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Neuroprotective effects of Suhexiang Wan on the in vitro and in vivo models of Parkinson’s disease

Journal of Traditional Chinese Medicine 2019年第6期39卷 800-808页

作者： Liu Quanfeng Sang Heon Kim Yung-Wei Sung Sok Cheon Pak Wonwoong Lee Jongki Hong Jaehwan Jang Kyoung Sang Cho Songhee Jeon byung-soo koo Department of Oriental Medicine Dongguk UniversityGyeogju38066Republic of Korea Department of Oriental Neuropsychiatry Graduate School of Oriental MedicineDongguk UniversityGyeonggi-do 10326Republic of Korea College of Pharmacy Kyung Hee UniversitySeoul 02447Republic of Korea School of Biomedical Sciences Charles Sturt UniversityBathurstNew South Wales2795Australia Department of Biological Sciences Konkuk UniversitySeoul 05029Republic of Korea Department of Biomedical Sciences Center for Creative Biomedical Scientists at Chonnam National UniversityGwangju 61469Korea

OBJECTIVE:To examine the role of KSOP1009(a modified formulation of Suhexiang Wan essential oil)in an animal model of Parkinson's disease(PD)induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydro-pyridine(MPTP)***:Cell toxicity,apoptosis,and reactive oxygen species(ROS)levels were analyzed in the human neuroblastoma cell line SH-SY5 *** that,changes in animal behavior and tyrosine hydroxylase(TH)protein levels in the substantia nigra(SN)of MPTP-injected mice were *** different doses of KSOP1009(30,100,and 300 mg/kg,n=8 for each group)were administered daily for 7 d before MPTP injection and 14 d after MPTP injection,totaling 21 ***:MPP+,the active metabolite of MPTP,decreased the viability of SH-SY5 Y cells,whereas KSOP1009 alleviated MPP+-induced ***1009(10 and 50 mg/m L)reduced MPP+-induced ROS generation compared with the control *** with 1 m M MPP+increased the percentage of depolarized/live cells,whereas KSOP1009 intake at a dose of 10 mg/m L decreased the percentage of these *** mean latency to fall in the rotarod test was reduced in mice treated with MPTP compared with the control ***,mice receiving three different doses of KSOP1009 performed better than MPTP-treated ***-treated mice were more hesitant and took longer to traverse the balance beam than the control *** contrast,KSOP1009-treated mice performed significantly better than MPTPtreated ***,the KSOP1009-treated groups had a significantly higher number of TH-positive neurons in the lesioned SN and significantly higher expression of TH in the striatum than the MPTP-treated *** treatment strongly induced Jun-N-terminal kinase(JNK)activation,whereas KSOP1009 suppressed MPTP-induced JNK *** addition,KSOP1009 intake reversed the decrease in the phosphorylation levels of c AMP-response element-binding protein in the brain of MPTP-treated ***1009 also restored the decrease in dopaminergic

关键词： Parkinson disease 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine Mitochondria Reactive oxygen species Suhexiang Wan

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Transparent high-performance piezoceramics through pressureless sintering

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Journal of Advanced Ceramics 2024年第5期13卷 561-567页

作者： Hye-Lim Yu Woo-Seok Kang Ju-Hyeon Lee Temesgen Tadeyos Zate Young-Jin Lee Bo-Kun koo Dong-Jin Shin Min-soo Kim soon-Jong Jeong Young Ghyu Ahn Wook Jo Department of Material Science and Engineering Ulsan National Institute of Science and TechnologyUlsan 44919Republic of Korea Energy Conversion Research Center Korea Electrotechnology Research InstituteChangwon 51543Republic of Korea MLCC Development Team Component Biz.UnitSamsung Electro-Mechanics Co.Ltd.Suwon 16674Republic of Korea

Piezoelectricity offers an electromechanical coupling that is widely utilized in transducer *** has been a consistent demand for transparent piezoelectric materials for optoelectrical ***,despite the inherent tradeoff between the transparency and the piezoelectricity,numerous strategies have been explored to develop the transparent piezoelectric ***,the most transparent piezoelectric materials developed to date is either a single crystal or materials that achieve transparency via hot-press sintering,limiting its industrial ***,we introduce a novel piezoelectric material that ensures transparency through co-doping and pressureless sintering of polycrystalline *** this study,we employed a compositional optimization approach to enhance the synergistic effect between the transparency and the piezoelectric properties of 0.71Pb(Mg_(1/3)Nb_(2/3))O_(3)–0.29PbTiO_(3)(PMN–0.29PT)*** utilizing the tape casting process for mass production and large-area manufacturing,our Pb_(0.913)La_(0.0145)Sm_(0.0145)(Mg_(1/3)Nb_(2/3))_(0.71)Ti_(0.29)O_(3)(TP2.9)ceramics exhibited over 60%transparency and large piezoelectric coefficient(d33)of 1104 pC/*** material holds considerable promise for a wide range of industrial applications in both the optical and electronic domains.

关键词： piezoelectric ceramics transparency pressureless sintering co-doping tape casting

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Multifunctional MXene/Carbon Nanotube Janus Film for Electromagnetic Shielding and Infrared Shielding/Detection in Harsh Environments

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Nano-Micro Letters 2024年第10期16卷 543-560页

作者： Tufail Hassan Aamir Iqbal byungkwon Yoo Jun Young Jo Nilufer Cakmakci Shabbir Madad Naqvi Hyerim Kim Sungmin Jung Noushad Hussain Ujala Zafar soo Yeong Cho Seunghwan Jeong Jaewoo Kim Jung Min Oh Sangwoon Park Youngjin Jeong Chong Min koo School of Advanced Materials Science and Engineering Sungkyunkwan UniversitySeobu-ro 2066Jangan-guSuwon-siGyeonggi-do 16419Republic of Korea Department of Materials Science and Engineering Soongsil UniversitySeoul 06978Republic of Korea Institute of Advanced Composite Materials Korea Institute of Science and Technology92 Chudong-roBongdong-eupWanju-gunJeollabuk-do 55324Republic of Korea R&D Center INNOMXENE Co. Ltd.Daejeon 34365Republic of Korea School of Chemical Engineering Sungkyunkwan UniversitySeobu-ro 2066Jangan-guSuwon-siGyeonggi-do 16419Republic of Korea

Multifunctional,flexible,and robust thin films capable of operating in demanding harsh temperature environments are crucial for various cutting-edge *** study presents a multifunctional Janus film integrating highly-crystalline Ti_(3)C_(2)T_(x) MXene and mechanically-robust carbon nanotube(CNT)film through strong hydrogen *** hybrid film not only exhibits high electrical conductivity(4250 S cm^(-1)),but also demonstrates robust mechanical strength and durability in both extremely low and high temperature environments,showing exceptional resistance to thermal *** hybrid Janus film of 15μm thickness reveals remarkable multifunctionality,including efficient electromagnetic shielding effectiveness of 72 dB in X band frequency range,excellent infrared(IR)shielding capability with an average emissivity of 0.09(a minimal value of 0.02),superior thermal camouflage performance over a wide temperature range(−1 to 300℃)achieving a notable reduction in the radiated temperature by 243℃ against a background temperature of 300℃,and outstanding IR detection capability characterized by a 44%increase in resistance when exposed to 250 W IR *** multifunctional MXene/CNT Janus film offers a feasible solution for electromagnetic shielding and IR shielding/detection under challenging conditions.

关键词： MXene/carbon nanotube Janus film Electromagnetic interference shielding Infrared shielding Thermal camouflage Infrared detection

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Generation of double knockout cattle via CRISPR-Cas9 ribonucleoprotein(RNP)electroporation

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Journal of Animal Science and Biotechnology 2024年第1期15卷 456-462页

作者： Gyeong-Min Gim Kyeong-Hyeon Eom Dong-Hyeok Kwon Dae-Jin Jung Dae-Hyun Kim Jun-koo Yi Jae-Jung Ha Ji-Hyun Lee Seong-Beom Lee Woo-Jae Son soo-Young Yum Won-Wu Lee Goo Jang Laboratory of Theriogenology and Biotechnology Department of Veterinary Clinical ScienceCollege of Veterinary Medicine and the Research Institute of Veterinary ScienceSeoul National UniversitySeoulRepublic of Korea LARTBio Co. Ltd.SeoulRepublic of Korea Gyeongsangbukdo Livestock Research Institute YeongjuRepublic of Korea Comparative Medicine Disease Research Center Seoul National UniversitySeoulRepublic of Korea

Background Genome editing has been considered as powerful tool in agricultural ***,genome editing progress in cattle has not been fast as in other mammal species,for some disadvantages including long gestational periods,single pregnancy,and high raising ***,technically demanding methods such as microinjection and somatic cell nuclear transfer(SCNT)are needed for gene editing in *** this point of view,electroporation in embryos has been risen as an *** First,editing efficiency of our electroporation methods were tested for *** of mutation on embryo was confirmed by T7E1 *** first combination,mutation rates for MSTN and PRNP were 57.6%±13.7%and 54.6%±13.5%,*** case of MSTN/BLG,mutation rates were 83.9%±23.6%for MSTN,84.5%±18.0%for ***,the double-KO embryos were transferred to surrogates and mutation rate was identified in resultant calves by targeted deep *** recipients were transferred for MSTN/PRNP,4 calves were delivered,and one calf underwent an induction for double *** surrogates were given double-KO embryos for MSTN/BLG,and four of the six calves that were born had mutations in both *** These data demonstrated that production of genome edited cattle via electroporation of RNP could be effectively ***,MSTN and PRNP from beef cattle and MSTN and BLG from dairy cattle have been born and they will be valuable resources for future precision breeding.

关键词： Beta-lactoglobulin Cattle CRISPR-Cas9 Electroporation Knockout MSTN PRNP

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Superior electrocatalytic negative electrode with tailored nitrogen functional group for vanadium redox flow battery

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Journal of Energy Chemistry 2023年第3期78卷 148-157,I0005页

作者： Min Gu Kang Wook Ahn Joonhee Kang Shin Ae Song Kiyoung Kim Ju Young Woo Yong-Cheol Jeong Bonwook koo Dae soo Jung Sung Nam Lim Micro/Nano Scale Manufacturing Group Korea Institute of Industrial Technology143 HanggaulroSangrok-guAnsan-siGyeonggi-do 15588Republic of Korea Department of Energy Systems Engineering Soonchunhyang University22 Soonchunhyang-roShinchang-myeonAsan-siChungcheongnam-do 31538Republic of Korea Department of Nanoenergy Engineering Pusan National UniversityBusan 46241Republic of Korea Department of Nano Fusion Technology Pusan National UniversityBusan 46241Republic of Korea Energy Storage Materials Center Energy&Environmental DivisionKorea Institute of Ceramic Engineering&Technology(KICET)101 Soho-roJinju-siGyeongsangnam-doRepublic of Korea

Development of electrodes with high electrocatalytic activity and stability is essential for solving problems that still restrict the extensive application of vanadium redox flow batteries(VRFBs).Here,we designed a novel negative electrode with superior electrocatalytic activity by tailoring nitrogen functional groups,such as newly formed nitro and pyridinic-N transformed to pyridonic-N,from the prenitrogen-doped *** was experimentally confirmed that an electrode with pyridonic-N and nitro fuctional groups(tailored nitrogen-doped graphite felt,TNGF) has superior electrocatalytic acivity with enhanced electron and mass *** functional theory calulations demonstrated the pyridonic-N and nitro functional groups promoted the adsorption,charge transfer,and bond formation with the vanadium species,which is consistent with expermental *** addition,the V2+/V3+redox reaction mechanism on pyridonic-N and nitro functional groups was estabilised based on density functional theory(DFT) *** TNGF was applied to a VRFB,it enabled enhanced-electrolyte utilization and energy efficiencies(EE) of 57.9% and 64.6%,respectively,at a current density of 250 mA cm^(-2).These results are 18.6% and 8.9% higher than those of VRFB with electrode containing graphitic-N and pyridinicN ***,TNGF-based VRFB still operated with an EE of 59% at a high current density of300 mA cm^(-2).The TNGF-based VRFB exhibited stable cycling performance without noticeable decay of EE over 450 charge-discharge cycles at a current density of 250 mA cm^(-2).The results of this study suggest that introducing pyridonic-N and nitro groups on the electrode is effective for improving the electrochemical performance of VRFBs.

关键词： Tailored nitrogen functional group Pyridonic-N Nitro Negative electrode Density functional theory Vanadium redoxﬂow batteries

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Anatomical resection of hepatocellular carcinoma: A critical review of the procedure and its benefits on survival

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World Journal of Gastroenterology 2017年第7期23卷 1139-1146页

作者： koo Jeong Kang Keun soo Ahn Division of Hepatobiliary and Pancreatic Surgery Department of SurgerySchool of MedicineKeimyung University Dong-san Medical CenterDaegu 41931South Korea

Hepatocellular carcinoma(HCC) is the sixth most common type of cancer and the third most frequent cause of cancer-related death. Advances in preoperative assessment of HCC(e.g., imaging studies and liver function tests), surgical techniques, and postoperative care have improved the surgical outcomes and survival of patients who undergo hepatic resection for HCC. However, in the last 20 years, the long-term survival after hepatectomy has remained unsatisfactory owing to the high rates of local recurrence and multicentric occurrence. Anatomical liver resection(AR) was introduced in the 1980 s. Although several studies have revealed tangible benefits of AR for HCC, these benefits are still debated. Because most HCCs occur in patients with liver cirrhosis and poor hepatic function, there are many factors that affect survival, including the surgical method. Nevertheless, many studies have documented the perioperative and long-term benefits of AR in various conditions. In this article, we review the results of several recently published, well-designed comparative studies of AR, to investigate whether AR provides real benefits on survival outcomes. We also discuss the potential pitfalls associated with this approach.

关键词： Hepatocellular 癌肝硬化药品解剖切除术预后

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Flash‑Induced High‑Throughput Porous Graphene via Synergistic Photo‑Effects for Electromagnetic Interference Shielding

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纳微快报:英文版 2023年第11期15卷 1-18页

作者： Jin soo Lee Jeong‑Wook Kim Jae Hee Lee Yong koo Son Young Bin Kim Kyoohee Woo Chanhee Lee Il‑Doo Kim Jae Young Seok Jong Won Yu Jung Hwan Park Keon Jae Lee Department of Materials Science and Engineering Korea Advanced Institute of Science and Technology(KAIST)291 Daehak‑roYuseong‑guDaejeon 34141Republic of Korea School of Electrical Engineering Korea Advanced Institute of Science and Technology(KAIST)291 Daehak‑roYuseong‑guDaejeon 34141Republic of Korea Department of Printed Electronics Nano‑Convergence Manufacturing Systems Research DivisionKorea Institute of Machinery and Materials(KIMM)156 Gajeongbuk‑RoYuseong‑GuDaejeon 34103Republic of Korea Department of Mechanical System Design Engineering Seoul National University of Science and Technology232 Gongneung‑roNowon‑guSeoul 01811Republic of Korea Department of Mechanical Engineering(Department of Aeronautics Mechanical and Electronic Convergence Engineering)Kumoh National Institute of Technology61 Daehak‑roGumiGyeongbuk 39177Republic of Korea

Porous 2D materials with high conductivity and large surface area have been proposed for potential electromagnetic interference(EMI)shielding materials in future mobility and wearable applications to prevent signal noise,transmission inaccuracy,system malfunction,and health ***,we report on the synthesis of lightweight and flexible flash-induced porous graphene(FPG)with excellent EMI shielding *** broad spectrum of pulsed flashlight induces photo-chemical and photo-thermal reactions in polyimide films,forming 5×10 cm^(2)-size porous graphene with a hollow pillar structure in a few *** resulting material demonstrated low density(0.0354 g cm^(−3))and outstanding absolute EMI shielding effectiveness of 1.12×10^(5) dB cm^(2) g^(−1).The FPG was characterized via thorough material analyses,and its mechanical durability and flexibility were confirmed by a bending cycle ***,the FPG was utilized in drone and wearable applications,showing effective EMI shielding performance for internal/external EMI in a drone radar system and reducing the specific absorption rate in the human body.

关键词： Porous graphene Flash lamp Photo-pyrolysis High-throughput Electromagnetic interference shielding

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Effects of Momentum Ratio and Weber Number on Spray Half Angles of Liquid Controlled Pintle Injector

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Journal of Thermal Science 2015年第1期24卷 37-43页

作者： Min Son Kijeong Yu Jaye koo Oh Chae Kwon Jeong soo Kim Korea Aerospace University School of Aerospace and Mechanical Engineering Korea Aerospace University School of Mechanical Engineering Sungkyunkwan University Department of Mechanical Engineering Pukyong National University

一个舵栓注射者为扼杀一台液体火箭引擎并且减少引擎重量是有益的。这研究为液体气体燃料在舵栓注射者的水花特征上以各种各样的注射条件探索动量比率和威伯数字的效果。一张液体表从一张中心舵栓嘴被注射，它被一口煤气的喷气从环形的... 详细信息

一个舵栓注射者为扼杀一台液体火箭引擎并且减少引擎重量是有益的。这研究为液体气体燃料在舵栓注射者的水花特征上以各种各样的注射条件探索动量比率和威伯数字的效果。一张液体表从一张中心舵栓嘴被注射，它被一口煤气的喷气从环形的差距打破。燃料的压力落下，和舵栓洞距离被看作控制变量；使用 0.1 1.0 液体注射作为为压力的一个酒吧落下，为为舵栓洞距离的煤气的喷气和 0.2 1.0 公里的压力落下的 0.010.2 酒吧。分泌物系数在 0.75 公里的舵栓洞距离前线性地被减少然后，系数稍微被增加。水花图象被一个互补金属氧化物半导体照相机与高分辨率捕获。然后，阴影和反映的图象被分析。水花分布被 patternator 从一个舵栓尖端与 50 公里的轴的距离测量。最后，角度有指数地减少的水花一半动量比率由威伯数字划分了的关联。另外，水花一半从水花分发的角度与从捕获的图象测量的那些相比被低估。

关键词：液体控制喷雾角动量比喷油器针阀韦伯液体火箭发动机 CMOS摄像头轴向距离

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Molecular heterogeneity in intrahepatic cholangiocarcinoma

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World Journal of Hepatology 2020年第12期12卷 1148-1157页

作者： Keun soo Ahn koo Jeong Kang Department of Surgery Keimyung University Dongsan HospitalKeimyung University School of MedicineDaegu 42601South Korea

Intrahepatic cholangiocarcinoma(iCCA)is a heterogeneous primary liver cancer,and currently there exist only a few options of targeted ***,iCCA is sub-classified according to morphology(mass forming type,periductal infiltrating type,and intraductal growing type)and histology(small duct type and large duct type).According to different histopathological types,clinical features such as risk factors and prognosis *** developments in genomic profiling have revealed several molecular markers for poor prognosis and activation of oncogenic *** of molecular characteristics of iCCA in each patient is a major challenge in a clinical setting,and there is no effective molecular-based targeted ***,several recent studies suggested molecular-based subtypes with corresponding clinical and pathological *** though the subtypes have not yet been validated,it is possible that molecular features can be predicted based on clinicopathological characteristics and that this could be used for a more rational approach to integrative clinical and molecular subclassification and targeted *** this review,we explored the genomic landscape of iCCA and attempted to find relevance between clinicopathologic and molecular features in molecular subtypes in several published *** results reveal future directions that may lead to a rational approach to the targeted therapy.

关键词： Cholangiocarcinoma Mutation Gene expression Pathway Target therapy Molecular

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World Journal of Clinical Cases 2021年第24期9卷 7205-7211页

作者： So-My koo Ki-Up Kim Yang-Ki Kim soo-Taek Uh Department of Internal Medicine Soonchunhyang University Seoul HospitalSeoul 04401South Korea

BACKGROUND Epidermal growth factor receptor tyrosine kinase inhibitors(EGFR-TKIs)are tolerable drugs used for patients with EGFR-mutant advanced non-small cell lung cancer(NSCLC).Serious adverse reactions are uncommon compared with cytotoxic *** SUMMARY A 52-year-old man presented with general weakness and *** had been taking erlotinib for 11 mo to treat *** pathological diagnosis from the right upper lobe mass was adenocarcinoma with an EGFR mutation in exon 21(L858R).He had previously received paclitaxel/carboplatin,gemcitabin/vinorelbine chemotherapy,stereotactic radiosurgery for brain metastasis,and whole-brain radiotherapy as treatment for *** diagnosed the patient with acute myeloid leukemia(AML).During the induction and consolidation chemotherapy for AML,the erlotinib was *** complete remission of the AML was achieved,since the lung masses were increased,pemetrexed/cisplatin for the NSCLC was *** two cycles of chemotherapy,the cytopenia was *** relapse occurred with the same *** Therapy-related acute myeloid neoplasm(t-MN)is a rare but fatal late *** a patient may be taking EGFR-TKIs,the possibility of t-MN should be *** studies are needed to determine whether EGFR-TKI usage is a predisposing factor for t-MN.

关键词： Acute myeloid leukemia Erlotinib Neoplasm,second primary Non-small cell lung cancer Case report

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