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Clinical implications and perspectives of portal venous circulating tumor cells in pancreatic cancer

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World Journal of Gastrointestinal Oncology 2023年第4期15卷 632-643页

作者： Sung Woo Ko Seung Bae yoon Department of Internal Medicine College of MedicineThe Catholic University of KoreaSeoul 06591South Korea Department of Internal Medicine Eunpyeong St.Mary’s HospitalSeoul 03312South Korea

Despite recent improvements in the diagnosis and treatment of pancreatic cancer(PC),clinical outcomes remain ***,there are no effective prognostic or predictive biomarkers or options beyond carbohydrate antigen 19-9 for personalized and precise *** tumor cells(CTCs),as a member of the liquid biopsy family,could be a promising biomarker;however,the rarity of CTCs in peripheral venous blood limits their clinical *** the first venous drainage of PC is portal circulation,the portal vein can be a more suitable location for the detection of *** ultrasound-guided portal venous sampling of CTCs is both feasible and *** studies have suggested that the detection rate and number of CTCs may be higher in the portal blood than in the peripheral *** counts in the portal blood are highly associated with hepatic metastasis,recurrence after surgery,and *** phenotypic and genotypic properties measured in the captured portal CTCs can help us to understand tumor heterogeneity and predict the prognosis of *** sample sizes and heterogeneous CTC detection methods limit the studies to ***,a large number of prospective studies are needed to corroborate portal CTCs as a valid biomarker in PC.

关键词： Circulating tumor cell Pancreatic cancer Portal vein Outcomes Prognosis Survival

Question-Answering Pair Matching Based on Question Classification and Ensemble Sentence Embedding

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Computer Systems Science & Engineering 2023年第9期46卷 3471-3489页

作者： Jae-Seok Jang Hyuk-yoon Kwon Department of Computer Science and Engineering Seoul National University of Science and TechnologySeoul01811Korea Department of Industrial Engineering/Graduate School of Data Science Seoul National University of Science and TechnologySeoul01811Korea

Question-answering(QA)models find answers to a given *** necessity of automatically finding answers is increasing because it is very important and challenging from the large-scale QA data *** this paper,we deal with the QA pair matching approach in QA models,which finds the most relevant question and its recommended answer for a given *** studies for the approach performed on the entire dataset or datasets within a category that the question writer manually *** contrast,we aim to automatically find the category to which the question belongs by employing the text classification model and to find the answer corresponding to the question within the *** to the text classification model,we can effectively reduce the search space for finding the answers to a given ***,the proposed model improves the accuracy of the QA matching model and significantly reduces the model inference ***,to improve the performance of finding similar sentences in each category,we present an ensemble embedding model for sentences,improving the performance compared to the individual embedding *** real-world QA data sets,we evaluate the performance of the proposed QA matching *** a result,the accuracy of our final ensemble embedding model based on the text classification model is 81.18%,which outperforms the existing models by 9.81%∼14.16%***,in terms of the model inference speed,our model is faster than the existing models by 2.61∼5.07 times due to the effective reduction of search spaces by the text classification model.

关键词： Question-answering text classification model data augmentation text embedding

Sarcopenia in pancreatic cancer:Effect on patient outcomes

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World Journal of Gastrointestinal Oncology 2022年第12期14卷 2302-2312页

作者： Moon Hyung Choi Seung Bae yoon Department of Radiology Eunpyeong St.Mary’s HospitalCollege of MedicineThe Catholic University of KoreaSeoul 03312South Korea Division of Gastroenterology Department of Internal MedicineCollege of MedicineThe Catholic University of KoreaSeoul 03312South Korea

Pancreatic cancer is a challenging disease with an increasing incidence and extremely poor *** clinical outcomes of pancreatic cancer depend on tumor biology,responses to treatments,and malnutrition or *** represents a severe catabolic condition defined by the age-related loss of muscle mass and strength and affects as much as 70%of malnourished pancreatic cancer *** lumbar skeletal muscle index,defined as the total abdominal muscle area at the L3 vertebral level adjusted by the square of the height,is widely used for assessing sarcopenia in patients with pancreatic *** studies have suggested that sarcopenia may be a risk factor for perioperative complications and decreased recurrence-free or overall survival in patients with pancreatic cancer undergoing *** could also intensify chemotherapyinduced toxicities and worsen the quality of life and survival in the neoadjuvant or palliative chemotherapy ***,not only at the time of diagnosis but also during treatment,decreases survival in patients with pancreatic ***,multimodal interventions may improve sarcopenia and clinical outcomes;however,no study has reported positive *** prospective studies are needed to confirm the prognostic role of sarcopenia and the effects of multimodal interventions in patients with pancreatic cancer.

关键词： Sarcopenia Pancreatic cancer Skeletal muscle Computed tomography Outcomes Survival

Introduction to the Special Issue on“Innovation and Application of Intelligent Processing of Data,Information and Knowledge in E-Commerce”

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Computer Modeling in Engineering & Sciences 2022年第4期131卷 19-21页

作者： Honghao Gao Jung yoon Kim Yuyu Yin School of Computer Engineering and Science Shanghai UniversityShanghaiChina Department of Game Media College of Future IndustryGachon UniversitySeongnam-si13120Gyeonggi-doSouth Korea School of Computer Hangzhou Dianzi UniversityHangzhouChina

In the context of E-Commerce eco-system,there are hundreds of millions of consumers,thousands of businesses and shops,and hundreds of delivery *** E-Commerce businesses such as Alibaba Group need to support a large number of applications and business modules,and cater for hundreds of business requirements and independent changes on a daily *** intersection of these information technologies and business models provides ample research opportunities in intelligent processing of data,information and *** this special issue,we have accepted 7 papers from open calls and invitations.A summary of these papers is outlined below.

关键词： hundreds intersection invitation

Stroke Based Painterly Rendering with Mass Data through Auto Warping Generation

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Computer Modeling in Engineering & Sciences 2022年第3期130卷 1441-1457页

作者： Taemin Lee Beomsik Kim Sanghyun Seo Kyunghyun yoon Davinci SW Education Institute Chung-Ang UniversitySeoul06974South Korea School of Computer Science and Engineering Chung-Ang UniversitySeoul06974South Korea College of Art&Technology Chung-Ang UniversityGyeonggi-do17546South Korea

Painting is done according to the artist’s *** most representative of the style is the texture and shape of the brush *** simulations allow the artist’s painting to be produced by taking this stroke and pasting it onto the *** is called stroke-based *** quality of the result depends on the number or quality of this stroke,since the stroke is taken to create the *** is not easy to render using a large amount of information,as there is a limit to having a stroke *** this work,we intend to produce rendering results using mass data that produces large amounts of strokes by expanding existing strokes through *** this,we have produced results that have higher quality than conventional ***,we also compare the correlation between the amount of data and the results.

关键词： Painterly rendering stroke based rendering image mass data stroke warping non-photorealistic rendering

Throughput-oriented associated transaction assignment in sharding blockchains for IoT social data storage

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Digital Communications and Networks 2022年第6期8卷 885-899页

作者： Liping Tao Yang Lu Xu Ding Yuqi Fan Jung yoon Kim School of Computer Science and Information Engineering Hefei University of TechnologyHefei230009China Engineering Research Center of Safety Critical Industrial Measurement and Control Technology Ministry of EducationHefei University of TechnologyHefei230009China Institute of Industry&Equipment Technology Hefei University of TechnologyHefei230009China Key Laboratory of Knowledge Engineering with Big Data(Hefei University of Technology) Ministry of EducationHefei230009China Graduate School of Game Gachon UniversitySeongnam-Si461-701South Korea

Blockchain is a viable solution to provide data integrity for the enormous volume of 5G IoT social data, while we need to break through the throughput bottleneck of blockchain. Sharding is a promising technology to solve the problem of low throughput in blockchains. However, cross-shard communication hinders the effective improvement of blockchain throughput. Therefore, it is critical to reasonably allocate transactions to different shards to improve blockchain throughput. Existing research on blockchain sharding mainly focuses on shards formation, configuration, and consensus, while ignoring the negative impact of cross-shard communication on blockchain throughput. Aiming to maximize the throughput of transaction processing, we study how to allocate blockchain transactions to shards in this paper. We propose an Associated Transaction assignment algorithm based on Closest Fit (ATCF). ATCF classifies associated transactions into transaction groups which are then assigned to different shards in the non-ascending order of transaction group sizes periodically. Within each epoch, ATCF tries to select a shard that can handle all the transactions for each transaction group. If there are multiple such shards, ATCF selects the shard with the remaining processing capacity closest to the number of transactions in the transaction group. When no such shard exists, ATCF chooses the shard with the largest remaining processing capacity for the transaction group. The transaction groups that cannot be completely processed within the current epoch will be allocated in the subsequent epochs. We prove that ATCF is a 2-approximation algorithm for the associated transaction assignment problem. Simulation results show that ATCF can effectively improve the blockchain throughput and reduce the number of cross-shard transactions.

关键词： IoT social data Blockchain Shar ding Associated transactions Transaction assi gnment

Zero-static-power nonvolatile logic-in-memory circuits for flexible electronics

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Nano Research 2017年第7期10卷 2459-2470页

作者： byung ChulJang Sang yoon Yang Hyejeong seong Sung Kyu Kim Junhwan Choi Sung Gap Im Sung-Yool Choi School of Electrical Engineering Graphene/2D Materials Research Center Korea Advanced Institute of Science and Technology (KAIST) Daejeon 34141 Republic of Korea Department of Chemical and Biomolecular Engineering Graphene/2D Materials Research Center Korea Advanced Institute of Science and Technology (KAIST) Daejeon 34141 Republic of Korea Department of Materials Science and Engineering Korea Advanced Institute of Science and Technology (KAIST) Daejeon 34141 Republic of Korea

Flexible logic circuits and memory with ultra-low static power consumption are in great demand for battery-powered flexible electronic systems. Here, we show that a flexible nonvolatile logic-in-memory circuit enabling normally-off computing can be implemented using a poly（1,3,5-trivinyl-l,3,5-trimethyl cyclotrisiloxane）（pV3D3）-based memristor array. Although memristive logic-in-memory circuits have been previously reported, the requirements of additional components and the large variation of memristors have limited demonstrations to simple gates within a few operation cycles on rigid substrates only. Using memristor-aided logic （MAGIC） architecture requiring only memristors and pV3D3-memristor with good uniformity on a flexible substrate, for the first time, we experimentally demonstrated our implementation of MAGIC-NOT and -NOR gates during multiple cycles and even under bent conditions. Other functions, such as OR, AND, NAND, and a half adder, are also realized by combinations of NOT and NOR gates within a crossbar array. This research advances the development of novel computing architecture with zero static power consumption for battery- powered flexible electronic systems.

关键词： memristor memristive logic circuit flexible nonvolatilelogic-in-memory circuit normally-off computing memristor-aided logic(MAGIC) architecture

Heterojunction between bimetallic metal-organic framework and TiO_(2):Band-structure engineering for effective photoelectrochemical water splitting

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Nano Research 2022年第9期15卷 8502-8509页

作者： Ji Won yoon Jae-Hyeok Kim Young-Moo Jo Jong-Heun Lee Department of Materials Science and Engineering Korea UniversitySeoul 02841Republic of Korea

Bimetallic Fe/Ni-based metal-organic frameworks(MOFs)with different Fe/Ni ratios were coated on TiO_(2)nanorods(NRs),and the performances of the heterojunction photoanodes in photoelectrochemical water splitting were *** bandgaps and band positions of the MOFs could be modulated by changing the ratio of the Fe and Ni *** ideal band alignment was achieved between the TiO_(2)NRs and bimetallic MOFs with an optimum ratio of[Fe]/[Ni]=0.25/0.75,which allowed efficient light absorption and charge *** coating of NH_(2)-Mil(Fe)-88 layer on the TiO_(2)NRs decreased the photocurrent density by 33%.In comparison,TiO_(2)/NH_(2)-Mil(Ni)-88 showed a modest improvement in photocurrent density(0.85 mA·cm^(−2)at 1.23 V vs.a reversible hydrogen electrode(RHE)).When bimetallic NH_(2)-Mil(Fe_(0.25)Ni_(0.75))-88 was coated on the TiO_(2)NRs,the photocurrent density reached 1.56 mA·cm^(−2),which was an efficiency enhancement of 3.2 *** mechanism underlying high photoelectrochemical performance was investigated.

关键词： band-structure engineering bimetallic metal-organic frameworks(MOFs) solar water splitting TiO_(2)nanorods NH_(2)-Mil-88

Real-time porosity reduction during metal directed energy deposition using a pulse laser

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Journal of Materials Science & Technology 2022年第21期116卷 214-223页

作者： Hoon Sohn Peipei Liu Hansol yoon Kiyoon Yi Liu Yang Sangjun Kim Department of Civil and Environmental Engineering Korea Advanced Institute of Science and Technology(KAIST)Daejeon 34141Republic of Korea Center for 3D Printing Nondestructive Testing Korea Advanced Institute of Science and Technology(KAIST)Daejeon 34141Republic of Korea Global R&D Center SQ EngineeringSeoul 05818Republic of Korea Department of Civil and Environmental Engineering The Hong Kong University of Science and TechnologyClear Water BayKowloonHong KongChina

Porosity is a challenging issue in additive manufacturing and is detrimental to the quality of the additively manufactured *** this study,a real-time porosity reduction technique was developed by incorporating a pulse laser into a laser metal powder directed energy deposition(DED)*** incorporated pulse laser can accelerate fluid flow within the melt pool and facilitate the escape of pores before complete *** achieves this real-time porosity reduction by inducing accelerated and turbulent Marangoni flow,ultrasonic waves,and shock waves into the melt *** uniqueness and advantages of the proposed technique include the following:(1)For a laser metal powder DED process,this study proposed a noncontact,nondestructive,and real-time porosity reduction technique at the melt pool level.(2)It was experimentally and numerically validated that the developed technique did not alter the geometry and the grain structure of the manufactured Ti-6Al-4V samples.(3)Because the porosity reduction is accomplished at the melt pool level,its application is not limited by the size,shape,or complexity of the printing target.(4)The developed technique can be readily incorporated into the existing DED systems without any modification of the original tool-path *** experimental results showed that the pore volume fraction decreased from 0.132%to 0.005%,no pores larger than 6×10^(4)μm^(3) were observed,and a 91%reduction in the total pore number was achieved when the pulse laser energy reached 11.5 mJ.

关键词： Real-time porosity reduction Pulse laser Melt pool Directed energy deposition Ti-6Al-4V