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埃万妥单抗联合拉泽替尼治疗EGFR突变晚期NSCLC患者的临床研究

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中国临床药理学杂志 2024年第17期40卷 2478-2478页

作者： cho B C 戴荣源

韩国延世大学医学院cho团队研究了埃万妥单抗联合拉泽替尼治疗初治表皮生长因子受体(epidermal growth factor receptor,EGFR)突变晚期非小细胞肺癌(non-small-cell lung cancer,NSCLC)患者的临床疗效与安全性。在这项Ⅲ期国际随机试验... 详细信息

韩国延世大学医学院cho团队研究了埃万妥单抗联合拉泽替尼治疗初治表皮生长因子受体(epidermal growth factor receptor,EGFR)突变晚期非小细胞肺癌(non-small-cell lung cancer,NSCLC)患者的临床疗效与安全性。在这项Ⅲ期国际随机试验中,研究团队按2∶2∶1的比例将先前未经治疗的EGFR突变(外显子19缺失或L858R)、局部晚期或转移性NSCLC患者分配接受埃万妥单抗-拉泽替尼(试验组,以开放标签方式)、奥西替尼(以盲法方式)或拉泽替尼(盲法方式,评估治疗成分的作用)。主要终点是与奥西替尼组相比,试验组的无进展生存率。

关键词： EGFR突变晚期非小细胞肺癌表皮生长因子受体晚期NSCLC 评估治疗随机试验盲法拉泽

A Study on the Design Method of Hybrid MOSFET-CNTFET Based SRAM-A Secondary Publication

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Journal of Electronic Research and Application 2024年第1期8卷 106-112页

作者： Geunho cho Department of Electronic Engineering Seokyeong UniversitySeoulSouth Korea

More than 10,000 carbon nanotube field-effect transistors(CNTFETs)have been successfully integrated into one semiconductor chip using conventional semiconductor design procedures and manufacturing *** transistors offer advantages such as high carrier mobility,large saturation velocity,low intrinsic capacitance,flexibility,and *** three-dimensional multilayer structure of the CNTFET semiconductor chip,along with ongoing research in CNTFET manufacturing processes,increases the potential for creating a hybrid MOSFET-CNTFET semiconductor *** chip combines conventional metal-oxide-semiconductor field-effect transistors(MOSFETs)and CNTFETs in one integrated *** paper discusses a methodology to design 6T binary static random-access memory(SRAM)using a hybrid *** paper introduces a method for designing a hybrid MOSFET-CNTFET SRAM by leveraging existing MOSFET SRAM or CNTFET SRAM design ***,this paper compares its performance with conventional MOSFET SRAM and CNTFET SRAM designs.

关键词： MOSFET CNTFET SRAM Hybrid Carbon nanotube

Laser micromachining of CNT/Fe/Al_2O_3 nanocomposites

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中国有色金属学会会刊：英文版 2009年第B9期19卷 189-193页

作者： Kwang-Ryul KIM byoung-Deog choI Jun-Sin YI Sung-Hak cho Yong-Ho choA Dong-Soo SHIN Dong-Ho BAE Myung-Chang KANG Young-Keun JEONG School of Information and Communication Engineering Sungkyunkwan University Korea Institute of Machinery and Materials Department of Chemical Engineering Hanyang University NANOBASE Inc. School of Mechanical Engineering Sungkyunkwan University National Core Research Center for Hybrid Materials Solution Pusan National University

CNT/Fe/Al2O3 mixed powders were synthesized from Fe/Al2O3 nanopowders using thermal CVD for the homogeneous dispersion of carbon nanotubes CNTs. CNTs consisted of MWNT, and the diameter was approximately 20-30 nm. After sintering, CNTs were homogenously located throughout Al2O3 grain boundary and were buckled. A femto-second laser installed with special optical systems was used for micromachining of the nanocomposites. The relationship between material ablation rate and energy fluence was theoretically investigated and compared with experimental results from cross-sectional SEM analysis. The nanocomposites which have higher content of CNT show a fairly good machining result due to its higher thermal conductivity and smaller grain size as well as lower light transmittance.

关键词：纳米复合材料激光光学系统热化学气相沉积碳纳米管 Al2O3 扫描电镜分析均匀分散纳米粉体

《海篇心镜》四种版本的详细书目考察以及朝鲜的接受样态

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中国文字研究 2024年第1期 219-231页

作者： [韩]赵成德韩国庆星大学韩国汉字研究所韩国釜山48434

朝鲜中期以后的几种文献对《海篇心镜》有所言及,但将它作为一种普通字典来使用的例子并不多见。本论文将考察韩国文献的内容,对《海篇心镜》给予朝鲜的影响以及它之所以未能取得一部字典的地位的原因进行探讨。本论文考察朝鲜本《玉堂... 详细信息

朝鲜中期以后的几种文献对《海篇心镜》有所言及,但将它作为一种普通字典来使用的例子并不多见。本论文将考察韩国文献的内容,对《海篇心镜》给予朝鲜的影响以及它之所以未能取得一部字典的地位的原因进行探讨。本论文考察朝鲜本《玉堂厘整字义韵律海篇心镜(鲜)》和版本及内容与之有别的中国本明本《翰林笔削字义韵律大板海篇心镜(中)》《翰林详校字义韵律鳌头海篇心镜(中)》《翰林详校字义韵律鳌头海篇心镜(中)》等四种《海篇心镜》,对著录方面的版本、体制等相关内容进行分析,再对内容方面的字形变化、墨等修改、注释内容变化、笔划数变化、标题字的增删进行分析,从而阐明四种版本各自具有的特征和区别之处。

关键词：《海篇心镜》字形字释朝鲜本中国本

Damage and penetration behavior of aluminum foam at various impacts

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Journal of Central South University 2014年第9期21卷 3442-3448页

作者： cho Hosun cho Jaeung Division of Mechanical Engineering Graduate School Kongju National University Division of Mechanical and Automotive Engineering Kongju National University

In this work, the damage and penetration behavior of aluminum foam at various types of impact were examined through experiments. The impact energy of a striker was applied on the fixed aluminum foam having a thickness of 25 mm while increasing its impact by 2 J at each strike from 6 J to 16 J. The results show that the impact energies from 6 J to 12 J could not penetrate aluminum foam. However, the aluminum foam applied with the impact energy of 12 J incurred severe damages on its lower part. Finally, the aluminum foam applied with the impact energy of 14 J was penetrated. The striker having the impact energy of 6 J could penetrate aluminum foam around 10 mm. At this moment, aluminum foam could absorb the impact energy of around 9 J. When the impact energy of 14 J was applied on the aluminum foam, the aluminum foam was penetrated and it absorbed the impact energy of around 17.2 J. It is possible to create the safer structure against impact using the results of this work. The simulation results for the verification of the experimental results imply that the results for all the experiments in this work are reliable. It is possible to predict the structural safety of the aluminum foam for an impact if the impact behavior of aluminum foam performed in this work is utilized.

关键词： aluminum foam absorbed energy finite element analysis impact energy impact load

Association between the Different Phenotypes of Polycystic Ovary Syndrome and the Outcome in in Vitro Fertilization at Human Reproductive Center Paul et Chantal Biya-Yaoundé

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Open Journal of Obstetrics and Gynecology 2024年第1期14卷 18-28页

作者： Ngono Akam Vanina Ngah Minala Belinga Etienne Belinga Etienne Mpono Pascale Nyada Serges Onana Y. Kasia cho Joselyne Kasia Florence Adjessa Abega Kasia Jean Marie Gynaecological Endoscopic Surgery and Human Reproductive Teaching Hospital Yaoundé Cameroon Department of Gynecology and Obstetrics Faculty of Medicine and Biomedical Sciences University of Yaoundé 1 Yaoundé Cameroon

Background: In Vitro Fertilization/Intracytoplasmic Sperm Injection (IVF/ICSI) represents the final step in the management of Polycystic Ovarian Syndrome (PCOS). Our objective was to study the association between PCOS phenotypes and IVF/ICSI results in women admitted to Gynaecological Endoscopic Surgery and Human Reproductive Teaching Hospital (CHRACERH). Material and Method: We carried out a cohort study with historical-prospective data collection over a period of seven years (January 2016 to March 2023) at Chracerh. PCOS patients were subdivided into 4 subgroups A, B, C and D. Results: We recruited 128 patients including 64 PCOS patients divided into four phenotypes and 64 non-PCOS patients constituting the control group. Phenotype D without hyperandrogenism had used the lowest dose of gonadotropins, i.e. 1939.7 ± 454.3 IU, and had produced a greater quantity of estradiol on the day ovulation was triggered (6529.8 ± 4324.8 ng/ml). The average number of punctured follicles and mature oocytes were higher in the phenotype D group. Ovarian hyperstimulation syndrome (OHSS) occurred mainly in phenotype D (3/35), with an estimated prevalence of 2.3%. The fertilization rate seemed lower in the hyperandrogenic phenotypes A, B, C compared to the group without hyperandrogenism without significant difference (p = 0.461). The biological pregnancy rate and live birth rate were comparable between the different groups. Conclusion: Phenotype D used less dose of gonadotropins. Biological pregnancy and live birth rates were comparable between the different phenotypes.

关键词： Phenotype Polycystic Ovarian Syndrome IVF/ICSI Prognosis CHRACERH

GENUS MINIMIZING IN SYMPLECTIC 4-MANIFOLDS

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Chinese Annals of Mathematics,Series B 2000年第1期21卷 115-120页

作者： cho YONGSEUNG cho MISUNG Department of Mathematics Ewha Women’s University Seoul Korea

The authors show that a symplectically embedded surface in a symplectic 4-manifold with hi greater than one minimizes genus in its homology class.

关键词： Generalized Thom Conjecture Seiberg-Witten invariant Symplectic 4-manifolds

Effect of barley straw biochar application on greenhouse gas emissions from upland soil for Chinese cabbage cultivation in short-term laboratory experiments

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Journal of Mountain Science 2016年第4期13卷 693-702页

作者： Se-Won KANG Dong-Cheol SEO Yong-Hwa CHEONG Ju-Wang PARK Jong-Hwan PARK Hang-Won KANG Ki-Do PARK Yong Sik ok Ju-Sik cho Department of Medicinal & Industrial Crops Korea National College of Agriculture and Fisheries Division of Applied Life Science (BK21 Program) & Institute of Agriculture and Life Sciences Gyeongsang National University Department of Bio-environmental Sciences Sunchon National University National Institute of Crop Science Rural Development Association Korea Biochar Research Center & Department of Biological Environment Kangwon National University

Chinese cabbage was cultivated in upland soil with the addition of biochar in order to investigate the potential for reduction of greenhouse gas emissions. Barley straw biochar(BSB) was introduced in a Wagner pot(1/5000a) in amounts of 0(BSB0, control), 100(BSB100), 300(BSB300), and 500(BSB500) kg 10a^(-1). After the addition of BSB into the upland soil, carbon dioxide(CO_2) emission increased while methane(CH_4) and nitrous oxide(N_2O) emissions decreased. The highest CO2 flux was measured for the BSB500 sample,(84.6 g m^(-2)) followed by BSB300, BSB100, and BSB0 in decreasing order. Relative to those of control, the total CH_4 flux and N_2O flux for the BSB500 treatment were lower by 31.6% and 26.1%, respectively. The global warming potential(GWP) of the treatment without biochar was 281.4 g CO_2 m-2 and those for treatments with biochar were in the range from 194.1 to 224.9 g CO_2 m^(-2). Therefore, introducing BSB into upland soil to cultivate Chinese cabbages can reduce the global warming potential.

关键词： Biochar Carbon dioxide Methane Nitrous oxide Global warming

Effect of PAIP1 on the metastatic potential and prognostic significance in oral squamous cell carcinoma

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International Journal of Oral Science 2022年第1期14卷 113-122页

作者： Neeti Swarup Kyoung-ok Hong Kunal Chawla Su-Jung choi Ji-Ae Shin Kyu-Young Oh Hye-Jung Yoon Jae-Il Lee Sung-Dae cho Seong-Doo Hong Department of Oral Pathology School of Dentistry and Dental Research InstituteSeoul National UniversitySeoulRepublic of Korea Department of Computer Science School of Interactive ComputingGeorgia Institute of TechnologyAtlantaGAUSA

Poly Adenylate Binding Protein Interacting protein 1(PAIP1) plays a critical role in translation initiation and is associated with the several cancer types. However, its function and clinical significance have not yet been described in oral squamous cell carcinoma(OSCC) and its associated features like lymph node metastasis(LNM). Here, we used the data available from Gene Expression Omnibus(GEO), The Cancer Genome Atlas(TCGA), and Clinical Proteomic Tumor Analysis Consortium(CPTAC) to analyze PAIP1 expression in oral cancer. The publicly available data suggests that PAIP1 mRNA and protein levels were increased in OSCC. The high PAIP1 expression was more evident in samples with advanced stage, LNM, and worse pattern of invasion. Moreover, the in vitro experiments revealed that PAIP1 knockdown attenuated colony forming, the aggressiveness of OSCC cell lines, decreasing MMP9 activity and SRC phosphorylation. Importantly, we found a correlation between PAIP1 and pSRC through the analysis of the IHC scores and CPTAC data in patient samples. Our findings suggest that PAIP1 could be an independent prognostic factor in OSCC with LNM and a suitable therapeutic target to improve OSCC patient outcomes.

关键词： squamous invasion metastasis