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Metabolomic and transcriptomic study to understand changes in metabolic and immune responses in steers under heat stress

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Animal Nutrition 2022年第4期11卷 87-101页

作者： Jun Sik Eom Da Som Park Sang Jin Lee Bon-Hee Gu Shin Ja Lee Sang-Suk Lee Seon-Ho kim byeong-woo kim Sung Sill Lee Myunghoo kim Institute of Agriculture and Life Science Gyeongsang National UniversityJinju52828Republic of Korea Department of Animal Science College of Natural Resources&Life SciencePusan National UniversityMiryang50463Republic of Korea Life and Industry Convergence Research Institute Pusan National UniversityMiryang50463Republic of Korea University-Centered Labs Gyeongsang National UniversityJinju52828Republic of Korea Ruminant Nutrition and Anaerobe Laboratory Department of Animal Science and TechnologySunchon National UniversitySuncheon57922Republic of Korea Division of Applied Life Science(BK21) Gyeongsang National UniversityJinju52828Republic of Korea

Heat stress(HS)damages livestock by adversely affecting physiological and immunological ***,fundamental understanding of the metabolic and immunological mechanisms in animals under HS remains elusive,particularly in *** understand the changes on metabolic and immune responses in steers under HS condition,we performed RNA-sequencing and proton nuclear magnetic resonance spectroscopy-based metabolomics on HS-free(temperature humidity index[THI]value:64.92±0.56)and HS-exposed(THI value:79.13±0.56)Jersey steer(n=8,body weight:559.67±32.72 kg).This study clarifies the metabolic changes in 3 biofluids(rumen fluid,serum,and urine)and the immune responses observed in the peripheral blood mononuclear cells of HS-exposed *** integrated approach allowed the discovery of HS-sensitive metabolic and immunological *** metabolomic analysis indicated that HS-exposed steers showed potential HS biomarkers such as isocitrate,formate,creatine,and riboflavin(P<0.05).Among them,there were several integrative metabolic pathways between rumen fluid and ***,HS altered mRNA expression and immune-related signaling pathways.A meta-analysis revealed that HS decreased riboflavin metabolism and the expression of glyoxylate and dicarboxylate metabolism-related ***,metabolic pathways,such as the hypoxia-inducible factor-1 signaling pathway,were downregulated in immune cells by HS(P<0.05).These findings,along with the datasets of pathways and phenotypic differences as potential biomarkers in steers,can support more in-depth research to elucidate the interrelated metabolic and immunological *** would help suggest new strategies to ameliorate the effects of HS,including disease susceptibility and metabolic disorders,in Jersey steers.

关键词： Heat stress Jersey steer Metabolome Transcriptome Immunity Metabolism

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DISCRETE MINUS ONE NORM LEAST-SQUARES FOR THE STRESS FORMULATION OF LINEAR ELASTICITY WITH NUMERICAL RESULTS

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Journal of Computational Mathematics 2003年第6期21卷 689-702页

作者： Sang Dong kim byeong Chun Shin Seokchan kim Gyungsoo woo Department of Mathematics Kyungpook National University Taegu 702-701 KoreaDepartment of Mathematics Chonnam National University Kwangju 500-757 KoreaDepartment of Mathematics Changwon Nationnal University Changwon 641-773 KoreaDepartment of Mathematics Changwon Nationnal University Changwon 641-773 Korea

This paper studies the discrete minus one norm least-squares methods for the stress formulation of pure displacement linear elasticity in two dimensions. The proposed least-squares functional is defined as the sum of the L2- and H-1-norms of the residual equations weighted appropriately. The minus one norm in the functional is replaced by the discrete minus one norm and then the discrete minus one norm least-squares methods are analyzed with various numerical results focusing on the finite element accuracy and multigrid convergence performances.

关键词： H-1 least-squares Linear elasticity Multigrid method.

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Effect of Al addition on corrosion behavior of high-purity Mg in terms of processing history

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Journal of Magnesium and Alloys 2023年第3期11卷 851-868页

作者： Sang Kyu woo byeong-Chan Suh Ha Sik kim Chang Dong Yim Helmholtz Zentrum Hereon Max-Planck-Straße 1Geesthacht D-21502Germany Korea Institute of Materials Science 797 Changwondae-roSeongsan-guChangwonGyeongnam 51508Republic of Korea University of Science and Technology 217 Gajeong-roYuseong-guDaejeon 34113Republic of Korea

In this study,the effects of Al addition on the corrosion behavior of pure Mg with controlled impurity contents were systematically analyzed according to the processing *** results revealed that the corrosion behavior of high-purity Mg-Al alloys is strongly related to changes in the microstructure,including theβphase and Al-Mn or Al-Fe phases,and the protectiveness of the surface film according to the Al content and processing *** the as-cast alloys,the corrosion rate increased due to the increase ofβphase as the Al content increased,but in the as-extruded alloys,the corrosion rate,which was high due to intermetallic compounds caused by impurities in the low Al alloy,decreased as the Al content increased,and then increased *** is due to the combined effect of the increase of theβphase and decrease of the impurity effect,and the increase of the dissolved Al *** results suggest that it is necessary to analyze the effect of alloying elements on the corrosion behavior of pure Mg with information concerning the impurity content and processing history.

关键词： Mg High purity Mg-Al alloys Processing history Micro-galvanic Surface film

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Effect of Korea red ginseng on cerebral blood flow and superoxide production

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Acta Pharmacologica Sinica 2002年第12期23卷 99-103页

作者： CukSeong kim,Jin Bong PARK,Kwang-Jin kim,Seok Jong CHANG,Sung-woo RYOO,byeong Hwa JEON Department of Physiology College of Medicine Chungnam National University Taejon KOREA Department of Physiology College of Medicine Chungnam National University Taejon KOREA Department of Physiology College of Medicine Chungnam National University Taejon KOREA Department of Physiology College of Medicine Seonam University Namwon KOREA Division of Genomics ＆ Proteomics Korea Research Institute of Bioscience and Biotechnology(KRIBB) Yusong Taejon Korea Correspondence to byeong Hwa JEON MD PhD.Department of Physiology College of Medicine Chungnam National University 6 Munhwa-dong Jung-gu Taejon South Korea 301131

AIM: To investigate the effects of Korea red ginseng (KRG) on the cerebral perfusion rate in the rats and the generation of superoxide anion in the endothelial cells. METHODS: The cerebral perfusion rate was measured using laser-doppler flowmetry before and after the administration of crude saponin (CS) and saponin-free fraction (SFF) of KRG in the anesthetized rats. The superoxide generation was measured by the method based on lucigenin-enhanced chemiluminescence in the cultured endothelial cells. RESULTS: The relative cerebral perfusion rate (rCBF) was significantly increased by the intraperitoneal injection of CS (100 mg/kg) in the rats, but SFF had no effect on the rCBF. Chronic treatment with CS for 7 d significantly inhibited the decrease of forebrain cerebral blood flow induced by clamping both carotid arteries in the rats. Furthermore, CS (0.1 g/L) significantly sup-pressed NADPH-induced superoxide generation in the human umbilical vein endothelial cells (P<0.01). CONCLUSION: The present study d

关键词： Korean red ginseng cerebral blood flow superoxides vascular endothelium

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Evolution of microstructure and tensile properties of cold-drawn hyper-eutectoid steel wires during post-deformation annealing

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Journal of Materials Science & Technology 2020年第6期41卷 1-11页

作者： Majid Jafari Chan-woo Bang Jong-Chan Han Kyeong-Min kim Seon-Hyeong Na Chan-Gyung Park byeong-Joo Lee Department of Materials Science and Engineering POSTECH Pohang 37673 South Korea

Manufacturing temperatures of severely cold-drawn hyper-eutectoid steel wires are sufficiently high to influence the mobility of dislocations and alloy elements,thereby affecting the materials’mechanical ***,we describe the evolution of microstructure and tensile strength of the as-drawn 3.45 GPa steel wire during post-deformation annealing for 30 min at 150-450℃.Annealing at 150℃raised the strength to 3.77 GPa by age-hardening through activation of dislocations pinning by carbon,while further temperature rising up to 450℃caused a severe loss of *** was proved that annealing at 300 and 450℃destabilizes the lamellar microstructure,promoting the formation of carbon-deficient(Fe,Mn,Cr)3 C-type cementite particles with preferentially rounded and partially faceted *** at 450℃yielded the accumulation of Mn and Cr at the ferrite/particle interfaces,and their concentrations at the interfaces were dependent on the interface structure;i.e.,lower concentrations at rounded interfaces(formed through capillarity–driven coarsening of the spheroidized cementite),and higher concentrations at faceted interfaces(that are initially existing in the as-drawn state).Our proof-of-principle observations,supported by thermodynamic calculations and kinetic assessments,provide a pathway for understanding the changes in microstructural and tensile properties during manufacturing of the hyper-eutectoid steel wires.

关键词： Three-dimensional atom probe(3DAP) High resolution transmission electron microscopy(HRTEM) Nano-grained low-carbon steel Annealing Tensile behavior

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Assessment tools for differential diagnosis of neglect: Focusing on egocentric neglect and allocentric neglect

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World Journal of Clinical Cases 2022年第24期10卷 8625-8633页

作者： Sang-Hyeok Lee byeong-Chan Lim Chan-Young Jeong Jun-Hyeok kim woo-Hyuk Jang Department of Occupational Therapy College of Health ScienceKangwon National UniversityGangwon-do 25949South Korea

BACKGROUND There are very few studies on the differential diagnosis between egocentric neglect(EN)and allocentric neglect(AN).AIM To investigate the overall trend of the previously developed assessment tools by conducting a descriptive review of the studies on assessment tools that can perform a differential diagnosis of EN and *** The data were collected by using databases such as Google Scholar,PubMed,and *** most commonly used search terms were“neglect”,“stroke”,“egocentric neglect”,and“allocentric neglect”.RESULTS A total of seven studies that met the inclusion criteria were selected and *** were able to confirm the research process,test method,and differential diagnosis criteria of the seven presented assessment tools from four studies on paper-based tests and three studies on computerized *** majority of the tests were carried out via the cancellation method using stimuli such as everyday objects or *** distinguished the left from right based on the test paper,while AN distinguished the left from right based on *** order to perform differential diagnosis,the difference in the number of left and right responses or non-responses was used based on the EN and AN *** It was confirmed that all the seven assessment tools can effectively perform differential diagnosis of EN and *** study may provide important data that can be used in clinical practice for differential diagnosis and future intervention planning for neglect patients.

关键词： Egocentric neglect Allocentric neglect Brain damage Assessment tools Cancellation

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Contrast evaluation methods for natural color images in display systems: within- and cross-content evaluations

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Journal of Zhejiang University-Science C(Computers and Electronics) 2011年第11期12卷 897-909页

作者： Choon-woo kim School of Information and Communication Engineering Inha University

Contrast evaluation can be used as a criterion to evaluate performance of contrast enhancement algorithms and to compare contrast capability of display systems. This paper deals with contrast evaluation models for natural color images. Two separate models are defined for within- and cross-content evaluations. The former is to differentiate the perceived contrast of the images with the same content. The latter is to discriminate the differences in contrast among the images with different contents. Perception mechanisms are quite different for within- and cross-content evaluations. Local contrast plays an important role in within-content evaluation. In contrast, global contrast dominates the contrast perception for cross-content evaluation. Results of human visual experiments show that the proposed evaluation models outperform previous methods for both within- and cross-content evaluations.

关键词： Contrast evaluation Global contrast Local contrast Within content Cross content Statistical significance

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Microenvironmental regulation of stem cells injected in the area at risk of neurodegenerative diseases

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BIOCELL 2022年第10期46卷 2231-2234页

作者： JU HYUNG LEE IL-KWON kim SANG woo kim SOYEON LIM SEAHYOUNG LEE KI-CHUL HWANG byeong-wooK SONG Graduate Program of Biomedical Engineering Yonsei UniversitySeoul03722Korea Institute for Bio-Medical Convergence College of MedicineCatholic Kwandong UniversityGangwon-do25601Korea Department for Medical Science College of MedicineCatholic Kwandong UniversityGangwon-do25601Korea

The complex mechanism of degenerative diseases and the non-specific modulation of regenerative targets aretopics that need to be elucidated in order to advance the use of stem cells in improvement of neurodegenerative *** pre-transplantation through post-transplantation, there are many changes in the conditions, both inside andoutside of the stem cells that have not been carefully considered. This has hindered development in the field of celltherapy and regeneration. This viewpoint highlights the potential implications of intracellular and extracellularalterations of stem cells in transplanted areas at risk of neurodegenerative disease.

关键词： Cell therapy Microenvironment Neurodegenerative disease Stem cells

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Effect of change of sand properties on travel distance of ricocheted debris

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Defence Technology（防务技术） 2021年第4期17卷 1486-1495页

作者： Yoon Keon kim woo Chun Choi Department of Mechanical Engineering Korea University145 Anam-roSeongbuk-guSeoul02841Republic of Korea

The debris from exploded buildings can ricochet after colliding with the ground,thus increasing the debris travel distance and danger from any associated impacts or *** reduce this danger,the travel distance of ricocheted debris must be accurately *** study analyzed the change in the travel distance of ricocheted concrete debris relative to changes in the properties of a sand *** shear tests were conducted to measure the change in internal friction angle as a function of temperature and water content of the *** element analysis(FEA)was then applied to these variables to predict the speed and angle of the debris after *** FEA results were compared with results of low-speed ricochet experiments,which employed variable temperature and water *** travel distance of the debris was calculated using MATLAB,via trajectory equations considering the drag *** the internal friction angle decreased,the shear stress decreased,leading to deeper penetration of the debris into the *** the loss of kinetic energy increased,the velocity and travel distance of the ricocheted debris *** in the ricochet velocity and travel distance of the debris,according to changes in the internal friction angle,indicated that the debris was affected by the environment.

关键词： Ricochet Exploded debirs Environmental change Sand Temperature Water content Internal friction angle Travel distance

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Characteristics of machined surface controlled by cutting tools and conditions in machining of brittle material

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中国有色金属学会会刊：英文版 2009年第B9期19卷 194-201页

作者： Yong-woo kim Soo-Chang CHOI Jeung-woo PARK Deug-woo LEE Department of Nano Fusion Technology Pusan National University Department of Mechanical Design Engineering Chosun University Department of Nanosystem and Nanoprocess Engineering Pusan National University

One of the ultra-precision machining methods was adapted for brittle material as well as soft material by using multi-arrayed diamond tips and high speed spindle. Conventional machining method is too hard to control surface roughness and surface texture against brittle material because the particles of grinding tools are irregular size and material can be fragile. Therefore, we were able to design tool paths and machine controlled pattern on surface by multi-arrayed diamond tips with uniform size made in MEMS fabrication and high speed spindle, and the maximum speed was about 3×105 r/min. We defined several parameters that can affect the machining surface. Those were multi-array of diamond tips (n×n), speed of air spindle and feeding rate. The surface roughness and surface texture can be controlled by those parameters for micro machining.

关键词：加工表面脆性材料条件控制刀具路径表面粗糙度特征高速主轴加工方法

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