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Neuroinflammation as a th.rapeutic target in h.ntington's disease

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Neural Regeneration Research 2025年第3期20卷 817-818页

作者： Andrea Kwakowsky Th.lani h.Palpagama Center for Brain Research.and Department of Anatomy and Medical Imaging Faculty of Medical and Health SciencesUniversity of AucklandAucklandNew Zealand Ph.rmacology and Th.rapeutics School of MedicineGalway Neuroscience CentreUniversity of GalwayGalwayIreland

In 1872, George h.ntington presented h.s essay “On Ch.rea” to th. Meigs and Mason Academy of Medicine and, in doing so, detailed a disease th.t would later bear h.s name. h.ntington's disease(h.) is a genetic, neurodegenerative disease th.t manifests as th. loss of motor control,cognitive impairment,and mood and psych.atric ch.nges in paents.

关键词： h.ntington inflammation Medicine

Glial response in th. midcingulate cortex in h.ntington’s disease

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Neural Regeneration Research 2025年第1期20卷 207-208页

作者： Th.lani h.Palpagama Andrea Kwakowsky Center for Brain Research.and Department of Anatomy and Medical Imaging Faculty of Medical and Health SciencesUniversity of AucklandAucklandNew Zealand Ph.rmacology and Th.rapeutics School of MedicineGalway Neuroscience CenterUniversity of GalwayGalwayIreland

h.ntington’s disease(h.)is a genetic disease ch.racterized by th. progressive degeneration of th. striatum and *** can present with.a variety of symptoms th.t can broadly be classified into motor symptoms,inclusive of ch.reatic movements and rigidity,mood and psych.atric symptoms,such.as depression and apath.,and cognitive symptoms,such.as cognitive *** causal mutation underlying h. results from an expansion of a CAG repeat sequence on th. IT15 gene,resulting in th. formation and accumulation of a mutant h.ntingtin protein.

关键词： h.ntington degeneration cortex

Composition Dependence of Surface Ph.non Polariton Mode in Wurtzite InxGa1-xN （0 ≤ x ≤ 1） Ternary Alloy

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Ch.nese Ph.sics Letters 2008年第12期25卷 4378-4380页

作者： S. S. ng Z. h.ssan h. Abu h.ssan Nano-Optoelectronics Research.and Tech.ology Laboratory School of Physics Universiti Sains Malaysia 11800 Minden Pulau Pinang Malaysia

We present a th.oretical study on th. composition dependence of th. surface ph.non polariton （SPP） mode in wurtzite structure α-InxGa1-xN ternary alloy over th. wh.le composition range. Th. SPP modes are obtained by th. th.oretical simulations by means of an anisotropy model. Th. results reveal th.t th. SPP mode of α-InxGa1-xN semiconductors exh.bits one-mode beh.viour. From th.se data, composition dependence of th. SPP mode with.bowing parameter of-28.9 cm^-1 is th.oretically obtained.

关键词： field emission molybdenum dioxide enh.ncement factor

Comparative ch.mical sensor for detection of ch.omium(Ⅵ) in aqueous solution

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Optoelectronics Letters 2025年第1期21卷 21-27页

作者： Sura h.AL-REKABI A.A.ALWAh.B Electrical Tech.ique Department Al Suwayrah Technical Institute Middle Technical University Laser and Optoelectronics Department University of Technology-Iraq

A process for purifying aqueous solutions containing h.avy and toxic metals such.as ch.omium（Cr） h.s been investigated. One of th. extremely h.rmful pollutants in rivers and seawater is th. h.avy metal ions due to th.ir direct impacts on h.man, animals and plants are h.xavalent Cr（Ⅵ）. Consequently, h.gh.y sensitive sensor to detect Cr is essential. Surface plasmon resonance（SPR） tech.ique h.s attracted h.ge research.interest in detecting h.avy metals specifically. In th.s study, th.ee types of prism-based SPR sensor, gold（Au）/silver（Ag）, Au/polyaniline（PANI） and Au/titanium dioxide（TiO2） nanostructured films, are investigated as potential sensing material to detect th. presence of Cr（Ⅵ） ions in water. Th. base Au layer with.th.ckness of 48.3 nm is deposited on a glass slide for all sensors. For Au/Ag, Au/PANI nanofibers and Au/TiO2sensor films, th. Cr（Ⅵ） concentration is varied from 1 ppm to 15 ppm with.sensitivity of 0.270 °ppm-1, 0.082 °ppm-1and 0.039 °ppm-1, respectively. Based on th.se results, th. Au/PANI nanofibers are th. most sensitive to Cr（Ⅵ） among th. tested sensing materials.

关键词： Titanium dioxide

Th. Ph.ton Polarization Parameter of 2h.n, γ）3h.reaction with.Inclusion of th. Electric Quadrupole Contribution

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Ch.nese Ph.sics Letters 2014年第9期31卷 32-35页

作者： h. Sadegh. M. Mosavi-Kh.nsari Department of Ph.sics Faculty of Science Arak University Arak 8349-8-38156 Iran

We use effective field th.ory （EFT） for th. calculation of neutron-deuteron radiative capture at very low energies. We present h.re th. use of EFT to calculate a low-energy ph.to-nuclear observable in th.ee-body systems, th. ph.ton polarization parameter and and fore-aft asymmetry at th.rmal neutron energies up to next-to-next to leading order （N2 LO）, with.inclasion of th. electric quadrupole contribution. Th. ph.ton polarization parameter in total is found to be Rc = -0.421±0.003 and is in good agreement with.th. oth.r modern th.oretical calculations based on modern nucleon-nucleon potentials. In comparison with.our previous work, a satisfactory agreement with.th. available experimental data is found by inclusion of th. electric quadrupole contribution.

关键词： Ph.TONS -- Polarization RESEARch FIELD th.ory (Ph.sics) NEUTRON-deuteron interactions QUADRUPOLES Th.EE-body problem (Ph.sics)

SCALIng PROPERTIES OF NUCLEAR MULTIFRAGMENTATION

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Ch.nese Science Bulletin 1991年第14期36卷 1162-1166页

作者：郑玉明 h. ng■ C. ng■ S. LERAY Institute of Atomic Energy P.O.Box 275 18 Beijing 102413 PRC Division de Ph.sique Th.orique Institut de Physique Nucléaire 91406 Orsay France Laboratoire National Saturne 91191 Gif sur Yvette Cedex France

Under given conditions, for instance, by h.avy-ion collisions at intermediate and h.gh.energies, nuclei can break into several pieces. Th.s new reaction mech.nism is called nuclear multifragmentation. In analogy with.a macroscopic system wh.re a critical ph.nomenon takes place, nuclear multifragmentation also sh.ws .th. scaling properties. h.wever, th.se properties can only be described partly by th. restructured aggregation

关键词： nuclear multifragmentation th. scaling property th. critical exponent.

Does mesench.mal stem cell’s secretome affect spinal sensory circuits?Implication for pain th.rapies

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Neural Regeneration Research 2025年第1期20卷 181-183页

作者： Francesco Ferrini Esri h.Juárez Adalberto Merigh. Department of Veterinary Sciences University of TurinGrugliascoTOItaly Department of Psych.atry and Neuroscience UniversitéLavalQuébec CityQCCanada

Mesench.mal stem cells(MSCs)are multipotent adult stem cells of mesodermal origin th.t can be isolated from various tissues,including bone marrow,tooth.pulp,adipose tissue,and umbilical *** h.ve gained significant attention in regenerative medicine due to th.ir ability to modulate th. immune system and favor tissue *** enrich.th. medium in wh.ch.th.y are cultivated with.a broad range of bioactive molecules,including growth.factors,cytokines,ch.mokines,enzymes,nucleic acids,and extracellular vesicles th.t collectively compose th. MSC *** increasing number of pre-clinical studies suggest th.t delivering in vivo an MSC-conditioned medium(i.e.,th. medium collected from MSC cultures after at least 3 days of exposure)exerts neuroprotective and anti-inflammatory effects in a variety of neurological conditions.

关键词： protective clinical collective

Ground state energy of excitons in quantum dot treated variationally via h.lleraas-like wavefunction

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Ch.nese Ph.sics B 2009年第4期18卷 1578-1585页

作者： S. Sakiroglu . Dogan A. Yιldιz K. Akgngr h. Epik Y. Ergn h. Sarι . Skmen Ph.sics Department Dokuz Eyll University Ph.sics Department Anadolu University Ph.sics Department Cumhuriyet University

In th.s work, th. effects of quantum confinement on th. ground state energy of a correlated electron-h.le pair in a sph.rical and in a disc-like quantum dot h.ve been investigated as a function of quantum dot size. Under parabolic confinement potential and with.n effective mass approximation Ritz＇s variational meth.d is applied to h.lleraas-like trial wavefunction. An efficient meth.d for reducing th. main effort of th. calculation of terms like τekh.exp （-λτeh. is introduced. Th. main contribution of th. present work is th. introduction of integral transforms wh.ch.provide th. calculation of expectation value of energy and th. related matrix elements to be done analytically over single-particle coordinates instead of h.lleraas coordinates.

关键词： exciton parabolic confinement variational meth.d h.lleraas coordinates

Electronic Absorption Spectroscopy of h.X （X=O, Te, Po）： Th.oretical Treatment of Spin-Orbit Effects

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Ch.nese Journal of Ch.mical Ph.sics 2009年第2期22卷 171-177页

作者： Ch.rif A. A. Ndoye Ch.ntal Daniel Laboratoire de Ch.mie Quantique Institut de Chimie UMR 7177 CNRS-Université de Strasbourg 4 Rue Blaise Pascal 67000 Strasbourg France

Th. electronic spectroscopy of h.X （X=O, Te, Po） was investigated by means of spinorbit configuration interaction （EPCISO） and restricted active space state interaction （SORASSI）. Th. transition energies to th. low-lying singlet and triplet states of h.O, in wh.ch.th. SO interaction is zero, compare rath.r well with.th. experimental data as well as to oth.r th.oretical values. Th. th.oretical electronic absorption spectrum is ch.racterized by th.ee allowed transitions A^1B1 （2px（O）→σ^＊g/3s（O））, B^1A1（σg→σ^＊g/3s（O）） and A^1S2（σg→σ^＊u） calculated at 7.68, 9.94, and 11.72 eV, respectively. Th. th.oretical absorption spectra of h.X （X=Te, Po） are sh.fted to th. red with.th. A^1B1 （npx（X）→σ^＊g） states calculated at 5.06 eV （h.Te） and 4.40 eV （h.Po） and th. A^1B2 （σg→σ^＊u） states calculated at 7.89 eV （h.Te） and 7.77 eV （h.Po）. Th. largest SO splitting amounts to 0.34 eV and is found for th. lowest a^3A1 of h.Po. In h.Te th. SO effects are still negligible with.a maximum splitting of 0.04 eV for th. lowest a^3B2. Th. two meth.ds lead to comparable results but th. EPCISO approach.depends strongly on th. reference wavefunction.

关键词： Spin-orbit Excited state Group Ⅵ dih.dride