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Clinicopathologic factors and molecular markers related to lymph node metastasis in early gastric cancer

World Journal of Gastroenterology 2015年第2期21卷 571-577页

作者： Eun Hyo Jin Dong ho Lee Sung-Ae Jung Ki-nam Shim Ji Yeon Seo Nayoung Kim Cheol Min Shin Hyuk Yoon Hyun Chae Jung Department of Internal Medicine and Liver Research Institute Seoul National University College of MedicineSeoul 110-744South Korea Department of Internal Medicine Seoul National University Bundang HospitalGyeonggi-do 463-707South Korea Department of Internal Medicine Ewha Womans University College of MedicineSeoul 158-710South Korea

AIM: To analyze predictive factors for lymph node metastasis in early gastric ***: We analyzed 1104 patients with early gastric cancer(EGC) who underwent a gastrectomy with lymph-node dissection from May 2003 through July 2011. The clinicopathologic factors and molecular markers were assessed as predictors for lymph node metastasis. Molecular markers such as microsatellite instability, human mut L homolog 1, p53, epidermal growth factor receptor(EGFR) and human epidermal growth factor receptor 2(HER2) were included. The χ2 test and logistic regression analysis were used to determine clinicopathologic ***: Lymph node metastasis was observed in 104(9.4%) of 1104 patients. Among 104 cases of lymph node positive patients, 24 patients(3.8%) were mucosal cancers and 80 patients(16.7%) were submucosal. According to histologic evaluation, the number of lymph node metastasis found was 4(1.7%) for well differentiated tubular adenocarcinoma, 45(11.3%) for moderately differentiated tubular adenocarcinoma, 36(14.8%) for poorly differentiated tubular adenocarcinoma, and 19(8.4%) for signet ring cell carcinoma. Of 690 EGC cases, 77 cases(11.2%) showed EGFR overexpression. HER2 overexpression was present in 110 cases(27.1%) of 406 EGC patients. With multivariate analysis, female gender(OR = 2.281, P = 0.009), presence of lymphovascular invasion(OR = 10.950, P hovascular invasion and EGFR overexpression were predictive risk factors for lymph node metastasis in EGC.

关键词： Receptor Epidermal growth factor Stomach neoplasms

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Mass-forming ischemic colitis that mimics colon cancer

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Chinese Medical Journal 2020年第10期133卷 1253-1254页

作者： ho Seung Kim Fozan Sauri Jae Hyun Kang nam Kyu Kim Division of Colorectal Surgery Department of SurgerySeverance HospitalYonsei University College of MedicineSeoul 03722Korea.

To the Editor:Rarely,ischemic colitis can also mimic a carcinoma during colonoscopy and on computed tomography(CT)*** colonoscopy,an ulceration,a submucosal mass,and a narrowed colon segment with an ulcerated mucosa have all been described as mimicking this kind of *** reports have documented this type of mass-forming ischemic colitis variant.[1-4]Here,we described two patients with ischemic colitis who presented with lesions mimicking colon cancer.

关键词： colon cancer. colitis

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Orthokeratology lens related infections

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World Journal of Ophthalmology 2014年第3期4卷 63-70页

作者： Kelvin ho-nam Wan Vishal Jhanji Alvin L Young Department of Ophthalmology Tuen Mun Hospital and Tuen Mun Eye Center Department of Ophthalmology and Visual Sciences The Chinese University of Hong Kong Department of Ophthalmology and Visual Sciences Prince of Wales Hospital Alice ho Liu Ling Nethersole hospital

Orthokeratology is a reversible technique that temporarily changes the curvature of the cornea with the aim of addressing refractive errors. The United States Food and Drug Administration(FDA) granted approval for using reverse geometry contact lenses to correct myopia without any age restriction. Information from the pre-market applications to the FDA was rated as level Ⅱ evidence. Another unapproved use of overnight orthokeratology is for the prevention of myopic progression. Although orthokeratology is advocated to reduce myopic progression, there are limited long-term studies with substantial evidence of its benefits. Much of this evidence comes from non-robust experimental studies using historical or self-selected controls with relative high dropout rates. Although some positive results have been published in temporarily reducing the myopic refractive error and its progression, the use of these lenses can be associated with serious complications such as microbial keratitis. Microbial keratitis is a potentially vision-threatening adverse response associated with contact lens wear. In fact, contact lens wearhas been shown to be the predominant risk factor of microbial keratitis in some developed countries. Most of the published cases on overnight orthokeratology related microbial keratitis occurred in children or adolescents. Parents considering orthokeratology must make an informed decision about its temporary benefit and its potential for permanent loss of vision. The ophthalmic community should be reminded of the potential complications of orthokeratology.

关键词： Orthokeratology Infections Microbial keratitis Cornea Corneal ulcer Contact lens Myopia

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Adsorption Isotherms of Quercetin and Catechin Compounds on Quercetin-MIP

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Chemical Research in Chinese Universities 2007年第4期23卷 412-416页

作者： ROW Kyung ho Center for Advanced Bioseparation Technology and Department of Chemical Engineering Inha University253 Yonghyun-DongNam-KuIncheon 402-751Korea

A molecular imprinted polymer（MIP） was prepared with quereetin as the template and methaerylie acid（MAA） as the functional monomer. Aeetonitrile and methanol were used as the porogen with ethylene glycol dimethaerylate （EGDMA） as the erosslinker and 2,2＇-azobis （ isobutyronitrile ）（ AIBN ） as the initiator. The experimental parameters of the equilibrium isotherms were estimated via linear and nonlinear regression analyses. The linear equadon as the functions of the adsorption concentration of the single compound in its solution and the competitive adsorption of the single compound in its mixed compounds solution was then expressed, and the adsorption equilibrium data were correlated to Langmuir and Freundlich isotherm models. The mixture compounds show competitive adsorption on the specific binding sites of quereetin-MIP. Furthermore, the competitive Langmnir isotherms were applied to the mixture compounds. The adsorption concentrations of quercetin, （＋）eatechin（＋C）, and （-）epieateehin（EC） on the quercetin molecular imprinted polymer were compared. The quercetin-imprinted polymer shows extraordinarily higher adsorption ability for quercetin than for the two eateehin compounds that were also assessed.

关键词： Adsorption isotherm Molecular imprinted polymer Quercetin (+) Catechin (-) Epicatechin

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A Secure Routing Method for Detecting False Reports and Wormhole Attacks in Wireless Sensor Networks

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Wireless Sensor Network 2013年第3期5卷 33-40页

作者： Hyeon Myeong Choi Su Man nam Tae ho Cho College of Information and Communication Engineering Sungkyunkwan University Suwon South Korea

Wireless sensor networks (WSNs) consist of a large number of sensor nodes that monitor the environment and a few base stations that collect the sensor readings. Individual sensor nodes are subject to compromised security because they may be deployed in hostile environments and each sensor node communicates wirelessly. An adversary can inject false reports into the networks via compromised nodes. Furthermore, an adversary can create a wormhole by directly linking two compromised nodes or using out-of-band channels. If these two kinds of attacks occur simultaneously in a network, existing methods cannot defend against them adequately. We thus propose a secure routing method for detecting false report injections and wormhole attacks in wireless sensor networks. The proposed method uses ACK messages for detecting wormholes and is based on a statistical en-route filtering (SEF) scheme for detecting false reports. Simulation results show that the proposed method reduces energy consumption by up to 20% and provide greater network security.

关键词： Wireless Sensor Network Security Statistical En-Route Wormhole Secure Routing

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Performance evaluation of a two-way relay network with energy harvesting^and hardware noises

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Digital Communications and Networks 2021年第1期7卷 45-54页

作者： Nguyen Tien Tung Pham Minh nam Phu Tran Tin Faculty of Electronics Technology Industrial University of Ho Chi Minh CityHo Chi Minh CityVietnam Wireless Communcations Research Group Faculy of Electrical and Electronics EngineeringTon Duc Thang UniversityHo Chi Minh CityVietnam

In this paper,we propose a Two-Way Cognitive Relay Network(TWCRN)where the secondary users operate on an underlay mode to access the licensed *** the proposed protocols,two secondary sources transmit their data to a relay in the first time slot,and then the relay would forward the received information to both sources in the remaining ***,the relay is self-powered by harvesting energy from ambient Radio Frequency(RF)signals,using the Time Switching(TS)and the Power Switching(PS)*** paper concentrates on eval-uating the performance of the secondary networks under the impact of hardware impairments and co-channel interference from the primary *** particular,based on the secondary transmitters'constraint power,we derive the closed-form expressions of the outage probability and the throughput over Rayleigh fading channels in two cases:TS and *** also investigate the energy efficiency issue and the locally optimal position of the relay to maximize the system throughput,which provides much information to install the relay ***,our derivations are verified by Monte Carlo simulation.

关键词： Energy harvesting Two-way relay Energy efficiency Hardware impairments Cognitive network

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Corneal transplantation: Beyond the horizon

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World Journal of Ophthalmology 2015年第2期5卷 36-44页

作者： Kelvin ho-nam Wan Evan Po-Fat Yiu Alvin L Young Department of Ophthalmology Tuen Mun Eye Centre and Tuen Mun Hospital Department of Ophthalmology and Visual Sciences the Chinese University of Hong Kong Department of Ophthalmology and Visual Sciences Prince of Wales Hospital and Alice Ho Liu Ling Nethersole Hospital

Evolving techniques in keratoplasty have undoubtedly led to thinner corneal grafts. These newer iterations of keratoplasty aim to reduce graft rejections, improve visual acuity and visual rehabilitation. Each technique poses its own advantages and disadvantages; the surgeon should select patients suitable for a particular technique while accounting for their surgical competency given the learning curve associated with these newer techniques. Alternatives to corneal transplant may have a role in addressing the shortages of corneal graft, these bioengineered material and medical treatment still need further studies to demonstrate its clinical applicability.

关键词： Cornea Cell therapy Keratoplasty Bullous keratopathy Techniques

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A Comparison of Brain Activity between Healthy Subjects and Stroke Patients on fMRI by Acupuncture Stimulation

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Chinese Journal of Integrative Medicine 2013年第4期19卷 269-276页

作者： Seung-Yeon Cho Mia Kim Jong Joo Sun Geon-ho Jahng Hengjun J Kim Seong-Uk Park Woo-Sang Jung Chang-nam Ko Jung-Mi Park Department of Cardiology and Neurology of Korean Medicine College of Korean MedicineKyung Hee UniversitySeoulKorea Department of Radiology Kyung Hee University Hospital at GangdongCollege of MedicineKyung Hee UniversitySeoulKorea Division of Magnetic Resonance Research Korea Basic Science InstituteCheongwongunChungbukKorea

Objective： To investigate brain activity patterns during acupuncture in stroke patients, and to compare the result with normal subjects using functional magnetic resonance imaging （fMRI）. Methods： A total of 11 stroke patients with motor weakness and 10 healthy subjects were studied, fMRI was performed during acupuncture on the left side at points Quchi （Llll） and Zusanli （ST36）. Data were analyzed using statistical parametric maps of brain activation induced by acupuncture stimulation. Results： The results showed that stimulation of both LI11 and ST36 produced significantly different brain activation patterns between the two groups. The normal group showed a greater overall activation than the stroke group. In the normal group, parts of the frontal lobe, parietal lobe, sub-lobar, cerebellum and midbrain regions were activated by acupuncture at the left LI11. On the other hand, only the right side of the inferior parietal Iobule region was activated in the stroke patients. When the left ST36 was stimulated in the normal group, both sides of the frontal lobe, parietal lobe, temporal lobe, and sub-lobar, and the left side of occipital lobe, and the right side of cerebellum and midbrain regions were activated. For the same stimulation in the stroke group, only both sides of the inferior parietal Iobule and cerebellum regions were activated （P〈0.05, cluster level）. Deactivation pattern was not noted during any acupuncture stimulation in both groups. Conclusion： Brain signal activations during the same acupuncture were different between the healthy and the stroke patients, and the effects showed a correlation of different acupuncture points.

关键词： acupuncture functional magnetic resonance imaging stroke LI11 ST36 basal ganglia

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Massive Hematochezia Following Blunt Trauma in a Patient with Crohn＇s Disease： Intraluminal Bleeding without Hemoperitoneum

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Chinese Medical Journal 2016年第2期129卷 246-247页

作者： Jung Soo Park Jin hong Min Jun ho Kang Yong nam In Department of Emergency Medicine College of Medicine Chungbuk National University Hospital Chungbuk Korea

To the Editor： A 29-year-old woman arrived via ambulance to the emergency department with hematochezia 1 h after sustaining blunt abdominal trauma as a passenger in a traffic accident. The patient also had Crohn＇s d... 详细信息

关键词： woman arrived emergency department diverting ileostomy

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Acute Myocardial Infarction Due to Stent Thrombosis After Administration of Intravenous Epinephrine for Anaphylaxis

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Chinese Medical Journal 2015年第19期128卷 2692-2693页

作者： Jung Soo Park Jin hong Min Jun ho Kang Yong nam In Department of Emergency Medicine Chungbuk National University HospitalCheongju-siChungbuk 361-763Republic of Korea

To the Editor：The guidelines of several collaborating organizations recommend epinephrine injection for prompt initial treatment of anaphylaxis.[1] The dose and route of administration are generally based on the severity of symptoms and the rapidity with which a response is ***,epinephrine is widely used to treat anaphylaxis,reports of severe complications such as acute coronary syndrome,arrhythmia,and intracranial bleeding are rare.

关键词： complications coronary syndrome

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