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Role of computed tomographic colonoscopy of postoperative surveillance in patient with gastric cancer

World Journal of Gastroenterology 2007年第11期13卷 1646-1651页

作者： Dae Won Jun Oh Young Lee Hyun chul Lim Sung Joon Kwon Hang Lak Lee byung chul yoon Ho Soon Choi Joon Soo Hahm Min Ho Lee Dong Hoo Lee Department of Internal Medicine Hanyang University College of Medicine Seoul Korea Department of Radiology Hanyang University College of Medicine Seoul Korea Department of General Surgery Hanyang University College of Medicine Seoul Korea

AIM： TO examine the diagnostic yield of colorectal neoplasia at computed tomographic colonoscopy （CTC） as well as the feasibility of contrast enhanced CTC in patients with gastric cancer. METHODS： To examine the incidence of colon polyp we selected postoperative 188 gastric cancer patients, which we refer to as the ‘colon polyp survey group’. To examine the feasibility of CTC for early detection of colon cancer or advanced colon adenoma, we selected 47 gastric cancer patients （M：F 29：18, mean age 53.8 years）, which we call the ‘CT colonoscopy group’. All the 47 patients underwent successive CTC and colonoscopy on the same day. RESULTS： Totally 109 colon polyps were observed from 59 out of 188 gastric cancer patients, the inddence rate of colon polyps in gastric cancer patients being 31.4%. The sensitivity of CTC in detecting individuals with at least 1 lesion of any size was 57.1%, the specificity was 72.7%, the positive predictive value was 47.1%, and the negative predictive value was 71.9%. When the cutoff size was decreased to 6 mm, the sensitivity and specificity were 80.0% and 92.9%, respectively, with positive and negative predictive values of 57.1% and 97.5%, respectively. Only one patient was classified as false negative by virtual colonoscopy. CONCLUSION： The diagnostic yield of colorectal polyp was 31.4% in patients with gastric cancer, and contrast enhanced CTC is an acceptable tool for the detection of synchronous colorectal advanced adenoma and postoperative surveillance of gastric cancer patients.

关键词： Stomach cancer Colon cancer Computed tomocjraphic colonoscopy

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Food intolerance and skin prick test in treated and untreated irritable bowel syndrome

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World Journal of Gastroenterology 2006年第15期12卷 2382-2387页

作者： Dae-Won Jun Oh-Young Lee Ho-Joo yoon Seok-Hwa Lee Hang-Lak Lee Ho-Soon Choi byung-chul yoon Min-Ho Lee Dong-Hoo Lee Sang-Hoen Cho Department of Internal Medicine College of Medicine Hanyang UniversitySeoulKorea Department of Food and Nutrition College of Human Ecology Hanyang UniversitySeoulKorea Department of Internal Medicine College of Medicine Seoul National UniversitySeoulSouth Korea

AIM： To correlate the clinical features of treated and untreated patients with irritable bowel syndrome （IBS） to the results of skin prick test （SPT） for food and inhalant allergens. METHODS： We recruited 105 subjects to form three different target groups： treated group （n=44） undergoing treatment for IBS, untreated group （n =31） meeting the Rome Ⅱ criteria without treatment for IBS, control group （n = 30） with no IBS symptoms. RESULTS： SPT results were different among the three groups in which SPT was positive in 17 （38.6%） treated patients, in 5 （16.1%） untreated patients and in 1 （3.3%） control （P〈0.01）. The number of positive SPTs was greater in the IBS group than in the control group （P〈 0.001）. The number of positive food SPTs was higher in the treated IBS group than in the untreated IBS group （P= 0.03）. CONCLUSION： Positive food SPT is higher in IBS patients than in controls.

关键词： Irritable bowel syndrome Skin prick test Food allergy

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Chest wall metastasis from unknown primary site of hepatocellular carcinoma

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World Journal of Gastroenterology 2006年第13期12卷 2139-2142页

作者： Yil Sik Hyun Ho Soon Choi Joong Ho Bae Dae Won Jun Hang Lak Lee Oh Young Lee byung chul yoon Min Ho Lee Dong Hoo Lee Choon Shuk Kee Jung Ho Kang Moon Hyang Park Department of Internal Medicine Hanyang University College of Medicine SeoulKorea Department of Thoracic Surgery Hanyang University College of Medicine SeoulKorea Department of Pathology Hanyang University College of Medicine SeoulKorea

Previous reports of a solitary metastatic hepatocellular carcinoma have been rare. Because this tumor has a different treatment modality and prognosis, an accurate differential diagnosis is essential. Here we report a rare case of a solitary chest wall metastasis from unknown primary site of hepatocellular carcinoma. It involves a 51-year-old man who was admitted to our hospital because of a palpable left upper chest wall mass. The mass was resected and pathologic examination confirmed a diagnosis of metastatic hepatocellular carcinoma. Despite our investigation, no evidence was found that indicated the primary origin of the hepatocellular carcinoma. Four months later, the patient was admitted again because of spinal cord compression at the third and fourth thoracic vertebrae. Emergent decompressive laminectomy was performed and microscopic features revealed the same pathology as the initial chest wall mass resected 4 months earlier. After one year, a follow-up abdominal computed tomography （CT） still revealed no evidence of primary hepatocellular carcinoma.

关键词： Chest wall Hepatocellular carcinoma Metastasis

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Fabrication of High-Density Out-of-Plane Microneedle Arrays with Various Heights and Diverse Cross-Sectional Shapes

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Nano-Micro Letters 2022年第2期14卷 60-78页

作者： Hyeonhee Roh Young Jun yoon Jin Soo Park Dong-Hyun Kang Seung Min Kwak byung chul Lee Maesoon Im Brain Science Institute Korea Institute of Science and Technology(KIST)Seoul 02792South Korea Division of Electrical Engineering College of EngineeringKorea UniversitySeoul 02841South Korea Micro/Nano Fabrication Center KISTSeoul 02792South Korea Division of Bio‑Medical Science&Technology KIST SchoolUniversity of Science&Technology(UST)Seoul 02792South Korea

Out-of-plane microneedle structures are widely used in various applications such as transcutaneous drug delivery and neural signal recording for brain machine *** work presents a novel but simple method to fabricate high-density silicon(Si)microneedle arrays with various heights and diverse cross-sectional shapes depending on photomask pattern *** proposed fabrication method is composed of a single photolithography and two subsequent deep reactive ion etching(DRIE)***,a photoresist layer was patterned on a Si substrate to define areas to be etched,which will eventually determine the final location and shape of each individual ***,the 1st DRIE step created deep trenches with a highly anisotropic etching of the Si ***,the photoresist was removed for more isotropic etching;the 2nd DRIE isolated and sharpened microneedles from the predefined trench *** on diverse photomask designs,the 2nd DRIE formed arrays of microneedles that have various height distributions,as well as diverse cross-sectional shapes across the *** these simple steps,high-aspect ratio microneedles were created in the high density of up to 625 microneedles mm^(-2)on a Si *** tests showed a small force as low as~172μN/microneedle is required for microneedle arrays to penetrate the dura mater of a mouse *** demonstrate a feasibility of drug delivery application,we also implemented silk microneedle arrays using molding *** fabrication method of the present study is expected to be broadly applicable to create microneedle structures for drug delivery,neuroprosthetic devices,and so on.

关键词： Microneedle Various heights Cross-sectional shapes Isotropic etch Deep reactive ion etching

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Anti-integrin therapy for inflammatory bowel disease

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World Journal of Gastroenterology 2018年第17期24卷 1868-1880页

作者： Sung chul Park yoon Tae Jeen Division of Gastroenterology and Hepatology Department of Internal Medicine Kangwon National University School of Medicine Division of Gastroenterology and Hepatology Department of Internal Medicine Korea University Anam Hospital orea University College of Medicine

In inflammatory bowel disease(IBD), tumor necro-sis factor plays an important role in mediating infla-mmation, but several other pathways are also involved in eliciting an inflammatory response. One such pathway is the invasion of the intestinal mucosa by leukocytes. Leukocytes within the systemic circulation move to sites of inflammation, and blocking this pathway could be an important treatment strategy for IBD. Anti-integrin therapy blocks the action of integrin on the surface of circulating immune cells and endothelial cell adhesion molecules, thereby inhibiting the interactions between leukocytes and intestinal blood vessels. Natalizumab, which acts on α4-integrin, was the first such drug to be approved for Crohn's disease, but its use is limited due to the risk of progressive multifocal leukoencephalopathy. Vedolizumab produces few systemic adverse effects because it acts on gut-trophic α4β7 integrin, and has been approved and is being used to treat IBD. Currently, several anti-integrin drugs, including etrolizumab, which acts on β7-integrin, and PF-00547569, which targets mucosal addressin cell adhesion molecule-1, are undergoing clinical trials and the results are being closely watched.

关键词： Integrin Ulcerative colitis Crohn’s disease Natalizumab Abrilumab Etrolizumab PF-00547659 Inflammatory bowel disease AJM300 Vedolizumab

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Shadow Detection and Removal From Photo-Realistic Synthetic Urban Image Using Deep Learning

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Computers, Materials & Continua 2020年第1期62卷 459-472页

作者： Hee-Jin yoon Kang-Jik Kim Jun-chul Chun Department of Computer Science Kyonggi UniversityGyeonggi-do16227Korea

Recently,virtual reality technology that can interact with various data is used for urban design and ***,one of the most important elements in virtual reality technology,means visual expression so that a person can experience three-dimensional space like *** obtain this realism,real-world data are used in the various *** example,in order to increase the realism of 3D modeled building textures real aerial images are utilized in 3D ***,the aerial image captured during the day can be shadowed by the sun and it can cause the distortion or deterioration of *** resolve this problem,researches on detecting and removing shadows have been conducted,but the detecting and removing shadow is still considered as a challenging *** this paper,we propose a novel method for detecting and removing shadows using deep *** this work,we first a build a new dataset of photo-realistic synthetic urban data based on the virtual environment using 3D spatial information provided by *** detecting and removing shadow from the dataset,firstly,the 1-channel shadow mask image is inferred from the 3-channel shadow image through the ***,to generate a shadow-free image,a 3-channel shadow image and a detected 1-channel shadow mask into the GAN is *** the experiments,we can prove that the proposed method outperforms the existing methods in detecting and removing shadow.

关键词： Deep-learning shadow detection shadow removal synthetic data

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Modeling the effects of constructed wetland on nonpoint source pollution control and reservoir water quality improvement

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Journal of Environmental Sciences 2010年第6期22卷 834-839页

作者： Jonghwa Ham Chun G.yoon Hyung-Joong Kim Hyung-chul Kim Rural Research Institute of KRC Environmental Science Department Konkuk University

This article describes the integrated modeling approach for planning the size and the operation of constructed wetlands for maximizing retention of nonpoint source pollutant loads and reservoir water-quality improvement at a catchment scale. The experimental field-scale wetland systems （four sets, 0.88 ha each） have been in operation since 2002, where water depth was maintained at 30-50 cm and hydraulic loading rate was at 6.3-18.8 cm/day. The wetland system was found to be adequate for treating polluted stream water with stable removal efficiency even during the winter. The integrated modeling system （modified-BASINS） was applied to the Seokmoon estuarine reservoir watershed and calibrated with monitoring data from constructed wetland, stream, and reservoir. The calibrated integrated modeling system estimated that constructing wetlands on 0.5% （about 114 ha） of the watershed area at the mouth of reservoir could reduce 11.61% and 13.49% of total external nitrogen and phosphorus loads, respectively. It also might improve the nitrogen and phosphorus concentration of the reservoir by 9.69% and 16.48%, respectively. The study suggested that about 0.1%-1.0% of the watershed area should be allocated for constructed wetland to meet specified water-quality standards for the estuarine reservoir at the polder area where land use planning is relatively less complicated.

关键词： constructed wetland estuarine reservoir integrated modeling system nonpoint source pollution control polder area water quality improvement

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Continuity control method of cutter posture vector for efficient five-axis machining

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Journal of Central South University 2011年第6期18卷 1969-1975页

作者： HWANG Jong-dae KIM Sang-myung JUNG Hyun-chul JUNG yoon-gyo School of Mechatronics Changwon National University

During five-axis machining of impeller, the excessive local interference avoidance leads to inconsistency of cutter posture, low quality of machined surface and increase of processing time. Therefore, in order to improve the efficiency of five-axis machining of impellers, it is necessary to minimize the cutter posture changes and create a continuous tool path while avoiding interference. By using an MC-space algorithm for interference avoidance, an MB-spline algorithm for continuous control was intended to create a five-axis machining tool path with excellent surface quality and economic feasibility. A five-axis cutting experiment was performed to verify the effectiveness of the continuity control. The result shows that the surface shape with continuous method is greatly improved, and the surface roughness is generally favorable. Consequently, the effectiveness of the suggested method is verified by identifying the improvement of efficiency of five-axis machining of an impeller in aspects of surface quality and machining time.

关键词： five-axis control machining configuration-space B-spline continuity control method impeller interference

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Development of practical postprocessor for 5-axis machine tool with non-orthogonal rotary axes

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Journal of Central South University 2011年第1期18卷 159-164页

作者： JUNG Hyoun-chul HWANG Jong-Dae PARK Ki-Beom JUNG yoon-Gyo School of Mechatronics Changwon National University

In order to develop a practical postprocessor for 5-axis machine tool,the general equations of numerically controlled(NC) data for 5-axis configurations with non-orthogonal rotary axes were exactly expressed by the inverse kinematics,and a windows-based postprocessor written with Visual Basic was developed according to the proposed *** developed postprocessor is a general system suitable for all kinds of 5-axis machines with orthogonal and non-orthogonal rotary *** implementation of the developed postprocessor and verification by a cutting simulation and machining experiment,the effectiveness of the proposed algorithm is *** is improved by allowing exchange of data formats such as rotational total center position(RTCP) controlled NC data,vector post NC data,and program object file(POF) cutter location(CL) data,and convenience is increased by adding the function of work-piece origin ***,a practical post-processor for 5-axis machining is developed.

关键词： post-processor 5-axis machining non-orthogonal rotary axes numerically controlled (NC) data CL data

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Colonic J-pouch anal anastomosis after ultralow anterior resection with upper sphincter excision for low-lying rectal cancer

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World Journal of Gastroenterology 2005年第17期11卷 2570-2573页

作者： Jae-Gahb Park Min Ro Lee Seok-byung Lim Chang Won Hong Sang Nam yoon Sung-Bum Kang Seung chul Heo Seung-Yong Jeong Kyu Joo Park Department of Surgery Seoul National University College of Medicine 28 Yongon-dongChongno-guSeoul 110-744Korea Cancer Research Institute and Cancer Research CenterSeoul National University28 Yongon-dongChongno-guSeoul 110-744Korea Research Institute and HospitalNational Cancer Center809 Madu-dongIlsan-guGoyangGyeonggi 411-764Korea Department of Surgery Seoul National University College of Medicine 28 Yongon-dongChongno-guSeoul 110-744Korea Research Institute and Hospital National Cancer Center 809 Madu-dongIlsan-guGoyangGyeonggi 411-764Korea

AIM:There is some evidence of functional superiority of colonic J-pouch over straight coloanal anastomosis (CM) in ultralow anterior resection (ULAR) or intersphincteric resection. On the assumption that colonic J-pouch anal anastomosis is superior to straight CM in ULAR with upper sphincter excision (USE: excision of the upper part of the internal sphincter) for low-lying rectal cancer, we compare functional outcome of colonic J-pouch vsthe straight CM. METHODS: Fifty patients of one hundred and thirty-three rectal cancer patients in whom lower margin of the tumors were located between 3 and 5 cm from the anal verge received ULAR including USE from September 1998 to January 2002. Patients were randomized for reconstruction using either a straight (n = 26) or a colonic J-pouch anastomosis (n = 24) with a temporary diverting-loop ileostomy. All patients were followed-up prospectively by a standardized questionnaire [Fecal Inco-ntinence Severity Index (FISI) scores and Fecal Incontinence Quality of Life (FIQL) scales]. RESULTS: We found that, compared to straight anastomosis patients, the frequency of defecation was significantly lower in J-pouch anastomosis patients for 10 mo after ileostomy takedown. The FISI scores and FIQL scales were significantly better in J-pouch patients than in straight patients at both 3 and 12 mo after ileostomy takedown. Furthermore, we found that FISI scores highly correlated with FIQL scales. CONCLUSION: This study indicates that colonic J-pouch anal anastomosis decreases the severity of fecal incontinence and improves the quality of life for 10 mo after ileostomy takedown in patients undergoing ULAR with USE for low-lying rectal cancer.

关键词： Upper sphincter excision Ultralow anterior resection Coloanal anastomosis Rectal cancer

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