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Diphlorethohydroxycarmalol,a phlorotannin contained in brown edible seaweed Ishige okamurae,prevents AGE-related diabetic nephropathy by suppression of AGE-RAGE interaction

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Food Bioscience 2023年第3期53卷 1541-1550页

作者： Chi Heung Cho Guijae yoo Mingyeong Kim Chang Jun Lee In-Wook Choi Bomi Ryu byoung-Mok Kim Sang-hoon Lee Division of Functional Food Research Korea Food Research Institute245 nongsaengmyeong-roIseo-myeonWanju-gunJeollabuk-do55365Republic of Korea Department of Food Biotechnology University of Science and TechnologyDaejeon34113Republic of Korea Department of Food Science and Technology Chonbuk National UniversityJeollabuk-do54896Republic of Korea Major of Food Science and Nutrition Pukyong National UniversityBusan48513Republic of Korea Research Group of Food Processing Korea Food Research Institute245 nongsaengmyeong-roIseo-myeonWanju-gunJeollabuk-do55365Republic of Korea

Advanced glycation end-products(AGEs)are complex and heterogeneous compounds generated through various steps and are naturally produced during the glycation *** generated AGEs bind to long-lived proteins such as collagen and cause renal dysfunction,leading to AGE-related diabetic nephropathy(DN).In this study,we aimed to confirm the therapeutic potential of marine biological resources by evaluating the role of diphlorethohydroxycarmalol(DPHC),a major phlorotannin compound contained in edible brown algae Ishige okamurae,in the key mechanisms involved in the pathogenesis and progression of AGE-induced *** AGE formation inhibitory and AGE-collagen cross-link inhibiting/breaking ability assay were performed to evaluate the anti-glycation effect of *** AGE-RAGE interaction inhibitory effect was evaluated through molecular docking *** renoprotective effect of DPHC was confirmed in mouse glomerular mesangial *** treatment exhibited anti-glycation ability through suppression of AGE formation and AGE-collagen cross-linking generation,and disruption of cross-links formed between *** addition,DPHC pre-treatment significantly suppressed reactive oxygen species(ROS)production,intracellular methylglyoxal(MGO)/AGEs accumulation,and activation of apoptosis cascade by ***,DPHC suppressed AGE-receptor for AGE(RAGE)interaction by competing with MG-H1 for the binding site of ***,DPHC pre-treatment regulated apoptosis-related protein expression and increased Nrf2,Glo-1,HO-1,CAT,NQO1,and *** findings prove that the chemical structural characteristics of DPHC have the potential to prevent or manage AGE-induced DN by effectively mediating the key mechanisms responsible for its pathogenesis.

关键词： Diphlorethohydroxycarmalol Molecular docking RAGE Methylglyoxal Renoprotective effect

Fluid flow and heat transfer characteristics of spiral coiled tube: Effects of Reynolds number and curvature ratio

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Journal of Central South University 2012年第2期19卷 471-476页

作者： yoo Geun-jong CHOI hoon-ki DONG Wa-ryong School of Mechatronics Changwon National University

Numerical analysis was performed to investigate flow and heat transfer characteristics in spiral coiled tube heat exchanger. Radius of curvature of the spiral coiled tube was gradually increased as total rotating angle reached 12n. As the varying radius of curvature became a dominant flow parameter, three-dimensional flow analysis was performed to this flow together with different Reynolds numbers while constant wall heat flux condition was set in thermal field. From the analysis, centrifugal force due to curvature effect is found to have significant role in behavior of pressure drop and heat transfer. The centrifugal force enhances pressure drop and heat transfer to have generally higher values in the spiral coiled tube than those in the straight tube. Even then, friction factor and Nusselt number are found to follow the proportionality with square root of the Dean number. Individual effect of flow parameters of Reynolds number and curvature ratio was investigated and effect of Reynolds number is found to be stronger than that of curvature effect.

关键词： spiral coiled tube heat exchanger Reynolds number curvature ratio secondary flow friction factor Nusselt number

Characteristics of radiation and convection heat transfer in indirect near-infrared-ray heating chamber

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Journal of Central South University 2011年第3期18卷 731-738页

作者： CHOI hoon-ki yoo Geun-jong KIM Churl-hwan School of Mechatronics Changwon National University

Numerical study was performed to evaluate the characteristics of combined heat transfer of radiation, conduction and convection in indirect near infrared ray （N/R） heating chamber. The effects of important design parameters such as the shape of heat absorbing cylinder and heat releasing fin on the pressure drop and heat transfer coefficient were analyzed with different Reynolds numbers. The Reynolds numbers were varied from 103 to 3x106, which was defined based on the hydraulic diameter of the heat absorbing cylinder. Analyses were performed to obtain the inner and outer flow and the temperature distributions in the heat absorbing cylinder and the rates of radiation heat transfer and convection heat transfer. As the Reynolds number increases, the convection heat transfer rate is increased while the radiation heat transfer rate is decreased. The average convection heat transfer rate follows a power rule of the Reynolds number. Addition of three-dimensional heat releasing fin to the outside of the heat absorbing cylinder enhances the convection heat transfer.

关键词： near infrared ray indirect near infrared ray heater absorbing cylinder heat releasing fin radiation heat transfer convection heat transfer Reynolds number

Verification of Beam Models for Ionic Polymer-Metal Composite Actuator

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Journal of Bionic Engineering 2009年第3期6卷 232-238页

作者： hoon Cheol Park Quoc Viet Nguyen Jang Woo Lee Young Tai yoo Artificial Muscle Research Center Konkuk University Department of Advanced Technology Fusion Konkuk University Department of Materials Chemistry and Engineering Konkuk University

Ionic Polymer-Metal Composite (IPMC) can work as an actuator by applying a few voltages.A thick IPMC actuator,where Nafion-117 membrane was synthesized with polypyrrole/alumina composite filler,was analyzed to verify the equivalent beam and equivalent bimorph beam *** blocking force and tip displacement of the IPMC actuator were measured with a DC power supply and Young's modulus of the IPMC strip was measured by bending and tensile tests *** calculated maximum tip displacement and the Young's modulus by the equivalent beam model were almost identical to the corresponding measured *** element analysis with thermal analogy technique was utilized in the equivalent bimorph beam model to numerically reproduce the force-displacement relationship of the IPMC *** results by the equivalent bimorph beam model agreed well with the force-displacement relationship acquired by the measured *** is confirmed that the equivalent beam and equivalent bimorph beam models are practically and effectively suitable for predicting the tip displacement,blocking force and Young's modulus of IPMC actuators with different thickness and different composite of ionic polymer membrane.

关键词： jonic polymer-metal composite beam model displacement force

Materials and devices for flexible and stretchable photodetectors and light-emitting diodes

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Nano Research 2021年第9期14卷 2919-2937页

作者： Jun-Kyul Song Min Sung Kim Seungwon yoo Ja hoon Koo Dae-Hyeong Kim Center for Nanoparticle Research Institute for Basic Science(IBS)Seoul 08826Republic of Korea School of Chemical and Biological Engineering and Institute of Chemical Processes Seoul National UniversitySeoul 08826Republic of Korea Interdisciplinary Program for Bioengineering Seoul National UniversitySeoul 08826Republic of Korea Department of Materials Science and Engineering Seoul National UniversitySeoul 08826Republic of Korea

Recently,significant efforts have been directed at overcoming the limitations of conventional rigid optoelectronic devices,particularly their poor mechanical stability under bending,folding,and stretching *** of major approaches for rendering optoelectronic devices mechanically deformable is to replace the conventional electronic/optoelectronic materials with functional nanomaterials or organic materials that are intrinsically flexible/***,advanced device designs and unconventional fabrication methods have also contributed to the development of soft optoelectronic ***,new devices such as bio-inspired curved image sensors,wearable light emitting devices,and deformable bio-integrated optoelectronic devices have been *** this review,recent progress in the development of soft optoelectronic materials and devices is ***,various materials such as nanomaterials,organic materials,and their hybrids that are suitable for developing deformable photodetectors,are ***,the nanomaterials and organic/polymeric materials that are applicable in deformable light-emitting diodes are ***,representative system-level applications of flexible and stretchable photodetectors and light-emitting diodes are reviewed,and future prospects are discussed.

关键词： nanomaterial organic material photodetector light-emitting diode flexible optoelectronics stretchable optoelectronics

Characteristics of turbulent flow distribution in branch piping system

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Journal of Central South University 2012年第11期19卷 3208-3214页

作者： yoo Geun-jong CHOI hoon-ki KIM Chul-hwan School of Mechatronics Changwon National UniversityChangwon 641-773Korea

Flow distribution in branch piping system is affected by flow characteristics and different geometric variations. Most of the flow distribution studies are performed with one-dimensional analysis to yield overall information only. However, detailed analysis is required to find effects of design parameters on the flow distribution. For this aspect, three-dimensional turbulent flow analysis was performed to assess turbulence model performance and effects of upstream pressure and branch pipe geometry. Three different turbulence models of standard k-e model, realizable k-e model and standard k-co yield similar results, indicating small effects of turbulence models on flow characteristics analysis. Geometric variations include area ratio of main and branch pipes, branch pipe diameter, and connection shape of main and branch pipes. Among these parameters, area ratio and branch diameter and shape show strong effect on flow distribution due to high friction and minor loss. Uniform flow distribution is one of common requirements in the branch piping system and this can be achieved with rather high total loss design.

关键词： flow distribution pipe flow branch pipe turbulent flow

Thermal performance analysis of borehole size effect on geothermal heat exchanger

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Journal of Central South University 2012年第12期19卷 3524-3529页

作者： CHOI hoon-ki yoo Geun-jong LIM Kyung-bin LEE Sang-hoon LEE Chang-hee Department of Mechanical Design and Manufacturing Engineering Changwon National UniversityChangwon 641-773Korea Department of Mechanical Design Engineering Hanbat National UniversityDaejon 305-719Korea Department of Energy Engineering Jeonju UniversityJeonju 560-759Korea STX Institute of Technology Changwon 642-845Korea

Thermal performance was the most important factor in the development of borehole heat exchanger utilizing geothermal energy. The thermal performance was affected by many different design parameters, such as configuration type and borehole size of geothermal heat exchanger. These eventually determined the operation and cost efficiency of the geothermal heat exchanger system. The main purpose of this work was to assess the thermal performance of geother^nal heat exchanger with variation of borehole sizes and numbers of U-tubes inside a borehole. For this, a thermal response test rig was established with line-source theory. The thermal response test was performed with in-line variable input heat source. Effective thermal conductivity and thermal resistance were obtained from the measured data. From the measurement, the effective thermal conductivity is found to have similar values for two- pair type （4 U-tubes） and three-pair type （6 U-tubes） borehole heat exchanger systems indicating similar heat transfer ability. Meanwhile, the thermal resistance shows lower value for the three-pair type compared to the two-pair type. Measured data based resistance have lower value compared to computed result from design programs. Overall comparison finds better thermal performance for the three-pair type, however, fluctuating temperature variation indicates complex flow behavior inside the borehole and requires further study on flow characteristics.

关键词： large size borehole heat exchanger thermal response test effective thermal conductivity thermal resistance borehole

Characteristic analysis of bleeding effect on standing column well (SCW) type geothermal heat exchanger

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Journal of Central South University 2012年第11期19卷 3202-3207页

作者： CHOI hoon-ki yoo Geun-jong LIM Kyung-bin LEE Sang-hoon LEE Chang-hee Department of Mechanical Design/Manufacturing Engineering Changwon National UniversityChangwon 641-773Korea Department of Mechanical Design Engineering Hanbat National UniversityDaejon 305-719Korea Department of Energy Engineering Jeonju UniversityJeonju 560-759Korea STX Institute of Technology Gyeongnam 642-845Korea

Thermal performance is the most important factor in the development of a borehole heat exchanger utilizing geothermal *** thermal performance is affected by many different design parameters and different operating conditions such as *** eventually determines the operation and cost efficiency of the borehole heat exchanger *** thermal performance of an open standing column well (SCW) type geothermal heat exchanger was assessed under the influence of *** this,a thermal response test rig was established with line-source *** test rig also had a bleeding function by releasing fluid while taking additional underground water through the heat *** thermal response test was performed with an additional constant input heat *** thermal conductivity and thermal resistance were obtained from the measured *** the measurement,the effective thermal conductivity is found to have 1.47 times higher value when bleeding is *** thermal resistance also increases by 1.58 times compared to a non-bleeding *** trend indicates enhanced heat transfer in the SCW type heat exchanger with a bleeding ***,therefore,could be an effective method of achieving a high heat transfer rate in the SCW type heat exchanger with sufficient underground water supply.

关键词： standing column well type thermal response test effective thermal conductivity thermal resistance bleeding effect

Mimicking a Superhydrophobic Insect Wing by Argon and Oxygen Ion Beam Treatment on Polytetrafluoroethylene Film

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Journal of Bionic Engineering 2009年第4期6卷 365-370页

作者： Youngjong Lee Yonghoon yoo Jihoon Kim Sriyulianti Widhiarini Baeho Park hoon Cheol Park Kwang Joon yoon Doyoung Byun Department of Aerospace Information Engineering Konkuk UniversitySeoul 143-701Republic of Korea Department of Physics Konkuk UniversitySeoul 143-701Republic of Korea Department of Advanced Technology Fusion Konkuk UniversitySeoul 143-701Republic of Korea

Biological tiny structures have been observed on many kinds of surfaces such as lotus leaves and insect wings,which enhance the hydrophobicity of the natural surfaces and play a role of *** presented the fabrication technology of a superhydrophobic surface using high energy ion *** insect wings that mimic the morphology and the superhydrophobocity of cicada's wings were successfully fabricated using argon and oxygen ion beam treatment on a polytetrafluoroethylene (PTFE)*** wing structures were supported by carbon/epoxy fibers as artificial flexible veins that were bonded through an autoclave *** morphology of the fabricated surface bears a strong resemblance to the wing surface of a cicada,with contact angles greater than 160°,which could be sustained for more than two months.

关键词： superhydrophobic insect wing mimicry of the wing ion beam treatment artificial flapper dynamic contact angle