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Field-effect transistor with a chemically synthesized MoS2 sensing channel for label-free and highly sensitive electrical detection of DNA hybridization

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Nano Research 2015年第7期8卷 2340-2350页

作者： doo-Won lee Jinhwan lee II Yung Sohn Bo-Yeong Kim Young Min Son Hunyoung Bark JaehyuckJung Minseok Choi Tae Hyeong Kim Changgu lee Nae-Eung lee Department of Advanced Materials Science & Engineering Sungkyunkwan University Suwon Gyunggi-do 440-746 Republic of Korea Department of Mechanical Engineering Sungkyunkwan University Suwon Gyunggi-do 440-746 Republic of Korea SKKU Advanced Institute of Nanotechnology (SAINT) Sungkyunkwan University Suwon Gyunggi-do 440-746 Republic of Korea Samsung Advanced Institute for Health Sciences & Technology (SAIHST) Sungkyunkwan University Suwon Gyeonggi-do 440-746 Republic of Korea New Materials Team Future Device R&D Department LG Electronics Advanced Research Institute Seou1137-724 Republic of Korea These authors contributed equally to this work.

A field-effect transistor （FET） with two-dimensional （2D） few-layer MoS2 as a sensing-channel material was investigated for label-free electrical detection of the hybridization of deoxyribonucleic acid （DNA） molecules. The high-quality MoS2-channel pattern was selectively formedthrough the chemical reaction of the Mo layer with H2S gas. The MoS2 FET was very stable in an electrolyte and inert to pH changes due to the lack of oxygen-containing functionalities on the MoS2 surface. Hybridization of single-stranded target DNA molecules with single-stranded probe DNA molecules physically adsorbed on the MoS2 channel resulted in a shift of the threshold voltage （Vt,） in the negative direction and an increase in the drain current. The negative shift in Vth is attributed to electrostatic gating effects induced by the detachment of negatively charged probe DNA molecules from the channel surface after hybridization. A detection limit of 10 fM, high sensitivity of 17 mWdec, and high dynamic range of 106 were achieved. The results showed that a bio-FET with an ultrathin 2D MoS2 channel can be used to detect very small concentrations of target DNA molecules specifically hybridized with the probe DNA molecules.

关键词： two-dimensional(2D)materials, MoS2,field-effect transistor, biosensor,deoxyribonucleic acid (DNA) hybridization

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Ileal angiomyolipoma manifested by small intestinal intussusception

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World Journal of Gastroenterology 2009年第11期15卷 1398-1400页

作者： Chang Ho lee Jong Hun Kim doo Hyun Yang Yong Hwang Myoung Jae Kang Young Kon Kim Min Ro lee Department of Surgery Chonbuk National University Medical SchoolJeonju 561-180 South Korea Department of Pathology Chonbuk National University Medical SchoolJeonju 561-180 South Korea Department of Radiology Chonbuk National University Medical SchoolJeonju 561-180South Korea

Angiomyolipomas(AMLs),a form of benign mesenchymal hamartoma,arise primarily in the kidneys of patients with or without tuberous ***-renal AMLs are very rare and are most commonly found in the liver. AMLs of the small intestine are exceedingly ***, a case of a 28-year-old man,who presented with ileal intussusception caused by ileal AML is *** clinicopathological and immunohistochemical findings of ileal AMLs are discussed and the literature on small intestinal AMLs is reviewed.

关键词： Angiomyolipoma Intussusception Hamartoma Ileum Colectomy

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Paraaortic lymph node metastasis in patients with intra-abdominal malignancies:CT vs PET

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World Journal of Gastroenterology 2009年第35期15卷 4434-4438页

作者： Mi-Jung lee Mi Jin Yun Mi-Suk Park Seung Hwan Cha Myeong-Jin Kim Jong doo lee Ki Whang Kim Department of Diagnostic Radiology Research Institute of Radiological Science and Institute ofGastroenterology Yonsei University College of Medicine 134Sincheon-Dong Seodaemun-Gu Seoul 120-752 South Korea Department of Nuclear medicine Yonsei University College of Medicine 134 Sincheon-Dong Seodaemun-Gu Seoul 120-752 South Korea Department of Diagnostic Radiology Yonsei University Wonju College of Medicine Wonju 220-701South Korea

AIM： To compare the diagnostic accuracy of computed tomography （CT） and positron emission tomography （PET） for the preoperative detection of paraaortic lymph node （PAN） metastasis in patients with intra- abdominal malignancies. METHODS： Sixty-six patients with intra-abdominal malignancies who underwent both CT and PET before lymphadenectomy were included in this study. Histopathologicaliy, 13 patients had metastatic PAN, while 53 had non-metastatic PAN. The CT criteria for metastasis were： short diameter ：）f 〉 8 mm, Iobular or irregular shape, and/or combined ancillary findings, including necrosis, conglomeration, vessel encasement, and infiltration. The PET criterion was positive fluorodeoxyglucose （FDG） uptake. The sensitivity, specificity, positive predictive value （PPV）, negative predictive value （NPV）, and accuracy of both modalities were compared with the pathologic findings, and the false positive and false negative cases with both CT and PET were ***： The sensitivity, specificity, PPV, NPV, and accuracy of CT were 61.5%, 84.9%, 50%, 90% and 80.3%, respectively. For PET, the percentages were 46.2%, 100%, 100%, 88.3%, and 89.4%. Additionally, there were 8 false positive CT cases （8/53, 15.1%） and zero false positive PET cases. Of the 13 metastatic PANs, there were 5 false negative CT scans （38.5%） and 7 （53.9%） false negative PET ***： For detecting PAN metastasis, CT is more sensitive than PET, while PET is more specific.

关键词： Malignancy Paraaortic lymph node Computed tomography Positron emission tomography Sensitivity Specificity

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Discharge Characteristics of Large-Area High-Power RF Ion Source for Positive and Negative Neutral Beam Injectors

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Plasma Science and Technology 2016年第12期18卷 1220-1224页

作者： doo-Hee CHANG Seung Ho JEONG Min PARK Tae-Seong KIM Bong-Ki JUNG Kwang Won lee Sang Ryul IN Division of Nuclear Fusion Engineering & Technology Development Korea Atomic Energy Research Institute

A large-area high-power radio-frequency（RF） driven ion source was developed for positive and negative neutral beam injectors at the Korea Atomic Energy Research Institute（KAERI）. The RF ion source consists of a driver region, including a helical antenna and a discharge chamber, and an expansion region. RF power can be transferred at up to 10 kW with a fixed frequency of 2 MHz through an optimized RF matching system. An actively water-cooled Faraday shield is located inside the driver region of the ion source for the stable and steady-state operations of high-power RF discharge. Plasma ignition of the ion source is initiated by the injection of argongas without a starter-filament heating, and the argon-gas is then slowly exchanged by the injection of hydrogen-gas to produce pure hydrogen plasmas. The uniformities of the plasma parameter,such as a plasma density and an electron temperature, are measured at the lowest area of the driver region using two RF-compensated electrostatic probes along the direction of the shortand long-dimensions of the driver region. The plasma parameters will be compared with those obtained at the lowest area of the expansion bucket to analyze the plasma expansion properties from the driver region to the expansion region.

关键词： neutral beam injector RF ion source plasma ignition power loading plasma parameters

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Machining characteristics of complex prism pattern on electroplated roll by copper

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中国有色金属学会会刊：英文版 2009年第B9期19卷 288-294页

作者： Tae-Jin JE Sang-Cheon PARK Kang-Won lee Yeong-Eun YOO doo-Sun CHOI Kyung-Hyun WHANG Myung-Chang KANG Nano-Machining Laboratory Division of Nano-Mechanical Systems Korea Institute of Machinery and Materials Nano-Mechatronics Department University of Science and TechnologySinseongnoYouseong-GuDaejeonKorea National Core Research Center for Hybrid Materials Solution Pusan National University

The BLU (back light unit) is the core component of the LCD for notebook, mobile-phone, navigation, as well as large sized TV, PID (public information display), etc. In order to enhance optical efficiency of LCD, optical films with the uniform prism patterns have been used for BLU by stacking two films up orthogonally. In this case, light interference-phenomenon occurred such as Morie, wet-out, u-turning, etc. It caused several problems such as low brightness, spots and stripes in LCD. Recently, the high-luminance micro complex prism patterns are actively studied to avoid the light interference-phenomenon and enhance the optical efficiency. In this study, the roll master to manufacture complex micro prism pattern film was machined by using the high precision lathe. The machined patterns on the roll master were 50, 45, 40, 35, 30, 25, 20, 15, 10 and 5 μm in the pitch with 25.0, 22.5, 20.0, 17.5, 15.0, 12.5, 10.0, 7.5, 5.0 and 2.5 μm in the peak height, respectively. The roll was 2 000 mm in length and 320 mm in diameter. The electroplated roll by copper and the natural single crystal diamond tool was used for machining the patterns. The cutting force was measured and analyzed for each cutting condition by using the dynamometer. The chips and the surfaces after being machined were analyzed by SEM and microscope.

关键词：车床加工微棱镜铜电镀特征光学效率光学薄膜笔记本电脑金刚石工具

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Influence of tool deflection on micro channel pattern of 6:4 brass with rectangular tool

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中国有色金属学会会刊：英文版 2009年第B9期19卷 164-170页

作者： Tae-Jin JE Kang-Won lee Sang-Cheon PARK Jae-Gu KIM doo-Sun CHOI Kyoung-Taik PARK Kyung-Hyun WHANG Nano Mechanical Systems Research Division Korea Institute of Machinery & Materials (KIMM)

Machining experiment of micro channel structure with 6:4 brass was carried out by shaping process using a single crystal diamond tool. FEM simulation using solid cantilever beam model was analyzed. In result of experiment, tool deflection is observed as machining characteristics through result of experiments such as surface roughness, cutting force and burr formations. And the influence of tool deflection is experimentally proved.

关键词：金刚石工具挠度通道模式黄铜矩形实验证明加工特性有限元模拟

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Flow stress equation in range of intermediate strain rates and high temperatures to predict roll force in four-pass continuous rod rolling

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Transactions of Nonferrous Metals Society of China 2013年第3期23卷 742-748页

作者： Sang-min BYON doo-hyun NA Young-seog lee Department of Mechanical Engineering Dong-A UniversityBusan 604-714Korea Department of Mechanical Engineering Chu ng-Ang UniversitySeoul 156-756Korea

A flow stress equation was proposed to compute the roll force in the finishing stands of an actual rod mill where the strain rate and the temperature of the material range from 100 to 400 s-1 and from 900 to 1050 ℃,*** underlying idea is to modify the Shida model and Misaka model,which provide flow stress equations（constitutive equations） frequently used to depict deformation behavior of high temperature material at different strain *** modified model was coupled with finite element method to compute the roll force during four-pass continuous rod rolling,where strain rates are in the range of 100-400 s-1 at high temperatures（900-1050 ℃）.The roll forces and the surface temperatures of the material at each stand were measured,and the measured data were compared with the computed *** reveal that the Misaka model is better than the Shida model for high temperatures and intermediate strain *** roll force error was-5.7 % when the Misaka model was used at 900 ℃.However,the error increased by-15.2% at 1050 ℃.When the modified Misaka model was used,the error was reduced to 1.8% on *** can consequently be deduced that the modified Misaka model can be used to depict the deformation resistance behavior in intermediate ranges of strain rate and high temperature ranges in continuous rod rolling process.

关键词： roll force strain rate deformation resistance rod rolling Shida model Misaka model

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Emerging Technologies of Liquid Crystal Displays

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光学学报 2003年第S1期23卷 797-798页

作者： Sin-doo lee Chang-Jae Yu Jae-Hong Park Min-Sik Jung School of Electrical Engineering #032 Seoul National University Kwanak P.O. Box 34 Seoul 151-742 KoreaSchool of Electrical Engineering #032 Seoul National University Kwanak P.O. Box 34 Seoul 151-742 KoreaSchool of Electrical Engineering #032 Seoul National University Kwanak P.O. Box 34 Seoul 151-742 KoreaSchool of Electrical Engineering #032 Seoul National University Kwanak P.O. Box 34 Seoul 151-742 Korea

The general features and the emerging technologies of liquid crystal displays are described from the viewpoints of wide viewing and fast response technologies. The device applications of liquid crystals for optical co... 详细信息

关键词： of in on it as LCD Emerging Technologies of Liquid Crystal Displays been mode DSG

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Spatio-temporal change in forest cover and carbon storage considering actual and potential forest cover in South Korea

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Science China(Life Sciences) 2015年第7期58卷 713-723页

作者： NAM Kijun lee Woo-Kyun KIM Moonil KWAK doo-Ahn BYUN Woo-Hyuk YU Hangnan KWAK Hanbin KWON Taesung SUNG Joohan CHUNG Dong-Jun lee Seung-Ho Division of Environmental Science and Ecological Engineering Korea University GIS/RS Center for Environmental Resources Korea University Division of Forest Ecology Korea Forest Research Institute National Forestry Cooperative Federation Division of Forest Economics & Management Korea Forest Research Institute

This study analyzes change in carbon storage by applying forest growth models and final cutting age to actual and potential forest cover for six major tree species in South Korea. Using National Forest Inventory data, the growth models were developed to estimate mean diameter at breast height, tree height, and number of trees for Pinus densiflora, Pinus koraiensis, Pinus rigida, Larix kaernpferi, Castanea crenata and Quercus spp. stands. We assumed that actual forest cover in a forest type map will change into potential forest covers according to the Hydrological and Thermal Analogy Groups model. When actual forest cover reaches the final cutting age, forest volume and carbon storage are estimated by changed forest cover and its growth model. Forest volume between 2010 and 2110 would increase from 126.73 to 157.33 m^3 hm^-2. Our results also show that forest cover, volume, and carbon storage could abruptly change by 2060. This is attributed to the fact that most forests are presumed to reach final cutting age. To avoid such dramatic change, a regeneration and yield control scheme should be prepared and implemented in a way that ensures balance in forest practice and yield.

关键词： climate change final cutting age carbon storage national forestry inventory forest growth model

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Estimation of carbon storage based on individual tree detection in Pinus densiflora stands using a fusion of aerial photography and LiDAR data

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Science China(Life Sciences) 2010年第7期53卷 885-897页

作者： KIM So-Ra KWAK doo-Ahn lee Woo-Kyun SON Yowhan BAE Sang-Won KIM Choonsig YOO Seongjin Division of Environmental Science and Ecological Engineering Korea University Forest Practice Research Center Korea Forest Research Institute Departement of Forest Resources Jinju National University

The objective of this study was to estimate the carbon storage capacity of Pinus densiflora stands using remotely sensed data by combining digital aerial photography with light detection and ranging(LiDAR) data.A digital canopy model(DCM),generated from the LiDAR data,was combined with aerial photography for segmenting crowns of individual *** eliminate errors in over and under-segmentation,the combined image was smoothed using a Gaussian filtering *** processed image was then segmented into individual trees using a marker-controlled watershed segmentation *** measuring the crown area from the segmented individual trees,the individual tree diameter at breast height(DBH) was estimated using a regression function developed from the relationship observed between the field-measured DBH and crown *** above ground biomass of individual trees could be calculated by an image-derived DBH using a regression function developed by the Korea Forest Research *** carbon storage,based on individual trees,was estimated by simple multiplication using the carbon conversion index(0.5),as suggested in guidelines from the Intergovernmental Panel on Climate *** mean carbon storage per individual tree was estimated and then compared with the field-measured *** study suggested that the biomass and carbon storage in a large forest area can be effectively estimated using aerial photographs and LiDAR data.

关键词： LiDAR aerial photograph region growing marker-control watershed segmentation carbon storage

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