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A new nano approach to prevent tumor growth in the local treatment of glioblastoma: Temozolomide and rutin-loaded hybrid layered composite nanofiber

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Asian Journal of Pharmaceutical Sciences 2024年第6期19卷 101-122页

作者： Melis Ercelik Cagla Tekin Melisa Gurbuz Yagmur Tuncbilekli Hazal Yılmaz Dogan busra mutlu Pınar Eser Gulcin Tezcan Fatma Nur Parın Kenan Yildirim Mehmet Sarihan Gurler Akpinar Murat Kasap Ahmet Bekar Hasan Kocaeli Mevlut Ozgur Taskapilioglu Secil Ak Aksoy Rıfat Ozpar Bahattin Hakyemez Berrin Tunca Department of Medical Biology Faculty of MedicineBursa Uludag UniversityBursaTurkey Department of Neurosurgery Faculty of MedicineBursa Uludag UniversityBursaTurkey Department of Metallurgical and Materials Engineering Bursa Technical UniversityBursaTurkey Central Research Laboratory Bursa Technical UniversityBursaTurkey Department of Fundamental Sciences Faculty of DentistryBursa Uludag UniversityBursaTurkey Department of Polymer Materials Engineering Faculty of Engineering and Natural SciencesBursa Technical UniversityBursaTurkey Department of Medical Biology/Proteomics Laboratory Kocaeli UniversityKocaeliTurkey Department of Neurosurgery Faculty of MedicineIstanbul Yeni Yuzyıl UniversityIstanbulTurkey Inegol Vocation School Bursa Uludag UniversityBursaTurkey Department of Radiology Faculty of MedicineBursa Uludag UniversityBursaTurkey

Total resection of glioblastoma(GB)tumors is nearly impossible,and systemic administration of temozolomide(TMZ)is often *** study presents a hybrid layered composite nanofiber network(LHN)designed for localized treatment in GB tumor *** LHN,consisting of polyvinyl alcohol and core-shell polylactic acid layers,was loaded with TMZ and *** vitro analysis revealed that LHN^(TMZ) and LHNrutin decelerated epithelial-mesenchymal transition and growth of stem-like cells,while the combination,LHN^(TMZ)+rutin,significantly reduced sphere size compared to untreated and LHNTMZ-treated cells(P<0.0001).In an orthotopic C6-induced GB rat model,LHNTMZ+rutin therapy demonstrated a more pronounced tumor-reducing effect than LHNTMZ *** volume,assessed by magnetic resonance imaging,was significantly reduced in LHN^(TMZ)+rutin-treated rats compared to untreated *** changes in tumor mitochondria,reduced membrane potential,and decreased PARP expression indicated the activation of apoptotic pathways in tumor cells,which was further confirmed by a reduction in PHH3,indicating decreased mitotic activity of tumor ***,the local application of LHNs in the GB model mitigated aggressive tumor features without causing local tissue inflammation or adverse systemic *** was evidenced by a decrease in the angiogenesismarker CD31,the absence of inflammation or necrosis in H&E staining of the cerebellum,increased production of IFN-γ,decreased levels of interleukin-4 in splenic T cells,and lower serum AST *** findings collectively indicate that LHN^(TMZ)+rutin is a promising biocompatible model for the local treatment of GB.

关键词： Glioblastoma Local treatment Temozolomide Rutin Hybrid layered composite nanofiber network

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Some Properties of Probiotic Yoghurt Ice Cream Supplemented with Carob Extract and Whey Powder

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Advances in Microbiology 2016年第14期6卷 1010-1020页

作者： mutlu B. Guler-Akin busra Goncu Musa Serdar Akin Department of Food Engineering Agricultural Faculty Harran University sanl&#108 urfa Turkey

In this study, some properties of probiotic yoghurt ice cream supplemented with carob extract and whey powder and viability of L. acidophilus and Bifidobacterium BB-12 on ice-cream were investigated. For this purpose 6 different ice cream was produced with different ratios whey powder and carob extract. The viable probiotic bacteria counts were determined on 1st, 7th, 30th, 60th and 90th days of storage. Addition of carob extract and whey powder significantly affected all properties of ice-creams. Results showed that the most positive effect on physical, sensory and microbiological properties was observed on sample D which produced with 1% carob extract and 1% whey powder addition.

关键词： Probiotic Yoghurt Ice-Cream Carob Extract Whey Powder

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Some Properties of Bio-Yogurt Enriched with Cellulose Fiber

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Advances in Microbiology 2018年第1期8卷 54-64页

作者： mutlu B.Güler-Akin busra Goncu M.Serdar Akin Department of Food Engineering Engineering FacultyHarran UniversitySanliurfaTurkey

In this study, bio-yogurts, which contain L. acidophilus and Bifidobacterium animalis subsp. lactis, were produced with cellulose fiber (CF) addition at a various level (0%, 0.5%, 1% and 2%) and stored at 4°C ± 1°C for 20 days. Bio-yogurts were analysed 1, 10 and 20 days after production. The storage period significantly influenced overall properties of the samples. Addition of CF has positively affected the physical and textural properties of yoghurt, such as serum separation, water holding capacity, viscosity, firmness, adhesiveness, cohesiveness, springiness, gumminess and chewiness (p < 0.05). It also slightly stimulated the development of probiotic bacteria (p < 0.05). Bio-yogurt, which contains 0.5% CF in sensory aspect, is the most appreciated.

关键词： Bio-Yogurt Cellulose Fiber Prebiotic Effect Yogurt Quality

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