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Pulmonary embolism after shoulder surgery:Is it a real threat?

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World Journal of Methodology 2025年第1期15卷 42-50页

作者： Charalampos Pitsilos Pericles Papadopoulos Panagiotis Givissis byron Chalidis 2^(nd)Orthopaedic Department Aristotle University of ThessalonikiSchool of MedicineThessaloniki 54635Greece 1^(st)Orthopaedic Department Aristotle University of ThessalonikiSchool of MedicineThessaloniki 57010Greece

Pulmonary embolism(PE)is a rare but devastating complication of shoulder *** from increased morbidity and mortality rates,it may significantly impair postoperative recovery and functional *** frequency accounts for up to 5.7%of all shoulder surgery procedures with a higher occurrence in women and patients older than 70 *** is most commonly associated with thrombophilia,diabetes mellitus,obesity,smoking,hypertension,and a history of *** usually occurs secondary to upper or lower-extremity deep vein thrombosis(DVT).However,in rare cases,the source of the thrombi cannot be *** for PE following shoulder surgery remains a topic of debate,and the standard of care does not routinely require prophylactic medication for DVT *** ambulation and elastic stockings are important preventative measures for DVT of the lower extremity and medical agents such as aspirin,low-molecular-weight heparin,and vitamin K antagonists are indicated for high-risk patients,long-lasting operations,or concomitant severe acute respiratory syndrome coronavirus 2 *** most common symptoms of PE include chest pain and shortness of breath,but PE can also be asymptomatic in patients with intrinsic tolerance of *** with DVT may also present with swelling and pain of the respective *** treatment of PE includes inpatient or outpatient anticoagulant therapy if the patient is hemodynamically unstable or stable,*** instability may require transfer to the intensive care unit,and cardiovascular arrest can be implicated in fatal *** important issue for patients with PE in the postoperative period after shoulder surgery is residual stiffness due to a delay in rehabilitation and a prolonged hospital *** physiotherapy and range-of-motion exercises do not adversely affect the prognosis of PE and are highly recommended to preserve shoulder mobility and function.

关键词： Pulmonary embolism Venous thromboembolism Shoulder surgery Shoulder arthroscopy Shoulder arthroplasty

Hepatocellular carcinoma recurrence after liver transplant:An Australian single-centre study

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World Journal of Transplantation 2025年第1期15卷 105-114页

作者： Matthew G Garas Luis Calzadilla-Bertot Briohny W Smith Luc Delriviere byron Jaques Lingjun Mou Leon A Adams Gerry C MacQuillan George Garas Gary P Jeffrey Michael C Wallace Medical School University of Western AustraliaNedlands 6009Western AustraliaAustralia Department of Hepatology Sir Charles Gairdner HospitalNedlands 6009Western AustraliaAustralia Department of Surgery Sir Charles Gairdner HospitalNedlands 6009Western AustraliaAustralia

BACKGROUND Hepatocellular carcinoma(HCC)is a leading cause of cancer-related deaths *** transplantation(LT)offers the most effective *** recurrence is the strongest risk factor that decreases post-LT survival in patients transplanted for *** rate of HCC recurrence is generally reported as 8%-20%in the *** predictors of HCC have already been researched,however,to our knowledge there are no published studies on this topic using Australian *** To determine the rate and identify predictors of HCC recurrence in a contemporary Western Australian LT *** We performed a retrospective cohort study of all liver transplants in patients with HCC at Sir Charles Gairdner Hospital between 2006 and *** was collected from various health record databases and included recipient demographics,serum biochemistry,radiology,operation notes,explant histopathology and details of *** survival of HCC patients post-LT,stratified for recurrence,was calculated by Kaplan Meier *** and multivariate Cox regression was used to determine predictors of HCC recurrence *** Between 1/1/2006 and 12/31/2021,119 patients were transplanted with HCC.8.4%of subjects developed recurrent HCC after LT with median follow-up time of 5.4 *** median time to recurrence was 2.9 years±0.75 *** comparing baseline characteristics,a greater proportion of subjects with recurrence had common characteristics on explant histopathology,including>3 viable nodules(P=0.001),vascular invasion(P=0.003)and poorly differentiated HCC(P=0.03).Unadjusted survival curves showed lower 1-year,3-year,5-year and 10-year survival rates in subjects with HCC recurrence compared to those without HCC recurrence(90%vs 92%,70%vs 88%,42%vs 80%,14%vs 76%,respectively;log rank P<0.001).CONCLUSION HCC recurrence was low at 8.4%in this contemporary Australian cohort,however it significantly impacted post-LT *** studies are requir

关键词： Liver cancer Recurrence Liver transplantation Hepatocellular carcinoma Predictors Post-transplant survival Australian data

Baptism by fire: the pivotal role of ancient conflagrations in evolution of the Earth's flora

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National Science Review 2018年第2期5卷 237-254页

作者： Tianhua He byron B.Lamont Department of Environment and Agriculture Curtin University

Fire became a defining feature of the Earth's processes as soon as land plants evolved 420 million years ago and has played a major role in shaping the composition and physiognomy of many ecosystems ever ***, there remains a general lack of appreciation of the place of fire in the origin, evolution, ecology and conservation of the Earth's biodiversity. We review the literature on the presence of fire throughout the Earth's history following the evolution of land plants and examine the evidence for the origin and evolution of adaptive functional traits, biomes and major plant groups in relation to fire. We show that:(1) fire activities have fluctuated throughout geological time due to variations in climate, and more importantly in atmospheric oxygen, as these affected fuel levels and flammability;(2) fire promoted the early evolution and spread of major terrestrial plant groups;(3) fire has shaped the floristics, structure and function of major global biomes; and(4) fire has initiated and maintained the evolution of a wide array of fire-adapted functional traits since the evolution of land plants. We conclude that fire has been a fundamental agent of natural selection on terrestrial plants throughout the history of life on the Earth's land surface. We suggest that a paradigm shift is required to reassess ecological and evolutionary theories that exclude a role for fire,and also there is a need to review fire-suppression policies on ecosystem management and biodiversity conservation in global fire-prone regions.

关键词： angiosperms ecosystems fossil charcoal palaeo-atmospheric oxygen terrestrial floras wildfire

VColor^(*):a practical approach for coloring large graphs

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Frontiers of Computer Science 2021年第4期15卷 133-149页

作者： Yun PENG Xin LIN byron CHOI Bingsheng HE Department of Computer Science Hong Kong Baptist UniversityHong Kong 999077China School of Computer Science and Technology East China Normal UniversityShanghai 200062China School of Computing National University of SingaporeSingapore 119077Singapore

Graph coloring has a wide range of real world applications,such as in the operations research,communication network,computational biology and compiler optimization *** our recent work[1],we propose a divide-andconquer approach for graph coloring,called *** an approach has three generic subroutines.(i)Graph partition subroutine:VColor partitions a graph G into a vertex cut partition(VP),which comprises a vertex cut component(VCC)and small non-overlapping connected components(CCs).(ii)Component coloring subroutine:VColor colors the VCC and the CCs by efficient algorithms.(iii)Color combination subroutine:VColor combines the local colors by exploiting the maximum matchings of color combination bigraphs(CCBs).VColor has revealed some major bottlenecks of efficiency in these ***,in this paper,we propose VColor^(*),an approach which addresses these efficiency bottlenecks without using more colors both theoretically and *** technical novelties of this paper are the following.(i)We propose the augmented VP to index the crossing edges of the VCC and the CCs and propose an optimized CCB construction algorithm.(ii)For sparse CCs,we propose using a greedy coloring algorithm that is of polynomial time complexity in the worst case,while preserving the approximation ratio.(iii)We propose a distributed graph coloring *** extensive experimental evaluation on real-world graphs confirms the efficiency of VColor^(*).In particular,VColor^(*)is 20X and 50X faster than VColor and uses the same number of colors with VColor on the Pokec and PA datasets,***^(*)also significantly outperforms the state-ofthe-art graph coloring methods.

关键词： graph coloring approximation algorithm distributed algorithm

Prediction of Low-Energy Building Energy Consumption Based on Genetic BP Algorithm

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Computers, Materials & Continua 2022年第9期72卷 5481-5497页

作者： Yanhua Lu Xuehui Gong Andrew byron Kipnis School of Urban Construction Yangtze UniversityJingzhou434023China Beijing Sifang Automation Co. Ltd.Beijing100085China Australian National University Canberra2600-2601Australia

Combined with the energy consumption data of individual buildings in the logistics group of Yangtze University,the analysis model scheme of energy consumption of individual buildings in the university is studied by using Back Propagation(BP)neural network to solve nonlinear problems and have the ability of global approximation and *** analyzing the influence of different uses,different building surfaces and different energysaving schemes on the change of building energy consumption,the grey correlation method is used to determine the main influencing factors affecting each building energy consumption,including uses,building surfaces and energy-saving schemes,which are used as the input of the model and the building energy consumption as the output of the model,so as to establish the building energy consumption analysis model based on BP neural ***,in practical application,BP neural network has the defects of slow convergence and easy to fall into local *** view of this,this paper uses genetic algorithm to optimize the weight and threshold of BP neural network,completes the improvement of various building energy consumption analysis models,and realizes the qualitative analysis of building energy *** model verification results show that the viscosity of the building energy consumption analysis model based on genetic algorithm improved BP neural network algorithm(GABP)in this paper is relatively high,which is more accurate than the results of the traditional BP neural network model,and the relative error of the analysis model is reduced from 11.56%to 8.13%,which proves that the GABP can be better suitable for the study of school building energy consumption analysis model,It is applied to the prediction of building energy consumption,which lays a foundation for the realization of carbon neutralization in the South expansion plan of Yangtze University.

关键词： Energy consumption analysis model BP neural network genetic algorithm

Management of geriatric acetabular fractures:Contemporary treatment strategies

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World Journal of Clinical Cases 2024年第13期12卷 2151-2156页

作者： Theodoros Tosounidis byron Chalidis Academic Department of Orthopaedic Surgery Heraklion University HospitalUniversity of CreteGreeceHeraklion 71500Greece 1^(st)Department of Orthopaedic School of MedicineFaculty of Health SciencesAristotle University of ThessalonikiThessaloniki 57010Greece

Acetabular fractures in the geriatric population are typically low-energy fractures resulting from a fall from standing *** bone quality in the elderly,as well as this population’s concomitant medical comorbidities,render the management of such fractures challenging and ***-operative management remains the mainstay of treatment,although such a choice is associated with numerous and serious complications related to both the hip joint as well as the general condition of the *** the other hand,operatively treating acetabular fractures(e.g.,with osteosynthesis or total hip arthroplasty)is gaining *** can be performed with open reduction and internal fixation or with minimally invasive *** hip arthroplasty could be performed either in the acute phase combined with osteosynthesis or as a delayed procedure after a period of non-operative management or after failed osteosynthesis of the *** of the implemented treatment,orthogeriatric co-management is considered extremely crucial,and it is currently one of the pillars of a successful outcome after an acetabular fracture.

关键词： Acetabular fractures Geriatric fractures Fracture fixation Total hip arthroplasty Mortality Morbidity

Prevention of post-operative recurrence of Crohn's disease

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World Journal of Gastroenterology 2014年第5期20卷 1147-1154页

作者： byron Philip Vaughn Alan Colm Moss Division of Gastroenter-ology Beth-Israel Deaconess Medical CenterBoston MA 02115 United States

Endoscopic and clinical recurrence of Crohn’s disease (CD) is a common occurrence after surgical resection. Smokers, those with perforating disease, and those with myenteric plexitis are all at higher risk of recurrence. A number of medical therapies have been shown to reduce this risk in clinical trials. Metronidazole, thiopurines and anti-tumour necrosis factors (TNFs) are all effective in reducing the risk of endoscopic or clinical recurrence of CD. Since these are preventative agents, the benefits of prophylaxis need to be weighed-against the risk of adverse events from, and costs of, therapy. Patients who are high risk for post-operative recurrence should be considered for early medical prophylaxis with an anti-TNF. Patients who have few to no risk factors are likely best served by a three-month course of antibiotics followed by tailored therapy based on endoscopy at one year. Clinical recurrence rates are variable, and methods to stratify patients into high and low risk populations combined with prophylaxis tailored to endoscopic recurrence would be an effective strategy in treating these patients.

关键词： Inflammatory bowel disease, Crohn’ s disease, Postoperative recurrence, Medical treatment, Biologics

5-Fluorouracil dose escalation generated desensitized colorectal cancer cells with reduced expression of protein methyltransferases and no epithelial-to-mesenchymal transition potential

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Oncology Research 2024年第6期32卷 1047-1061页

作者： KIMBERLY FENECH ISAAC MICALLEF byron BARON Centre for Molecular Medicine and Biobanking University of MaltaMsidaMSD 2080Malta Department of Tumor Genetics and Biology Graduate School of Medical SciencesFaculty of Life SciencesKumamoto UniversityKumamoto860-8556Japan

Background:Colorectal cancer(CRC)is one of the most frequently diagnosed *** many cases,the poor prognosis of advanced CRC is associated with resistance to treatment with chemotherapeutic drugs such as 5-Fluorouracil(5-FU).The epithelial-to-mesenchymal transition(EMT)and dysregulation in protein methylation are two mechanisms associated with chemoresistance in many *** study looked into the effect of 5-FU dose escalation on EMT and protein methylation in *** and Methods:HCT-116,Caco-2,and DLD-1 CRC cell lines were exposed to dose escalation treatment of *** motility and invasive potentials of the cells before and after treatment with 5-FU were investigated through wound healing and invasion *** was followed by aWestern blot which analyzed the protein expressions of the epithelial marker E-cadherin,mesenchymal marker vimentin,and the EMT transcription factor(EMTTF),the snail family transcriptional repressor 1(Snail)in the parental and desensitized *** blotting was also conducted to study the protein expressions of the protein methyltransferases(PMTs),Euchromatic histone lysine methyltransferase 2(EHMT2/G9A),protein arginine methyltransferase(PRMT5),and SET domain containing 7/9(SETD7/9)along with the global lysine and arginine methylation ***:The dose escalation method generated 5-FU desensitized CRC cells with distinct morphological features and increased tolerance to high doses of *** 5-FU desensitized cells experienced a decrease in migration and invasion when compared to the parental *** was reflected in the observed reduction in E-cadherin,vimentin,and Snail in the desensitized cell ***,the protein expressions of EHMT2/G9A,PRMT5,and SETD7/9 also decreased in the desensitized cells and global protein lysine and arginine methylation became dysregulated with 5-FU ***:This study showed that continuous,dose-escalation treatment of 5-FU in CRC cells generated 5-FU

关键词： Chemoresistance Epithelial-to-mesenchymal transition Protein methylation Protein methyltransferases

Simulating streamflow and water table depth with a coupled hydrological model

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Water Science and Engineering 2010年第3期3卷 241-256页

作者： Alphonce Chenjerayi GUZHA Thomas byron HARDY Department of Agricultural and Biological Engineering Southwest Florida Research and Education CenterUniversity of Florida River Systems Institute Texas State University

A coupled model integrating MODFLOW and TOPNET with the models interacting through the exchange of recharge and baseflow and river-aquifer interactions was developed and applied to the Big Darby Watershed in Ohio, USA. Calibration and validation results show that there is generally good agreement between measured streamflow and simulated results from the coupled model. At two gauging stations, average goodness of fit （ R2 ）, percent bias （ PB ）, and Nash Sutcliffe efficiency （ENS） values of 0.83, 11.15%, and 0.83, respectively, were obtained for simulation of streamflow during calibration, and values of 0.84, 8.75%, and 0.85, respectively, were obtained for validation. The simulated water table depths yielded average R2 valuesof0.77 and 0.76 for calibration and validation, respectively. The good match between measured and simulated streamflows and water table depths demonstrates that the model is capable of adequately simulating streamflows and water table depths in the watershed and also capturing the influence of spatial and temporal variation in recharge.

关键词： hydrological modeling model coupling," streamflow groundwater," TOPNET model," MODFLOW model," Big Darby Watershed