displays should fit the curved area of indoor space of the vehicle, the TSPs for automobiles need to be fabricated on the flexible and stretchable substrate film. In this study, we selected the thermo-plastic polyurethane film as the substrate film and examined the materials and process for fabrication of metal mesh type transparent conducting electrode films suitable for TSPs of automobile displays. The optimum UV resin system was established by the evaluation of various UV resin formulations in the UV imprinting process to make 3 × 3.5 μm trench patterns on the metal mesh type electrode film utilizing the embossed metal mask plate. The Ag paste has also been prepared by synthesis of Ag nanoparticles and formulation with the binder polymers. The inlay (filling) of Ag paste in the trench layer of transparent electrode film showed that the variation of electrical resistance was within 10% upon bending up to 100,000 times to radius of 3 mm.

关键词： Touch Screen Panel Silver Paste Stretchable substrate Film UV Imprinting UV Resin Formulation

Taxonomic study of Favolus and Neofavolus gen. nov. segregated from Polyporus (Basidiomycota, Polyporales)

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Fungal Diversity 2013年第1期58卷 245-266页

作者： Kozue Sotome Yasunori Akagi su See lee Noemia K.Ishikawa Tsutomu Hattori Fungus/Mushroom Resource and Research Center Faculty of AgricultureTottori UniversityMinami 4-101KoyamaTottoriTottori 680-8553Japan Laboratory of plantpathology Faculty of AgricultureTottori UniversityMinami 4-101KoyamaTottoriTottori 680-8553Japan Mycology and Pathology Forestry DivisionForest Research Institute Malaysia(FRIM)Kepong 52109 SelangorMalaysia Coordenação de Biodiversidade Instituto Nacional de Pesquisas da Amazônia(INPA)Av.AndréAraújo2.936PetrópolisCEP 69060-001ManausAMBrazil Kansai Research Center Forestry and Forest Products Research InstituteNagai-KyutaroMomoyamaFushimiKyoto 612-0855Japan

We present a taxonomic study of‘group Favolus’and related species in *** analyses of nurLsu and ITS regions revealed that the infrageneric‘group Favolus’is divided into two main *** within the group share laterally stipitate basidiocarps,with non-crustose stipe surfaces,and are distinguishable by the morphology of the pileus *** clade is characterized by species with hyaline to brown cutis,composed of hyaline to brown agglutinated generative *** other clade accommodates species with radially striate pileus,and lacks any distinct cutis of agglutinated *** propose Neofavolus ***.,typified by ***,for the former clade,and revise the genus Favolus,typified by ***,for the latter *** includes *** and *** ***.,known only from temperate eastern Asia,in addition to *** includes members of the Polyporus grammocephalus complex,the *** complex,and *** reveal that the polypore known as‘***’in Asia includes *** and ***(0 ***),whereas‘***’includes three distinct species;*** from tropical America,and *** and *** from tropical *** descriptions and illustrations are provided for the accepted species in Favolus and Neofavolus.

关键词： Polypores Polyporaceae Type study Wooddecaying fungi

Effect of CuO addition on microstructure and properties of aluminum composites produced by quick spontaneous infiltration process

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China Foundry 2014年第3期11卷 191-196页

作者： Zhang Jingjing lee Jung-Moo Cho Young-Hee Kim su-Hyeon Yu Huashun Key Laboratory of Liquid Structure and Heredity of Materials Ministry of Education Shandong University Light Metal Division Korea Institute of Materials Science

Al matrix composites with a high volume fraction of reinforcements were fabricated with a compact of Al-Ti-B4C powder mixtures by quick spontaneous infiltration(QSI) process in an aluminum melt. Given the exothermal nature of the reaction between CuO and Al, a certain amount of CuO addition to the Al-Ti-B4C system dramatically increases the adiabatic temperature and thereby enables the complete combustion reaction in an aluminum melt(about 1,173 K). After the QSI process, the compact fabricated with CuO retains its original shape and the obtained composite exhibits sound microstructure containing reaction products of TiB2, Al3BC and B4C. The formation of such reinforcements when adding CuO contributes to enhancing the properties of the composites that show far superior hardness and elastic modulus of 3.03 GPa and 158.9 GPa, respectively, with lower coefficient of thermal expansion(9.44 ppm?K-1) compared to those with no CuO addition.

关键词： Al composite CuO addition Al-Ti-B4C microstructure mechanical properties

Generation and measurement of arbitrary four-dimensional spatial entanglement between photons in multicore fibers

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Photonics Research 2019年第1期7卷 19-27页

作者： HEE JUNG lee HEE su PARK Korea Research Institute of Standards and Science(KRISS) Agency for Defense Development

High-dimensional entanglement is a valuable resource for secure and efficient quantum information processing.A major challenge for practical use of multidimensional quantum systems is the establishment of controls over arbitrary superposition states in realistic conditions. This work demonstrates spatially entangled photon pairs propagating through two separate four-core optical fibers with the amplitudes and phases of the superposition being independently controllable. Using quantum state analyzers that can detect arbitrary multicore superposition states, Bell-type CGLMP inequalities in two, three, and four dimensions are directly tested. Enhanced violation of the inequality by slight nonmaximality of entanglement is also demonstrated.

关键词： High-dimensional entanglement efficient quantum demonstrates spatially

Fabrication and characterization of 3D scaffold using 3D plotting system

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Chinese Science Bulletin 2010年第1期55卷 94-98页

作者： lee Jun-Hee PARK su-A PARK KoEun KIM Jae-Hyun KIM Kyung-Shik lee Jihye Kim WanDoo Bio-Mechatronics Team Division of Nano-Machinery Korea Institute of Machinery and Materials (KIMM) Nano-Mechanics Team Division of Nano-Machinery Korea Institute of Machinery and Materials (KIMM) Nano-Mechatronics Team Division of Nano-Machinery Korea Institute of Machinery and Materials (KIMM)

In this paper, we design and fabricate a 3D scaffold using rapid prototyping (RP) technology for tissue engineering. The scaffold should have a three-dimensional interconnected pore network. We fabricate a polycaprolactone (PCL) scaffold with interconnecting pores and uniform porosity for cell ingrowth using a 3D plotting system. In order to keep the three dimensional shape under mechanical loading while implanted, we design an oscillating nozzle system to increase elastic modulus and yield strength of PCL strand. We characterize the influence of pore geometry, compressive modulus of the scaffold, elastic modulus and yield strength of the strand using SEM, dynamical mechanical analysis (DMA) and Nano-UTM. Finally the cell responses on scaffolds are observed.

关键词：三维形状绘图系统表征支架制作动态机械分析弹性模量细胞反应

CT Brain Image:Abnormalities Recognition and Segmentation

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Journal of Donghua University(English Edition) 2010年第2期27卷 246-249页

作者： TONG Hau-lee Mohammad Faizal Ahmad Fauzi Ryoichi Komiya HAW su-Cheng Faculty of Information Technology Multimedia UniversityJalan Multimedia Faculty of Engineering Multimedia UniversityJalan Multimedia

In order to develop an automated segmentation system for Computed Tomography （CT） brain images, a new approach which consists of several unsupervised segmcotation techniques was introduced. The system segments the CT brain images into three partitions, i. e., abnormalities, cerebrospinal fluid （CSF）, and brain matter. Our approach consists of two phase-segmentation methods. In the first phase segmentation, k-means and fuzzy cmeans （FCM） methods were implemented to segment and transform the images into the binary images. Based on the connected component in binary images, a decision tree was employed for the annotation of normal or abnormal regions. In the second phase segmentation, the modified FCM with population-diameter independent （PDI） segmentation was applied to segment the images into CSF and brain matter. The experimental results have shown that our proposed system is feasible and yield satisfactory results.

关键词： computed tomography ursupervised segmentation k-means fuzzy c-means population-diameter indepentdent

Effects of Cu addition on formability and surface delamination phenomenon in high-strength high-Mn steels

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Journal of Materials Science & Technology 2020年第8期36卷 44-51页

作者： Min Chul Jo Jisung Yoo Min Cheol Jo Alireza Zargaran Seok su Sohn Nack J.Kim sunghak lee Center for Advanced Aerospace Materials Pohang University of Science and TechnologyPohang 37673South Korea Graduate Institute of Ferrous Technology Pohang University of Science and TechnologyPohang 37673South Korea Department of Materials Science and Engineering Korea UniversitySeoul 02841South Korea

The formability of austenitic high-Mn steels is a critical issue in automotive applications under nonuniformly-deformed environments caused by dynamic strain *** austenite stabilizing alloying elements in those steels,Cu has been known as an effective element to enhance tensile properties via controlling the stacking fault energy and stability of *** effects of Cu addition on formability,however,have not been sufficiently reported *** this study,the Cu addition effects on formability and surface characteristics in the austenitic high-Mn TRIP steels were analyzed in consideration of inhomogeneous microstructures containing the segregation of Mn and *** reveal determining factors,various mechanical parameters such as total elongation,post elongation,strain hardening rate,normal anisotropy,and planar anisotropy were correlated to the hole-expansion and cup-drawing test *** respect to microstructural parameters,roles of(Mn,Cu)-segregation bands and resultant Cu-rich FCC precipitates on the formability and surface delamination were also discussed.

关键词： High-Mn steel Cu effects Cu-rich FCC phase Hole-expansion test Formability Stretch-flangeablity surface delamination