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5-Fluorouracil dose escalation generated desensitized colorectal cancer cells with reduced expression of protein methyltransferases and no epithelial-to-mesenchymal transition potential

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Oncology Research 2024年第6期32卷 1047-1061页

作者： kIMBERLY FENECH ISAAC MICALLEF byron BARON Centre for Molecular Medicine and Biobanking University of MaltaMsidaMSD 2080Malta Department of Tumor Genetics and Biology Graduate School of Medical SciencesFaculty of Life SciencesKumamoto UniversityKumamoto860-8556Japan

Background:Colorectal cancer(CRC)is one of the most frequently diagnosed *** many cases,the poor prognosis of advanced CRC is associated with resistance to treatment with chemotherapeutic drugs such as 5-Fluorouracil(5-FU).The epithelial-to-mesenchymal transition(EMT)and dysregulation in protein methylation are two mechanisms associated with chemoresistance in many *** study looked into the effect of 5-FU dose escalation on EMT and protein methylation in *** and Methods:HCT-116,Caco-2,and DLD-1 CRC cell lines were exposed to dose escalation treatment of *** motility and invasive potentials of the cells before and after treatment with 5-FU were investigated through wound healing and invasion *** was followed by aWestern blot which analyzed the protein expressions of the epithelial marker E-cadherin,mesenchymal marker vimentin,and the EMT transcription factor(EMTTF),the snail family transcriptional repressor 1(Snail)in the parental and desensitized *** blotting was also conducted to study the protein expressions of the protein methyltransferases(PMTs),Euchromatic histone lysine methyltransferase 2(EHMT2/G9A),protein arginine methyltransferase(PRMT5),and SET domain containing 7/9(SETD7/9)along with the global lysine and arginine methylation ***:The dose escalation method generated 5-FU desensitized CRC cells with distinct morphological features and increased tolerance to high doses of *** 5-FU desensitized cells experienced a decrease in migration and invasion when compared to the parental *** was reflected in the observed reduction in E-cadherin,vimentin,and Snail in the desensitized cell ***,the protein expressions of EHMT2/G9A,PRMT5,and SETD7/9 also decreased in the desensitized cells and global protein lysine and arginine methylation became dysregulated with 5-FU ***:This study showed that continuous,dose-escalation treatment of 5-FU in CRC cells generated 5-FU

关键词： Chemoresistance Epithelial-to-mesenchymal transition Protein methylation Protein methyltransferases

Helium Plasma Effects on Polymer Surfaces:from Plasma Parameters and Surface Properties towards Bioengineering Applications

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Chinese Journal of Polymer Science 2024年第8期42卷 1156-1166页

作者： Andrei Vasile Nastuta Maria Butnaru byron Cheatham Ramona Huzum Vasile Tiron Ionut Topala Physics and Biophysics Education Research Laboratory(P&B-EduResLab) Biomedical Science DepartmentFaculty of Medical Bioengineering‘Grigore T.Popa’University of Medicine and Pharmacy IasiM.Kogalniceanu 9-13Iasi 700454Romania Faculty of Medical Bioengineering ‘Grigore T.Popa’University of Medicine and Pharmacy IasiM.Kogalniceanu 9-13Iasi 700454Romania Cytoviva Inc.570 Devall Drive Suite 301Auburn 36832ALUSA Integrated Center of Environmental Science Studies in the North-Eastern Development Region(CERNESIM) Department of Exact and Natural SciencesInstitute of Interdisciplinary Research‘Alexandru Ioan Cuza’University of IasiBlvd.Carol I no.11Iasi 700506Romania Research Center on Advanced Materials and Technologies(RAMTECH) Department of Exact and Natural SciencesInstitute of Interdisciplinary Research‘Alexandru Ioan Cuza’University of IasiBlvd.Carol I no.11Iasi 700506Romania Iasi Plasma Advanced Research Center(IPARC) Faculty of Physics‘Alexandru Ioan Cuza’University of IasiBlvd.Carol I no.11Iasi 700506Romania

Plasma treatment is necessary to optimize the performance of biomaterial *** enhances and regulates the performance of biomaterial su rfaces,creating an effective interface with the human *** treatments have the ability to modify the chemical com position and physical structu re of a surface while leaving its properties *** possess the ability to modify material su rfaces,eliminate contaminants,conduct investigations on cancer therapy,and facilitate wound *** subject of study in question involves the integration of plasma science and technology with biology and *** a helium plasma jet source,applying up to 18 kV,with an average power of 10 W,polymer foils were treated for 60 *** treatment has the ability to alter the chemical composition and physical structure of a su rface while maintaining its *** investigation involved the application of helium plasma at atmospheric pressure to polyamide 6 and polyethylene terephthalate *** inquiry involves monitoring and assessing the plasma source and polymer materials,as well as analyzing the impacts of plasma *** the mean power of the discharge aids in assessing the economic efficacy of the plasma *** discharge in helium at atmospheric pressure has beneficial effects in technology,where it increases the surface free energy of polymer *** biomedicine,it is used to investigate cytotoxicity and cell survival,particularly in direct blood exposure situations that can expedite *** the specific parameters that influence the plasma source in the desired manner for the intended application is of utmost im portance.

关键词： Atmopheric pressure plasmas Plasma-polymer interaction Plasma Medicine Plasma diagnosis Polymer characterization

雄激素受体基因CAG多态性与前列腺癌的关系

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临床泌尿外科杂志 2001年第2期16卷 51-53页

作者：陈越 Beilin J Zajac J D Favaloro J N Davey R byron k Harewood H 唐涌志孟荟上海市静安区中心医院泌尿外科上海200040 澳大利亚皇家墨尔本医院内科澳大利亚皇家墨尔本医院分子生物实验室澳大利亚皇家墨尔本医院泌尿外科

目的 :进一步探讨雄激素受体 (AR)基因 CAG多态性与前列腺癌的关系。方法 :采用分子生物学方法对 35 8例前列腺癌患者 AR基因 CAG进行测试 ,分析 CAG长度与临床各种指标的关系。结果 :经统计学分析 ,显示 AR基因 CAG与年龄之间呈高相关... 详细信息

目的 :进一步探讨雄激素受体 (AR)基因 CAG多态性与前列腺癌的关系。方法 :采用分子生物学方法对 35 8例前列腺癌患者 AR基因 CAG进行测试 ,分析 CAG长度与临床各种指标的关系。结果 :经统计学分析 ,显示 AR基因 CAG与年龄之间呈高相关性 (P =0 .0 0 7,γ=0 .114) ,但与 PSA、肿瘤分级及分期无显著相关性。结论 :AR基因 CAG的长度与患者年龄成正比 ,即前列腺癌患者年龄越轻 ,其 CAG长度越短。

关键词：雄激素受体 CAG片断前列腺癌基因多态性

Impact of ethnicity on the outcomes of acute pancreatitis:insights from US National Inpatient Sample

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Journal of Pancreatology 2024年第1期7卷 86-89页

作者： Ali Jaan Sheza Malik Joel E.McFarland Erik T.Olson byron Cryer Department of Internal Medicine Rochester General HospitalRochesterNY Department of Gastroenterology Rochester General HospitalRochesterNY Department of Gastroenterology Baylor University Medical CenterDallasTX

Introduction Acute pancreatitis(AP),characterized by inflammation of the pancreas,is a critical medical condition with potentially life-threatening consequences.[1]Despite significant advancements in medical science,the prognosis of AP remains challenging and is influenced by a multitude of *** these factors,ethnicity has emerged as a compelling variable that may play a pivotal role in determining the outcomes and severity of AP.[2]Understanding the influence of ethnicity on AP outcomes has immense significance for several ***,it provides a unique opportunity to gain critical insights into the pathophysiology of the disease.

关键词： pancreatitis insight consequences

Baptism by fire: the pivotal role of ancient conflagrations in evolution of the Earth's flora

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National Science Review 2018年第2期5卷 237-254页

作者： Tianhua He byron B.Lamont Department of Environment and Agriculture Curtin University

Fire became a defining feature of the Earth's processes as soon as land plants evolved 420 million years ago and has played a major role in shaping the composition and physiognomy of many ecosystems ever ***, there remains a general lack of appreciation of the place of fire in the origin, evolution, ecology and conservation of the Earth's biodiversity. We review the literature on the presence of fire throughout the Earth's history following the evolution of land plants and examine the evidence for the origin and evolution of adaptive functional traits, biomes and major plant groups in relation to fire. We show that:(1) fire activities have fluctuated throughout geological time due to variations in climate, and more importantly in atmospheric oxygen, as these affected fuel levels and flammability;(2) fire promoted the early evolution and spread of major terrestrial plant groups;(3) fire has shaped the floristics, structure and function of major global biomes; and(4) fire has initiated and maintained the evolution of a wide array of fire-adapted functional traits since the evolution of land plants. We conclude that fire has been a fundamental agent of natural selection on terrestrial plants throughout the history of life on the Earth's land surface. We suggest that a paradigm shift is required to reassess ecological and evolutionary theories that exclude a role for fire,and also there is a need to review fire-suppression policies on ecosystem management and biodiversity conservation in global fire-prone regions.

关键词： angiosperms ecosystems fossil charcoal palaeo-atmospheric oxygen terrestrial floras wildfire

Natural orifice translumenal endoscopic surgery: Progress in humans since white paper

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World Journal of Gastroenterology 2011年第13期17卷 1655-1665页

作者： byron F Santos Eric S Hungness Department of Surgery Feinberg School of Medicine Northwestern University Chicago IL 60611 United States

Since the first description of the concept of natural orifice translumenal endoscopic surgery (NOTES), a substantial number of clinical NOTES reports have appeared in the literature. This editorial reviews the available human data addressing research questions originally proposed by the white paper, including determining the optimal method of access for NOTES, developing safe methods of lumenal closure, suturing and anastomotic devices, advanced multitasking platforms, addressing the risk of infection, managing complications, addressing challenges with visualization, and training for NOTES procedures. An analysis of the literature reveals that so far transvaginal access and closure appear to be the most feasible techniques for NOTES, with a limited, but growing transgastric, transrectal, and transesophageal NOTES experience in humans. The theoretically increased risk of infection as a result of NOTES procedures has not been substantiated in transvaginal and transgastric procedures so far. Development of suturing and anastomotic devices and advanced platforms for NOTES has progressed slowly, with limited clinical data on their use so far. Data onthe optimal management and incidence of intraoperative complications remain sparse, although possible factors contributing to complications are discussed. Finally, this editorial discusses the likely direction of future NOTES development and its possible role in clinical practice.

关键词： Natural orifice translumenal endoscopic surgery Outcomes Complications Endoscopic Surgery

Prediction of Low-Energy Building Energy Consumption Based on Genetic BP Algorithm

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Computers, Materials & Continua 2022年第9期72卷 5481-5497页

作者： Yanhua Lu Xuehui Gong Andrew byron kipnis School of Urban Construction Yangtze UniversityJingzhou434023China Beijing Sifang Automation Co. Ltd.Beijing100085China Australian National University Canberra2600-2601Australia

Combined with the energy consumption data of individual buildings in the logistics group of Yangtze University,the analysis model scheme of energy consumption of individual buildings in the university is studied by using Back Propagation(BP)neural network to solve nonlinear problems and have the ability of global approximation and *** analyzing the influence of different uses,different building surfaces and different energysaving schemes on the change of building energy consumption,the grey correlation method is used to determine the main influencing factors affecting each building energy consumption,including uses,building surfaces and energy-saving schemes,which are used as the input of the model and the building energy consumption as the output of the model,so as to establish the building energy consumption analysis model based on BP neural ***,in practical application,BP neural network has the defects of slow convergence and easy to fall into local *** view of this,this paper uses genetic algorithm to optimize the weight and threshold of BP neural network,completes the improvement of various building energy consumption analysis models,and realizes the qualitative analysis of building energy *** model verification results show that the viscosity of the building energy consumption analysis model based on genetic algorithm improved BP neural network algorithm(GABP)in this paper is relatively high,which is more accurate than the results of the traditional BP neural network model,and the relative error of the analysis model is reduced from 11.56%to 8.13%,which proves that the GABP can be better suitable for the study of school building energy consumption analysis model,It is applied to the prediction of building energy consumption,which lays a foundation for the realization of carbon neutralization in the South expansion plan of Yangtze University.

关键词： Energy consumption analysis model BP neural network genetic algorithm

Prevention of post-operative recurrence of Crohn's disease

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World Journal of Gastroenterology 2014年第5期20卷 1147-1154页

作者： byron Philip Vaughn Alan Colm Moss Division of Gastroenter-ology Beth-Israel Deaconess Medical CenterBoston MA 02115 United States

Endoscopic and clinical recurrence of Crohn’s disease (CD) is a common occurrence after surgical resection. Smokers, those with perforating disease, and those with myenteric plexitis are all at higher risk of recurrence. A number of medical therapies have been shown to reduce this risk in clinical trials. Metronidazole, thiopurines and anti-tumour necrosis factors (TNFs) are all effective in reducing the risk of endoscopic or clinical recurrence of CD. Since these are preventative agents, the benefits of prophylaxis need to be weighed-against the risk of adverse events from, and costs of, therapy. Patients who are high risk for post-operative recurrence should be considered for early medical prophylaxis with an anti-TNF. Patients who have few to no risk factors are likely best served by a three-month course of antibiotics followed by tailored therapy based on endoscopy at one year. Clinical recurrence rates are variable, and methods to stratify patients into high and low risk populations combined with prophylaxis tailored to endoscopic recurrence would be an effective strategy in treating these patients.

关键词： Inflammatory bowel disease, Crohn’ s disease, Postoperative recurrence, Medical treatment, Biologics

Simulating streamflow and water table depth with a coupled hydrological model

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Water Science and Engineering 2010年第3期3卷 241-256页

作者： Alphonce Chenjerayi GUZHA Thomas byron HARDY Department of Agricultural and Biological Engineering Southwest Florida Research and Education CenterUniversity of Florida River Systems Institute Texas State University

A coupled model integrating MODFLOW and TOPNET with the models interacting through the exchange of recharge and baseflow and river-aquifer interactions was developed and applied to the Big Darby Watershed in Ohio, USA. Calibration and validation results show that there is generally good agreement between measured streamflow and simulated results from the coupled model. At two gauging stations, average goodness of fit （ R2 ）, percent bias （ PB ）, and Nash Sutcliffe efficiency （ENS） values of 0.83, 11.15%, and 0.83, respectively, were obtained for simulation of streamflow during calibration, and values of 0.84, 8.75%, and 0.85, respectively, were obtained for validation. The simulated water table depths yielded average R2 valuesof0.77 and 0.76 for calibration and validation, respectively. The good match between measured and simulated streamflows and water table depths demonstrates that the model is capable of adequately simulating streamflows and water table depths in the watershed and also capturing the influence of spatial and temporal variation in recharge.

关键词： hydrological modeling model coupling," streamflow groundwater," TOPNET model," MODFLOW model," Big Darby Watershed