检索结果-南通市图书馆

Small bowel ulcer bleeding due to suspected clopidogrel use in a patient with clopidogrel resistance:A case report

World Journal of Clinical Cases 2021年第15期9卷 3689-3695页

作者： Sang Hoon Lee Dong Ryeol Ryu Sung Joon Lee Sung Chul Park byung ryul cho Seung Koo Lee Sang Ji choi Hyun Seok cho Division of Gastroenterology Department of Internal MedicineKangwon National University HospitalKangwon National University School of MedicineChuncheon-si 24289South Korea Division of Cardiology Department of Internal MedicineKangwon National University HospitalKangwon National University School of MedicineChuncheon-si 24289South Korea Department of Anatomic Pathology Kangwon National University HospitalKangwon National University School of MedicineChuncheon-si 24289South Korea Department of Surgery Kangwon National University HospitalKangwon National University School of MedicineChuncheon-si 24289South Korea Department of Hospital Medicine Kangwon National University HospitalChuncheon-si 24289South Korea

BACKGROUND Clopidogrel is a platelet aggregation inhibitor used for the management of cardiovascular *** antiplatelet therapy decreases cardiovascular events after successful coronary drug-eluting stenting,it increases the risk of gastrointestinal(GI)*** 20%of the patients who take clopidogrel exhibit resistance to the *** SUMMARY We report the first case of a small bowel bleeding ulcer in an 86-year-old man with clopidogrel *** had a history of taking clopidogrel due to unstable *** was no evidence of bleeding in the stomach,duodenum,or colon through upper and lower GI *** abdominal computed tomography showed the extravasation of radiocontrast media at the *** of unstable vital signs,emergency surgery was *** ulcers with inflammation were found in the *** pathologic findings revealed simple *** VerifyNow P2Y12 test showed clopidogrel *** year after changing to aspirin,capsule endoscopy was performed and the small bowel ulcers were *** Small bowel ulcers and bleeding due to clopidogrel are not very common,but the prevalence is expected to increase in older age patients with risk factors despite clopidogrel resistance.

关键词： Clopidogrel Resistance Small bowel Multiple ulcers Hematochezia Surgery Case report

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Safety and efficacy of transradial coronary angiography and intervention in patients older than 80 years： from the Korean Transradial Intervention Prospective Registry

引用

Journal of Geriatric Cardiology 2017年第2期14卷 81-86页

作者： Hoyoun Won Wang Soo Lee Sang-Wook Kim byung ryul cho Young Jin Youn Young-Hyo Lim Min-Ho Lee Jae-Hwan Lee Seung-Woon Rha Cardiovascular & Arrhythmia Center Chung-Ang University Hospital Chung-Ang University College of Medieine Seoul South Korea Division of Cardiology Kangwon National University Hospital Chuncheon South Korea Division of Cardiology Yonsei University Wonju College of Medicine Wonju South Korea Division of Cardiology College of Medicine Hanyang University Seoul South Korea Department of Cardiology Soonchunhyang University College of Medicine Seoul South Korea Department of Cardiology Chungnam National University Hospital Daejeon South Korea Department of Cardiology Korea University Guro Hospital Seoul South Korea

Background Radial artery access for coronary procedures is a safe and beneficial technique. However, elderly patients have been considered as a higher risk group of access site related complications compared to younger patients. This study was conducted to investigate the feasibility and safety oftransradial coronary angiography or intervention in the elderly. Methods A total of 6132 patients from Korean Transradial Intervention Prospective Registry at 20 centers were analyzed. Patients were divided into the non-elderly group （n = 5667） and the elderly （_〉 80 years） group （n = 465）. Using propensity score matching, the elderly group （n = 465） was compared with one-to-one matched the non-elderly group （n = 465）. Results After propensity score matching, mean age was 64.3 ＋ 10.3 years in the non-elderly group and 83.5 -4- 3.3 years in the elderly group. There was no difference of procedural characteristics, procedural and fluoroscopic times. Access site cross-over rate was not different between the non-elderly group and elderly group （7.5% vs. 6.2%, P = 0.074）. Bleeding compli- cations occurred similarly in two groups （2.6% of the non-elderly group vs. 1.9% of the elderly group, P -~ 0.660）. Access site complications were 1.9% of the non-elderly group and 0.9% of the elderly group （P = 0.263）. Both of in hospital death and cardiovascular death for one year were also similar between two groups. Conclusions Transradial angiography or intervention was safe and feasible in elderly patients. Complication rates and clinical outcomes in elderly patients were comparable with those in non-elderly patients.

关键词： The elderly patients Transmdial coronary angiography Transradial coronary intervention

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Nonalcoholic fatty liver disease is associated with coronary artery disease in Koreans

引用

World Journal of Gastroenterology 2013年第38期19卷 6453-6457页

作者： Dae Hee choi Sung Joon Lee Chang Don Kang Myoung Ok Park Dong Wook choi Tae Suk Kim Wonho Lee byung ryul cho Yong Hoon Kim Bong-ki Lee Dong Ryeol Ryu Ji Won Lee Department of Internal Medicine Kangwon National University School of Medicine Department of Radiology Kangwon National University School of Medicine

AIM:To investigate whether nonalcoholic fatty liver disease(NAFLD)affects coronary artery disease(CAD)and identify candidate ***:Patients who underwent coronary angiography were consecutively *** patients were classified into four groups by coronary artery stenosis:A,insignificant;B,one-vessel disease;C,two-vessel disease;and D,three-vessel *** ultrasonography was performed to determine the presence of a fatty liver and categorize by grade:0,no evidence;1,mild;2,moderate;and 3,*** measured not only known CAD risk factors,but also serum insulin,HOMA-index,adiponectin,interleukin-6,tumor necrosis factor-αand high-sensitivity C-reactive protein ***:Of the 134 patients who met the inclusion criteria,82(61.2%)had ultrasonographically diagnosed *** the 46 patients with CAD,37(80.4%)had evidence of a fatty *** two groups(A vs B-D)were significantly different in terms of age,total cholesterol,triglycerides,low-density lipoprotein levels and fatty *** artery stenosis was strongly associated with fatty liver in a grade-dependent manner(P=0.025).In binary logistic regression,NAFLD was a significant independent predictor of CAD(P=0.03,OR=1.685;95%CI:1.051-2.702).Among the candidate mediators,the serum adiponectin level showed a trend toward lowering based on CAD progression(P=0.071).CONCLUSION:NAFLD is an independent risk factor for CAD in a grade-dependent ***,adiponectin might be related to the pathogenesis of NAFLD.

关键词： Nonalcoholic fatty liver disease Coronary artery disease Coronary angiography Adiponectin Insulin resistance

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Laser micromachining of CNT/Fe/Al_2O_3 nanocomposites

引用

中国有色金属学会会刊：英文版 2009年第B9期19卷 189-193页

作者： Kwang-ryul KIM Byoung-Deog choI Jun-Sin YI Sung-Hak cho Yong-Ho choA Dong-Soo SHIN Dong-Ho BAE Myung-Chang KANG Young-Keun JEONG School of Information and Communication Engineering Sungkyunkwan University Korea Institute of Machinery and Materials Department of Chemical Engineering Hanyang University NANOBASE Inc. School of Mechanical Engineering Sungkyunkwan University National Core Research Center for Hybrid Materials Solution Pusan National University

CNT/Fe/Al2O3 mixed powders were synthesized from Fe/Al2O3 nanopowders using thermal CVD for the homogeneous dispersion of carbon nanotubes CNTs. CNTs consisted of MWNT, and the diameter was approximately 20-30 nm. After sintering, CNTs were homogenously located throughout Al2O3 grain boundary and were buckled. A femto-second laser installed with special optical systems was used for micromachining of the nanocomposites. The relationship between material ablation rate and energy fluence was theoretically investigated and compared with experimental results from cross-sectional SEM analysis. The nanocomposites which have higher content of CNT show a fairly good machining result due to its higher thermal conductivity and smaller grain size as well as lower light transmittance.

关键词：纳米复合材料激光光学系统热化学气相沉积碳纳米管 Al2O3 扫描电镜分析均匀分散纳米粉体

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A comparative study on machine learning-based classification to find photothrombotic lesion in histological rabbit brain images

引用

Journal of Innovative Optical Health Sciences 2021年第6期4卷 81-89页

作者： Sang Hee Jo Yoonhee Kim Yoon Bum Lee Sung Suk Oh Jong-ryul choi School of Biomedical Engineering Daegu Catholic University(DCU)Gyeongsan 38430Republic of Korea Medical Device Development Center Daegu-Gyeongbuk Medical Innovation Foundation(DGMIF) Daegu 41061Republic of Korea Laboratory Animal Center Daegu-Gyeongbuk Medical Innovation Foundation(DGMIF) Daegu 41061Republic of Korea

Recently,research has been conducted to assist in the processing and analysis of histopathological images using machine learning *** this study,we established machine learning-based algorithms to detect photothrombotic lesions in histological images of photothrombosis-induced rabbit *** machine learning-based algorithms for binary classification were applied,and the accu-racies were compared to classify normal tissues and photothrombotic *** lesion classification model consisting of a 3-layered neural network with a rectified linear unit(ReLU)activation function,Xavier initialization,and Adam optimization using datasets with a unit size of 128×128 pixels yielded the highest accuracy(0.975).In the validation using the tested histological images,it was confirmed that the model could identify regions where brain damage occurred due to photochemical ischemic *** the development of machine learning-based photothrombotic lesion classi-fication models and performance comparisons,we confirmed that machine learning algorithms have the potential to be utilized in histopathology and various medical diagnostic techniques.

关键词： Machine learning histopathological images photothrombotic lesion rabbit brain binary classification logistic regression multi-layer neural networks

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Validation of pharmacodynamic assessment method after administration of voglibose in healthy subjects

Validation of pharmacodynamic assessment method after admini...

引用

第十五届国际药理学大会

作者： Tae Yu-Mi Kim Jung - ryul Lim Kyoung Soo Kim JaeWoo Kim Bo-Hyung Jeon Ji - Young cho Joo - Youn Yu Kyung - Sang Jang In - Jin Shin Sang-Goo Department of Pharmacology and Clinical Pharmacology Unit Seoul National University College of Medicine and Hospital Seoul Republic of Korea Department of Pharmacology and Clinical Pharmacology Unit Seoul National University College of Medicine and Hospital Seoul Republic of Korea Department of Pharmacology and Clinical Pharmacology Unit Seoul National University College of Medicine and Hospital Seoul Republic of Korea Department of Pharmacology and Clinical Pharmacology Unit Seoul National University College of Medicine and Hospital Seoul Republic of Korea Department of Pharmacology and Clinical Pharmacology Unit Seoul National University College of Medicine and Hospital Seoul Republic of Korea Department of Pharmacology and Clinical Pharmacology Unit Seoul National University College of Medicine and Hospital Seoul Republic of Korea Department of Pharmacology and Clinical Pharmacology Unit Seoul National University College of Medicine and Hospital Seoul Republic of Korea Department of Pharmacology and Clinical Pharmacology Unit Seoul National University College of Medicine and Hospital Seoul Republic of Korea Department of Pharmacology and Clinical Pharmacology Unit Seoul National University College of Medicine and Hospital Seoul Republic of Korea Department of Pharmacology and Clinical Pharmacology Unit Seoul National University College of Medicine and Hospital Seoul Republic of Korea

＜正＞ BACKGROUND Voglibose is an alpha- glucosidase inhibitor. Due to negligible oral absorption, measuring drug concentration in the blood is impractical. So we proposed a pharmacodynamic assessment method to reflect drug effect, and this study aimed to validate this *** A placebo - controlled, selective two - period clinical study was conducted in 20 healthy male subjects. Period Ⅰ: On day 1. subjects received a placebo and a sucrose - rich fluid meal 20 min after dosing. Blood samples were taken during 3 hours. On day 2. subjects received 0.3 mg voglibose instead of *** Ⅱ: 9 subjects in whom effects of drug were observed in Period Ⅰ participated in a multiple dose study （placebo: 8. 11 pm on day - 1. and 9 am on day 1 / voglibose: 2. 8. 11 pm on day 1. and 9 am on day 2）. RESULTS The average percent decreases of AUEClh （area under the serum glucose level- time curve to 1h） and Gmax （maximum serum glucose level） were 19.6% （P＜0.001） and 22.2% （P＜0.001）. respectively. CONCLUSIONS Significant drug effects of voglibose were revealed after multiple doses. Changes of AUEClh and Gmax compared to placebo may be alternative parameters to AUC and Cmax for an equivalence study.

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

SAFETY, TOLERABILITY, AND PHARMACOKINETICS OF CKD- 501,A NOVEL PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA/GAMMA DUAL AGONIST

SAFETY, TOLERABILITY, AND PHARMACOKINETICS OF CKD- 501,A NOV...

引用

第十五届国际药理学大会

作者： Shin Sang-Goo Kim Jung-ryul cho Joo-Youn Lim Kyoung Soo Kim JaeWoo Kim Bo-Hyung Shin Hyun Suk Yu Kyung-Sang Shin Jae-Soo Ahn Soon-Kil Jang In-Jin Department of Pharmacology Seoul National University College of MedicineKorea. Department of Pharmacology Seoul National University College of MedicineKorea. Department of Pharmacology Seoul National University College of MedicineKorea. Department of Pharmacology Seoul National University College of MedicineKorea. Department of Pharmacology Seoul National University College of MedicineKorea. Department of Pharmacology Seoul National University College of MedicineKorea. Department of Pharmacology Seoul National University College of MedicineKorea. Department of Pharmacology Seoul National University College of MedicineKorea. chong Kun Dang Pharm. Korea. chong Kun Dang Pharm. Korea. Department of Pharmacology Seoul National University College of Medicine Korea.

＜正＞ CKD-501 is a novel peroxisome proliferator-activated receptor α/γ dual agonist for the treatment of diabetes mellitus. This study aimed to investigate safety, tolerability, and pharmacokinetics of CKD-501 in healthy volunteers. A randomized, placebo-controlled, double-blind, parallel-group, dose-rising study was performed. Thirty-six healthy male subjects received single oral doses ranging from 0.5-8 mg CKD- 501 or placebo. In the multipledose study, 24 subjects received 1-4 mg once daily for 7 days. Serial blood and urine samples were collected. No serious adverse events （AEs） were observed and AEs reported were all of mild severity. In the single-dose study, mean Cmax and AUCinf increased linearly up to the 8 mg dose *** and t1/2 ranged from 0.5-4 h and 7.8-9.8 h. respectively. Less than 1 % CKD-501 was excreted in urine. After multiple dosing, accumulation index was around 1.2. Mean apparent clearance, Tmax and t1/2 in steady state were independent of dose and time. Single oral doses up to 8 mg CKD- 501 and multiple doses up to 4 mg were safe and well tolerated. Mean Cmax and AUCinf were dose proportional and there was no remarkable accumulation after multiple dosing.

关键词： PPAR clinical trial

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：