检索结果-南通市图书馆

Deciphering the molecular mechanisms of Simiaowan in the treatment of hyperuricemia: in vivo and in silico approaches

在线全文

学校读者我要写书评

暂无评论

Traditional Medicine Research 2025年第2期10卷 37-54页

作者： Yong-Chang Zeng jun-Hong Wu Dan-Dan Xu kang He Chang-Qing Liu Li-Fei Song Zheng-Zhi Wu Qian-Qian Jiang Shao-Yu Liang Department of Neurology The First Affiliated Hospital of Shenzhen UniversityShenzhen 518020China Pharmaceutical Department The Affiliated TCM Hospital of Guangzhou Medical UniversityGuangzhou 510000China School of Pharmacy Guizhou University of Traditional Chinese MedicineGuiyang 550025China Guangzhou Zeli Medical Technology Co. Ltd.Guangzhou 510700China

Background:Simiaowan(SMW),a well-known traditional Chinese medicine,has been employed to treat hyperuricemia(HUA)and gout for ***,the bioactive components and underlying mechanisms have not been *** objective of this study was to identify the active components and potential mechanisms of SMW by integrating pharmacological experimentation,serum pharmacochemistry,network pharmacology and molecular ***:HUA rats modelling by high-fat/high-sugar diet and potassium oxonate/adenine oral administration were used to evaluate the pharmacodynamic effects of ***-Q-Exactive-MS/MS was employed to detect the bioactive components present in SMW-containing *** pharmacology and molecular docking were utilized to elucidate the potential targets and underlying ***:SMW effectively ameliorated HUA rats via the inhibition of uric acid(UA)production,promotion of UA excretion,improvement of lipid and glucose metabolic abnormalities,antioxidant,anti-inflammatory and anti-insulin resistance effects.A total of 73 compounds detected in SMW-containing serum were identified as potential active components,with alkaloids,flavonoids,organic acids,and terpenoids emerging as the primary active *** 203 corresponding targets were obtained as SMW anti-HUA/gout targets,which mainly participated in apoptosis,insulin resistance,TNF,PI3K-Akt,HIF-1,NF-κB,MAPK,IL-17 and TLR signaling *** docking indicated that active compounds(***,phellodendrine,quercetin,formononetin,ferulic acid)had superior binding abilities to the key targets(*** carrier family 22 member 12(URAT1),solute carrier family 22 member 6(OAT1),ATP-binding cassette sub-family G member 2(ABCG2),solute carrier family 2,facilitated glucose transporter member 9(GLUT9),xanthine dehydrogenase/oxidase(XDH),transcription factor p65(RELA),toll-like receptor 4(TLR4),prostaglandin G/H synthase 2(PTGS2),caspase-3(CASP3),insulin(INS)).Conclusion:S

关键词： hyperuricemia network pharmacology serum pharmacochemistry Simiaowan UPLC-Q-Exactive-MS/MS

In?uence of Carbon Equivalent Value on the Weld Bead Bending Properties of High-Strength Low-Alloy Steel Plates

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Materials Science & Technology 2017年第4期33卷 321-329页

作者： Ki Hyuk Kim In jun Moon Ki Won Kim Ki Bong kang byung Gyu Park Kwang Seok Lee R&D Center of Dongkuk Steel Mill Co. Ltd Pohang 790-729 South Korea Korea Institute of Materials Science Implementation Research Division Materials Deformation Department 797 Changwondaero Changwon Gyeongnarn642-831 South Korea

The contribution of chemical compositions in terms of carbon equivalent value（CEV） on impending crack propagation during weld bead bend tests（WBBTs） was studied with five different high-strength lowalloy steel plates that underwent different rolling processes. The test showed that cracks developed at the weld joint, easily passed through the coarse-grain heat-affected zone（CGHAZ）, and finally were arrested within the heat-affected zone（HAZ）. An apparent decrease in the average crack length, which consequently indicated improvement in crack arrestability, was found with decreasing CEV. In addition,the relatively fine microstructure in the HAZ of low-CEV steel plates helped in preventing the crack from further propagation. Special emphasis was placed on the empirical expectation of critical CEV above which WBBT might fail.

关键词： Mechanical characterization Steel Welding Fracture Crack arrestability against bending

Fabrication of High-Density Out-of-Plane Microneedle Arrays with Various Heights and Diverse Cross-Sectional Shapes

在线全文

学校读者我要写书评

暂无评论

Nano-Micro Letters 2022年第2期14卷 60-78页

作者： Hyeonhee Roh Young jun Yoon Jin Soo Park Dong-Hyun kang Seung Min Kwak byung Chul Lee Maesoon Im Brain Science Institute Korea Institute of Science and Technology(KIST)Seoul 02792South Korea Division of Electrical Engineering College of EngineeringKorea UniversitySeoul 02841South Korea Micro/Nano Fabrication Center KISTSeoul 02792South Korea Division of Bio‑Medical Science&Technology KIST SchoolUniversity of Science&Technology(UST)Seoul 02792South Korea

Out-of-plane microneedle structures are widely used in various applications such as transcutaneous drug delivery and neural signal recording for brain machine *** work presents a novel but simple method to fabricate high-density silicon(Si)microneedle arrays with various heights and diverse cross-sectional shapes depending on photomask pattern *** proposed fabrication method is composed of a single photolithography and two subsequent deep reactive ion etching(DRIE)***,a photoresist layer was patterned on a Si substrate to define areas to be etched,which will eventually determine the final location and shape of each individual ***,the 1st DRIE step created deep trenches with a highly anisotropic etching of the Si ***,the photoresist was removed for more isotropic etching;the 2nd DRIE isolated and sharpened microneedles from the predefined trench *** on diverse photomask designs,the 2nd DRIE formed arrays of microneedles that have various height distributions,as well as diverse cross-sectional shapes across the *** these simple steps,high-aspect ratio microneedles were created in the high density of up to 625 microneedles mm^(-2)on a Si *** tests showed a small force as low as~172μN/microneedle is required for microneedle arrays to penetrate the dura mater of a mouse *** demonstrate a feasibility of drug delivery application,we also implemented silk microneedle arrays using molding *** fabrication method of the present study is expected to be broadly applicable to create microneedle structures for drug delivery,neuroprosthetic devices,and so on.

关键词： Microneedle Various heights Cross-sectional shapes Isotropic etch Deep reactive ion etching

A New Simulation Model for Recoil Analysis of Deep-Water Drilling Risers After Emergency Disconnection

在线全文

学校读者我要写书评

暂无评论

China Ocean Engineering 2023年第4期37卷 637-644页

作者： WU jun-kang MENG Shuai State Key Laboratory of Ocean Engineering Shanghai Jiao Tong UniversityShanghai 200240China

The recoil response of a deep-water drilling riser following an ED(Emergency Disconnection)scenario is a transient and sensitive *** recoiling displacement of the riser is the resultant of recoil motion and axial ***-ever,it is typically represented by one variable in recoil *** axial deformation is quite small compared with axial motion in the recoil process,it inevitably introduces numerical errors(i.e.,a large number annihilating a small number).Thus,it is hard to perform a quantitative analysis of axial deformation,although a consensus initial deformation is essential for recoil ***,the triggered axial natural modes have never been examined *** this study,the recoil response is decomposed into two parts:recoil motion and axial deformation,and a novel model is developed by Galerkin *** has demonstrated that the initial stretch has a significant effect at the initial stage in *** existing models underestimate the effects of axial *** new model can capture information of triggered natural modes and figure out the modes undergoing dynamic *** study can be beneficial to overpull setting,determination of ED time and anti-recoil control optimization.

关键词： recoil analysis drilling riser emergency disconnection axial deformation Galerkin method

Introduction to the CDEX experiment

在线全文

学校读者我要写书评

暂无评论

Frontiers of physics 2013年第4期8卷 412-437页

作者： Ke-jun kang Department of Engineering Physics Tsinghua University Beijing 100084

It is believed that weakly interacting massive particles （WIMPs） are candidates for dark matter （DM） in our universe which come from outer space and might interact with the standard model （SM） matter of our detectors on the earth. Many collaborations in the world are carrying out various experiments to directly detect DM particles. China Jinping underground Laboratory （CJPL） is the deepest underground laboratory in the world and provides a very promising environment for DM search. China Dark matter EXperiment （CDEX） is going to directly detect the WIMP flux with high sensitivity in the low WIMP-mass region. Both CJPL and CDEX have achieved a remarkable progress in recent three years. CDEX employs a point-contact germanium （PCGe） semi-conductor detector whose energy threshold is less than 300 eV. In this report we present the measurement results of muon flux, monitoring of radioactivity and radon concentration carried out in CJPL, as well describing the structure and performance of the 1 kg-PCGe detector in CDEX-1 and 10 kg- PCGe detector array in CDEX-10 including the detectors, electronics, shielding and cooling systems. Finally we discuss the physics goals of CDEX-1, CDEX-10 and the future CDEX-1T experiments.

关键词： China Dark matter EXperiment (CDEX) dark matter poit-contact germanium detector China Jinping underground Laboratory (CJPL)

Distribution of Equilibrium Free Energies in a Thermodynamic System with Broken Ergodicity

在线全文

学校读者我要写书评

暂无评论

Communications in Theoretical Physics 2008年第3期49卷 659-664页

作者： ZHOU Hai-jun LI kang Institute of Theoretical Physics the Chinese Academy of Sciences Beijing 100080 China

At low temperatures the configurational phase space of a macroscopic complex system （e.g., a spin-glass） of N - 10^23 interacting particles may split into an exponential number Ωs - exp（const × N） of ergodic sub-spaces （thermodynamic states）. It is usually assumed that the equilibrium collective behavior of such a system is determined by its ground thermodynamic states of the minimal free-energy density, and that the equilibrium free energies follow the distribution of exponentied decay. But actually for some complex systems, the equilibrium free-energy values may follow a Gaussian distribution within an intermediate temperature range, and consequently their equilibrium properties are contributed by excited thermodynamic states. Based on this analysis, the re-weighting parameter y in the cavity approach of spin-glasses is easily understood. Depending on the free-energy distribution, the optimal y can either be equal to or be strictly less than the inverse temperature β.

关键词： free-energy distribution spin-glass thermodynamic state cavity approach broken ergodicity

A synthesizing control model of networked control systems to guarantee QoP and QoS

在线全文

学校读者我要写书评

暂无评论

控制理论与应用（英文版） 2008年第4期6卷 379-384页

作者： jun kang Guanzhong DAI College of Automation Northwestern Polytechnical University Xi＇an Shannxi 710072 China

The whole performance of the networked control system （NCSs） depends on two interaction factors, namely the quality of control performance （QoP） and quality of network service （QoS）. So, to optimize the whole perfor-mance of NCSs, the problem of guaranteeing QoP and QoS plays an important role in the design of NCSs. However, up to now, little work has been done in this field. In this paper, a synthesizing control model of NCSs to guarantee QoP and QoS is proposed, and a feasible condition of optimizing whole performance of NCSs is also suggested. Finally, the simulation results show that the proposed model is effective.

关键词： Networked control system (NCSs) Synthesizing control Quality of control performance (QoP) Quality of network service (QoS)

A Full-Scale Optimization of a Crop Spatial Planting Structure and its Associated Effects

在线全文

学校读者我要写书评

暂无评论

Engineering 2023年第9期28卷 139-152页

作者： Qi Liu jun Niu Taisheng Du Shaozhong kang Center for Agricultural Water Research in China China Agricultural UniversityBeijing 100083China State Key Laboratory of Efficient Utilization of Agricultural Water Resources Beijing 100083China National Field Scientific Observation and Research Station on Efficient Water Use of Oasis Agriculture in Wuwei of Gansu Province Wuwei 733000China Key Laboratory of Agricultural Water Saving of the Ministry of Water Resources Beijing 100083China

Driven by the concept of agricultural sustainable development,crop planting structure optimization(CPSO)has become an effective measure to reduce regional crop water demand,ensure food security,and protect the ***,traditional optimization of crop planting structures often ignores the impact on regional food supply–demand relations and interprovincial food ***,using a system analysis concept and taking virtual water output as the connecting point,this study proposes a theoretical CPSO framework based on a multi-aspect and full-scale evaluation index *** this end,a water footprint(WF)simulation module denoted as soil and water assessment tool–water footprint(SWAT-WF)is constructed to simulate the amount and components of regional crop WFs.A multi-objective spatial CPSO model with the objectives of maximizing the regional economic water productivity(EWP),minimizing the blue water dependency(BWFrate),and minimizing the grey water footprint(GWFgrey)is established to achieve an optimal planting *** various benefits,a fullscale evaluation index system based on region,province,and country scales is *** an entropy weight technique for order preference by similarity to an ideal solution(TOPSIS)comprehensive evaluation model,the optimal plan is selected from a variety of CPSO *** proposed framework is then verified through a case study of the upper–middle reaches of the Heihe River Basin in Gansu province,*** combining the theory of virtual water trading with system analysis,the optimal planting structure is *** sacrificing reasonable regional economic benefits,the optimization of the planting structure significantly improves the regional water resource benefits and ecological benefits at different scales.

关键词： Planting structure optimization Full-scale evaluation index system Water footprint SWAT-WF module Interprovincial food trade Entropy weight TOPSIS

Changes in Soil Properties Under the Influences of Cropping and Drip Irrigation During the Reclamation of Severe Salt-Affected Soils

在线全文

学校读者我要写书评

暂无评论

Agricultural Sciences in China 2009年第10期8卷 1228-1237页

作者： TAN jun-li kang Yue-hu Key Laboratory of Water Cycle and Related and Land Surface Processes Institute of Geographic Sciences and Natural Resource ResearchChinese Academy of Sciences Beijing 100101 P.R.China Graduate School Chinese Academy of Sciences Beijing 100039 P.R.China College of Civil Engineer and Water Conservancy Ningxia University Yinchuan 750021 P.R.China

Reclamation of salt-affected land plays an important role in mitigating the pressure of agricultural land due to competition with industry and construction in China. Drip irrigation was found to be an effective method to reclaim salt-affected land. In order to improve the effect of reclamation and sustainability of salt-affected land production, a field experiment （with reclaimed 1-3 yr fields） was carried out to investigate changes in soil physical, chemical, and biological properties during the process of reclamation with cropping maize and drip irrigation. Results showed that soil bulk density in 0-20 cm soil layer decreased from 1.71 g·cm-3 in unreclaimed land to 1.44 g ·cm^-3 in reclaimed 3 yr fields, and saturated soil water content of 0-10 cm layer increased correspondingly from 20.3 to 30.2%. Both soil salinity and pH value in 0-40 cm soil layer dropped markedly after reclaiming 3 yr. Soil organic matter content reduced, while total nitrogen, total phosphorus, and total potassium all tended to increase after cropping and drip irrigation. The quantities of bacteria, actinomycete, and fungi in 0-40 cm soil layer all greatly increased with increase of reclaimed years, and they tended to distribute homogeneously in 0-40 cm soil profile. The urease activity and alkaline phosphatase activity in 0-40 cm soil layers were also enhanced, but the sucrase activity was not greatly changed. These results indicated that after crop cultivation and drip irrigation, soil physical environment and nutrients status were both improved. This was benefit for microorganism＇s activity and plant＇s growth.

关键词： reclamation drip irrigation changes of soil properties salt-affected soil