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Hwangryunhaedoktang exerts anti-inflammation on LPS-induced NO production by suppressing MAPK and NF-κB activation in RAW264.7 macrophages

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Journal of Integrative Medicine 2017年第4期15卷 326-336页

作者： byung hyuk han Yun Jung Lee Jung Joo Yoon Eun Sik Choi Seung Namgung Xian Jun Jin Da Hye Jeong Dae Gill Kang Ho Sub Lee College of Oriental Medicine and Professional Graduate School of Oriental Medicine Wonkwang University hanbang Body-fluid Research Center Wonkwang University

OBJECTIVE： This study aimed to evaluate whether Hwangryunhaedoktang （HHT）, a herbal compound, has an inhibitory effect on lipopolysaccharide （LPS）-induced inflammation in RAW264.7 macrophages. METHODS： The effects of HHT were evaluated by confirming nitric oxide （NO） production and expression of inducible NO synthase （iNOS） and mitogen-activated protein kinases （MAPKs） in LPS-stimulated RAW264.7 macrophages via the Griess assay, Western blotting, and real-time reverse transcription quantitative polymerase chain reaction. Western blot analyses and luciferase assays were used to evaluate whether HHT has an effect on the phosphorylation and translocation of nuclear factor-κB （NF-κB）. The secretion and expression of tumor necrosis factor-α （TNF-α） and interleukin-6 （IL-6） were determined via enzyme-linked immunosorbent assay and Western blot analyses. RESULTS： HHT suppressed LPS-induced NO production and expression of iNOS in a dose-dependent manner. Additionally, MAPKs activation was also attenuated via inhibition of phosphorylation of extracellular signal-regulated kinases 1/2, c-Jun N-terminal kinase and p38 which were related to inflammatory pathway. Furthermore, HHT also effectively attenuated NF-κB activation and its translocation to the nucleus, a process that is closely linked to inflammation. LPS normally induced the expression of inflammatory cytokines such as TNF-α and IL-6, but the secretion and expression of TNF-α and IL-6 were significantly attenuated by pretreating the cells with HHT. CONCLUSION： HHT suppressed LPS-induced NO production by blocking the activation of NF-κB and MAPK signaling pathways in RAW264.7 macrophages. Furthermore, HHT may have an anti-inflammatory effect by suppressing the LPS-induced secretion of TNF-α and IL-6. Therefore, the traditional herbal formula HHT might be a useful potential therapeutic agent for inflammation.

关键词： medicine, Chinese traditional lipopolysaccharide nitric oxide nuclear factor-κB mitogen-activatedprotein kinases tumor necrosis factor-a inflammation

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Involvement of heme oxygenase-1 induction in anti-vascular inflammation effects of Xanthoceras sorbifolia in human umbilical vein endothelial cells

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Journal of Traditional Chinese Medicine 2018年第6期38卷 803-814页

作者： Jung Joo Yoon byung hyuk han Eun Sik Choi Seung Namgung Da Hye Jeong Song Nan Jin Yun Jung Lee Dae Gill Kang Ho Sub Lee College of Oriental Medicine and Professional Graduate School of Oriental Medicine Wonkwang University hanbang Cardio-Renal Syndrome Research Center Wonkwang University Institute of Materia Medica Taishan Medical University

OBJECTIVE: To define the effects of Xanthoceras sorbifolia(EXS) on vascular inflammation and the mechanisms in endothelial ***: Vascular protective effects of an ethanol extract of seeds from EXS(1-50 μg/mL) against tumor necrosis factor-α(TNF-α)-induced vascularinflammation were examined in human umbilical vein endothelial cells(HUVECs).RESULTS: EXS significantly decreased TNF-α-induced expression of cell adhesion molecules, such as intracellular adhesion molecule-1, vascular cell adhesion molecule-1, and endothelial cell selectin,in a dose-dependent manner. Pre-treatment with EXS significantly inhibited translocation and transcriptional activity of nuclear factor-κB(NF-κB) increased by TNF-α. EXS also significantly inhibited formation of intracellular reactive oxygen species(ROS). Moreover, the vascular protective effects of EXS were linked to up-regulation of heme oxygenase-1(HO-1) and nuclear factor E2-related factor-2(Nrf-2) expression. EXS-induced HO-1 expression was significantly decreased in SnPP(HO-1 inhibitor)-and HO-1 siRNA-treated cells, whereas an increase was found in cobalt protoporphyrin IX(CoPP)(HO-1 inducer)-treated cells. In addition, pretreatment with EXS increased HO-1 and Nrf-2 expression under TNF-α stimulation with or without N-acetyl-L-cysteine. Furthermore, the inhibitory effects of EXS on TNF-α-induced vascular inflammation were partially reversed in SnPP-and of HO-1siRNA-treated cells but increased by ***: These results suggest that EXS may have important implications for prevention of vascular complications associated with vascular inflammation by inhibition of the NF-κB/ROS pathway and activation of the Nrf-2/HO-1 pathway.

关键词： Sapindaceae Vascular disease inflammation Human umbilical vein endothelial cells Cell adhesion molecules NF-kappa B Heme oxy-genase-1

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Knot impingement after arthroscopic rotator cuff repair mimicking infection:A case report

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World Journal of Clinical Cases 2022年第15期10卷 5097-5102页

作者： Du-han Kim Jong-hyuk Jeon byung-Chan Choi Chul-Hyun Cho Department of Orthopedic Surgery Keimyung University Dongsan HospitalKeimyung University School of MedicineDaegu 42601South Korea

BACKGROUND Knot impingement as a complication after arthroscopic rotator cuff repair(ARCR)has been suggested as a cause of persistent pain with limited *** report on a case involving a patient who developed knot impingement after ARCR who complained of acute onset of pain with limited motion,which was confused with *** SUMMARY A 55-year-old female who complained of severe pain with limited motion of the right shoulder visited our emergency *** range of motion could not be evaluated due to the patient’s severe *** patient had undergone ARCR using a suture-bridge technique at a local clinic four months ago for treatment of a small supraspinatus tear of the right *** erosive change of the undersurface of the acromion was observed on plain radiographs of the right shoulder,and a moderate amount of bursal fluid and synovial thickening with enhancement was observed by magnetic resonance *** of an analysis of the aspirated fluid showed that the WBC count was 3960 with 90% *** arthroscopic view showed healing of the repaired supraspinatus tendon and loose suture threads and knots with severe subacromial bursitis were *** of inflammatory tissues of the glenohumeral joint and subacromial space was performed for the removal of all suture *** patient’s symptoms subsided immediately after the surgical *** Although the incidence of knot impingement is rare,the possibility of knot impingement after ARCR should be a consideration.

关键词： Rotator cuff Knot impingement Shoulder Infection Arthroscopy Case report

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Effects of initial texture on deformation behavior during cold rolling and static recrystallization during subsequent annealing of AZ31 alloy

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Journal of Materials Science & Technology 2021年第7期66卷 139-149页

作者： Sang Won Lee Gukin han Tea-Sung Jun Sung hyuk Park School of Materials Science and Engineering.Kyungpook National University Daegu 41566Republic of Korea Department of Mechanical Engineering Incheon National UniversityIncheon 22012Republic of Korea

This study demonstrates that the initial texture of Mg alloy significantly affects the microstructure developed during cold rolling and the recrystallization behavior during subsequent annealing. In a sample with a texture oriented toward the normal direction(ND sample), thick and large-sized shear bands are intensively formed during cold rolling and the deformation is strongly localized along these bands. In contrast,in a sample with a texture oriented toward the transverse direction(TD sample), many {10-12} twins are formed at the early stage of cold rolling, and then, numerous small-sized shear bands are formed in these twins. Results of nanoindentation tests reveal that the cold-rolled ND sample has internal strain energy that is substantially concentrated along the shear bands, whereas the cold-rolled TD sample has a large amount of internal strain energy that is homogeneously distributed throughout the material;this latter behavior is strongly related to the extensive {10-12} twinning and the resultant microstructural variations in the TD sample. During subsequent annealing, recrystallization occurs locally along the shear bands in the ND sample, which leads to the formation of a bimodal grain structure comprising fine recrystallized grains and coarse unrecrystallized grains. In contrast, during subsequent annealing of the TD sample, static recrystallization occurs homogeneously throughout the material, which results in the formation of a uniform grain structure that mostly comprises equiaxed recrystallized grains.

关键词： Magnesium alloy Cold rolling Initial texture Twinning Static recrystallization

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Current status and challenges for cell-cultured milk technology: a systematic review

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Journal of Animal Science and Biotechnology 2024年第5期15卷 1778-1792页

作者： hyuk Cheol Kwon Hyun Su Jung Vahinika Kothuri Sung Gu han Department of Food Science and Biotechnology of Animal Resources Konkuk UniversitySeoulRepublic of Korea

Cellular agriculture is an innovative technology for manufacturing sustainable agricultural products as an alternative to traditional *** most cellular agriculture is predominantly centered on the production of cultured meat,there is a growing demand for an understanding of the production techniques involved in dairy products within cellular *** review focuses on the current status of cellular agriculture in the dairy sector and technical challenges for cell-cultured milk *** agriculture technology in the dairy sector has been classified into fermentation-based and animal cell culture-based cellular ***,various companies synthesize milk components through precision fermentation ***,several startup companies are pursuing animal cell-based technology,driven by public concerns regarding genetically modified organisms in precision fermentation ***,this review offers an up-to-date exploration of animal cell-based cellular agriculture to produce milk components,specifically emphasizing the structural,functional,and productive aspects of mammary epithelial cells,providing new information for industry and academia.

关键词： Cell culture system Cell-cultured milk Mammary epithelial cells Precision fermentation

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Increasing concentrations of dietary threonine,tryptophan,and glycine improve growth performance and intestinal health with decreasing stress responses in broiler chickens raised under multiple stress conditions

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Animal Nutrition 2024年第3期18卷 145-153页

作者： Hyun Woo Kim Jong hyuk Kim Gi Ppeum han Dong Yong Kil Department of Animal Science and Technology Chung-Ang UniversityAnseong-siGyeonggi-do 17546Republic of Korea Department of Animal Science Chungbuk National UniversityCheongju 28644Republic of Korea

The current study aimed to compare the effects of increasing concentrations of dietary threonine(Thr),tryptophan(Trp),and glycine(Gly)on growth performance,stress biomarkers,and intestinal function in broiler chickens under multiple stress *** hundred sixty broiler chickens at 21 d old were randomly allotted to 5 treatments with 8 *** in a positive control(PC)treatment were raised under low stock density(16.9 birds/m^(2) per cage)with recommended environmental conditions,whereas birds in 4 treatments were subjected to multiple stress conditions:a cyclic heat stress of 30±0.3℃ for 10 h and 23±0.2℃ for 14 h per day with high stock density(25.3 birds/m^(2) per cage).A basal diet was assigned to both PC and negative control(NC)*** additional diets were individually formulated to contain double concentrations of digestible Thr,Trp,or Gly+Ser compared with their concentrations in the basal *** experiment lasted for 14 *** showed that NC treatment had less growth performance(Phan PC *** treatment showed the least(Phan NC *** conclusion,increasing concentrations of dietary Thr,Trp,or Gly improve the growth performance and intestinal health in broiler chickens with decreasing stress response under multiple stress conditions.

关键词： Broiler chicken Glycine Multiple stress Threonine Tryptophan

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A novel strategy for gas mitigation during swine manure odour treatment using seaweed and a microbial consortium

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Frontiers of Environmental Science & Engineering 2020年第3期14卷 203-214页

作者： Madhavaraj Lavanya Ho-Dong Lim Kong-Min Kim Dae-hyuk Kim Balasubramani Ravindran Gui Hwan han Center for Industrialization of Agricultural and Livestock Microorganisms(CIALM) Jeongeup-si 56212Republic of Korea Department of Molecular Biology Institute for Molecular Biology and GeneticsJeonbuk National UniversityJeonju 561-756Republic of Korea Department of Environmental Energy&Engineering Kyonggi UniversitySuwon-si 16227Republic of Korea

Gas emissions from swine farms have an impact on air quality in the Republic of *** manure stored in deep pits for a long time is a major source of harmful gas ***,we evaluated the mitigation of emissions of ammonia(N H 3),hydrogen sulfide(H2S)and amine gases from swine manure with biological products such as seaweed(Sargassum homeri)and a microbial consortium(Bacillus subtilis(1.2×10^9 CFU/mL),Thiobacillus sp.(1.0×10^10 CFU/mL)and Saccharomyces cerevisiae(2.0×10^9 CFU/mL))used as additives due to their promising benefits for nutrient ***,seaweed powder masking over two days provided notable control of over 98%-100%of the gas ***,significant control of gas emissions was especially pronounced when seaweed powder masking along with a microbial consortium was applied,resulting in a gas reduction rate of 100%for NH 3,amines and H2S over 10 days of *** results also suggested that seaweed powder masking and a microbial consortium used in combination to reduce the gas emissions from swine manure reduced odour compared with that observed when the two additives were used *** the consortium,seaweed decreased total volatile fatty acid(VFA)*** proposed novel method of masking with a microbial consortium is promising for mitigating hazardous gases,simple,and environmentally *** research is warranted to determine the mechanisms underlying the seaweed and substrate interactions.

关键词： Seaweed Consortium Mitigation Ammonia H2S Volatile fatty acids(VFAs)

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Bilateral dislocation of the long head of biceps tendon with intact rotator cuff tendon:A case report

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World Journal of Clinical Cases 2023年第26期11卷 6304-6310页

作者： hyuk-Joon Sohn Chul-Hyun Cho Du-han Kim Department of Orthopedic Surgery Keimyung University Dongsan HospitalKeimyung University School of MedicineDaegu 42601South Korea

BACKGROUND Dislocation of the long head of biceps tendon(LHBT)usually involves rotator cuff injury,and isolated dislocation with an intact rotator cuff is *** cases of isolated dislocation have been ***,to the best of our knowledge,there has been no report of bilateral dislocation of the LHBT without rotator cuff *** SUMMARY A 23-year-old male presented to our outpatient clinic with left side dominant pain in both *** patient had no history of trauma or *** patient underwent intra-articular injection and physical therapy,but his symptoms *** on preoperative imaging,the diagnosis was bilateral dislocation of the *** of the bicipital groove was detected in both *** dislocation of the biceps tendon over an intact subscapularis tendon was identified by diagnostic *** biceps tenodesis was performed and continuous passive motion therapy was administered immediately after *** patient’s pain was resolved,and full functional recovery was achieved,and he was satisfied with the condition of his *** This study describes a rare case of bilateral dislocations of the LHBT without rotator cuff injury due to dysplasia of the bicipital groove.

关键词： Shoulder Biceps Dislocation Rotator cuff Tenodesis Case report

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Improvement in tensile strength of extruded Mg-5Bi alloy through addition of Sn and its underlying strengthening mechanisms

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Journal of Magnesium and Alloys 2022年第11期10卷 3100-3112页

作者： Sang-Cheol Jin Jae Won Cha Jeong Hun Lee Taekyung Lee Sang-Ho han Sung hyuk Park School of Materials Science and Engineering Kyungpook National UniversityDaegu 41566Republic of Korea Ulsan Regional Division Korea Institute of Industrial TechnologyUlsan 44413Republic of Korea School of Mechanical Engineering Pusan National UniversityBusan 46241Republic of Korea Department of Materials Analysis Korea Institute of Materials ScienceChangwon 51508Republic of Korea

Through an investigation of the microstructure and mechanical properties of extruded Mg–5Bi–x Sn(BT5x, x = 0, 2, 4, and 6 wt%) alloys,this study demonstrates that the addition of Sn to an Mg–5Bi binary alloy significantly improves the tensile strength of the extruded *** the extruded alloys exhibit a typical basal fiber texture and a partially dynamically recrystallized(DRXed) microstructure consisting of fine DRXed grains and coarse un DRXed grains. As the Sn content increases from 0 wt% to 6 wt%, the average size of the DRXed grains decreases from 4.2 to 2.8 μm owing to the increase in the amount of precipitates via their grain-boundary pinning effect. The extruded B5 and BT52 alloys contain numerous Mg_(3)Bi_(2) precipitates, but their size and number density are smaller and higher, respectively, in the latter *** Mg_(2)Sn precipitates as well as Mg_(3)Bi_(2)precipitates are present in the extruded BT54 and BT56 alloys, and the number density of the Mg_(2)Sn precipitates is higher in the latter alloy because of its higher Sn content. The addition of 2 wt% Sn to the B5 alloy significantly improves the yield strength(YS) and ultimate tensile strength(UTS) of the extruded alloy—by 76 and 57 MPa, respectively. This drastic improvement is the combined outcome of enhanced grain-boundary hardening, precipitation hardening, and solid-solution hardening effects induced by the refined DRXed grains, numerous precipitates, and Sn solute atoms, respectively. The further addition of 2 wt% or 4 wt% Sn to the BT52 alloy leads to moderate increments in the YS and UTS of the extruded alloy. Specifically, each addition of 2 wt% Sn increases the YS and UTS by ~26 and ~20 MPa, respectively, which is attributed mainly to the additional precipitation hardening effect induced by the Mg_(2)Sn precipitates.

关键词： Mg-Bi-Sn alloy Extrusion Precipitation Microstructure Tensile property

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Characterization of Micro-arc Oxidized Titanium

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Journal of Wuhan University of Technology(Materials Science) 2005年第B12期20卷 178-180页

作者： Inho han Jai hyuk Choi Bao Hong Zhao Hong Koo Baik In-Seop Lee Department of Metallurgical Engineering Yonsei University Seoul 120-749 Korea Atomic-scale Surface Science Research Center Yonsei University Seoul 120-749 Korea Institute of Physics ＆ Applied Physics Yonsei University Seoul 120-749 Korea

The observation of the sparkling discharges during the micro-arc oxidation process in KOH aqueous electrolyte was achieved. The change of surface morphology was progressively observed and a plausible pore formation mechanism is proposed. Cell proliferation and ALP activity of micro- arc oxidized titanium was evaluated by human body derived osteoblasts and sligtaly better than those of blasted surface.

关键词： Micro-arc oxidation titanium oxide dental implant morphology

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