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The Arabidopsis Floral Repressor BFT DelaysFlowering by Competing with FT for FD Bindingunder High Salinity

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molecular Plant 2014年第2期7卷 377-387页

作者： Jae Yong Ryu[a] Hyo-Jun Lee[a] Pil Joon seo[a][b] Jae-Hoon Jung[c] Ji Hoon Ahn[d] Chung-mo Park[a][e] [a] Department of Chemistry Seoul National University Seoul 151-742 Korea [b] Present address: Department of Chemistry Chonbuk National University Jeonju 561-756 Korea [c] The Sainsbury Laboratory University of Cambridge Cambridge UK [d] Creative Research Initiatives Division of Life Sciences Korea University Seoul 136-701 Korea [e] PGBI Seoul National University Seoul 151-742 Korea

Soil salinity is one of the most serious agricultural problems that significantly reduce crop yields in the aridand semi-arid regions. It influences various phases of plant growth and developmental processes, such as seed germina-tion, leaf and stem growth, and reproductive propagation. Salt stress delays the onset of flowering in many plant spe-cies. We have previously reported that the Arabidopsis BROTHER OF FT AND TFL1 （BFT） acts as a floral repressor undersalt stress. However, the molecular mechanisms underlying the BFT function in the salt regulation of flowering inductionis unknown. In this work, we found that BFT delays flowering under high salinity by competing with FLOWERING LOCUST （FT） for binding to the FD transcription factor. The flowering time of FD-deficient fd-2 mutant was insensitive to highsalinity. BFT interacts with FD in the nucleus via the C-terminal domain of FD, which is also required for the interactionof FD with FT, and interferes with the FT-FD interaction. These observations indicate that BFT constitutes a distinct saltstress signaling pathway that modulates the function of the FT-FD module and possibly provides an adaptation strategythat fine-tunes photoperiodic flowering under high salinity.

关键词： Arabidopsis BFT FD flowering time FT salt stress

Efficacy of Saam acupuncture treatment on improvement of immune cell numbers in cancer patients:a pilot study

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Journal of Traditional Chinese Medicine 2014年第5期34卷 550-554页

作者： Dae-Joon Kim seong-Hoon Park Jung-Chul seo Kyung Soon Kim Ki Cheul Sohn Im Hee Shin Hun mo Ryoo Department of Internal Medicine Oriental Medical HospitalDaegu Haany UniversityDaegu 730-090Korea Department of Research Comprehensive and Integrative Medicine InstituteDaegu 705-030Korea Department of Preventive Medicine Hospital of Catholic University of DaeguDaegu 705-718Korea Department of Medical Statistics School of MedicineCatholic University of DaeguDaegu 705-718Korea Department of Internal Medicine School of MedicineCatholic University of DaeguDaegu 705-718Korea

OBJECTIVE: To collect preliminary data on the effects of Saam acupuncture with regard to the immunity in cancer ***: Ten cancer patients were analyzed for improvements in immunity. Acupuncture was applied at the 5 acupuncture points, Jingqu(LU 8), Zutonggu(BL 66), Yanggu(SI 5), Yangchi(TE 4), and Zhongwan(CV 12) for 2 weeks with 4 sessions. We assessed the effect of Korean Saam acupuncture on the immune system in cancer patients by measuring particular blood cell subsets, including CD3 +,CD4+, CD8+, CD19+, and CD56+ cells, as well as total white blood cell count, absolute neutrophil count, and fatigue score. The measurement was performed before and after acupuncture and at a 2-week ***: There was a statistically significant increase in the number of CD3+(P=0.023) and CD8+ cells(P<0.001) and T-cell subsets, as well as a decrease in the fatigue severity scale(FSS) score(P=0.001) after Saam acupuncture using the 5 ***: Acupuncture may improve the immune system by increasing the counts of a few immune cells and relieve fatigue in cancer patients by decreasing FSS scores. Although this was a non-controlled study, it constitutes preliminary research investigating the potential effects of Saam acupuncture in increasing the counts of several immune cells in cancer patients.

关键词： Acupuncture Leukocyte count Neutro-phils Fatigue severity scale Pilot projects

Statistics of oxidation resistance of Ni-(0-15)Co-(8-15)Cr-(0-5)mo-(0-10)W-(3-8)Al-(0-5)Ti-(0-10)Ta-0.1C-0.01B superalloys at 1000℃ by compositional variations

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Rare Metals 2020年第8期39卷 918-927页

作者： Si-Jun Park Kyu-Hyuk Lee seong-moon seo Hi-Won Jeong Young-Soo Yoo HeeJin Jang Multi-Material Research Center Gwangju-Jeonnam DivisionKorea Automotive Technology InstituteGwangju 62207Republic of Korea Department of Advanced Materials Engineering Chosun UniversityGwangju 61452Republic of Korea High Temperature Materials Group Korea Institute of Materials ScienceChangwon 51508Republic of Korea Department of Materials Science and Engineering Chosun UniversityGwangju 61452Republic of Korea

The effects of alloying elements(Co,Cr,mo,W,Al,Ti,and Ta)on the oxidation resistance of Ni-(0-15)Co-(8-15)Cr-(0-5)mo-(0-10)W-(3-8)Al-(0-5)Ti-(0-10)Ta-0.1 C-0.01 B alloys were *** sample compositions were designed by the Box-Behnken method of design of experiments(DOE).The alloying elements show complicated effects on the mass gain due to oxidation,depending on the alloy *** reduces the mass gain *** other elements except Al do not appear to exert a strong effect on the oxidation rate on average,but their influences are shown clearly in the alloys with a low Al ***,W,and Ta reduce the oxidation rate,while Cr,mo,and Ti promote *** is the most effective element in reducing the oxidation rate of the alloy with a low Al *** is confirmed that a continuous Al2O3 layer is essentially required for high oxidation *** oxide scale of easily oxidized alloys has various oxides such as NiCr2O4,NiAl2O4,NiO,Cr2O3,CrTaO4,and TiO2.

关键词： High temperature oxidation Alloy composition Ni-based superalloy Oxidation resistance Design of experiments

Clinical outcomes of targeted therapies in elderly patients aged ≥ 80 years with metastatic colorectal cancer

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World Journal of Clinical Cases 2022年第28期10卷 10066-10076页

作者： Hee Ryeong Jang Hui-Young Lee seo-Young Song Kyu-Hyoung Lim Department of Internal Medicine Kangwon National University HospitalKangwon National University School of MedicineChuncheon-siGangwon-do 24289South Korea

BACKGROUND The 5-fluorouracil-based chemotherapy combined with oxaliplatin or irinotecan is usually used in colorectal cancer(CRC).The addition of a targeted agent(TA) to this combination chemotherapy is currently the standard treatment for metastatic ***,the efficacy and safety of combination chemotherapy for metastatic CRC in patients aged above 80 years has yet to be *** To assess the clinical outcomes and feasibility of combination chemotherapy using a TA in extremely elderly patients with *** Eligibility criteria were:(1) Age above 80 years;(2) Metastatic colorectal cancer;(3) Palliative chemotherapy na?ve;(4) Eastern Cooperative Oncology Group performance status 0-1;and(5) Adequate organ *** received at least one dose of combination chemotherapy with or without *** was evaluated every 8 *** Of 30 patients,the median age of 15 patients treated with TA was 83.0 years and that of those without TA was 81.3 *** median progression-free survival(PFS) and overall survival(OS) in patients treated with TA were 7.4 mo and 15.4 mo,respectively,compared with 4.4 mo and 15.6 mo,respectively,in patients treated without *** was no significant difference in PFS(P:0.193) and OS(P:0.748) between patients treated with and without *** grade 3/4 hematologic toxicities were anemia(16.7%) and neutropenia(10.0%).After disease progression,the median OS of patients who were treated with and without salvage chemotherapy were 23.5 mo and 7.0 mo,respectively,suggesting significant difference in OS(P = 0.001).CONCLUSION Combination chemotherapy with TA for metastatic CRC may be considered feasible in patients aged above 80 years,when with careful *** chemotherapy can help improve OS in some selected of these elderly patients.

关键词： Combination chemotherapy Targeted agent Colorectal cancer Salvage chemotherapy Elderly patient

Auxin Mediates Adaptation Responses to Both Biotic and Abiotic Stresses in Arabidopsis

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Auxin Mediates Adaptation Responses to Both Biotic and Abiot...

Successful kidney transplantation from an expanded criteria donor with long-term extracorporeal membrane oxygenation treatment: A case report

The 3rd Asian and Oceanian Conference on Photobiology

作者： Jung-Eun Park Suk Ki Kang Hye-kyoung Youn Pil Joon seo Chung-mo Park molecular Signaling Laboratory Department of ChemistrySeoul National UniversitySeoul 151-742Korea molecular Signaling Laboratory Department of ChemistrySeoul National UniversitySeoul 151-742Korea molecular Signaling Laboratory Department of ChemistrySeoul National UniversitySeoul 151-742Korea molecular Signaling Laboratory Department of ChemistrySeoul National UniversitySeoul 151-742Korea molecular Signaling Laboratory Department of ChemistrySeoul National UniversitySeoul 151-742Korea

＜正＞Plants monitor environmental fluctuations constantly to optimize their growth and metabolism;one example is adaptation to biotic and abiotic stresses. Here, we demonstrate that auxin homeostasis is an essential constituent of the complex network of auxin actions that mediates stress adaptation responses. The endogenous auxin pool is regulated through negative feedback by a group of auxin-inducible GH3 genes that encode auxin-conjugating enzymes. The Arabidopsis mutant wesl-D exhibits auxin-deficient traits and was found to overexpress a GH3 gene, WES1. Interestingly, WES1 is activated by pathogenic infections and abiotic stresses as well as by salicylic acid and abscisic acid. Accordingly, wes1-D is resistant to both biotic and abiotic stresses, and stress-regulated genes, including PR-1 and CBFs, are up-regulated in this mutant. We propose that GH3-mediated growth suppression directs reallocation of metabolic resources to resistance responses and provides a role for auxin in the fitness costs of induced resistance in plants.

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World Journal of Clinical Cases 2020年第3期8卷 540-545页

作者： Hye Won seo Sua Lee Hwa Young Lee Sun Cheol Park Byung Ha Chung Chul Woo Yang Tae Hyun Ban Division of Nephrology Department of Internal MedicineSeoul St.Mary’s HospitalCollege of MedicineThe Catholic University of KoreaSeoul 06591South Korea Transplant Research Center Department of Internal MedicineSeoul St.Mary’s HospitalCollege of MedicineThe Catholic University of KoreaSeoul 06591South Korea Division of Nephrology Department of Internal MedicineJeju National University HospitalJeju-do 63241South Korea Department of Surgery Seoul St.Mary’s HospitalCollege of MedicineThe Catholic University of Korea222 Banpo-daeroSeoul 06591South Korea Division of Nephrology Department of Internal MedicineEunpyeong St.Mary’s HospitalCollege of MedicineThe Catholic University of KoreaEunpyeong-guSeoul 03312South Korea

BACKGROUND Due to a shortage of donor kidneys, many centers have utilized graft kidneys from brain-dead donors with expanded criteria. Kidney transplantation(KT)from donors on extracorporeal membrane oxygenation(ECmo) has been identified as a successful way of expanding donor pools. However, there are currently no guidelines or recommendations that guarantee successful KT from donors undergoing ECmo treatment. Therefore, acceptance of appropriate allografts from those donors is solely based on clinician *** SUMMARY We report a case of successful KT from a brain-dead donor supported by ECmo for the longest duration to date. A 69-year-old male received a KT from a 63-yearold brain-dead donor who had been on therapeutic ECmo treatment for the previous three weeks. The recipient experienced slow recovery of graft function after surgery but was discharged home on post-operative day 17 free from hemodialysis. Allograft function gradually improved thereafter and was comparatively acceptable up to the 12 mo follow-up, with serum creatinine level of 1.67 mg/d *** This case suggests that donation even after long-term ECmo treatment could provide successful KT to suitable candidates.

关键词： Extracorporeal membrane oxygenation Kidney transplantation Delayed graft function Donor selection Case report

Iatrogenic aortic dissection during right transradial intervention in a patient with aberrant right subclavian artery:A case report

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World Journal of Clinical Cases 2022年第27期10卷 9897-9903页

作者： Kyungeun Ha Albert Youngwoo Jang Yong Hoon Shin Joonpyo Lee Jeongduk seo seok In Lee Woong Chol Kang Soon Yong Suh Division of Cardiology Department of Internal MedicineYonsei University College of Medicine50 Yonsei-roSeodaemun-guSeoulSouth Korea Division of Cardiology Department of Internal MedicineGil Medical CenterGachon University College of MedicineIncheonSouth Korea Department of Thoracic and Cardiovascular Surgery Gil Medical CenterGachon University College of MedicineIncheonIncheonSouth Korea

BACKGROUND Aberrant right subclavian artery(ARSA)is the most common congenital anomaly of the aortic *** patients having such anomalies receive transradial intervention(TRI),aortic dissection(AD)may ***,we discuss a case of iatrogenic type B AD occurring during right TRI in an ARSA patient,that was later salvaged by percutaneous *** SUMMARY A 73-year-old man presented to our hospital with intermittent chest *** computed tomography(CT)angiography revealed significant stenosis in the left anterior descending *** coronary angiography was performed via the right radial artery without ***,we were unable to advance the guiding catheter past the ostium of the right subclavian artery to the aortic arch for percutaneous coronary intervention,while the guidewire tended to go down the descending *** patient suddenly complained of chest and back *** CT aortography revealed type B AD propagating to the left renal artery(RA)with preserved renal ***,after 2 d,the patient suddenly complained of right lower limb pain where the femoral pulse was suddenly ***-up CT indicated further progression of dissection to the right external iliac artery(EIA)and left RA with limited *** performed percutaneous angioplasty of the right EIA and left RA without ***-up CT aortography at 8 mo showed optimal *** A caution is required during right TRI in ARSA to avoid *** angioplasty can be a treatment option.

关键词： Aberrant subclavian artery Coronary angiography Aortic dissection Aortography Percutaneous transluminal angioplasty Case report

Comparison of gemcitabine plus nab-paclitaxel and FOLFIRINOX in metastatic pancreatic cancer

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World Journal of Clinical Cases 2020年第17期8卷 3718-3729页

作者： Sung Yong Han Dong Uk Kim Young Mi seol Suk Kim Nam Kyung Lee Seung Baek Hong Hyung-Il seo Department of Internal Medicine and Biomedical Research Institute Division of GastroenterologyPusan National University HospitalBusan 49241South Korea Department of Hematology-Oncology Biomedical Research InstitutePusan National University HospitalBusan 49241South Korea Department of Radiology Biomedical Research InstitutePusan National University HospitalBusan 49241South Korea Department of Surgery Biomedical Research InstitutePusan National University HospitalBusan 49241South Korea

BACKGROUND Gemcitabine plus nab-paclitaxel(GA)and modified FOLFIRINOX(FFX)have been widely used as standard first-line treatment in pancreatic ***,it is unclear which regimen is more *** To evaluate a retrospective analysis comparing the efficacy and safety of FFX and GA as first-line chemotherapeutic regimens in patients with metastatic pancreatic *** We retrospectively analyzed and compared outcomes in 101 patients who presented with pancreatic cancer and were treated with either GA(n=54)or FFX(n=47).moreover,we performed subgroup analysis based on the neutrophil/lymphocyte ratio(NLR)and Eastern Cooperative Oncology Group(ECOG)performance *** There were no significant differences between two groups in baseline characteristics,except for the ECOG performance *** median progression-free survival(PFS)(6.43 mo vs 4.90 mo,P=0.058)was comparable between two groups;however,median overall survival(OS)(10.17 mo vs 6.93 mo,P=0.008)was longer in patients who received GA *** patients with ECOG 0(PFS:8.93 mo vs 5.43 mo,P=0.002;OS:16.10 mo vs 6.97 mo,P=0.000)and those with NLRmo vs 6.57 mo,P=0.008;OS:12.87 mo vs 9.93 mo,P=0.002),GA regimen showed higher *** GA regimen may be recommended to the patients with NLR<3 or ECOG 0 status although GA and FFX showed comparable efficacy outcomes in patients with metastatic pancreatic cancer.

关键词： Metastatic pancreatic carcinoma Chemotherapy FOLFIRINOX Nabpaclitaxel plus gemcitabine Predict marker Adverse event

Multimodal treatments of right gastroepiploic arterial leiomyosarcoma with hepatic metastasis:A case report and review of the literature

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World Journal of Clinical Cases 2018年第8期6卷 219-223页

作者： Hyung-Il seo Dong-Il Kim Youngsoo Chung Chang In Choi Minjoo Kim Sungpil Yun Suk Kim Do Youn Park Department of Surgery Biomedical Research InstitutePusan National University Hospital Department of Surgery Pusan National University Yangsan Hospital Department of Surgery On Hospital Department of Radiology Biomedical Research Institute Pusan National University Hospital Department of Pathology Biomedical Research Institute Pusan National University Hospital

Leiomyosarcoma of an artery is very rare, and cases with hepatic metastasis are even rarer. We describe a case of a 70-year-old man who after follow up due to rectal cancer, presented with an intra-abdominal hypervascular mass and a hepatic mass. After surgical resection, it was diagnosed as a leiomyosarcoma of the right gastroepiploic artery with hepatic metastasis. Multiple metastases had recurred at the liver. He has survived more than 53 mo through multimodal treatments(three surgical resections, radiofrequency ablation, transarterial chemoembolization, chemotherapies, and targeted therapy). Multimodal treatments, including active surgical resection, may behelpful in the treatment of aggressive diseases such as arterial leiomyosarcoma with metastasis.

关键词： Multimodal treatments Intra-abdominal arterial leiomyosarcoma Hepatic metastasis Arterial leiomyosarcoma Surgical resection