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Insights into the molecular mechanisms underlying responses of apple trees to abiotic stresses

Horticulture Research 2023年第8期10卷 310-323页

作者： Xuewei Li Ziqing Ma Yi Song Wenyun Shen Qianyu Yue Abid khan Muhammad Mobeen Tahir Xiaofei Wang Mickael Malnoy Fengwang Ma Vincent bus Shuangxi Zhou Qingmei Guan State Key Laboratory of Crop Stress Biology for Arid Areas/Shaanxi Key Laboratory of Apple College of HorticultureNorthwest A&F UniversityYanglingShaanxi 712100China Department of Horticulture The University of HaripurHaripur 22620Pakistan State Key Laboratory of Crop Biology Shandong Collaborative Innovation Center for Fruit and Vegetable Production with High Quality and EfficiencyCollege of Horticulture Science and EngineeringShandong Agricultural UniversityTai-AnShandong 271000China Research and Innovation Centre Fondazione Edmund MachSan Michele all’Adige 38098Italy The New Zealand Institute for Plant and Food Research Limited Havelock North 4157New Zealand Department of Biological Sciences Macquarie UniversityNorth RydeNSW 2109Australia

Apple(Malus×domestica)is a popular temperate fruit crop ***,its growth,productivity,and quality are often adversely affected by abiotic stresses such as drought,extreme temperature,and high *** to the long juvenile phase and highly heterozygous genome,the conventional breeding approaches for stress-tolerant cultivars are time-consuming and *** issues may be resolved by feasible molecular breeding techniques for apples,such as gene editing and marker-assisted ***,it is necessary to acquire a more comprehensive comprehension of the molecular mechanisms underpinning apples’response to abiotic *** this review,we summarize the latest research progress in the molecular response of apples to abiotic stressors,including the gene expression regulation,protein modifications,and epigenetic *** also provide updates on new approaches for improving apple abiotic stress tolerance,while discussing current challenges and future perspectives for apple molecular breeding.

关键词： breeding mechanisms consuming

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城市公共交通 2025年第1期319卷 82页

作者： Shenzhen Eastern bus Co.,Ltd 深圳市东部公共交通有限公司

“陈新华劳模和工匠人才创新工作室”正式揭牌成立2024年11月28日上午，“陈新华劳模和工匠人才创新工作室”在东部公交一分公司华龙车队正式揭牌成立，标志着东部公交在劳模引领创新发展道路上迈出了坚实而意义深远的一步。“陈新华劳...

“陈新华劳模和工匠人才创新工作室”正式揭牌成立2024年11月28日上午，“陈新华劳模和工匠人才创新工作室”在东部公交一分公司华龙车队正式揭牌成立，标志着东部公交在劳模引领创新发展道路上迈出了坚实而意义深远的一步。“陈新华劳模和工匠人才创新工作室”是以全国十大“最美公交司机”陈新华为领军人物，由基层服务人员、驾驶员及修理工组成的公司级劳模创新工作室团队，目前成员共计5人。

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Impact of selection of DC base values and DC link control strategies on sequential AC-DC power-flow convergence

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Frontiers in Energy 2015年第4期9卷 399-412页

作者： Shagufla khan Suman BHOWMICK Department of Electrical Engineering Delhi Technological University Delhi 110042 India

This paper demonstrates the convergence of the integrated AC-DC power-flow algorithm as affected by the selection of different base values for the DC quantities and adoption of different control strategies for the DC link. For power-flow modeling of integrated AC-DC systems, the base values of the various DC quantities can be defined in several ways, giving rise to different sets of per-unit system equations. It is observed that different per-unit system models affect the convergence of the power-flow algorithm differently. In a similar manner, the control strategy adopted for the DC link also affects the power- flow convergence. The sequential method is used to solve the DC variables in the Newton raphson （NR） power flow model, where AC and DC systems are solved separately and are coupled by injecting an equivalent amount of real and reactive power at the terminal AC buses. Now, for a majority of the possible control strategies, the equivalent real and reactive power injections at the concerned buses can be computed a-priori and are independent of the NR iterative loop. However, for a few of the control strategies, the equivalent reactive power injections cannot be computed a-priori and need to be computed in every NR iteration. This affects the performance of the iterative process. Two different per-unit system models and six typical control strategies are taken into consideration. This is validated by numerous case studies conducted on the IEEE 118-bus and 300-bus test systems.

关键词： AC-DC power-flow Newton-raphsonmethod high voltage direct current (HVDC) controlstrategy

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Different priming strategies improve distinct therapeutic capabilities of mesenchymal stromal/stem cells:Potential implications for their clinical use

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World Journal of Stem Cells 2023年第5期15卷 400-420页

作者： Vitale Miceli Giovanni Zito Matteo Bulati Alessia Gallo Rosalia busà Gioacchin Iannolo Pier Giulio Conaldi Department of Research IRCCS ISMETT(Istituto Mediterraneo per i Trapianti e Terapie ad alta Specializzazione)Palermo 90127Italy

Mesenchymal stromal/stem cells(MSCs)have shown significant therapeutic potential,and have therefore been extensively investigated in preclinical studies of regenerative ***,while MSCs have been shown to be safe as a cellular treatment,they have usually been therapeutically ineffective in human *** fact,in many clinical trials it has been shown that MSCs have moderate or poor *** inefficacy appears to be ascribable primarily to the heterogeneity of ***,specific priming strategies have been used to improve the therapeutic properties of *** this review,we explore the literature on the principal priming approaches used to enhance the preclinical inefficacy of *** found that different priming strategies have been used to direct the therapeutic effects of MSCs toward specific pathological ***,while hypoxic priming can be used primarily for the treatment of acute diseases,inflammatory cytokines can be used mainly to prime MSCs in order to treat chronic immune-related *** shift in approach from regeneration to inflammation implies,in MSCs,a shift in the production of functional factors that stimulate regenerative or anti-inflammatory *** opportunity to fine-tune the therapeutic properties of MSCs through different priming strategies could conceivably pave the way for optimizing their therapeutic potential.

关键词： Mesenchymal stromal/stem cells Mesenchymal stromal/stem cell therapeutic properties Mesenchymal stromal/stem cell paracrine effects Mesenchymal stromal/stem cell priming Pro-inflammatory priming Hypoxic priming,3D culture priming

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Ultrasound-enhanced milling in the synthesis of phase-pure, highly crystalline ZnAl-layered double hydroxide of low Zn（II） content

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Particuology 2016年第4期14卷 29-33页

作者： M.Szabados Cs. bus M. Adok-Sipiczki Z. Konya A. Kukovecz P. Sipos I. Palinko Department Qf Organic Chemistry University of Szeged Domter 8 Szeged H-6720 Hungary Material and Solution Structure Research Group Institute of Chemistry University of Szeged Aradi Vertanflk tere 1 Szeged H-6720 Hungary Department of Applied and Environmental Chemistry University of Szeged Rerrich B. ter 1 Szeged H-6720. Hungary MTA-SZTE Reaction Kinetics and Surface Chemistry Research Croup Rerrich B ter 1 Szeged H-6720 Hungary MTA-SZTE "Lendulet" Porous Nanocomposites Research Group Rerrich B. ter 1 Szeged H-6720 Hungary Department of lnorganic and Analytical Chemistry University of Szeged Domter 7 Szeged H-6720 Hungary

Dry milling followed by ultrasonic irradiation in the presence of small amounts of aqueous NaOH, was used to synthesise ZnAl-layered double hydroxide （LDH）. The synthetic conditions were optimised and the Zn（OH）2, ZnO, and AI（OH）3 contaminants were removed by rinsing with aqueous NH3 solution from the sample prepared in the optimum conditions. Thus, phase-pure ZnAl-layered double hydroxide was obtained with high crystallinity. All materials produced during the syntheses were characterised by X- ray diffractometry, and a rose-like morphology was observed by scanning electron microscopy in the phase-pure sample. By changing the initial Zn/Al ratio, it was revealed that an LDH with low zinc content was always formed, probably through substitution of some of the Zn2. ions by AI3. ions in the gibbsite lattice.

关键词： ZnAl-layered double hydroxide Dry milling Ultrasonic irradiation

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Carbon nanodots:a new precursor to achieve reactive nanoporous HOPG surfaces

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Nano Research 2020年第12期13卷 3425-3432页

作者： Cristina Gutiérrez-Sánchez Emiliano Martínez-Periñán Carlos busó-Rogero Mónica Revenga-Parra Félix Pariente Encarnación Lorenzo Departamento de Química Analítica y Análisis Instrumental Universidad Autónoma de MadridCampus de CantoblancoMadrid28049Spain Institute for Advanced Research in Chemical Sciences(IAdChem) Universidad Autónoma de MadridCampus de CantoblancoMadrid28049Spain IMDEA-Nanoscience.Faraday 9 Campus Cantoblanco-UAMMadrid28049Spain

In the present work we develop an electrochemical assisted method to form nanopores on the surface of highly oriented pyrolytic graphite(HOPG),which was accomplished by a simple electrochemical route and a scalable nanomaterial,carbon nanodots,without applying high voltages,high temperatures or toxic *** electrodes are in a solution of N-enrich carbon nanodots in acidic media and the potential scans applied on HOPG lead to the formation of a spatially inhomogeneous porous *** diameter of the resulting nanopores can be tuned by controlling the number of electrochemical reduction *** resulting nanoporous surfaces are characterized by atomic force microscopy,raman spectroscopy,scanning electrochemical microscopy,electrochemical impedance spectroscopy and *** nanoporous HOPG showed high *** the potential of these surfaces to the development of energy storage devices is demonstrated.

关键词： nanoporous highly oriented pyrolytic graphite(HOPG) carbon nanodots supercapacitor

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Molecular characterization of intergeneric hybrids between Malus and Pyrus

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Horticulture Research 2023年第1期10卷 172-182页

作者： Giulia Pasqualetto Luisa Palmieri Stefan Martens Vincent G.M.bus David Chagné Claudia Wiedow Mickael A.Malnoy Susan E.Gardiner Research and Innovation Centre Edmund Mach FoundationSan Michele all’AdigeTN 38010Italy Department of Agricultural FoodEnvironmental and Animal SciencesUniversity of UdineUD 33100Italy The New Zealand Institute for Plant and Food Research Ltd(PFR) Hawke’s Bay Research CentreHavelock North 4442New Zealand PFR Fitzherbert Science CentrePalmerston NorthNew Zealand

Apple(Malus)and pear(Pyrus)are economically important fruit crops well known for their unique textures,f lavours,and nutritional *** genera are characterised by a distinct pattern of secondary metabolites,which directly affect not only resistance to certain diseases,but also have significant impacts on the f lavour and nutritional value of the *** identical chromosome numbers,similar genome size,and their recent divergence date,together with DNA markers have shown that apple and pear genomes are highly *** study utilized comparative genomic approaches,including simple sequence repeats,high resolution single nucleotide polymorphism melting analysis,and single nucleotide polymorphism chip analysis to identify genetic differences among hybrids of Malus and Pyrus,and F2 *** research has demonstrated and validated that these three marker types,along with metabolomics analysis are very powerful tools to detect and confirm hybridity of progeny derived from crosses between apple and pear in both cross ***,this work analysed the genus-specific metabolite patterns and the resistance to fire blight(Erwinia amylovora)in *** findings of this work will enhance and accelerate the breeding of novel tree fruit crops that benefit producers and consumers,by enabling marker assisted selection of desired traits introgressed between pear and apple.

关键词： crops utilized breeding

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An Adaptive Data-driven Method Based on Fuzzy Logic for Determining Power System Voltage Status

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Journal of Modern Power Systems and Clean Energy 2024年第3期12卷 707-718页

作者： Sirwan Shazdeh Hêmin Golpîra Hassan Bevrani the SMGRC University of KurdistanSanandajIran Power Systems Modeling&Simulation Lab Department of Electrical EngineeringUniversity of KurdistanKurdistanSanandaj 66177-15175Iran

This paper proposes an adaptive method based on fuzzy logic that utilizes data from phasor measurement units(PMUs) to assess and classify generating-side voltage trajectories. The voltage variable and its associated derivatives are used as the input variables of a fuzzy-logic block. In addition, the voltage trajectory is compared with the pre-selected pilot-bus voltage to make a reliable decision about the voltage operational state. Different types of short-term voltage dynamics are considered in the proposed method. The fuzzy membership functions are determined using a systematic method that considers the current situation of the voltage trajectory. Finally, the voltage status is categorized into four classes to determine appropriate remedial actions. The proposed method is validated on a IEEE 73-bus power system in a MATLAB environment.

关键词： Fuzzy logic fault-induced delayed voltage recovery phasor measurement unit(PMU) short-term voltage stability situational awareness voltage classification

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Hepatocellular carcinoma,hepatitis C virus infection and miRNA involvement:Perspectives for new therapeutic approaches

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World Journal of Gastroenterology 2022年第22期28卷 2417-2428页

作者： Ester Badami Rosalia busà Bruno Douradinha Giovanna Russelli Vitale Miceli Alessia Gallo Giovanni Zito Pier Giulio Conaldi Gioacchin Iannolo Regenerative Medicine and Immunotherapy Area Fondazione Ri.MEDPalermo 90127Italy Department of Research Mediterranean Institute for Transplantation and Advanced Specialized Therapies(IRCCS-ISMETT)Palermo 90127Italy

Chronic hepatitis C virus(HCV)infection is the principal etiology of cirrhosis and,ultimately,hepatocellular carcinoma(HCC).At present,approximately 71 million people are chronically infected with HCV,and 10%–20%of these are expected to develop severe liver complications throughout their *** evidence has clearly shown the causal association between miRNAs,HCV infection and *** it is not completely clear whether miRNA dysregulation in HCC is the cause or the consequence of its development,variations in miRNA patterns have been described in different liver diseases,including *** studies have analyzed the importance of circulating miRNAs and their effect on cell proliferation and *** this Review,we aim to summarize current knowledge on the association between miRNA,HCV and HCC from a diagnostic point of view,and also the potential implications for therapeutic approaches.

关键词： Hepatocellular carcinoma miRNA Liver Hepatitis C virus miRNAs Directacting antivirals Extracellular vesicles Transplantation

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Mesenchymal stromal cell secretome in liver failure:Perspectives on COVID-19 infection treatment

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World Journal of Gastroenterology 2021年第17期27卷 1905-1919页

作者： Cinzia Maria Chinnici Giovanna Russelli Matteo Bulati Vitale Miceli Alessia Gallo Rosalia busà Rosaria Tinnirello Pier Giulio Conaldi Gioacchin Iannolo Department of Research Mediterranean Institute for Transplantation and Advanced Specialized Therapies(IRCCS-ISMETT)Palermo 90127Italy Department of Regenerative Medicine Fondazione Ri.MEDPalermo 90127Italy Neuroscience Unit CNR Institute of Biomedicine and Molecular ImmunologyPalermo 90146Italy

Due to their immunomodulatory potential and release of trophic factors that promote healing,mesenchymal stromal cells(MSCs)are considered important players in tissue homeostasis and *** have been widely used in clinical trials to treat multiple conditions associated with inflammation and tissue *** evidence suggests that most of the MSC therapeutic effects are derived from their secretome,including the extracellular vesicles,representing a promising approach in regenerative medicine application to treat organ failure as a result of inflammation/*** recent outbreak of respiratory syndrome coronavirus,caused by the newly identified agent severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),has forced scientists worldwide to use all available instruments to fight the infection,including the inflammatory cascade caused by this pandemic *** use of MSCs is a valid approach to combat organ inflammation in different *** addition to the lungs,which are considered the main inflammatory target for this virus,other organs are compromised by the *** particular,the liver is involved in the inflammatory response to SARS-CoV-2 infection,which causes organ failure,leading to death in coronavirus disease 2019(COVID-19)*** herein summarize the current implications derived from the use of MSCs and their soluble derivatives in COVID-19 treatment,and emphasize the potential of MSCbased therapy in this clinical setting.

关键词： Mesenchymal stromal cell COVID-19 SARS-CoV-2 Organ failure Inflammation Transplantation

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