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Gram-negative bacteria and their lipopolysaccharides in Alzheimer’s disease:pathologic roles and therapeutic implications

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Translational Neurodegeneration 2021年第4期10卷 643-665页

作者： Hyeon soo Kim Sujin Kim Soo Jung Shin Yong ho Park Yunkwon nam Chae won Kim Kang won Lee Sung-Min Kim In Duk Jung Hyun Duk Yang Yeong-Min Park Minho Moon Department of Biochemistry College of MedicineKonyang UniversityDaejeon 35365Republic of Korea Research Institute for Dementia Science Konyang UniversityDaejeon 35365Republic of Korea Dandi Bioscience Inc 6th Floor of Real Company Building66Achasan-roSungdong-guSeoulRepublic of Korea Harvard Neurology Clinic 294 Gwanggyojungang-roSuji-guYongin 16943Republic of Korea Department of Immunology School of MedicineKonkuk University268ChungwondaeroChungju-siChungcheongbuk-doRepublic of Korea

Alzheimer's disease(AD)is the most serious age-related neurodegenerative disease and causes destructive and irreversible cognitive *** in the development of therapeutics targeting amyloid-β(Aβ)and tau;principal proteins inducing pathology in AD,suggest a paradigm shift towards the development of new therapeutic *** gram-negative bacteria and lipopolysaccharides(LPS)are attractive new targets for AD ***,an altered distribution of gram-negative bacteria and their LPS has been reported in AD ***,gram-negative bacteria and their LPS have been shown to affect a variety of AD-related pathologies,such as Aβ homeostasis,tau pathology,neuroinflammation,and ***,therapeutic approaches targeting gram-negative bacteria or gram-negative bacterial molecules have significantly alleviated AD-related pathology and cognitive *** multiple evidence showing that the gram-negative bacteria and their LPS play a crucial role in AD pathogenesis,the pathogenic mechanisms of gram-negative bacteria and their LPS have not been ***,we summarize the roles and pathomechanisms of gram-negative bacteria and LPS in ***,we discuss the possibility of using gram-negative bacteria and gram-negative bacterial molecules as novel therapeutic targets and new pathological characteristics for AD.

关键词： Alzheimer's disease Gram-negative bacteria Lipopolysaccharide Exotoxin Amyloid beta Tau

Novel endogenous endoplasmic reticulum transmembrane protein SURF4 suppresses cell death by negatively regulating the STING-STAT6 axis inmyeloid leukemia

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Cancer Communications 2023年第3期43卷 395-399页

作者： Jayoung Kim Hansong Lee Chae Mi hong Ji ho nam Hye Ju Yeo Woo Hyun Cho Hyung-Sik Kim Changwan hong Yun Hak Kim Dongjun Lee Department of Convergence Medicine School of MedicinePusan National UniversityYangsanGyeongsangnam-do 50612Republic of Korea Department of Biomedical Informatics School of MedicinePusan National UniversityYangsanGyeongsangnam-do 50612Republic of Korea Department of Radiation Oncology School of MedicinePusan National UniversityYangsanGyeongsangnam-do 50612Republic of Korea Division of Allergy Pulmonaryand Critical Care MedicineDepartment of Internal MedicinePusan National University Yangsan HospitalYangsanGyeongsangnam-do 50612Republic of Korea Department of Oral Pathology Dental and Life Science InstituteSchool of DentistryPusan National UniversityYangsanGyeongsangnam-do 50612Republic of Korea Department of Anatomy School of MedicinePusan National UniversityYangsanGyeongsangnam-do 50612Republic of Korea

Dear Editor,Myeloid differentiation was shown to be associated with reduced leukemic cell burden and leukemia-initiating cells and improved survival[1].Reactive oxygen species(ROS)are associated with leukemia and can induce endoplasmic reticulum(ER)*** stress induces several mechanisms,including cell death[2].The stimulator of interferon genes(STING)is also an ER transmembrane protein and promotes anti-tumor immunity by linking innate and adaptive immunity[3].Signal transducer and activator of transcription 6(STAT6)plays a prominent role in adaptive immunity by transducing signals fromextracellular cytokines and inducing apoptosis in cancer cells[4].

关键词： STAT6 immunity reticulum

A fully automated framework for helicopter rotor blades design and analysis including aerodynamics,structure, and manufacturing

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Chinese Journal of Aeronautics 2016年第6期29卷 1602-1617页

作者： Ngoc Anh Vu Jae Woo Lee Tuan Phuong nam Le Song Thanh Thao Nguyen Division of Computational Mechatronics Institute for Computational Science Ton Duc Thang University Faculty of Electrical & Electronics Engineering Ton Duc Thang University Department of Aerospace Information Engineering Konkuk University Faculty of Mechanical Engineering Industrial University of Ho Chi Minh City Department of Aerospace Engineering Ho Chi Minh City University of Technology Vietnam National University-Ho Chi Minh City

This study describes an integrated framework in which basic aerospace engineering aspects(performance, aerodynamics, and structure) and practical aspects(configuration visualization and manufacturing) are coupled and considered in one fully automated design optimization of rotor blades. A number of codes are developed to robustly perform estimation of helicopter configuration from sizing, performance analysis, trim analysis, to rotor blades configuration representation. These codes are then integrated with a two-dimensional airfoil analysis tool to fully design rotor blades configuration including rotor planform and airfoil shape for optimal aerodynamics in both hover and forward flights. A modular structure design methodology is developed for realistic composite rotor blades with a sophisticated cross-sectional geometry. A D-spar cross-sectional structure is chosen as a baseline. The framework is able to analyze all realistic inner configurations including thicknesses of D-spar, skin, web, number and ply angles of layers of each composite part,and materials. A number of codes and commercial software(ANSYS, Gridgen, VABS, Pre VABS,etc.) are implemented to automate the structural analysis from aerodynamic data processing to sectional properties and stress analysis. An integrated model for manufacturing cost estimation ofcomposite rotor blades developed at the Aerodynamic Analysis and Design Laboratory(AADL),Aerospace Information Engineering Department, Konkuk University is integrated into the framework to provide a rapid and dynamic feedback to configuration design. The integration of three modules has constructed a framework where the size of a helicopter, aerodynamic performance analysis, structure analysis, and manufacturing cost estimation could be quickly investigated. All aspects of a rotor blade including planform, airfoil shape, and inner structure are considered in a multidisciplinary design optimization without an exception of critical configuration.

关键词： Design optimization Helicopter rotor blades Integrated framework Modular structure design methodology Perform estimation

Efficacy of hepatic arterial infusion chemotherapy in advanced hepatocellular carcinoma

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World Journal of Gastroenterology 2012年第26期18卷 3426-3434页

作者： Yang Hyun Baek Kyoung Tae Kim Sung Wook Lee Jin Sook Jeong Byeong ho Park Kyung Jin nam Jin Han Cho Young hoon Kim Young hoon Roh Hyung Sik Lee Young Min Choi Sang Young Han Department of Internal Medicine Dong-A University College of MedicineBusan 602-103South Korea Department of Pathology Dong-A University College of MedicineBusan 602-103South Korea Department of Radiology Dong-A University College of MedicineBusan 602-103South Korea Department of Surgery Dong-A University College of MedicineBusan 602-103South Korea Department of Radiation Oncology Dong-A University College of MedicineBusan 602-103South Korea

AIM:To investigate the efficacy of hepatic arterial infusion chemotherapy(HAIC) using floxuridine(FUDR) in patients with advanced hepatocellular carcinoma(HCC) confined to the ***:Thirty-four patients who had advanced HCC with unresectability or unsuccessful previous therapy in the absence of extrahepatic metastasis were treated with intra-arterial FUDR chemotherapy at ourhospital between March 2005 and May *** the 34 patients,9 patients were classified as Child class C,and 18 patients had portal vein tumor thrombus(PVTT).One course of chemotherapy consisted of continuous infusion of FUDR(0.3 mg/kg during day 1-14) and dexamethasone(10 mg on day 1,4,7 and 11),and this treatment was repeated every 28 ***:Two patients(5.9%) displayed a complete response,and 12 patients(35.3%) had a partial *** tumor control rate was 61.8%.The median overall survival times were 15.3 mo,12.4 mo and 4.3 mo for the patients who were classified as Child class A,Child class B and Child class C,respectively(P = 0.0392).The progression-free survival was 12.9 mo,7.7 mo and 2.6 mo for the patients who were classified as Child class A,Child class B and Child class C,respectively(P = 0.0443).The cumulative survival differed significantly according to the Child-Pugh classification and the presence of *** addition to hepatic reserve capacity and PVTT,the extent of HCC was an independent factor in determining a poor *** most common adverse reactions to HAIC were mucositis,diarrhea and peptic ulcer disease,but most of these complications were improved by medical treatment and/or a delay of ***:The present study demonstrates that intra-arterial FUDR chemotherapy is a safe and effective treatment for advanced HCC that is recalcitrant to other therapeutic modalities,even in patients with advanced cirrhosis.

关键词： Hepatic arterial infusion chemotherapy Floxuridine Advanced hepatocellular carcinoma Child-Pugh classification Portal vein tumor thrombus

Modeling and Simulation of P-Aloha,CSMA /CA and MACAW Protocols for Underwater Acoustic Channel

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Journal of Donghua University(English Edition) 2015年第1期32卷 35-40页

作者： DAO Van-phuong 左加阔赵力 NGUYEN Dang-nam 邹采荣孙剑 Key Laboratory of Underwater Acoustic Signal Processing of Ministry of Education Southeast University ho Chi Minh City Industry and Trade College Petroleum Department Petrovietnam University School of Information Engineering Huangshan College

Medium access control( MAC) protocol of underwater acoustic communication network is a key technology for underwater acoustic networks( UANs). Most of the MAC protocols for wireless terrestrial communication networks have been designed with negligible propagation delay. If it is deployed directly in an underwater environment,the UANs will perform inefficiently. In this paper,the characteristics of underwater acoustic channel are modeled and simulated by using the OPNET simulation tool,which are the speed of sound, propagation loss, and four sources for ambient noise: the turbulence,shipping,wind driven waves and thermal noise. The performance of pure Aloha( P-Aloha),carrier sense multiple access with collision avoidance( CSMA / CA) and multiple access collision avoidance for wireless local area network( MACAW) protocols in underwater acoustic channel environment are evaluated. The different performance of protocols in underwater environment is compared in the simulation.

关键词： underwater acoustic channel OPNET simulation medium access control(MAC) protocol pure Aloha(P-Aloha) protocol carrier sense multiple access with collision avoidance(CSMA /CA) protocol multiple access collision avoidance for wireless local area network(MACAW) protocol

Central Composite Design for Optimized Extraction of Polysaccharides from Undaria pinnatifida

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Chemical Research in Chinese Universities 2012年第4期28卷 620-623页

作者： HEO Hyo-jung ROW Kyung-ho Department of Chemical Engineering Inha University253 Yonghyun-DongNam-KuIncheon 402-751Korea

Response surface methodology was used to optimize the extraction conditions of polysaccharides from Undaria *** effects of three independent variables,extraction time,extraction temperature and ratio of water to raw material were investigated by a central composite *** experimental data were fitted to a second-order polynomial equation via multiple regression analysis and also examined with the appropriate statistical *** adjusted coefficient of determination（R^2Adj） for the model was *** optimum extraction yield of 30.78% was obtained when the extraction temperature was 95 °C,extraction time was 4.5 h,and the ratio of water to raw material was 35（mL/g）.Under these conditions,validation experiments were done and the mean extraction yield of polysaccharides was 30.79%,which was in good agreement with the predicted model value.

关键词： Undaria pinnatifida Optimization Extraction Polysaccharide Response surface methodology

Microstructure and Mechanical Properties of Hyper-eutectic Al-Si Alloys Fabricated by Spray Casting

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Journal of Materials Science & Technology 2008年第1期24卷 48-50页

作者： Min Ryou Chul-Hyun Kim Myung-ho Kim School of Materials Science and Engineering Inha University 253 Yonghyun-DongNam-GuIncheon 402-751Korea Dong Yang Piston Co. LTD 1050Singil-DongDonwon-GuAnsanKyungki-DoKorea

Microstructure and mechanical properties of hyper-eutectic Al-Si alloy fabricated by spray casting were in- vestigated and then these results were compared with those by squeeze *** spray-cast specimen was found to have finer Si particles （～5μm） compared to the squeeze-cast specimen （10-25μm）.The tensile strength and elongation of the spray-cast specimen are also higher than those of the squeeze cast *** was considered that the increased mechanical properties of the spray-cast specimen were mainly due to finer size of the Si particles distributed in Al matrix.

关键词： Hyper-eutectic Al-Si alloy Squeeze casting Spray casting

Influence of Aging Treatment on the Mechanical and Electrical Properties of Cu-0.5%Be Alloy

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Journal of Materials Science & Technology 2008年第1期24卷 120-122页

作者： Min Ryou Byoung-Soo Lee Myung-ho Kim School of Materials Science and Engineering Inha University 253 Yonghyun-DongNam-GuIncheon 402-751Korea Nano Material Team Korea Institute of Industrial Technology 7-47Songdo-DongYeonsu-GuIncheon 406-130Korea

The influence of aging treatment on the microstructure,mechanical properties and electrical conductivity of Cu-0.5 wt pct Be alloy for connector material applications was *** properties of mechanical strength and electrical conductivity increase with increasing aging temperature and *** of the aged Cu-Be alloy revealed that grain size and fraction of low angle and high angle grain boundary were not greatly changed;however,transmission electron microscopy （TEM） analysis exhibited that beryllides precipitation （CoBe and NiBe） with a size of 50 nm were distributed in *** was,therefore concluded that these beryllide precipitates improved the mechanical strength and also it was favor in improvement of electrical conductivity.

关键词： Cu-Be alloy Connector materials Beryllide precipitates

Extraction and Purification of Depigmenting Agents from Chinese Plants

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Chemical Research in Chinese Universities 2006年第2期22卷 162-167页

作者： AHN So-young ROW Kyung-ho KIM Eun-ki School of Chemical and Biological Engineering Center for Advanced Bioseparation Technology Inha University Nam-Ku Incheon 402-751 Korea

Depigmenting agents were solvent-extracted and purified by preparative and analytical HPLC from three Chinese plants; Chrysanthemum morifolium Ramat（ Xizang Caijuhua）, Rhodiola sachalinensis, and Terminalia chebula Retzius. Four fractions obtained from the ethyl ether layer of C. m. Rama and two fractions from the ethyl acetate layer of Rhodiola salientness show depigmenting effects. At 8 200, the ethyl acetate layers of Chrysanthemum morifolium Ramat, Rhodiola sachalinensis and the methanol extract of Terminalia chebula Retzius, can inhibit the melanin production of mouse B16 melanoma cells by 92%, 60% and 90%, respectively, whereas 46% inhibition was observed by commercially available depigmenting agents（arbutin）. These results show the potential of these three Chinese plants as a novel resource for depigmenting agents in the cosmetic industry.

关键词： Chrysanthemum Morifolium Ramat Rhodiola Sachalinensis Terminalia Chebula Retzius Melanin Inhibitory Effect HPLC